Article
Nutrition & Dietetics
Patricia Paula da Fonseca Grili, Camila Vilarinho Vidigal, Geise Ferreira da Cruz, Ben-Hur Albergaria, Jose Luiz Marques-Rocha, Taisa Sabrina Silva Pereira, Valdete Regina Guandalini
Summary: This study aimed to identify nutrient patterns (NPs) and their association with bone mineral density (BMD) categories in postmenopausal women. The results showed that lower consumption of NP1 and NP2 was associated with an increased risk of osteopenia, but not osteoporosis.
Article
Nutrition & Dietetics
Alejandro Martinez-Rodriguez, Javier Sanchez-Sanchez, Maria Martinez-Olcina, Manuel Vicente-Martinez, Laura Miralles-Amoros, Juan Antonio Sanchez-Saez
Summary: The study found that older and trained players have better physical fitness; higher weight and BMI have a negative impact on power, agility, speed, and endurance; adherence to the Mediterranean diet is moderate, and beach handball seems to have a beneficial influence on bone condition.
Review
Nutrition & Dietetics
Daria Masztalerz-Kozubek, Monika A. Zielinska-Pukos, Jadwiga Hamulka
Summary: Evidence suggests that bone health may be programmed early in life, with factors such as maternal nutrition during the prenatal period influencing offspring's skeletal development and osteoporosis risk. Maternal vitamin D status, diet in pregnancy, anthropometry, and birth weight appear to impact bone mineral density, though additional factors like subsequent growth may play a role. Further well-designed studies are needed to address the ambiguity of current results.
Article
Environmental Sciences
Ke Xu, Bingqian Gao, Tingfeng Liu, Jiayi Li, Yixin Xiang, Yicheng Fu, Mingyi Zhao
Summary: Bone mass increases rapidly in adolescence, and the effects of metallic mercury on bone health are still controversial. This study investigated the association of blood mercury levels with bone mineral density (BMD) in adolescents using data from NHANES 2011-2018. The results showed a negative association between blood mercury levels and BMD in adolescents, although not statistically significant. Additionally, there was an inverted U-shaped association between blood mercury and BMD in male and Mexican-American adolescents, suggesting a potential benefit to bone health within a certain range of blood mercury levels.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hussein Sakr, Zenat Khired, Marzieh Moghadas
Summary: This study examined the effect of a wheat grain diet on bone turnover markers in rats. The results showed that rats fed whole or refined grains had lower bone density and mineral content compared to the control group. Additionally, levels of bone turnover indicators in the blood were altered, indicating a decrease in bone turnover and mass with a grain diet.
Article
Nutrition & Dietetics
Nasser M. Al-Daghri, Syed Danish Hussain, Abdullah M. Alnaami, Naji Aljohani, Shaun Sabico
Summary: Osteoporosis is a significant public health concern in Saudi Arabia, particularly among the aging population. This study examined the association between dietary calcium intake and osteoporosis risk in Saudi adults. Results showed that the overall mean calcium intake was very low and that certain dietary factors, such as tea intake and consumption of fish and eggs, were associated with a lower risk of osteoporosis.
Article
Biochemistry & Molecular Biology
Ewa Jowko, Barbara Dlugolecka, Igor Cieslinski, Jadwiga Kotowska
Summary: The aim of this study was to identify relevant factors that affect bone mineral content (BMC) and bone mineral density (BMD) in young, healthy men reaching peak bone mass. The results showed that age, BMI, engaging in combat and team sports at a competitive level, and certain genetic polymorphisms were significant predictors of BMD/BMC at different skeletal sites. Specifically, the SOD2 AG genotype was associated with lower BMC values, while the VDR FokI GG genotype was associated with lower BMD. However, the CALCR AG genotype was linked to higher arm BMD. These findings suggest that sports training may mitigate the negative impact of genetic factors on bone tissue and reduce the risk of osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Elham Kazemian, Ali Pourali, Fatemeh Sedaghat, Mehrdad Karimi, Vahid Basirat, Zohreh Sajadi Hezaveh, Sayed Hossein Davoodi, Michael F. Holick
Summary: A systematic review and meta-analysis evaluated the effects of vitamin D-3 supplementation on bone health in adults. The results showed a protective effect of vitamin D-3 supplementation on bone mineral density (BMD) at the lumbar spine, femoral neck, and total hip. Dose-response analysis revealed a linear relationship between vitamin D-3 supplementation doses and BMD. However, no significant effect of vitamin D-3 supplementation on whole-body or total hip BMD was found. The relationship between vitamin D-3 supplement doses and markers of bone turnover was nonlinear.
Review
Biochemistry & Molecular Biology
Kathryn Frost, Amy J. Naylor, Helen M. McGettrick
Summary: Bone remodelling is a dynamically regulated process involving osteoblasts, osteoclasts, and their progenitors. Dysregulation of bone remodelling can lead to disorders like osteoporosis and Paget's disease. The sphingosine-1-phosphate (S1P) signaling pathway has been identified as an important regulator of bone remodelling and inflammatory responses. This review discusses the role of S1P in bone homeostasis and disease, highlighting its potential as a biomarker and therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Alicia R. Jones, Koen Simons, Susan Harvey, Vivian Grill
Summary: Individuals with primary hyperparathyroidism have reduced cortical bone mineral density, but relatively preserved trabecular bone density. However, their fracture risk is still increased. Trabecular bone score may provide a more accurate assessment of bone quality and fracture risk. This study compared the effectiveness of bone mineral density and trabecular bone score in describing bone quality in patients with primary hyperparathyroidism, and also evaluated changes in trabecular bone score following parathyroidectomy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Kazuyoshi Shigehara, Kouji Izumi, Yoshifumi Kadono, Atsushi Mizokami
Summary: Bone fracture due to osteoporosis is a significant issue for elderly men, and testosterone replacement therapy has shown benefits in improving bone mineral density in symptomatic hypogonadal men with osteopenia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Geriatrics & Gerontology
Xiaowen Zhang, Warrington W. Q. Hsu, Chor-Wing Sing, Gloria H. Y. Li, Kathryn C. B. Tan, Annie W. C. Kung, Janus S. H. Wong, Ian Chi-Kei Wong, Ching-Lung Cheung
Summary: This study investigated the relationship between bone mineral density (BMD) and the risk of incident dementia, and found that higher BMD was associated with a reduced risk of dementia, particularly in women. Further research is needed to evaluate the clinical usefulness of BMD in predicting and managing dementia.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Marta Galvez-Fernandez, Maria Grau-Perez, Tamara Garcia-Barrera, Sara Ramirez-Acosta, Jose L. Gomez-Ariza, Beatriz Perez-Gomez, Inaki Galan-Labaca, Ana Navas-Acien, Josep Redon, Laisa S. Briongos-Figuero, Antonio Duenas-Laita, Jose Luis Perez-Castrillon, Maria Tellez-Plaza, Juan Carlos Martin-Escudero
Summary: The study evaluated the association between arsenic, cadmium, and selenium biomarkers with bone mineral density. Results showed that selenium was associated with BMD-related disease, while arsenic and cadmium were not. The non-linear association of selenium with BMD-related disease included a strong positive association with osteoporosis-related bone fractures risk at higher selenium exposure levels.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Endocrinology & Metabolism
Chin-Hao Hsu, Sheng-Feng Sung, Hsin-Yi Yang, Wan-Ting Huang, Cheng-Yang Hsieh
Summary: Despite being at higher risk, stroke survivors are less likely to receive bone mineral density testing and osteoporosis treatment compared to non-stroke patients. Factors such as female sex, osteoporosis, prior BMD testing, and low-trauma fractures after stroke increase the likelihood of receiving these measures, while greater stroke severity reduces the likelihood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Ming Qin, Yue Gao, Meichen Zhang, Junhua Wu, Yang Liu, Yuting Jiang, Xiaodi Zhang, Xin Wang, Yanmei Yang, Yanhui Gao
Summary: This study investigates the effects of fluorine and ADAMTS14_rs4747096 on bone mineral density (BMD). The findings suggest that fluoride exposure and mutation G allele in ADAMTS14_rs4747096 may be risk factors for decreased BMD, and there is an interaction between the two influencing factors.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Editorial Material
Nutrition & Dietetics
Katie Schraders, Giancarla Zatta, Marlena Kruger, Jane Coad, Janet Weber, Louise Brough, Jasmine Thomson
Correction
Nutrition & Dietetics
Katie Schraders, Giancarla Zatta, Marlena Kruger, Jane Coad, Janet Weber, Louise Brough, Jasmine Thomson
Article
Nutrition & Dietetics
Hajar Mazahery, Cathryn A. Conlon, Kathryn L. Beck, Owen Mugridge, Marlena C. Kruger, Welma Stonehouse, Carlos A. Camargo, Barbara J. Meyer, Bobby Tsang, Pamela R. von Hurst
Review
Biochemistry & Molecular Biology
Umani S. Walallawita, Frances M. Wolber, Ayelet Ziv-Gal, Marlena C. Kruger, Julian A. Heyes
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Medicinal
Matthew R. Miller, Marlena C. Kruger, Chris Wynne, Devonie Waaka, Weili Li, Chris Frampton, Fran M. Wolber, Charles Eason
Article
Chemistry, Multidisciplinary
Parkpoom Siriarchavatana, Marlena C. Kruger, Matthew R. Miller, Hong (Sabrina) Tian, Frances M. Wolber
APPLIED SCIENCES-BASEL
(2020)
Article
Nutrition & Dietetics
Christa Ellis, Herculina S. Kruger, Michelle Viljoen, Joel A. Dave, Marlena C. Kruger
Summary: The study found that changes in bone mineral density and bone resorption markers over two years were minimal in black postmenopausal women living with HIV. Despite a decrease in serum vitamin D, there were small or no changes in BMD and CTx over the 2-year period.
Article
Agriculture, Dairy & Animal Science
Keren E. Dittmer, Anastasia Chernyavtseva, Jonathan C. Marshall, Diana Cabrera, Frances M. Wolber, Marlena Kruger
Summary: Osteoporosis is a global public health issue, with approximately 3/4 of cases resulting from estrogen deficiency after menopause. This study used sheep as a model for osteoporosis and conducted experiments by performing ovariectomy and administering glucocorticoids. The results demonstrated that the expression of the klotho gene in the kidney showed the most significant difference in ovariectomized sheep treated with glucocorticoids for 2 months followed by a recovery period of 3 months. Klotho, known as the anti-aging hormone, is involved in the regulation of calcium and phosphorus metabolism, and it may play an important role in the recovery of bone mineral density in ovariectomized sheep treated with glucocorticoids for 2 months followed by euthanasia at 5 months.
Article
Biochemistry & Molecular Biology
Maryam Abshirini, Diana Cabrera, Karl Fraser, Parkpoom Siriarchavatana, Frances M. Wolber, Matthew R. Miller, Hong Sabrina Tian, Marlena C. Kruger
Summary: This study examined the changes in lipid and metabolite profiles of OVX rats with diet-induced MetOA after GSM supplementation using LC-MS metabolomics approach. Potential biomarkers for the effect of HFHS diet and GSM supplementation were identified, but further studies are needed for validation.
Article
Health Care Sciences & Services
Bolaji Lilian Ilesanmi-Oyelere, Nicole C. Roy, Marlena C. Kruger
Summary: This study aims to investigate the effects of synbiotic supplementation, exercise intervention, or a combination of both on gut microbiota, inflammation, and bone biomarkers in postmenopausal women. Recruitment of participants will begin in September 2021, with an anticipated completion date of June 2022. This will be the first randomized controlled trial to analyze the effects of both a synbiotic supplement and an exercise intervention in postmenopausal women.
JMIR RESEARCH PROTOCOLS
(2021)
Article
Biochemistry & Molecular Biology
Ivana R. Sequeira, Marlena C. Kruger, Roger D. Hurst, Roger G. Lentle
Summary: This study developed an assay using a Shimadzu HPLC system to determine urinary lactulose and mannitol. The assay is simple, easy to use, and can be applied in routine clinical settings for quantification of intestinal permeability.
Article
Nutrition & Dietetics
Marlena C. Kruger, Hajar Mazahery, Owen Mugridge, Sophie Turner, Pamela von Hurst
Summary: This study compared the effectiveness of deer milk (DM) and a commercially available oral nutritional supplement (ONS) for improving the nutritional status, muscle mass, and physical performance of older women. The results showed that DM may improve the nutritional status and physical performance of women at risk of malnutrition and/or with lower BMI, while also improving muscle mass in women with a higher BMI.
CLINICAL NUTRITION ESPEN
(2023)
Article
Nutrition & Dietetics
Maryam Abshirini, Jane Coad, Frances M. M. Wolber, Pamela von Hurst, Matthew R. R. Miller, Hong Sabrina Tian, Marlena C. C. Kruger
Summary: The study investigated the effects of whole meat GSM powder on gut microbiota abundance, body composition, and iron status markers in overweight or obese postmenopausal women. Forty-nine healthy postmenopausal women were randomly assigned to receive GSM powder or placebo for three months. The results showed no significant changes in gut microbiota abundance, body composition, and iron markers, except for a reduction in ferritin levels. However, there was a trend of increased abundance of Bacteroides and Bifidobacteria in the GSM group. These findings contribute to the knowledge of the effects of GSM powder in postmenopausal women.
JOURNAL OF NUTRITIONAL SCIENCE
(2023)
Review
Green & Sustainable Science & Technology
Matthew R. Miller, Maryam Abshirini, Frances M. Wolber, Te Rerekohu Tuterangiwhiu, Marlena C. Kruger
Summary: Greenshell mussels (GSMs) are a key aquaculture species in New Zealand and hold cultural and nutritional significance. They have attracted scientific attention due to their omega-3 fatty acids, which have anti-inflammatory properties and are being promoted for arthritis treatment. This review examines the composition, sustainability, and health benefits of GSMs, as well as the mechanisms behind their bioactive components.
Article
Endocrinology & Metabolism
C. Ellis, H. S. Kruger, P. Ukegbu, I. M. Kruger, M. Viljoen, M. C. Kruger
JOURNAL OF ENDOCRINOLOGY METABOLISM AND DIABETES OF SOUTH AFRICA
(2019)