Journal
NEUROSCIENCE BULLETIN
Volume 33, Issue 1, Pages 17-27Publisher
SPRINGER
DOI: 10.1007/s12264-016-0069-y
Keywords
Parkinson's disease; Cynomolgus monkeys; MPTP; Motor behavior; Spontaneous recovery; Clinical evolution
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Funding
- National High-Tech Development Project of Ministry of Sciences and Technology of China [2012AA020703]
- National Natural Science Foundation of China [31472056]
- Scientific Project of the Science and Technology Department of Guangxi Zhuang Autonomous Region, China [1598025-31]
- Scientific Project of the Science and Technology Bureau of Nanning Municipality, Guangxi Zhuang Autonomous Region, China [20145194, 20155192]
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In this study, we developed a systemic PD model in middle-aged cynomolgus monkeys using individualized low-dose MPTP, to explore effective indicators for the early prediction of clinical outcomes. MPTP was not stopped until the animals showed typical PD motor symptoms on days 10 to 13 after MPTP administration when the Kurlan score reached 10; this abrogated the differences in individual susceptibility to MPTP. The clinical symptoms persisted, peaking on days 3 to 12 after MPTP withdrawal (rapid progress stage), and then the Kurlan score plateaued. A Kurlan score at the end of the rapid progress stage > 15 reflected stable or slowly-progressive PD, while a score < 15 indicated spontaneous recovery. The entire clinical evolution and outcome of the systemic PD model was characterized in this study, thus providing options for therapeutic and translational research.
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