Programmed Death Ligand-1 on Microglia Regulates Th1 Differentiation via Nitric Oxide in Experimental Autoimmune Encephalomyelitis

IL-12-polarized Th1 cells produce GM-CSF and induce EAE independent of IL-23

(2015) Heather M. Grifka-Walk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differential control of CD4+ T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma

(2015) Jaclyn W. McAlees et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

PD-1/SHP-2 Inhibits Tc1/Th1 Phenotypic Responses and the Activation of T Cells in the Tumor Microenvironment

(2014) J. Li et al.   CANCER RESEARCH

Adoptive transfer of cytokine-induced immunomodulatory adult microglia attenuates experimental autoimmune encephalomyelitis in DBA/1 mice

(2014) Xing-Mei Zhang et al.   GLIA

Cutting Edge: Th1 Cells Facilitate the Entry of Th17 Cells to the Central Nervous System during Experimental Autoimmune Encephalomyelitis

(2014) R. A. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Programmed Death 1 Deficiency Induces the Polarization of Macrophages/Microglia to the M1 Phenotype After Spinal Cord Injury in Mice

(2014) Anhui Yao et al.   Neurotherapeutics

The Role of Interleukin-6 in the Expression of PD-1 and PDL-1 on Central Nervous System Cells following Infection with Theiler's Murine Encephalomyelitis Virus

(2013) Y.-H. Jin et al.   JOURNAL OF VIROLOGY

Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation

(2013) Yichuan Xiao et al.   NATURE MEDICINE

Effects of L-arginine and Nω-nitro-L-arginine methylester on learning and memory and α7 nAChR expression in the prefrontal cortex and hippocampus of rats

(2013) Xiao-Ming Wei et al.   Neuroscience Bulletin

Polarization of macrophages and microglia in inflammatory demyelination

(2013) Li Cao et al.   Neuroscience Bulletin

Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models

(2013) Marta Caridade et al.   Frontiers in Immunology

Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells

(2012) Nir Yogev et al.   IMMUNITY

Galectin-1 Deactivates Classically Activated Microglia and Protects from Inflammation-Induced Neurodegeneration

(2012) Sarah C. Starossom et al.   IMMUNITY

Viral-induced encephalitis initiates distinct and functional CD103+ CD11b+ brain dendritic cell populations within the olfactory bulb

(2012) P. M. D'Agostino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

(2012) Dimitrios Davalos et al.   Nature Communications

Modeling the effector - regulatory T cell cross-regulation reveals the intrinsic character of relapses in Multiple Sclerosis

(2011) Nieves Vélez de Mendizábal et al.   BMC Systems Biology

Programmed Death-1 Pathway Limits Central Nervous System Inflammation and Neurologic Deficits in Murine Experimental Stroke

(2011) Xuefang Ren et al.   STROKE

Induction of inhibitory central nervous system-derived and stimulatory blood-derived dendritic cells suggests a dual role for granulocyte-macrophage colony-stimulating factor in central nervous system inflammation

(2010) Lysann Hesske et al.   BRAIN

Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis

(2010) Áine C. Murphy et al.   BRAIN BEHAVIOR AND IMMUNITY

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

Nitric oxide controls an inflammatory-like Ly6Chi PDCA1+ DC subset that regulates Th1 immune responses

(2010) Daniela Giordano et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Activated microglial cells acquire an immature dendritic cell phenotype and may terminate the immune response in an acute model of EAE

(2010) Beatriz Almolda et al.   JOURNAL OF NEUROIMMUNOLOGY

Decreased production of TNF-alpha by lymph node cells indicates experimental autoimmune encephalomyelitis remission in Lewis rats

(2010) Juliana Seger et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

(2010) Eugene D Ponomarev et al.   NATURE MEDICINE

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

Functional and Pathogenic Differences of Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis

(2010) Helena S. Domingues et al.   PLoS One

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Protective effects of microglia in multiple sclerosis

(2009) Isabella Napoli et al.   EXPERIMENTAL NEUROLOGY

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

(2009) Stanley H. Appel et al.   TRENDS IN IMMUNOLOGY

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: Implications for the lesion pathogenesis of multiple sclerosis

(2008) Sonja Ortler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE

(2008) Bettina Schreiner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ly6c+“inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis

(2008) Daniel R. Getts et al.   JOURNAL OF EXPERIMENTAL MEDICINE