Article
Multidisciplinary Sciences
Hyo Song Park, Sunyeup Kim, Christopher Seungkyu Lee, Suk Ho Byeon, Sung Soo Kim, Seung Won Lee, Yong Joon Kim
Summary: This study determined the changes in the incidence of retinal vascular occlusion during the COVID-19 era and found that infection with SARS-CoV-2 did not significantly increase the risk of retinal vascular occlusion.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Ha -Ram Park, Anahita Shiva, Portia Cummings, Seoyeon Kim, Sungsoo Kim, Eunhyeong Lee, Alessandra Leong, Subrata Chowdhury, Carrie Shawber, Richard Carvajal, Gavin Thurston, Joon-Yong An, Amanda W. Lund, Hee Won Yang, Minah Kim
Summary: The position of T-cells in the tumor microenvironment affects their ability to encounter the tumor and kill it. The vascular destabilizing factor ANGPT2 causes vascular integrity issues in the tumor periphery, leading to a lack of T-cell infiltration in the tumor core, which is associated with a poor response to immunotherapy.
Article
Gastroenterology & Hepatology
Gwang Hyeon Choi, Eun Sun Jang, Jin-Wook Kim, Sook-Hyang Jeong
Summary: Plasma levels of Ang-2 in HCC patients correlated with liver function, tumor stage, and tumor invasiveness, showing better performance in predicting OS and PFS compared to AFP, Ang-1, or VEGF.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jung Min Ha, Seo Yeon Jin, Hye Sun Lee, Hye Jin Kum, Farzaneh Vafaeinik, Hong Koo Ha, Sang Heon Song, Chi Dae Kim, Sun Sik
Summary: The study reveals the crucial role of Akt1 in regulating endothelial function and blood vessel stability through the Notch3/YAP-Ang1/2 signaling pathway in vascular smooth muscle cells.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Michal A. Stanczak, David E. Sanin, Petya Apostolova, Gabriele Nerz, Dimitrios Lampaki, Maike Hofmann, Daniel Steinmann, Robert Thimme, Gerhard Mittler, Cornelius F. Waller, Edward J. Pearce, Erika L. Pearce, Marvin Krohn-Grimberghe
Summary: The study suggests a potential association between IL-33 production and SARS-CoV-2 infection, and its correlation with CD4(+) T cell activation, antibody titers, and disease severity.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Elsa Brunet-Ratnasingham, Sai Priya Anand, Pierre Gantner, Alina Dyachenko, Gael Moquin-Beaudry, Nathalie Brassard, Guillaume Beaudoin-Bussieres, Amelie Pagliuzza, Romain Gasser, Mehdi Benlarbi, Floriane Point, Jeremie Prevost, Annemarie Laumaea, Julia Niessl, Manon Nayrac, Geremy Sannier, Catherine Orban, Marc Messier-Peet, Guillaume Butler-Laporte, David R. Morrison, Sirui Zhou, Tomoko Nakanishi, Marianne Boutin, Jade Descoteaux-Dinelle, Gabrielle Gendron-Lepage, Guillaume Goyette, Catherine Bourassa, Halima Medjahed, Laetitia Laurent, Rose-Marie Rebillard, Jonathan Richard, Mathieu Dube, Remi Fromentin, Nathalie Arbour, Alexandre Prat, Catherine Larochelle, Madeleine Durand, J. Brent Richards, Michael Chasse, Martine Tetreault, Nicolas Chomont, Andres Finzi, Daniel E. Kaufmann
Summary: This study conducted immunovirological assessments on plasma from 279 individuals to identify early predictors of mortality in patients infected with SARS-CoV-2. High vRNA, low specific immunoglobulin G and antibody-dependent cellular cytotoxicity, and elevated cytokines and tissue injury markers were strongly associated with mortality. A three-variable model combining vRNA, age, and sex was able to robustly identify patients with fatal outcomes.
Article
Ophthalmology
Emmi Kapiainen, Harri Elamaa, Ilkka Miinalainen, Valerio Izzi, Lauri Eklund
Summary: This study demonstrates the additive effect of Angpt4 in maintaining SC and activating Tie2, as well as the synergistic interaction between Angpt4 and Angpt2. The interplay between the angiopoietins is crucial for maintaining the integrity of the iridocorneal angle.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Physiology
Michael Thompson, Masahide Sakabe, Mark Verba, Jiukuan Hao, Stryder M. Meadows, Q. Richard Lu, Mei Xin
Summary: Proper vascular formation is regulated by multiple signaling pathways. The expression of PRDM16 in arterial endothelial cells (ECs) but not venous ECs plays a crucial role in maintaining arterial characteristics. Deletion of Prdm16 in ECs leads to abnormal venous marker expression in the artery and reduced recruitment of vascular smooth muscle cells. The ectopic expression of ANGIOPOIETIN2 in Prdm16 knockout ECs further suggests the role of PRDM16 in suppressing venous characteristics.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Camille Chauvin, Laurine Levillayer, Mathilde Roumier, Hubert Nielly, Claude Roth, Anupama Karnam, Srinivasa Reddy Bonam, Anne Bourgarit, Clemen Dubost, Aurore Bousquet, Sebastien Le Burel, Raphaele Mestiri, Damien Sene, Joris Galland, Marc Vasse, Matthieu Groh, Mathilde Le Marchand, Camille Vassord-Dang, Jean-Francois Gautier, Nhan Pham-Thi, Christiane Verny, Bruno Pitard, Cyril Planchais, Hugo Mouquet, Richard Paul, Etienne Simon-Loriere, Jagadeesh Bayry, Laurent Gilardin, Anavaj Sakuntabhai
Summary: Despite the efficacy of tocilizumab treatment in severe and critical COVID-19 patients, there is little evidence on its effect on B cell sub-populations and cross-neutralization of SARS-CoV-2 variants in convalescent patients. Immunological profiling of 69 convalescent patients revealed that disease severity, rather than tocilizumab treatment, influenced SARS-CoV-2-specific IgG1 titers. Plasma from both treated and non-treated patients showed neutralizing activity against ancestral and several variants, but reduced sensitivity to Gamma and Omicron viruses. Overall, tocilizumab therapy did not affect B cell and IgG responses to Spike antigens.
Article
Medicine, Research & Experimental
Peng Zhang, Ji Peng, Yun-Qin Ren, Han Zheng, Hong Yan
Summary: The study demonstrated that dexmedetomidine reduced lung injury and inflammation in a rat sepsis model by decreasing Ang2 levels and increasing VE-cadherin expression. These findings suggest a potential therapeutic application of dexmedetomidine in sepsis treatment.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Multidisciplinary Sciences
Camille Chauvin, Laurine Levillayer, Mathilde Roumier, Hubert Nielly, Claude Roth, Anupama Karnam, Srinivasa Reddy Bonam, Anne Bourgarit, Clement Dubost, Aurore Bousquet, Sebastien Le Burel, Raphaele Mestiri, Daminen Sene, Joris Galland, Marc Vasse, Matthieu Groh, Mathilde Le Marchand, Camille Vassord-Dang, Jean-Francois Gautier, Pham-Thi Nhan, Christian Verny, Bruno Pitaro, Cyril Planchais, Hugo Mouquet, Richard Paul, Etienne Simon-Loriere, Jagadeesh Bayry, Laurent Gilardin, Anavaj Sakuntabhai
Summary: Although tocilizumab treatment has shown efficacy in severe COVID-19 patients, its short-term use does not affect B cell sub-populations and cross-neutralization of SARS-CoV-2 variants in convalescent COVID-19 patients. The study found that SARS-CoV-2-specific IgG1 titers were dependent on disease severity rather than tocilizumab treatment. Both treated and non-treated patients had strong neutralizing activity against ancestral and several variants of SARS-CoV-2, but weaker activity against the Gamma and Omicron variants. Overall, tocilizumab therapy did not modify the robustness of cell and IgG responses to Spike antigens.
Article
Biochemistry & Molecular Biology
Haiyan Zhou, Tangting Chen, Yongjie Li, Jingcan You, Xin Deng, Ni Chen, Tian Li, Youkun Zheng, Rong Li, Mao Luo, Jianbo Wu, Liqun Wang
Summary: This study found that Tie-2 is modified by AGEs in diabetes, leading to the inhibition of Ang-1 signaling activation and angiogenesis. This finding provides a novel mechanism for Ang-1/Tie-2 signal dysfunction and angiogenesis failure in diabetic ischemic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Bobeck S. Modjtahedi, Duy Do, Tiffany Q. Luong, Jeremy Shaw
Summary: This study aims to assess whether there is a change in the incidence of retinal vascular occlusions after COVID-19 infection. The results showed that the incidence of new RVOs increased in the 6 months after COVID-19 infection, while the increase in RAOs was smaller. These events remain rare, and further research is needed to better understand their association with COVID-19 infection.
JAMA OPHTHALMOLOGY
(2022)
Article
Critical Care Medicine
Jurjan Aman, Erik Duijvelaar, Liza Botros, Azar Kianzad, Job R. Schippers, Patrick J. Smeele, Sara Azhang, Imke H. Bartelink, Ahmed A. Bayoumy, Pierre M. Bet, Wim Boersma, Peter Bonta, Karin A. T. Boomars, Lieuwe D. J. Bos, Job J. M. H. van Bragt, Gert-Jan Braunstahl, Lucas R. Celant, Katrien A. B. Eger, J. J. Miranda Geelhoed, Yurika L. E. van Glabbeek, Hans P. Grotjohan, Laura A. Hagens, Chris M. Happe, Boaz D. Hazes, Leo M. A. Heunks, Michel van den Heuvel, Wouter Hoefsloot, Rianne J. A. Hoek, Romke Hoekstra, Herman M. A. Hofstee, Nicole P. Juffermans, E. Marleen Kemper, Renate Kos, Peter W. A. Kunst, Ariana Lammers, Ivo van der Lee, E. Laurien van der Lee, Anke-Hilse Maitland-van der Zee, Pearl F. M. Mau Asam, Adinda Mieras, Mirte Muller, Elisabeth C. W. Neefjes, Esther J. Nossent, Laurien M. A. Oswald, Maria J. Overbeek, Carolina C. Pamplona, Nienke Paternotte, Niels Pronk, Michiel A. de Raaf, Bas F. M. van Raaij, Merlijn Reijrink, Marcus J. Schultz, Ary Serpa Neto, Elise M. A. Slob, Frank W. J. M. Smeenk, Marry R. Smit, A. Josien Smits, Janneke E. Stalenhoef, Pieter R. Tuinman, Arthur L. E. M. Vanhove, Jeroen N. Wessels, Jessie C. C. van Wezenbeek, Anton Vonk Noordegraaf, Frances S. de Man, Harm J. Bogaard
Summary: The study showed that imatinib did not significantly reduce the time to discontinuation of oxygen in COVID-19 patients, but may improve survival rates and reduce the duration of invasive mechanical ventilation. Safety evaluation revealed no significant adverse events associated with imatinib.
LANCET RESPIRATORY MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Rui Wang, Moua Yang, Longguang Jiang, Mingdong Huang
Summary: This review focuses on the various functions of the Ang-Tie axis in inflammation-induced vascular permeability, vascular remodeling, atherosclerosis, ocular angiogenesis, tumor angiogenesis, and metastasis. Therapeutic approaches to the Ang-Tie axis are also discussed.
PHARMACOLOGICAL RESEARCH
(2022)
