Article
Cell & Tissue Engineering
Zujia Wang, Hongting Chen, Peiyun Wang, Miaojin Zhou, Guangxu Li, Zhiqing Hu, Qian Hu, Junya Zhao, Xionghao Liu, Lingqian Wu, Desheng Liang
Summary: Mesenchymal stem cells (MSCs) have shown promise as a cellular vehicle for delivering anti-cancer factors to tumors. In this study, TRAIL was specifically integrated into the rDNA locus of human-induced pluripotent stem cells (iPSCs) using a non-viral vector and TALENickases. The genetically modified iPSCs were then differentiated into TRAIL-expressing MSCs, which demonstrated strong anti-tumor effects on various cancers both in vitro and in vivo.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Anatomy & Morphology
Daria S. Chulpanova, Zarema E. Gilazieva, Elvira R. Akhmetzyanova, Sevindzh K. Kletukhina, Albert A. Rizvanov, Valeriya V. Solovyeva
Summary: The study aimed to produce vesicles from mesenchymal stem cells with simultaneous overexpression of TRAIL, PTEN, and IFN-beta 1, and found that these vesicles could activate immune cells and induce apoptosis in various types of carcinomas in vitro. Further studies on animal models in vivo are required to fully understand the immunomodulatory and antitumor properties of these vesicles.
Review
Biochemistry & Molecular Biology
Blazej Nowak, Piotr Rogujski, Miroslaw Janowski, Barbara Lukomska, Anna Andrzejewska
Summary: Mesenchymal stem cells (MSCs) show potential in the treatment of glioblastoma (GBM), with possibilities of anti-tumor properties as well as risks of increasing tumor aggressiveness.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Oncology
Maria Patrizia Mongiardi, Mariachiara Buccarelli, Alessia Formato, Elisa Orecchini, Maria Salbini, Valentina Ricci, Tiziana Orsini, Sabrina Putti, Silvia Chiesa, Lucia Ricci-Vitiani, Quintino Giorgio D'Alessandris, Roberto Pallini, Andrea Levi, Maria Laura Falchetti
Summary: Glioblastoma is an aggressive primary brain tumor with poor prognosis. A recent clinical trial showed that the multikinase inhibitor regorafenib can significantly increase the overall survival of glioblastoma patients. However, little is known about the molecular mechanisms of regorafenib's effectiveness. This study found that regorafenib can limit glioblastoma cell proliferation but might also induce an invasive phenotype.
Review
Immunology
Ehsan Razeghian, Wanich Suksatan, Heshu Sulaiman Rahman, Dmitry O. Bokov, Walid Kamal Abdelbasset, Ali Hassanzadeh, Faroogh Marofi, Mahboubeh Yazdanifar, Mostafa Jarahian
Summary: TRAIL, as an immune cytokine, has the ability to selectively eliminate tumor cells but faces resistance issues. Studies have shown that overcoming TRAIL resistance can be achieved through combined treatment with other antitumor agents, the utilization of human MSCs and NPs for TRAIL delivery. These approaches show promise in enhancing the therapeutic efficacy and survival rate in cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Adriana G. Quiroz-Reyes, Paulina Delgado-Gonzalez, Jose F. Islas, Adolfo Soto-Dominguez, Carlos A. Gonzalez-Villarreal, Gerardo R. Padilla-Rivas, Elsa N. Garza-Trevino
Summary: This study evaluated the cytotoxic and proapoptotic activity of soluble TRAIL overexpressed by mesenchymal stem cells (MSC) in an oxaliplatin-resistant CRC cell line. The results demonstrated that oxaliplatin can enhance the apoptotic activity induced by soluble TRAIL.
Article
Biochemistry & Molecular Biology
Yeon-Jee Kahm, Uhee Jung, Rae-Kwon Kim
Summary: CTNNAL1 is a protein involved in cell-cell adhesion and has been found to have various roles in cancer development and progression. It acts as a cancer suppressor gene in breast cancer, but as a cancer driver gene in melanoma and lung cancer. This study reveals that CTNNAL1 regulates cancer stem cells (CSCs) in lung cancer and glioblastoma, affecting their ability to migrate, invade, and resist treatments like irradiation. Furthermore, CTNNAL1 is also involved in the secretion of CCL2, a chemokine known to influence malignancy and metastasis in cancer. These findings suggest that CTNNAL1 may serve as a potential target for treating lung CSCs and glioma stem cells, as well as a marker of malignancy.
Article
Oncology
Zhenbo Tu, Antoine E. Karnoub
Summary: Mesenchymal stem/stromal cells (MSCs) are a heterogeneous population of fibroblastic progenitor cells that reside in multiple tissues around the body and have the ability to differentiate into various connective tissue cells. They play critical regulatory roles in breast tumor development and progression, participating in multiple aspects of the process.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Oncology
Tingyu Shi, Jun Zhu, Xiang Zhang, Xinggang Mao
Summary: Glioblastoma multiforme (GBM) is a highly malignant brain tumor characterized by a small population of glioblastoma stem-like cells (GSCs) that possess self-renewal, proliferative, invasive, and tumorigenic capabilities, leading to radio- and chemoresistance. Hypoxia inducible factors (HIFs) play a crucial role in the maintenance and progression of GSCs. This review summarizes the roles of hypoxia-associated GSCs in GBM development, including hypoxia-induced signatures, genes, pathways, and metabolic alterations. The concept of the hypoxic peri-arteriolar niche of GSCs is discussed. Autophagy and potential causes of therapeutic resistance in GBM are explored, along with chemotherapeutic agents to enhance the effectiveness of chemo-, radio-, or immunotherapy. Hyperbaric oxygen therapy (HBOT) is proposed as an adjuvant therapy to reverse the hypoxic microenvironment in GBM. Overall, understanding the intricate interactions between hypoxia and GSCs can lead to the development of novel therapeutic strategies to improve GBM patient survival.
Article
Medicine, Research & Experimental
Peiwen Wang, Junwen Zhang, Qing Zhang, Fusheng Liu
Summary: The use of mesenchymal stem cells (MSCs) as vehicles of oncolytic adenovirus (oAd) is a promising strategy for enhancing the treatment efficacy of glioblastoma multiforme (GBM) by improving viral infiltration and protection from the host immune response.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Samantha V. Knoblauch, Shanay H. Desai, Jenna A. Dombroski, Nicole S. Sarna, Jacob M. Hope, Michael R. King
Summary: Glioblastoma multiforme (GBM), the most aggressive primary brain tumor, has a mean survival of less than 15 months after standard treatment. Temozolomide (TMZ) is the current standard of care, but its effectiveness is hindered by DNA repair and mutations in the p53 transcription factor. This study investigates the potential of activating Piezo1, a mechanoreceptor, to sensitize GBM cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) treatment. The results show that combining Piezo1 activation with TRAIL significantly increases apoptosis in GBM cells and overcomes TMZ resistance.
Article
Chemistry, Multidisciplinary
Lior Levy, Tzila Davidov, Krishna K. Kolluri, Avraham Fridman, Stasia Krishtul, Sam M. Janes, Marcelle Machluf
Summary: Utilizing immunotherapeutic-nano-ghosts (iNGs) for cancer cell therapy combines the advantages of mesenchymal stem cell (MSC) therapy and T cell immunotherapy, providing a powerful and effective treatment for malignant diseases.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Yuan Ding, Chenyang Wang, Zhongquan Sun, Yingsheng Wu, Wanlu You, Zhengwei Mao, Weilin Wang
Summary: MSCs have been proposed as a novel tool against cancer due to their tumor homing and immune privilege characteristics. Nonviral vectors have emerged as a potential solution to address limitations in MSC gene therapy, while viral vectors may pose risks.
Article
Biochemistry & Molecular Biology
Kalina Tumangelova-Yuzeir, Krassimir Minkin, Ivan Angelov, Ekaterina Ivanova-Todorova, Ekaterina Kurteva, Georgi Vasilev, Jeliazko Arabadjiev, Petar Karazapryanov, Kaloyan Gabrovski, Lidia Zaharieva, Tsanislava Genova, Dobroslav Kyurkchiev
Summary: The development of glioblastoma multiforme (GBM) is hypothesized to start with the transformation of neural stem cells into cancer stem cells (CSC), and it has been found that mesenchymal stem cells (MSC) also play a role in the tumor stroma. MSCs may give rise to CSC and suppress immune cells. Photodynamic therapy can reduce neural transdifferentiation capacity in GB-MSCs.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Oncology
Surendar Aravindhan, Sura Salman Ejam, Methaq Hadi Lafta, Alexander Markov, Alexei Valerievich Yumashev, Majid Ahmadi
Summary: The interaction between the tumor microenvironment and tumor cells plays a crucial role in tumor progression, with mesenchymal stem cells (MSCs) being key players in modulating the tumor microenvironment and influencing the fate of tumor cells. MSCs exhibit dual functions in the tumor microenvironment, either promoting tumorigenicity or inhibiting tumor growth. Their ability to release mediators such as exosomes and migrate to tumor sites facilitates efficient drug delivery and targeting of migrating tumor cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemical Research Methods
Peng Jiang, Jie Luo, Yiqi Wang, Pingji Deng, Bertil Schmidt, Xiangjun Tang, Ningjiang Chen, Limsoon Wong, Liang Zhao
Article
Oncology
Xing Rong Guo, Mu Yu Wu, Long Jun Dai, Yu Huang, Meng Ye Shan, Shi Nan Ma, Jue Wang, Hao Peng, Yan Ding, Qiu Fang Zhang, Jun Ming Tang, Xu Zhi Ruan, Dong Sheng Li
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Xiangjun Tang, Pengfei Xu, Bin Wang, Jie Luo, Rui Fu, Kuanming Huang, Longjun Dai, Junti Lu, Gang Cao, Hao Peng, Li Zhang, Zhaohui Zhang, Qianxue Chen
FRONTIERS IN ONCOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Shenqi Zhang, Gang Deng, Fuyao Liu, Bin Peng, Youmei Bao, Fengyi Du, Ann T. Chen, Jun Liu, Zeming Chen, Junning Ma, Xiangjun Tang, Qianxue Chen, Jiangbing Zhou
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Oncology
Kun Yang, Xiang-Jun Tang, Feng-Fei Xu, Jun-Hui Liu, Yin-Qiu Tan, Lun Gao, Qian Sun, Xiang Ding, Bao-Hui Liu, Qian-Xue Chen
Article
Genetics & Heredity
Zongli Zhang, Haiqing Wu, Longjun Dai, Yue Yuan, Yanshan Zhu, Zhipeng Ma, Xuzhi Ruan, Xingrong Guo
Article
Cell & Tissue Engineering
Yulin He, Xingrong Guo, Tingyu Lan, Jianbo Xia, Jinsong Wang, Bei Li, Chunyan Peng, Yue Chen, Xiang Hu, Zhongji Meng
Summary: The transplantation of hUC-MSCs can improve liver function, degree of fibrosis, and liver damage in rats with ACLI or ACLF, likely mediated by inhibiting Notch signaling and reversing the imbalance of the Stat1/Stat3 pathway.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Hao Peng, Xingrong Guo, Jinjuan He, Chao Duan, Minghuan Yang, Xianghua Zhang, Li Zhang, Rui Fu, Bin Wang, Dekang Wang, Hu Chen, Mengying Xie, Ping Feng, Longjun Dai, Xiangjun Tang, Jie Luo
Summary: This study compared the effects of two different transfection reagents on gene transfer, and tested a therapeutic application model using synthetic modified tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA. The research demonstrated that synthetic mRNA can be successfully delivered into the brain using commercially available transfection reagents, with TransIT-mRNA showing better results than in vivo-jetPEI kit. This model can be used for precise targeting and personalized gene therapy of glioma.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Cell Biology
Lin Hu, Jiarui Wei, Yue Zhang, Ziyuan Wang, Junming Tang, Jian Tang, Yujiu Gao, Xiaoqiao Zhang, Yifan Li, Yantong Liu, Shinan Ma, Xingrong Guo, Qiufang Zhang
Summary: Pathological cardiac hypertrophy is an independent risk factor for heart failure, and angiopoietin-like protein 8 (ANGPTL8) acts as a negative regulator in this process by binding to LILRB3 and inhibiting Akt/GSK3 beta activation.
CELL DEATH & DISEASE
(2022)
Article
Endocrinology & Metabolism
Jian Tang, Shinan Ma, Yujiu Gao, Fan Zeng, Ying Feng, Chong Guo, Lin Hu, Lingling Yang, Yanghui Chen, Qiufang Zhang, Yahong Yuan, Xingrong Guo
Summary: This study found that ANGPTL8 is highly expressed in the subcutaneous adipose tissue of obese patients and the liver of HFD-induced obese mice. ANGPTL8 knockout reduces weight gain and ectopic lipid deposition in organs. However, in female mice, especially in the HFD group, estrogen overexpression downregulates ANGPTL8 expression, counteracting the reduction in HFD-induced ectopic lipid deposition. Mechanistic studies demonstrate that ANGPTL8 promotes the differentiation of MSCs into adipocytes by inhibiting the Wnt/beta-Catenin pathway and upregulating PPAR gamma and c/EBP alpha mRNA expression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Zongli Zhang, Yue Yuan, Lin Hua, Jian Tang, Zhongji Meng, Longjun Dai, Yujiu Gao, Shinan Ma, Xiaoli Wang, Yahong Yuan, Qiufang Zhang, Weibin Cai, Xuzhi Ruan, Xingrong Guo
Summary: This study investigated the role of ANGPTL8 in the progression of NAFLD-associated liver fibrosis induced by a high-fat diet. The findings showed that ANGPTL8 deficiency suppresses inflammation, hepatic steatosis, and liver fibrosis. Restoring liver-derived ANGPTL8 expression accelerates HFD-induced liver fibrosis. Additionally, the FDA-approved anti-diabetic drug metformin was found to inhibit HFD-induced liver fibrosis.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Genetics & Heredity
Xiangjun Tang, Pengfei Xu, Ann Chen, Gang Deng, Shenqi Zhang, Lun Gao, Longjun Dai, Qianxue Chen
FRONTIERS IN GENETICS
(2020)
Letter
Biochemistry & Molecular Biology
Xing Rong Guo, Meng Ye Shan, Yu Huang, Zong Li Zhang, Yue Yuan, Long Jun Dai, Jue Wang, Xue Peng Zhou, Fu Yun Ji, Jun Ming Tang, Zhong Ji Meng, Xu Zhi Ruan
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2020)
