Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance

Mitochondrial dysfunction and cell senescence — skin deep into mammalian aging

(2016) Joao F. Passos et al.   Aging-US

Progressively heterogeneous mismatch of regional oxygen delivery to consumption during graded coronary stenosis in pig left ventricle

(2015) David J. C. Alders et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Stem cells, mitochondria and aging

(2015) Kati J. Ahlqvist et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondria: Are they causal players in cellular senescence?

(2015) Clara Correia-Melo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

(2015) Dirk M. Walther et al.   CELL

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome

(2015) Saeed Shoaie et al.   Cell Metabolism

Redox Homeostasis and Mitochondrial Dynamics

(2015) Peter H.G.M. Willems et al.   Cell Metabolism

Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer

(2015) Peter D. Adams et al.   Cell Stem Cell

A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity

(2015) Eric Ravussin et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Tipping the metabolic scales towards increased longevity in mammals

(2015) Celine E. Riera et al.   NATURE CELL BIOLOGY

On the theoretical limits of detecting cyclic changes in cardiac high-energy phosphates and creatine kinase reaction kinetics usingin vivo31P MRS

(2015) Kilian Weiss et al.   NMR IN BIOMEDICINE

Using Bioconductor Package BiGGR for Metabolic Flux Estimation Based on Gene Expression Changes in Brain

(2015) Anand K. Gavai et al.   PLoS One

New and Notable: Uncertainty Quantification

(2014) James B. Bassingthwaighte   BIOPHYSICAL JOURNAL

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging

(2014) A. Kowald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(2014) M. Sinha et al.   SCIENCE

mTOR and the health benefits of exercise

(2014) Kurt Watson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Defining the toxicology of aging

(2014) Jessica A. Sorrentino et al.   TRENDS IN MOLECULAR MEDICINE

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

Monitoring training status with HR measures: do all roads lead to Rome?

(2014) Martin Buchheit   Frontiers in Physiology

Inference of dynamical gene-regulatory networks based on time-resolved multi-stimuli multi-experiment data applying NetGenerator V2.0

(2013) Michael Weber et al.   BMC Systems Biology

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Predicting the impact of diet and enzymopathies on human small intestinal epithelial cells

(2013) Swagatika Sahoo et al.   HUMAN MOLECULAR GENETICS

A validated model of oxygen uptake and circulatory dynamic interactions at exercise onset in humans

(2013) Alan P. Benson et al.   JOURNAL OF APPLIED PHYSIOLOGY

Glutamatergic Function in the Resting Awake Human Brain is Supported by Uniformly High Oxidative Energy

(2013) Fahmeed Hyder et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

A community-driven global reconstruction of human metabolism

(2013) Ines Thiele et al.   NATURE BIOTECHNOLOGY

Increased Expression of Matrix Extracellular Phosphoglycoprotein (MEPE) in Cortical Bone of the Rat Tibia after Mechanical Loading: Identification by Oligonucleotide Microarray

(2013) Christianne M. A. Reijnders et al.   PLoS One

Glucose Regulation of Load‐Induced mTOR Signaling and ER Stress in Mammalian Heart

(2013) Shiraj Sen et al.   Journal of the American Heart Association

The evolution of genome-scale models of cancer metabolism

(2013) Nathan E. Lewis et al.   Frontiers in Physiology

The free-radical theory of ageing - older, wiser and still alive

(2012) Thomas B. L. Kirkwood et al.   BIOESSAYS

Exercise efficiency is reduced by mitochondrial uncoupling in the elderly

(2012) Kevin E. Conley et al.   EXPERIMENTAL PHYSIOLOGY

Elevated energy coupling and aerobic capacity improves exercise performance in endurance-trained elderly subjects

(2012) Kevin E. Conley et al.   EXPERIMENTAL PHYSIOLOGY

PGC1  and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders

(2012) S. Austin et al.   JOURNAL OF CELL SCIENCE

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Macromolecular deterioration as the ultimate constraint on human lifespan

(2011) Roger John Willis Truscott   AGEING RESEARCH REVIEWS

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

Screen-Based Entertainment Time, All-Cause Mortality, and Cardiovascular Events

(2011) Emmanuel Stamatakis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Human nutrition, the gut microbiome and the immune system

(2011) Andrew L. Kau et al.   NATURE

Simulating the physiology of athletes during endurance sports events: modelling human energy conversion and metabolism

(2011) J. H. G. M. van Beek et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Glycolytic Oscillations and Limits on Robust Efficiency

(2011) F. A. Chandra et al.   SCIENCE

A theory of biological relativity: no privileged level of causation

(2011) D. Noble   Interface Focus

The metabolic footprint of aging in mice

(2011) Riekelt H. Houtkooper et al.   Scientific Reports

Analyzing the Functional Properties of the Creatine Kinase System with Multiscale ‘Sloppy’ Modeling

(2011) Hannes Hettling et al.   PLoS Computational Biology

Cerebral blood flow and metabolic rate of oxygen, glucose, lactate, pyruvate, ketone bodies and amino acids

(2010) Ulla Lying-Tunell et al.   ACTA NEUROLOGICA SCANDINAVICA

Computational quantification of metabolic fluxes from a single isotope snapshot: application to an animal biopsy

(2010) Thomas W. Binsl et al.   BIOINFORMATICS

Metabolic Networks of Longevity

(2010) Riekelt H. Houtkooper et al.   CELL

Television Viewing Time and Mortality

(2010) D.W. Dunstan et al.   CIRCULATION

Identification of Nuclear Phosphatidylinositol 4,5-Bisphosphate-Interacting Proteins by Neomycin Extraction

(2010) Aurélia E. Lewis et al.   MOLECULAR & CELLULAR PROTEOMICS

Linking functional decline of telomeres, mitochondria and stem cells during ageing

(2010) Ergün Sahin et al.   NATURE

Large-scale in silico modeling of metabolic interactions between cell types in the human brain

(2010) Nathan E Lewis et al.   NATURE BIOTECHNOLOGY

Systems biology of ageing and longevity

(2010) T. B. L. Kirkwood   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice

(2010) Asimina Hiona et al.   PLoS One

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Measuring non-steady-state metabolic fluxes in starch-converting faecal microbiota in vitro

(2010) T. Binsl et al.   Beneficial Microbes

Rule-Based Cell Systems Model of Aging using Feedback Loop Motifs Mediated by Stress Responses

(2010) Andres Kriete et al.   PLoS Computational Biology

Frailty Syndrome: A Transitional State in a Dynamic Process

(2009) Pierre-Olivier Lang et al.   GERONTOLOGY

Sitting Time and Mortality from All Causes, Cardiovascular Disease, and Cancer

(2009) PETER T. KATZMARZYK et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Hyperpolarized 13C Lactate, Pyruvate, and Alanine: Noninvasive Biomarkers for Prostate Cancer Detection and Grading

(2008) M. J. Albers et al.   CANCER RESEARCH

The Cardiac Physiome: perspectives for the future

(2008) James Bassingthwaighte et al.   EXPERIMENTAL PHYSIOLOGY