Editorial Material
Endocrinology & Metabolism
Kyriaki Kostoglou, David M. Simpson, Stephen J. Payne
Summary: Studies have shown evidence of asymmetry in the response of cerebral autoregulation (CA) to increasing and decreasing pressure challenges. CA appears to be stronger during transient increases in arterial blood pressure and weaker during decreases. The measurement of this effect and its relevance in clinical settings remain questionable.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Clinical Neurology
Camilla Gelormini, Eleonora Ioannoni, Angela Scavone, Luca Pisapia, Francesco Signorelli, Nicola Montano, Marco Piastra, Anselmo Caricato
Summary: This study found that an increase in velocity in the middle cerebral artery (MCA) was associated with intracranial hypertension in traumatic brain injury (TBI) patients. Transcranial EcoDoppler (TCD) monitoring could be a useful method to detect and guide the therapy for this condition. It may serve as a tool for cause-oriented therapy of intracranial hypertension.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Navpreet Reehal, Stephanie Cummings, Michael T. Mullen, Wesley B. Baker, David Kung, William Tackett, Christopher G. Favilla
Summary: This study compared cerebral autoregulation in all major cerebral vessels and found that while the time course of autoregulation was similar in all vessels, the magnitude of hemodynamic regulation was lower in the posterior cerebral artery. However, after adjusting for baseline flow differences, normalized gain was similar in all vessels.
FRONTIERS IN NEUROLOGY
(2021)
Review
Endocrinology & Metabolism
Jui-Lin Fan, Ricardo C. Nogueira, Patrice Brassard, Caroline A. Rickards, Matthew Page, Nathalie Nasr, Yu-Chieh Tzeng
Summary: This article discusses the importance of reperfusion treatment in acute ischemic stroke patients and highlights the impact of blood pressure on cerebral perfusion. It emphasizes the importance of effective blood pressure management in the early stages of stroke, and suggests that bedside monitoring of cerebral perfusion and oxygenation can help guide treatment and improve outcomes.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Psychology, Biological
Weijun Zhang, Wen Fu, Luda Yan, Mengyu Wang, Baile Ning, Xiuyun Mo, Li Xiong, Jia Liu, Pandeng Zhang, Jingxin Zhong, Lu Sun, Wenbin Fu
Summary: The study found that impaired cerebral autoregulation (CA) was present in young adults with mild depression, and was negatively correlated with HAMD scores. The phase difference was identified as a valid indicator for identifying patients with depression, with a cutoff value of 29.66.
Review
Critical Care Medicine
Michael D. Wood, J. Gordon Boyd, Nicole Wood, James Frank, Timothy D. Girard, Amanda Ross-White, Akash Chopra, Denise Foster, Donald E. G. Griesdale
Summary: The studies suggest that altered cerebral perfusion may be associated with delirium in sepsis patients, but due to various factors, a meta-analysis is currently not feasible.
JOURNAL OF INTENSIVE CARE MEDICINE
(2022)
Article
Clinical Neurology
Juliana Caldas, Armin Alvaro Quispe-Cornejo, Ilaria Alice Crippa, Carles Subira, Jacques Creteur, Ronney Panerai, Fabio Silvio Taccone
Summary: The study aimed to assess the agreement between two validated dCA indices in sepsis patients, with ARI and Mxa showing poor agreement in classifying patients with impaired or intact dCA. Further investigation into specific factors influencing dCA analysis is needed for better selection of appropriate CAR index in critically ill sepsis patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Acoustics
Yijun Zheng, Meihua Shen, Lizhen Xuan, Simeng Pan, Song Chen, Ming Zhong, Biao Zhu
Summary: This study aims to understand the CBF changes during sepsis and explore their predictive value in sepsis-associated encephalopathy (SAE). The results show that abnormal CBF is present in SAE patients and different types of CBF alterations are related to different clinical features. Peak systolic velocity (VS) and pulsatility index (PI) may be useful markers to identify different types of SAE.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Olivier Desebbe, Etienne Bachelard, Marie Deperdu, Romain Manet, Brenton Alexander, Johanne Beuvelot, Joseph Nloga, Alexandre Joosten, Laurent Gergele
Summary: Maintaining a mean arterial pressure within the range of cerebral autoregulation is important during cardiac surgery to prevent postoperative morbidity. This study compared a quick determination of the lower limit of cerebral autoregulation using a two second averaging period with the reference lower limit using a ten second averaging period. The results showed that the quick determination had a higher detection rate but had large limits of agreement and significant interobserver variability, limiting its clinical utility.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Vladimir Semenyutin, Valery Antonov, Galina Malykhina, Vyacheslav Salnikov
Summary: The authors conducted a study on the systemic and cerebral hemodynamics in various neurosurgical pathologies using signal processing methods. Their proposed method based on continuous wavelet transform shows higher sensitivity and better localization compared to traditional methods. This research is important for finding effective treatment solutions for patients with different pathologies.
Article
Biophysics
Jie Chen, Pei Dong, Kehui Dong, Dapeng Mo, Yilong Wang, Xingquan Zhao, Yongjun Wang, Xiping Gong
Summary: The study found that dynamic cerebral autoregulation was impaired in IIH patients, but improved after venous sinus stenting, suggesting that CA assessment could be useful in investigating hemodynamics in IIH patients.
PHYSIOLOGICAL MEASUREMENT
(2021)
Review
Pharmacology & Pharmacy
Alwyn Gomez, Logan Froese, Amanjyot Singh Sainbhi, Carleen Batson, Frederick A. Zeiler
Summary: The study explores the association of continuous time-domain TCD based indices of cerebrovascular reactivity with global functional outcomes, cerebral physiologic correlates, and imaging evidence of lesion change. The findings suggest that these indices have prognostic utility following TBI. Indices based on mean flow velocities have the largest body of literature support, but recent studies indicate that indices based on systolic flow velocities may have the most prognostic utility and closely follow established measures of cerebrovascular reactivity.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Physiology
Lucy Beishon, Rebecca H. Clough, Meeriam Kadicheeni, Tamara Chithiramohan, Ronney B. Panerai, Victoria J. Haunton, Jatinder S. Minhas, Thompson G. Robinson
Summary: Global aging is increasing the burden of common age-related disorders, with cerebrovascular diseases playing a significant role. Understanding and promoting healthy vascular brain aging is becoming a growing priority for healthcare systems. Normal aging affects cerebral autoregulation and neurovascular coupling processes, leading to physiological adaptations that mitigate age-related declines.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Review
Critical Care Medicine
Alwyn Gomez, Carleen Batson, Logan Froese, Amanjyot Singh Sainbhi, Frederick Adam Zeiler
Summary: Transcranial Doppler (TCD) has been a valuable tool for non-invasively monitoring cerebral physiology in neurocritical care since the 1980s. It plays a significant role in managing patients with moderate and severe traumatic brain injury (TBI), providing insight into cerebral physiology and clinical evidence supporting its applications for determining intracranial pressure, detecting post-traumatic vasospasm, predicting patient outcome, and assessing cerebral autoregulation.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Physiology
Tiago Pedro, Andreia Costa, Juliana Ferreira, Ana Luisa Rocha, Elson Salgueiro, Gilberto Pereira, Elsa Azevedo, Pedro Castro
Summary: This study found that dynamic cerebral autoregulation is preserved in patients with severe aortic stenosis in the long term, and does not change after surgical aortic valve replacement. However, carbon dioxide vasoreactivity is impaired in these patients. The study suggests that severe aortic stenosis does not affect dynamic cerebral autoregulation, but reduces vasoreactivity to carbon dioxide. Surgical aortic valve replacement does not alter cerebral autoregulation or vasoreactivity.
EXPERIMENTAL PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Jui-Lin Fan, Ricardo C. Nogueira, Patrice Brassard, Caroline A. Rickards, Matthew Page, Nathalie Nasr, Yu-Chieh Tzeng
Summary: This article discusses the importance of reperfusion treatment in acute ischemic stroke patients and highlights the impact of blood pressure on cerebral perfusion. It emphasizes the importance of effective blood pressure management in the early stages of stroke, and suggests that bedside monitoring of cerebral perfusion and oxygenation can help guide treatment and improve outcomes.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Review
Endocrinology & Metabolism
Ricardo C. Nogueira, Marcel Aries, Jatinder S. Minhas, Nils Petersen, Li Xiong, Jana M. Kainerstorfer, Pedro Castro
Summary: Acute stroke is a serious condition with high morbidity and mortality rates. Research has been conducted on new therapies to improve clinical outcomes post stroke onset, but challenges remain. Additional treatments targeted to individual patients are needed for better results.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Review
Endocrinology & Metabolism
Jui-Lin Fan, Patrice Brassard, Caroline A. Rickards, Ricardo C. Nogueira, Nathalie Nasr, Fiona D. McBryde, James P. Fisher, Yu-Chieh Tzeng
Summary: Optimizing cerebral perfusion is crucial for rescuing salvageable ischemic brain tissue, yet there are no effective guidelines for blood pressure management in acute stroke. The control of cerebral blood flow involves complex pathways that are often overlooked in stroke management. The unique anatomy and physiology of cerebrovascular circulation are usually treated as a separate system rather than an integral part of the cardiovascular system.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Neurosciences
Matheus Schmidt Soares, Almir Ferreira de Andrade, Sergio Brasil, Marcelo De-Lima-Oliveira, Alessandro Rodrigo Belon, Edson Bor-Seng-Shu, Ricardo de Carvalho Nogueira, Daniel Agustin Godoy, Wellingson Silva Paiva
Summary: This study investigated the correlation between cerebral blood flow assessed by Doppler technique and variations of intracranial pressure (ICP) in an animal model. The results showed a significant correlation between pulsatility index (PI) and ICP, suggesting that PI can potentially be used as a parameter to evaluate patients with suspected elevated ICP.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2022)
Review
Endocrinology & Metabolism
Ronney B. Panerai, Patrice Brassard, Joel S. Burma, Pedro Castro, Jurgen A. H. R. Claassen, Johannes J. van Lieshout, Jia Liu, Samuel Je Lucas, Jatinder S. Minhas, Georgios D. Mitsis, Ricardo C. Nogueira, Shigehiko Ogoh, Stephen J. Payne, Caroline A. Rickards, Andrew D. Robertson, Gabriel D. Rodrigues, Jonathan D. Smirl, David M. Simpson
Summary: This study improved the evaluation method of cerebral autoregulation (CA) by introducing guidelines for data acquisition, analysis, and reporting, and proposed new recommendations to reflect recent advances in the field. The implementation of these recommendations is crucial for improving the reliability and reproducibility of studies.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Physiology
Sergio Brasil, Ricardo C. Nogueira, Angela S. M. Salinet, Marcia H. Yoshikawa, Manoel J. Teixeira, Wellingson Paiva, Luiz M. S. Malbouisson, Edson Bor-Seng-Shu, Ronney B. Panerai
Summary: This study found that in patients with acute brain injury, intracranial pressure (ICP) contributes less to cerebral blood flow autoregulation compared to mean arterial blood pressure (MAP). This has implications for the management of arterial blood pressure in neurocritical patients.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Daniel S. Abadjiev, Edgar Toschi-Dias, Angela S. M. Salinet, Nicole N. Gaykova, Men-Tzung Lo, Ricardo C. Nogueira, Kun Hu
Summary: A daily rhythm of dynamic cerebral autoregulation was observed in stroke patients, with better regulation of cerebral blood flow velocity in the afternoon. This finding may have implications for daily activity management in stroke patients.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Anesthesiology
Sergio Brasil, Gustavo Frigieri, Fabio Silvio Taccone, Chiara Robba, Davi Jorge Fontoura Solla, Ricardo de Carvalho Nogueira, Marcia Harumy Yoshikawa, Manoel Jacobsen Teixeira, Luiz Marcelo Sa Malbouisson, Wellingson Silva Paiva
Summary: This study assessed the correlation between noninvasive intracranial pressure waveforms (NICPW) and invasively measured intracranial pressure (ICP), as well as the prognostic value of NICPW in acute brain-injured patients. The results showed a significant correlation between NICPW and ICP, and the NICPW-derived P2/P1 ratio could predict intracranial hypertension and early death.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Critical Care Medicine
Sergio Brasil, Ricardo de Carvalho Nogueira, Angela Salomao Macedo Salinet, Marcia Harumy Yoshikawa, Manoel Jacobsen Teixeira, Wellingson Paiva, Luiz Marcelo Sa Malbouisson, Edson Bor-Seng-Shu, Ronney B. Panerai
Summary: This study evaluates the effects of intracranial pressure (ICP) variability on critical closing pressure (CrCP) and resistance-area product (RAP) among patients with acute brain injury (ABI). The results show a strong correlation between changes in ICP and corresponding changes in CrCP. Patients who underwent neurosurgical interventions have elevated cerebrovascular resistance despite increased arterial blood pressure responses.
NEUROCRITICAL CARE
(2023)
Editorial Material
Endocrinology & Metabolism
Sergio Brasil, Ronney B. Panerai, Edson Bor-Seng-Shu, Ricardo C. Nogueira
Summary: Cerebral perfusion pressure (CPP), which is commonly used in neurocritical care, is calculated as the difference between mean arterial blood pressure and mean intracranial pressure. This commentary discusses recent physiological advances and bedside practice issues, suggesting that considering CPP under this perspective may lead to inaccurate assumptions and potentially misleading decision making.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Letter
Critical Care Medicine
Sergio Brasil, Juliana Caldas, Lucy Beishon, Jatinder S. Minhas, Ricardo C. Nogueira
NEUROCRITICAL CARE
(2023)
Article
Surgery
Maira de Robertis Azevedo, Marcelo de-Lima-Oliveira, Alessandro Rodrigo Belon, Sergio Brasil, Manoel Jacobsen Teixeira, Wellingson Silva Paiva, Edson Bor-Seng-Shu
Summary: This study aimed to determine the normal optical nerve sheath (ONS) diameter using ultrasonography (ONSUS) and evaluate the potential effects of drugs on ONS diameter during anesthetic induction in healthy pigs. The results showed that sedation with thiopental led to a significant reduction in ONS diameter compared to propofol.
ACTA CIRURGICA BRASILEIRA
(2022)