Journal
ONCOTARGET
Volume 7, Issue 45, Pages 74393-74409Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.11911
Keywords
interferon-stimulated gene 15; interferon; tumorigenesis; digestive system; cancer
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Funding
- National Natural Science Foundation of China [81670103]
- Changsha City Third Science and Technology Project of China [K1403380-31]
- Xiangya clinical big data system construction project
- industry research and development projects of Hunan province development and reform commission
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The interferon-stimulated gene 15 ubiquitin-like modifier (ISG15) encodes an IFN-inducible, ubiquitin-like protein. The ISG15 protein forms conjugates with numerous cellular proteins that are involved in a multitude of cellular functions, including interferon-induced immune responses and the regulation of cellular protein turnover. The expression of ISG15 and ISG15-mediated conjugation has been implicated in a wide range of human tumors and cancer cell lines, but the roles of ISG15 in tumorigenesis and responses to anticancer treatments remain largely unknown. In this review, we discuss the findings of recent studies with regard to the role of ISG15 pathways in cancers of the digestive system.
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