Article
Oncology
Daniela Di Paolo, Francesca Pontis, Massimo Moro, Giovanni Centonze, Giulia Bertolini, Massimo Milione, Mavis Mensah, Miriam Segale, Ilaria Petraroia, Cristina Borzi, Paola Suatoni, Chiara Brignole, Patrizia Perri, Mirco Ponzoni, Ugo Pastorino, Gabriella Sozzi, Orazio Fortunato
Summary: Simultaneously targeting miR-126-3p and miR-221-3p to inhibit tumor growth and metastasis could be a novel therapeutic approach for lung cancer management.
MOLECULAR ONCOLOGY
(2021)
Article
Neurosciences
He Wang, Feng-Shou Chen, Zai-Li Zhang, Hong-Xu Zhou, Hong Ma, Xiao-Qian Li
Summary: Recent research has shown that hypoxia preconditioning can alter the microRNA profile in extracellular vesicles from neurons, leading to better neuroprotection effects. In particular, miR-126-3p plays a crucial role in attenuating IR-induced pain hypersensitivity by modulating the PIK3R2-mediated PI3K/Akt and NF-kappa B signaling pathways in the injured spinal cord.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu-Jen Chen, Chia-Tien Hsu, Shang-Feng Tsai, Cheng-Hsu Chen
Summary: Chronic allograft dysfunction (CAD) is a major condition affecting long-term kidney graft survival. In this study, the correlation between plasma miR-21 and the severity of CAD was investigated. RNA sequencing was performed and differentially expressed miRNAs in CAD were identified. MiR-21-5p, miR-20a-5p, and miR-101-3p were found to be associated with the TGF-beta pathway and CAD. These findings may lead to the development of early prediction miRNA biomarkers and therapeutic tools for CAD in the field of kidney transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chairmandurai Aravindraja, Syam Jeepipalli, Krishna Mukesh Vekariya, Ruben Botello-Escalante, Edward K. L. Chan, Lakshmyya Kesavalu
Summary: This study aimed to investigate the global miRNA expression kinetics during the progression of periodontitis in mice infected with T. denticola. The results showed that T. denticola infection led to bacterial colonization and increased alveolar bone resorption. A total of 70 miRNAs with differential expression were identified, and miR-486, miR-126-3p, and miR-126-5p were found to be potential invasive biomarkers of T. denticola in periodontal disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Michele Manganelli, Ilaria Grossi, Manuela Ferracin, Paola Guerriero, Massimo Negrini, Michele Ghidini, Chiara Senti, Margherita Ratti, Claudio Pizzo, Rodolfo Passalacqua, Sarah Molfino, Gianluca Baiocchi, Nazario Portolani, Eleonora Marchina, Giuseppina De Petro, Alessandro Salvi
Summary: The study investigated the longitudinal levels of cell-free long ncRNA GAS5 and microRNAs miR-126-3p and miR-23b-3p in patients with hepatocellular carcinoma (HCC) undergoing sorafenib treatment. The results highlighted the significant downregulation of miR-23b-3p in untreated HCC patients and its diagnostic relevance.
Article
Immunology
Feifei Liu, Yuan Wang, Dan Huang, Yanqiu Sun
Summary: This study investigates the role of LncRNA HOTAIR in synovial angiogenesis in rheumatoid arthritis (RA) by regulating the PI3K/AKT pathway through the miR-126-3p/PIK3R2 axis.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Nutrition & Dietetics
Haiyu Li, Xiaoxu Tian, Yongjuan Ruan, Junhui Xing, Zhe Meng
Summary: This study found that AA can alleviate AngII-induced cardiac hypertrophy and cardiac fibroblast collagen expression. The study also discovered the downregulation of miR-126 and activation of the PI3K/AKT signaling pathway in the AngII-induced cardiac hypertrophy model. Furthermore, it was determined that miR-126 targets PIK3R2 directly.
NUTRITION & METABOLISM
(2021)
Article
Cell Biology
Yan Zhou, Jianghua Ming, Yaming Li, Bochun Li, Ming Deng, Yonggang Ma, Zhonghui Chen, Yubiao Zhang, Jia Li, Shiqing Liu
Summary: Exosomal miRNA-126-3p derived from SFCs can effectively suppress chondrocyte inflammation and cartilage degeneration, exerting anti-apoptotic and anti-inflammatory effects on articular cartilage, suggesting therapeutic potential for OA treatment.
CELL DEATH DISCOVERY
(2021)
Article
Oncology
Chiara Verdelli, Irene Forno, Annamaria Morotti, Riccardo Maggiore, Gilberto Mari, Leonardo Vicentini, Stefano Ferrero, Elisabetta Kuhn, Valentina Vaira, Sabrina Corbetta
Summary: Tumors of the parathyroid glands display a distinct miRNA profile from normal glands, with miR-126-3p downregulated in parathyroid adenomas. Localization of miR-126-3p to endothelial cells and tumor-associated myofibroblasts suggests its role in promoting neoangiogenesis through VEGFA overexpression.
ENDOCRINE-RELATED CANCER
(2021)
Article
Cell Biology
Kevin Bassand, Laurent Metzinger, Meriem Naim, Nesrine Mouhoubi, Oualid Haddad, Vincent Assoun, Naima Zaidi, Odile Sainte-Catherine, Amena Butt, Erwan Guyot, Olivier Oudar, Christelle Laguillier-Morizot, Angela Sutton, Nathalie Charnaux, Valerie Metzinger-Le Meuth, Hanna Hlawaty
Summary: The study revealed the significant role of miR-126 in CXCL12-induced angiogenesis, with inhibition of miR-126-3p affecting cell angiogenesis and migration capabilities. Furthermore, SPRED-1, a target of miR-126-3p, plays a crucial role in the process of angiogenesis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Nina P. Jordan, Samuel J. Tingle, Victoria G. Shuttleworth, Katie Cooke, Rachael E. Redgrave, Esha Singh, Emily K. Glover, Hafiza B. Ahmad Tajuddin, John A. Kirby, Helen M. Arthur, Chris Ward, Neil S. Sheerin, Simi Ali
Summary: The down-regulation of miR-126-3p is associated with EndMT, with its over-expression preventing the process and maintaining endothelial characteristics while repressing fibronectin expression. Lineage tracing in cardiac and kidney fibrosis models revealed that a significant subpopulation of endothelial-derived cells undergo EndMT and express mesenchymal markers. MiR-126-3p expression is restricted to endothelial cells and down-regulated in fibrotic kidney and heart tissue, making it a potential target for miRNA-based therapeutics in fibrotic organs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Peng Zeng, Jie Yang, Lipei Liu, Xiaoxiao Yang, Zhi Yao, Chuanrui Ma, Haibo Zhu, Jiamin Su, Qian Zhao, Ke Feng, Shu Yang, Yan Zhu, Xiaoju Li, Wenguang Wang, Yajun Duan, Jihong Han, Yuanli Chen
Summary: The study showed a positive correlation between calcification in human aortic valves and ERK1/2 activity. Inhibition of ERK1/2 reduced atherosclerosis and calcification in animal models, as well as calcification in SMCs and arterial rings. The reduction of calcification was due to decreased expression of ALP, BMP2, and RUNX2, and activation of DKK1 and LRP6 expression, thereby inactivating Wnt signaling pathways in SMCs.
Review
Oncology
Perla El Zeinaty, Celeste Lebbe, Julie Delyon
Summary: Kaposi's sarcoma (KS) is a common neoplasm caused by human gammaherpesvirus-8 (HHV-8) in Eastern and Central Africa. The endemic KS subtype can be aggressive, with ulcerative skin lesions and soft tissue invasion. Treatment options include systemic chemotherapies, immunomodulators, immune checkpoint inhibitors, and antiangiogenic drugs.
Article
Medicine, Research & Experimental
Jizi Zhou, Ying Zhao, Ping An, Huanqiang Zhao, Xiaotian Li, Yu Xiong
Summary: This study reveals that circRNA hsa_circ_0002348 is significantly increased in preeclampsia placentas and correlates with the severity of clinical manifestations. It functions as an endogenous sponge for miR-126-3p to upregulate BAK1 expression, thereby regulating trophoblast proliferation and apoptosis. Hsa_circ_0002348 may serve as a potential therapeutic target for preeclampsia.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Milan Hromadka, Zuzana Motovska, Ota Hlinomaz, Petr Kala, Frantisek Tousek, Jiri Jarkovsky, Marketa Beranova, Pavel Jansky, Michal Svoboda, Iveta Krepelkova, Richard Rokyta, Petr Widimsky, Michal Karpisek
Summary: This study indicated that miR-223-3p and miR-126-3p are promising independent predictors of thrombotic events post-AMI, with miR-223-3p levels significantly associated with ischemic endpoints and the miR-126-3p to miR-223-3p ratio being related to risk reduction.
JOURNAL OF PERSONALIZED MEDICINE
(2021)