Article
Pediatrics
Tessa de Baat, Rebecca Lester, Lugano Ghambi, Hussein H. Twabi, Maryke Nielsen, Stephen B. Gordon, Mirjam M. van Weissenbruch, Nicholas A. Feasey, Queen Dube, Kondwani Kawaza, Pui-Ying Iroh Tam
Summary: In this study conducted in Malawi, suspected early-onset sepsis (EOS) was observed in nearly one-third of neonatal admissions, with a high mortality rate. The most commonly isolated pathogens were Staphylococcus aureus, Klebsiella pneumoniae, Enterobacter cloacae, Escherichia coli, and Acinetobacter baumanii. Low gestational age was associated with positive blood cultures, while low birth weight, low Apgar scores at 5 min, positive maternal venereal disease research laboratory status, and congenital anomalies were associated with mortality. Prolonged rupture of membranes was inversely associated with mortality. To improve outcomes and reduce antimicrobial resistance, better maternal and antenatal care and the development of rapid point of care methods for guiding antimicrobial use are needed in least developed countries.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Medicine, General & Internal
Giuseppe De Matteis, Maria Livia Burzo, Davide Antonio Della Polla, Amato Serra, Andrea Russo, Francesco Landi, Antonio Gasbarrini, Giovanni Gambassi, Francesco Franceschi, Marcello Covino
Summary: Dementia is associated with higher rates of admission and mortality in hospitals. This retrospective study aimed to investigate the impact of dementia on in-hospital mortality and identify the predictors of mortality in these patients. The study compared the clinical outcomes of dementia patients and non-dementia patients at admission to the Emergency Department.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Shelton W. Wright, Taniya Kaewarpai, Lara Lovelace-Macon, Deirdre Ducken, Viriya Hantrakun, Kristina E. Rudd, Prapit Teparrukkul, Rungnapa Phunpang, Peeraya Ekchariyawat, Adul Dulsuk, Boonhthanom Moonmueangsan, Chumpol Morakot, Ekkachai Thiansukhon, Direk Limmathurotsakul, Narisara Chantratita, T. Eoin West
Summary: A study in patients with melioidosis found that interleukin-6 and interleukin-8 concentrations were positively associated with 28-day mortality, and a biomarker-based model significantly improved mortality prediction accuracy. A model combining clinical variables with biomarkers outperformed a model using only clinical variables in predicting 28-day mortality.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Anucha Preechanukul, Thatcha Yimthin, Sarunporn Tandhavanant, Tobias Brummaier, Chalita Chomkatekaew, Sukanta Das, Basirudeen Syed Ahamed Kabeer, Mohammed Toufiq, Darawan Rinchai, T. Eoin West, Damien Chaussabel, Narisara Chantratita, Mathieu Garand
Summary: Sepsis is a complex condition with a lack of effective predictors for risk and outcome, hindering its management. This study investigates the role of ACVR1B in sepsis using publicly available transcriptomic data and identifies a knowledge gap. ACVR1B, a member of the TGF-beta superfamily, is upregulated in septic melioidosis, but its role in sepsis is not well-established. Further experiments are needed to address this knowledge gap.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Milin Peng, Fuxing Deng, Desheng Qi, Zhonghua Hu, Lina Zhang
Summary: This retrospective study analyzed the impact of hyperbilirubinemia on long-term outcomes in patients with sepsis, finding that TBIL levels ≥5 mg/dl were associated with increased long-term mortality risk. The study suggests potential cutoff values for early intervention in sepsis patients, which could improve prognosis.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Taniya Kaewarpai, Shelton W. W. Wright, Thatcha Yimthin, Rungnapa Phunpang, Adul Dulsuk, Lara Lovelace-Macon, Guilhem F. F. Rerolle, Denisse B. B. Dow, Viriya Hantrakun, Nicholas P. J. Day, Ganjana Lertmemongkolchai, Direk Limmathurotsakul, T. Eoin West, Narisara Chantratita
Summary: IL-1R2 and sTREM-1 are promising biomarkers for predicting mortality in melioidosis, and biomarker models containing IL-1R2 have improved prediction compared to clinical variable models.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Xiao Chen, Xiaofeng Zhu, Huichang Zhuo, Jiandong Lin, Xian Lin
Summary: This study reveals that the absence of basophils in ICU patients is strongly associated with poor prognosis and mortality. The findings suggest that basophil-mediated immunity may serve as a potential predictor for ICU patients' prognosis, and help identify patients who would benefit from intensified treatment and immunoenhancement therapy.
SCIENTIFIC REPORTS
(2023)
Article
Pediatrics
Tadele Bekele, Hailu Merga, Tamiru Tesfaye, Henok Asefa
Summary: This study aims to determine the predictors of mortality among neonates admitted with sepsis at Durame general hospital in southern Ethiopia. The study found that prematurity, convulsion, poor feeding, and respiratory distress were predictors of sepsis-related neonatal mortality.
Article
Multidisciplinary Sciences
Dominique Moser, Matthias Feuerecker, Katharina Biere, Bing Han, Marion Hoerl, Gustav Schelling, Ines Kaufmann, Alexander Chouker, Tobias Woehrle
Summary: Secondary infections can worsen the clinical course and outcome of critically ill patients. The immune response in severe COVID-19 patients differs from that in sepsis patients, which may have implications for personalized immune therapies.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Giuseppe De Matteis, Marcello Covino, Maria Livia Burzo, Davide Antonio Della Polla, Francesco Franceschi, Alexandre Mebazaa, Giovanni Gambassi
Summary: Hospitalizations and mortality rates for older patients with Acute Heart Failure (AHF) remain high. Infections, especially pneumonia, are the most common condition precipitating AHF. Age is a significant factor with higher mortality and early death rates for older patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Andrew Li, Lowell Ling, Hanyu Qin, Yaseen M. Arabi, Sheila Nainan Myatra, Moritoki Egi, Je Hyeong Kim, Mohd Basri Mat Nor, Do Ngoc Son, Wen-Feng Fang, Bambang Wahyuprajitno, Madiha Hashmi, Mohammad Omar Faruq, Boonsong Patjanasoontorn, Maher Jaffer Al Bahrani, Babu Raja Shrestha, Ujma Shrestha, Khalid Mahmood Khan Nafees, Kyi Kyi Sann, Jose Emmanuel M. Palo, Naranpurev Mendsaikhan, Aidos Konkayev, Khamsay Detleuxay, Yiong Huak Chan, Bin Du, Jigeeshu Vasishtha Divatia, Younsuck Koh, Charles D. Gomersall, Jason Phua
Summary: This study found that sepsis is a common reason for admission to ICUs in Asia, with a higher mortality rate in low-income and lower middle-income countries/regions compared to high-income countries/regions. Compliance with sepsis bundles remains low, and delaying antibiotic administration beyond 3 hours is associated with increased mortality.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Ji Hyun, Baek Gyu Jun, Minjong Lee, Hye Ah Lee, Tae Suk Kim, Jeong Won Heo, Da Hye Moon, Seong Hee Kang, Ki Tae Suk, Moon Young Kim, Young Don Kim, Gab Jin Cheon, Soon Koo Baik, Dong Joon Kim, Dae Hee Choi
Summary: This study compared the predictive performance of Sepsis-3 criteria and CLIF-SOFA scores for in-hospital mortality in cirrhotic patients with infections. The results showed that CLIF-SOFA scores had a better predictive performance compared to Sepsis-3 criteria. It can be a useful tool for risk stratification in cirrhotic patients requiring timely intervention for infection.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Chemistry, Analytical
Ling Deng, Xiaoyi He, Ke Liu, Yuanli Li, Han Xia, Hang Qian, Xiaoxue Lu, Xuhu Mao, Yang Xiang
Summary: We developed a One-Pot CRISPR-integrated assay for Instant and Visual Detection (OPC-IVD) of Burkholderia pseudomallei. This assay combines recombinase polymerase amplification and CRISPR-Cas12a recognition-activated trans-cleavage, enabling a simple sample-to-answer detection. The method can be completed within 30 min without complex DNA extraction. The OPC-IVD has a detection limit of 2.19 copy/μL plasmid DNA, 12.5 CFU/mL B. pseudomallei, and 61.5 CFU/mL bacteria in spiked blood samples. Clinical evaluation demonstrated 100% accuracy. This simplified workflow enables field-deployable, instrument-free, and rapid detection of B. pseudomallei in under-resourced settings.
ANALYTICA CHIMICA ACTA
(2023)
Article
Anesthesiology
Kai-Zhi Xu, Ping Xu, Juan-Juan li, A-Fang Zuo, Shu-Bao Wang, Fang Han
Summary: The study aimed to construct a prediction model to assess the 28-day mortality in patients with sepsis-induced myocardial injury (SIMI). Retrospective data from the MIMIC-IV clinical database was used to construct the model. The results showed that SIMI was independently associated with the 28-day mortality in septic patients, and the performance of the nomogram model was better than the single SOFA score and Troponin T.
BMC ANESTHESIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Caspar Mewes, Julius Runzheimer, Carolin Boehnke, Benedikt Buettner, Marcus Nemeth, Jose Hinz, Michael Quintel, Ashham Mansur
Summary: This study compared the mortality and sepsis-associated organ dysfunction between patients with sepsis following surgical intervention and those with sepsis without prior surgery. The results showed that non-surgical patients had a higher mortality rate and more severe organ dysfunction compared to surgical patients. These findings have important implications for clinical decision-making, patient management, and resource allocation in sepsis care.