Article
Biochemistry & Molecular Biology
Feifei Zhang, Hui Wang, Jiang Yu, Xueqing Yao, Shibin Yang, Weidong Li, Lijun Xu, Liang Zhao
Summary: The study found that CRNDE plays a key role in gastric cancer chemotherapy by regulating autophagy and alternative splicing events.
Article
Cardiac & Cardiovascular Systems
Yuanbiao Zhao, Andrew S. Riching, Walter E. Knight, Congwu Chi, Lindsey J. Broadwell, Yanmei Du, Mostafa Abdel-Hafiz, Amrut Ambardekar, David C. Irwin, Catherine Proenza, Hongyan Xu, Leslie A. Leinwand, Lori A. Walker, Kathleen C. Woulfe, Michael R. Bristow, Peter M. Buttrick, Kunhua Song
Summary: This study reveals that a long noncoding RNA, Trdn-as, regulates cardiac function and triadin levels in the heart by controlling alternative splicing of the triadin gene. Knockout of Trdn-as in mice leads to downregulation of cardiac triadin, impaired Ca2+ handling, and premature death. Furthermore, Trdn-as plays an essential role in recruiting splicing factors to triadin precursor mRNA. These findings suggest potential therapeutics for heart disease by targeting the long noncoding RNA or pathways regulating alternative splicing.
Review
Oncology
Yunze Liu, Xin Liu, Changwei Lin, Xianhong Jia, Hongmei Zhu, Jun Song, Yi Zhang
Summary: AS and ncRNAs play crucial roles in cancer by influencing the development of various diseases, especially in different aspects of cancer progression. Acting as regulatory molecules, ncRNAs can affect cell signaling pathways by influencing AS, thus impacting cancer progression.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemical Research Methods
Yulan Deng, Hao Luo, Zhenyu Yang, Lunxu Liu
Summary: The LncAS2Cancer database focuses on cancer-related alternative splicing of lncRNAs, with a comprehensive collection of RNA sequencing samples and six splicing algorithms. It not only confirms known cancer-associated lncRNA isoforms, but also indicates new ones. Through data comparison and analysis within the database, important insights into the functional roles of lncRNAs in human cancers can be gained for further research.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Biochemistry & Molecular Biology
Jihae Shin, Qingbao Ding, Luyang Wang, Yange Cui, Erdene Baljinnyam, Aysegul Guvenek, Bin Tian
Summary: APA is an important aspect of gene expression program critical for defining cell identity. A method named CRISPRpas, which enhances proximal PAS usage, is developed to alter APA isoform abundance. The efficiency of CRISPRpas is influenced by various factors. The study demonstrates the modulation of APA for multiple endogenous genes and highlights the impact of CRISPRpas on gene expression.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Carmelo Gurnari, Simona Pagliuca, Valeria Visconte
Summary: Alternative RNA splicing is an essential physiological function that plays a crucial role in cellular development. RNA splicing dysfunction has been implicated in the development of several cancers, including myeloid malignancies. Cancer cells exhibit marked gene expression alterations, including different usage of AS isoforms, potentially causing tissue-specific effects and disruptions of downstream pathways.
Review
Cell Biology
Koji Kitamura, Keisuke Nimura
Summary: RNA splicing is a crucial process in the maturation of mRNA, allowing for diversity in mature mRNA through the inclusion and exclusion of introns and exons. Cancer cells develop cancer-specific mechanisms through abnormal splicing regulation to resist treatment and promote malignancy. Dysregulation of splicing is caused by factors such as mutations in splicing factors and changes in genomic sequences, impacting the splicing profile related to cancer.
Review
Biochemistry & Molecular Biology
Yuqiu Wang, Xing Wang Deng, Danmeng Zhu
Summary: Gene regulation mediated by noncoding RNAs (ncRNAs) plays an important role in plant development and environmental responses. This review summarizes the current understanding of the roles of small nucleolar RNA (snoRNA) and regulatory long noncoding RNA (lncRNA) in plants, as well as the potential of these ncRNAs as genetic resources for improving agronomic traits and molecular breeding.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Panyisha Wu, Moya Zhang, Nicholas J. G. Webster
Summary: Alternative RNA splicing is an important biological process that has been linked to various clinical syndromes, but its applicability to common diseases is still uncertain. This review focuses on the changes in alternative RNA splicing in fatty liver disease and the role of splicing regulation in disease progression.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
X. Luo, Y. Jiang, F. Chen, Z. Wei, Y. Qiu, H. Xu, G. Tian, W. Gong, Y. Yuan, H. Feng, L. Zhong, N. Ji, X. Xu, C. Sun, T. Li, J. Li, X. Feng, P. Deng, X. Zeng, M. Zhou, Y. Zhou, H. Dan, L. Jiang, Q. Chen
Summary: A novel lncRNA variant ORAOV1-B was identified in oral squamous cell carcinoma (OSCC) and found to significantly enhance metastasis through the activation of the NF-κB-TNFα loop, leading to increased lung metastasis. The study highlights the crucial role of the ORAOV1 family members and the importance of genes located within 11q13 in promoting OSCC progression.
JOURNAL OF DENTAL RESEARCH
(2021)
Review
Medicine, Research & Experimental
Weijuan Xin, Yue Wang, Keqin Hua, Songping Liu
Summary: Long non-coding RNAs (lncRNAs), such as H19, have the potential to regulate gene expression at multiple levels and affect important cellular processes in gynecological diseases. The coexpression of lncRNA H19 is associated with the extracellular matrix and immune microenvironment during cancer progression, offering insights for diagnostic biomarkers and pharmaceutical targets in gynecological oncology. This comprehensive review presents the expression profiles and implications of lncRNA H19 in various gynecological pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Lirong Hu, Abdul Sammad, Congcong Zhang, Luiz F. Brito, Qing Xu, Yachun Wang
Summary: This study evaluated the changes in milk yield, physiological indicators, blood biochemical parameters, and alternative splicing patterns in lactating Holstein cows under heat stress conditions. The results showed that heat stress negatively impacted various biological processes of Holstein cows. Additionally, heat stress increased the occurrence of alternative splicing events, with genes involved in mRNA splicing, immune, and metabolic processes being enriched. Two candidate genes associated with heat stress responses in dairy cows were identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Yuan Tian, Qinfeng Gao, Shuanglin Dong, Yangen Zhou, Han Yu, Dazhi Liu, Wenzhao Yang
Summary: Alternative splicing (AS) is a key post-transcriptional regulatory mechanism that plays important roles in organisms' response to environmental stimuli. This study utilized 18 RNA-Seq datasets to investigate the potential roles of AS in salinity adaptation in three euryhaline teleosts. The results showed that different salinity environments altered the splicing patterns of RNA splicing regulators, potentially affecting downstream target genes. The study provides new insights into the molecular mechanisms of salinity adaptation in teleosts.
Review
Immunology
Yongli Pan, Qingzheng Jiao, Wei Wei, Tianyang Zheng, Xinyu Yang, Wenqiang Xin
Summary: This review summarizes the therapeutic effects and action mechanisms of long noncoding RNAs (lncRNAs) on ischemia by regulating inflammation and microglial activation, especially in the context of neuroinflammation in ischemic stroke. Studies have shown that lncRNAs have the potential to modulate inflammation by inhibiting and activating various signaling pathways, such as microRNAs, NF-kappa B, and ERK.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Cell Biology
Shibo Zhu, Jingqi Zhang, Xiaofeng Gao, Xiangliang Tang, Yanhong Cui, Dian Li, Wei Jia
Summary: Nephroblastoma, a pediatric kidney cancer, is associated with abnormal expression of lncRNA MYLK-AS1, which promotes cell proliferation and cycle distribution through the TCF7L2/CCNE1 signaling pathway. Silencing of MYLK-AS1 inhibits the tumorigenic ability of nephroblastoma cells in vivo, highlighting its potential as a biomarker for early detection and treatment.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
