Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model

ECM Signaling Regulates Collective Cellular Dynamics to Control Pancreas Branching Morphogenesis

(2016) Hung Ping Shih et al.   Cell Reports

Dynamic Proteomic Analysis of Pancreatic Mesenchyme Reveals Novel Factors That Enhance Human Embryonic Stem Cell to Pancreatic Cell Differentiation

(2016) Holger A. Russ et al.   Stem Cells International

Epigenetic Priming of Enhancers Predicts Developmental Competence of hESC-Derived Endodermal Lineage Intermediates

(2015) Allen Wang et al.   Cell Stem Cell

Islet formation in mice and men: lessons for the generation of functional insulin-producing β-cells from human pluripotent stem cells

(2015) Gopika Nair et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Human β-Cell Proliferation and Intracellular Signaling: Part 3

(2015) Andrew F. Stewart et al.   DIABETES

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

(2015) Kyle J Gaulton et al.   NATURE GENETICS

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

(2015) Martijn van de Bunt et al.   PLoS Genetics

Efficient Generation of NKX6-1+ Pancreatic Progenitors from Multiple Human Pluripotent Stem Cell Lines

(2015) M. Cristina Nostro et al.   Stem Cell Reports

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

(2014) Anubha Mahajan et al.   NATURE GENETICS

Differentiated human stem cells resemble fetal, not adult, β cells

(2014) Sinisa Hrvatin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

(2014) J. Fadista et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development-Inspired Reprogramming of the Mammalian Central Nervous System

(2014) R. Amamoto et al.   SCIENCE

Genetic Background Drives Transcriptional Variation in Human Induced Pluripotent Stem Cells

(2014) Foad Rouhani et al.   PLoS Genetics

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

Improved workflows for high throughput library preparation using the transposome-based nextera system

(2013) Sarah Lamble et al.   BMC BIOTECHNOLOGY

Dynamic Chromatin Remodeling Mediated by Polycomb Proteins Orchestrates Pancreatic Differentiation of Human Embryonic Stem Cells

(2013) Ruiyu Xie et al.   Cell Stem Cell

Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

(2013) Antigone S. Dimas et al.   DIABETES

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

(2013) Jennifer E. Bruin et al.   DIABETOLOGIA

Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome

(2013) A. C. Nica et al.   GENOME RESEARCH

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

(2013) S. C. J. Parker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells

(2013) Jennifer E. Bruin et al.   Stem Cell Research

Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

(2013) Alireza Rezania et al.   STEM CELLS

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells

(2012) Lina Sui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RNA-SeQC: RNA-seq metrics for quality control and process optimization

(2012) David S. DeLuca et al.   BIOINFORMATICS

GATA6 Mutations Cause a Broad Phenotypic Spectrum of Diabetes From Pancreatic Agenesis to Adult-Onset Diabetes Without Exocrine Insufficiency

(2012) E. De Franco et al.   DIABETES

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets

(2012) M. E. Travers et al.   DIABETES

Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells

(2012) C. H.-H. Cho et al.   DIABETOLOGIA

GENCODE: The reference human genome annotation for The ENCODE Project

(2012) J. Harrow et al.   GENOME RESEARCH

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells

(2012) M. Kajiwara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting SOX17 in Human Embryonic Stem Cells Creates Unique Strategies for Isolating and Analyzing Developing Endoderm

(2011) Pei Wang et al.   Cell Stem Cell

Stage-specific signaling through TGF  family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells

(2011) M. C. Nostro et al.   DEVELOPMENT

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells

(2011) Olivia G Kelly et al.   NATURE BIOTECHNOLOGY

GATA6 haploinsufficiency causes pancreatic agenesis in humans

(2011) Hana Lango Allen et al.   NATURE GENETICS

Deconstructing Pancreas Development to Reconstruct Human Islets from Pluripotent Stem Cells

(2010) Kristen D. McKnight et al.   Cell Stem Cell

Epithelial dynamics of pancreatic branching morphogenesis

(2010) A. Villasenor et al.   DEVELOPMENT

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Inherited Variation in Gene Expression

(2009) Daniel A. Skelly et al.   Annual Review of Genomics and Human Genetics

Parental origin of sequence variants associated with complex diseases

(2009) Augustine Kong et al.   NATURE

A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation

(2008) Philip A. Seymour et al.   DEVELOPMENTAL BIOLOGY

Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?

(2008) J. C. Florez   DIABETOLOGIA

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

Diminished Phosphodiesterase-8B Potentiates Biphasic Insulin Response to Glucose

(2007) Avital Dov et al.   ENDOCRINOLOGY