Article
Clinical Neurology
Lorena Melo, Mohsen Mosayebi-Samani, Elham Ghanavati, Michael A. Nitsche, Min-Fang Kuo
Summary: The study found that acute serotonin enhancement can modulate tDCS after-effects and has similar modulatory effects on motor cortex neuroplasticity regardless of the specific dosage. Only a minor dosage-dependent effect was observed for cathodal tDCS.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Zhihua Guo, Rui Qiu, Huake Qiu, Hongliang Lu, Xia Zhu
Summary: This study investigated the long-lasting and transfer effects of repeated sessions of transcranial direct current stimulation (tDCS) combined with concurrent cognitive training on response inhibition. The main findings showed that the combined protocol and stimulation alone significantly reduced stop-signal reaction time (SSRT) post-intervention and after 1 month. However, only the combined protocol improved SSRT in high-performing individuals. Transfer effects were not observed.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Jordan N. Williamson, Shirley A. James, Dorothy He, Sheng Li, Evgeny V. Sidorov, Yuan Yang
Summary: This study aimed to develop a non-invasive brain stimulation protocol to improve upper extremity rehabilitation in individuals with moderate-to-severe motor impairments post-stroke by facilitating the lesioned CST and inhibiting the contralesional CRST. The results suggest that HD-tDCS could enhance the function of the lesioned CST and reduce the excitability of the contralesional CRST, thus improving motor function in more severely impaired individuals.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Neurosciences
Xiao-Hua Zhang, Tao Gu, Xuan-Wei Liu, Ping Han, Hui-Lan Lv, Yu-Long Wang, Peng Xiao
Summary: The study demonstrates that both tDCS and FES significantly promote the recovery of leg motor function in stroke patients, with tDCS being more effective in the stroke recovery stage. The application value of SEP in stroke patients needs further exploration.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Yoonju Na, Jinuk Kim, Su-Hyun Lee, Jihye Kim, Jungsoo Lee, Se Young Shin, Won Hyuk Chang, Jin Whan Cho, Yun-Hee Kim
Summary: This study suggests that multichannel tDCS applied during treadmill gait training can improve gait velocity in patients with Parkinson's disease. The real tDCS group showed significant improvement in gait tests and some assessment measures, while the sham group did not. Therefore, tDCS may be an effective method for gait rehabilitation in Parkinson's disease, but further research is needed to confirm its effectiveness.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Sinan Yasaroglu, Joachim Liepert
Summary: This study aimed to characterize the changes in motor excitability and motor performance induced by a single session of anodal and cathodal transcranial direct current stimulation (tDCS) in stroke patients. The results showed that anodal tDCS significantly reduced short interval intracortical inhibition (SICI) without affecting intracortical facilitation (ICF) or long interval intracortical inhibition (LICI). Cathodal tDCS did not change motor excitability. Both types of tDCS did not alter motor performance. The SICI in the affected hemisphere was lower than in the unaffected hemisphere even before anodal tDCS, and it was correlated with changes in motor performance after anodal tDCS.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Arislander Jonathan Lopes Dumont, Veronica Cimolin, Rodolfo Borges Parreira, Danilo Armbrust, Daniela Rosana Pedro Fonseca, Adriano Luis Fonseca, Lorraine Cordeiro, Renata Calhes Franco, Natalia Almeida Carvalho Duarte, Manuela Galli, Claudia Santos Oliveira
Summary: The study examined the effects of combining anodal tDCS and treadmill training on gait speed in stroke survivors. The experimental group received anodal tDCS over the damaged hemisphere's primary motor cortex (M1) during treadmill training, while the control group received sham tDCS. Results showed no significant differences in spatiotemporal variables between the two groups. However, the experimental group demonstrated improvements in kinematic variables of the knee and ankle, and these results were maintained one month after treatment.
Article
Neurosciences
Milan Pantovic, Lidio Lima de Albuquerque, Sierra Mastrantonio, Austin S. Pomerantz, Erik W. Wilkins, Zachary A. Riley, Mark A. Guadagnoli, Brach Poston
Summary: Transcranial direct current stimulation (tDCS) applied to the primary motor cortex (M1) improves motor learning in relatively simple motor tasks performed with the hand and arm, but its effect on complex motor tasks involving whole-body coordination is unclear. This study found that tDCS applied over multiple days can improve motor learning in a complex overhand throwing task.
Review
Clinical Neurology
Shawn Hiew, Carine Nguemeni, Daniel Zeller
Summary: Transcranial direct current stimulation (tDCS) in multiple sclerosis (MS) shows inconsistent effects on motor symptoms but promising benefits in alleviating fatigue, pain, and cognitive symptoms.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Yasushi Kamii, Sho Kojima, Hideaki Onishi
Summary: This study aims to investigate the effect of anodal transcranial direct current stimulation on visuomotor performance and proprioception in the lower extremities. The results show that a-tDCS improves visuomotor performance and reduces the variable error in the joint position matching task.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Penghui Song, Siran Li, Wensi Hao, Min Wei, Jianghong Liu, Hua Lin, Shimin Hu, Xiaona Dai, Jing Wang, Rong Wang, Yuping Wang
Summary: This study demonstrates that simultaneous tNIRS and tDCS is more effective in enhancing cortical excitability compared to single stimulation, showing a synergistic effect on cortical plasticity that lasts for an extended period.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Ayuka Sasaki, Anri Aisawa, Naoyuki Takeuchi
Summary: This study investigates the effects of transcranial direct current electrical stimulation (tDCS) on backward walking training. The results show that tDCS can enhance gait performance, with different effects depending on the stimulated brain region. Stimulation of the primary motor cortex reduces gait variability and increases walking speed, while stimulation of the dorsolateral prefrontal cortex prioritizes walking speed over gait stability.
EXPERIMENTAL BRAIN RESEARCH
(2023)
Article
Clinical Neurology
Steven Pillen, Nicole Knodel, Dominik Hermle, Moritz Hanke, Ulf Ziemann, Til Ole Bergmann
Summary: Transcranial direct current stimulation (tDCS) has been used for over twenty years to modulate cortical excitability. However, its effects are highly variable, partially due to the lack of individual adjustment of stimulation intensity. This study explored an empirical approach of personalizing tDCS intensity based on dose-response curves (DRCs), but found that online tDCS effects were not sufficiently robust. Additionally, attempts to replicate the reported bidirectional online MEP modulation during tDCS were unsuccessful.
Article
Medicine, General & Internal
Fawaz Al-Hussain, Eman Nasim, Muhammad Iqbal, Nouf Altwaijri, Niaz Asim, Woo-Kyoung Yoo, Shahid Bashir
Summary: A novel approach using a combination of various techniques has been proposed to enhance motor function improvement in stroke patients, aiming to better understand the mechanisms of stroke recovery. The study is crucial for improving stroke therapeutics and utilizing two potential pathways to modulate brain function.
Article
Clinical Neurology
Chenxi Dai, Jianjie Wang, Jingru Li, Juan Wang, Lei Zhang, Changlin Yin, Yongqin Li
Summary: Repetitive anodal transcranial direct current stimulation (tDCS) after resuscitation in a rat model of asphyxial cardiac arrest improved neurological recovery and showed neuroprotective effects by preserving neuroplasticity, as evidenced by higher mean arterial pressure, better EEG characteristics, improved neurologic deficit scores, and increased levels of neuroplastic biomarkers compared to untreated and TTM groups.