Review
Oncology
Krystian Kaczmarek, Bartosz Malkiewicz, Artur Leminski
Summary: The number of lymph nodes removed during radical cystectomy can affect the prognosis of patients with muscle-invasive bladder cancer. However, this study found that for patients who received neoadjuvant chemotherapy, pelvic lymphadenectomy did not have a significant impact on survival outcomes.
Article
Oncology
Thomas A. Hope, Matthias Eiber, Wesley R. Armstrong, Roxanna Juarez, Vishnu Murthy, Courtney Lawhn-Heath, Spencer C. Behr, Li Zhang, Francesco Barbato, Francesco Ceci, Andrea Farolfi, Sarah M. Schwarzenboeck, Marcus Unterrainer, Helle D. Zacho, Hao G. Nguyen, Matthew R. Cooperberg, Peter R. Carroll, Robert E. Reiter, Stuart Holden, Ken Herrmann, Shaojun Zhu, Wolfgang P. Fendler, Johannes Czernin, Jeremie Calais
Summary: This study showed that in men with intermediate- to high-risk prostate cancer undergoing radical prostatectomy and lymph node dissection, the sensitivity and specificity of Ga-68-PSMA-11 PET were 0.40 and 0.95, respectively.
Review
Urology & Nephrology
Bernardo Rocco, Ahmed Eissa, Giorgia Gaia, Simone Assumma, Luca Sarchi, Giorgio Bozzini, Salvatore Micali, Tommaso Calcagnile, Maria C. Sighinolfi
Summary: Prostate cancer and bladder cancer are significant contributors to male cancers and newly diagnosed cancers, causing a substantial health and economic burden worldwide. Understanding lymph node status is crucial in managing solid tumors, with pelvic lymph node dissection (pLND) being a vital part of the diagnosis, management, and prognosis of prostate and bladder cancers. However, pLND may have associated complications. This review discusses the latest updates on lymph node metastasis patterns and incidence, the role of different imaging studies and nomograms in determining pLND eligibility, and anatomical templates for pLND in urologic patients with bladder or prostate cancer.
MINERVA UROLOGY AND NEPHROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
B. H. E. Jansen, Y. J. L. Bodar, G. J. C. Zwezerijnen, D. Meijer, J. P. van der Voorn, J. A. Nieuwenhuijzen, M. Wondergem, T. A. Roeleveld, R. Boellaard, O. S. Hoekstra, R. J. A. van Moorselaar, D. E. Oprea-Lager, A. N. Vis
Summary: The study found that F-18-DCFPyL PET/CT has high specificity but limited sensitivity for detecting pelvic lymph-node metastases in primary prostate cancer patients. Therefore, current PSMA PET/CT imaging cannot fully replace diagnostic ePLND. Further research is needed to determine the exact role of PSMA PET/CT imaging in the primary staging of prostate cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Urology & Nephrology
Randi M. Pose, Sophie Knipper, Christoph Wurnschimmel, Pierre Tennstedt, Uwe Michl, Tobias Maurer, Markus Graefen, Thomas Steuber
Summary: The technique of peritoneal fenestration significantly reduces the risk of symptomatic lymphocele formation after open retropubic radical prostatectomy with pelvic lymph node dissection, leading to a decreased need for further intervention.
Article
Oncology
Josh Gottlieb, Shu-Ching Chang, Jane Choe, Gary L. Grunkemeier, Douglas A. Hanes, David Krasne, Dave S. B. Hoon, Timothy G. Wilson
Summary: This study evaluated the significance of lymph node tumor burden in prostate cancer patients and found a significant association with biochemical recurrence-free survival. It also reported the importance of the anatomical location of tumor deposits within the lymph nodes and the extent of extranodal extension, although these factors did not show a significant association with biochemical recurrence-free survival due to a small sample size. The study emphasizes the need to consider lymph node tumor burden in nodal staging and post-operative clinical nomograms.
Article
Urology & Nephrology
Kai Yao, Yue Chen, Yunlin Ye, Zhiming Wu, Dong Chen, Hui Han, Zaishang Li, Zhuowei Liu, Yanjun Wang, Zike Qin, Yonghong Li, Zhiyong Li, Fangjian Zhou
Summary: The study provides a detailed map of pelvic lymph node metastasis in patients with penile carcinoma, showing that the external iliac and obturator packages are most commonly involved. Pelvic lymph node metastasis is associated with advanced T-stage. Some patients have crossover metastasis.
JOURNAL OF UROLOGY
(2021)
Article
Multidisciplinary Sciences
Stephanie A. Stillings, Debasish Sundi
Summary: The robotic approach to radical cystectomy offers advantages in terms of oncologic outcomes, surgical blood loss, and postoperative hospital stay, making it an important component of enhanced recovery programs. This paper discusses the critical steps and techniques of robotic surgery, as well as the increasing adoption of robotic techniques by bladder cancer surgeons.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Urology & Nephrology
Kishore Thekke Adiyat, Ginil Kumar Pooleri, Dinesh Thomas Cherian, Shagos Gopalan Nair Santhamma, K. Ravichandran, Shanmuga Sundaram
Summary: This study aimed to evaluate the negative predictive value of PSMA PET scan for lymph node staging in patients who underwent robotic radical prostatectomy and pelvic lymph node dissection. The overall negative predictive value of PSMA PET scan was found to be 71.6%. However, further analysis based on risk stratification showed that the negative predictive value varied among different risk groups, with values of 58.02%, 92.7%, and 90% for high, intermediate, and low-risk patients, respectively.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Review
Oncology
Wenqiang Qi, Minglei Zhong, Ning Jiang, Yongheng Zhou, Guangda Lv, Rongyang Li, Benkang Shi, Shouzhen Chen
Summary: This study found through network meta-analysis that extended PLND and super-extended PLND groups have advantages in recurrence-free survival compared to standard PLND and limited PLND groups. The super-extended PLND may have a better overall survival, but no significant impact on disease-specific survival. There were no significant differences in postoperative complications.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Takeru Matsuda, Ryuichiro Sawada, Hiroshi Hasegawa, Kimihiro Yamashita, Masako Utsumi, Hitoshi Harada, Naoki Urakawa, Hironobu Goto, Shingo Kanaji, Taro Oshikiri, Yoshihiro Kakeji
Summary: This study demonstrates that the transanal approach for LLND in patients with rectal cancer reduces operative time, blood loss, and postoperative complication rate compared to the conventional approach alone.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Gongwei Long, Zhiquan Hu, Zheng Liu, Zhangqun Ye, Shaogang Wang, Dongwen Wang, Chunguang Yang
Summary: The study aimed to compare the oncologic outcomes of bladder cancer patients after partial cystectomy and radical cystectomy combined with lymph node dissection. The study found that when the lymph node count in lymph node dissection was greater than 12, the partial cystectomy and radical cystectomy showed similar oncologic outcomes.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Oncology
Haixin Wang, Haiwen Huang, Meixia Shang, Han Hao, Zhijun Xi
Summary: The study compared the perioperative and survival outcomes of patients over 75 years and younger patients who received radical cystectomy. It found that elderly patients aged >75 had worse survival outcomes, but age >75 was not a risk factor for major complications after radical cystectomy.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Surgery
Shuai Wang, Dahong Zhang, Yuchen Bai, Feng Liu, Xiaolong Qi, Liping Xie
Summary: The study aimed to compare the clinical outcomes of bladder cancer patients undergoing extended pelvic lymph node dissection (ePLND) before or after robotic-assisted radical cystectomy (RARC). The results showed that performing ePLND before RARC resulted in shorter operation time and less blood loss, while performing ePLND after RARC led to a higher number of lymph nodes dissected and better survival rates.
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2023)
Article
Oncology
Felix Preisser, Reha-Baris Incesu, Pawel Rajwa, Marcin Chlosta, Mohamed Ahmed, Andre Luis Abreu, Giovanni Cacciamani, Luis Ribeiro, Alexander Kretschmer, Thilo Westhofen, Joseph A. Smith, Markus Graefen, Giorgio Calleris, Yannic Raskin, Paolo Gontero, Steven Joniau, Rafael Sanchez-Salas, Shahrokh F. Shariat, Inderbir Gill, Robert Jeffrey Karnes, Paul Cathcart, Henk van der Poel, Giancarlo Marra, Derya Tilki
Summary: Lymph node invasion is a poor prognostic factor for salvage prostatectomy patients. This study found that lymph node invasion significantly affects the oncologic outcomes after salvage prostatectomy. On the other hand, there is no benefit for lymph node dissection during salvage prostatectomy. These findings highlight the importance of cautious selection of lymph node dissection and strict postoperative monitoring for salvage prostatectomy patients with lymph node invasion.
Review
Urology & Nephrology
Angelo Porreca, Michele Colicchia, Alessandro Tafuri, Daniele D'Agostino, Gian Maria Busetto, Alessandro Crestani, Katia Odorizzi, Nelia Amigoni, Riccardo Rizzetto, Alessandra Gozzo, Sebastian Gallina, Lorenzo Bianchi, Matteo Ferro, Roberto Falabella, Daniele Romagnoli, Alessandro Antonelli, Paolo Corsi, Riccardo Schiavina
Summary: Holmium laser enucleation of the prostate (HoLEP) is a safe procedure with a low overall complication rate. Most reported perioperative complications are not severe, falling into Clavien-Dindo classification grades 1-2. Further randomized studies are necessary to fully understand and prevent surgical complications for continued improvement of this technique.
UROLOGIA INTERNATIONALIS
(2022)
Article
Urology & Nephrology
Lorenzo Bianchi, Riccardo Schiavina, Barbara Bortolani, Laura Cercenelli, Caterian Gaudiano, Angelo Mottaran, Matteo Droghetti, Francesco Chessa, Sara Boschi, Enrico Molinaroli, Eleonora Balestrazzi, Francesco Costa, Arianna Rustici, Giulia Carpani, Pietro Piazza, Alberta Cappelli, Alessandro Bertaccini, Rita Golfieri, Emanuela Marcelli, Eugenio Brunocilla
Summary: This study evaluated the impact of three-dimensional models on predicting surgical outcomes after robot-assisted partial nephrectomy, finding that certain three-dimensional parameters were significantly associated with surgical complications and operative indicators, providing new possibilities for outcome prediction.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Urology & Nephrology
Lorenzo Bianchi, Francesco Chessa, Pietro Piazza, Amelio Ercolino, Angelo Mottaran, Dario Recenti, Carla Serra, Caterina Gaudiano, Alberta Cappelli, Francesco Modestino, Rita Golfieri, Alessandro Bertaccini, Emanuela Marcelli, Angelo Porreca, Antonio Celia, Riccardo Schiavina
Summary: Partial nephrectomy showed higher disease-free survival rates at 5 years compared to local tumor ablation, but overall survival rates were similar. Local tumor ablation had a higher risk of recurrence but lower risk of complications compared to partial nephrectomy.
INTERNATIONAL JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Caterina Gaudiano, Lorenzo Bianchi, Beniamino Corcioni, Francesca Giunchi, Riccardo Schiavina, Federica Ciccarese, Lorenzo Braccischi, Arianna Rustici, Michelangelo Fiorentino, Eugenio Brunocilla, Rita Golfieri
Summary: In patients with PIRADSv2.1 3 lesions, multiparametric magnetic resonance imaging (mpMRI) was used to evaluate morphological pattern, diffusion parameters, and vascularisation to predict prostate cancer (PCa). Prostate volume, prostate-specific antigen (PSA) density, lesion zone, and the apparent diffusion coefficient were identified as significant predictors of PCa, with PSA density and lesion zone being independent predictors. Tumors located in the transition zone (TZ) had a greater risk of high-grade disease.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Endocrinology & Metabolism
Matteo Droghetti, Angelo Porreca, Lorenzo Bianchi, Pietro Piazza, Marco Giampaoli, Carlo Casablanca, Daniele D'Agostino, Giovanni Cochetti, Daniele Romagnoli, Riccardo Schiavina, Eugenio Brunocilla
Summary: Holmium laser enucleation of prostate (HoLEP) shows good long-term outcomes in treating BPH, but an increase in preoperative PVR and IPSS score may be independent predictors for symptom recurrence. Patients with a heavy preoperative symptom burden or high PVR should be carefully counseled on the risk of symptom recurrence.
Article
Oncology
Andrea Marchetti, Matteo Rosellini, Giacomo Nuvola, Elisa Tassinari, Veronica Mollica, Alessandro Rizzo, Matteo Santoni, Alessia Cimadamore, Andrea Farolfi, Rodolfo Montironi, Stefano Fanti, Francesco Massari
Summary: Prostate cancer remains a significant health issue in men, with new treatment options such as PARP inhibitors and radiometabolic approaches showing promising clinical benefits. The evolving understanding of molecular characteristics in prostate cancer is expanding treatment possibilities, particularly for patients with altered DNA repair genes. Ongoing clinical trials are focused on further exploring and expanding the use of these treatments in advanced prostate cancer.
Review
Oncology
Valentina Ambrosini, Lucia Zanoni, Angelina Filice, Giuseppe Lamberti, Giulia Argalia, Emilia Fortunati, Davide Campana, Annibale Versari, Stefano Fanti
Summary: Neuroendocrine neoplasms (NENs) are rare and heterogeneous tumors that require multidisciplinary discussion for optimal care. The theranostic approach plays a crucial role in the management of NENs, but further research is needed to verify its effectiveness.
Article
Chemistry, Multidisciplinary
Gianluca Carlini, Nico Curti, Silvia Strolin, Enrico Giampieri, Claudia Sala, Daniele Dall'Olio, Alessandra Merlotti, Stefano Fanti, Daniel Remondini, Cristina Nanni, Lidia Strigari, Gastone Castellani
Summary: Radiomic features can be used to successfully predict survival probability in cervical cancer patients. CT radiomic features proved to be better predictors than PET radiomic features in this specific case.
APPLIED SCIENCES-BASEL
(2022)
Article
Urology & Nephrology
Savio Domenico Pandolfo, Alp T. Beksac, Ithaar Derweesh, Antonio Celia, Riccardo Schiavina, Lorenzo Bianchi, Giovanni Costa, Umberto Carbonara, Davide Loizzo, Giuseppe Lucarelli, Clara Cerrato, Ciro Imbimbo, Vicenzo Mirone, Jeffrey Elbich, Giuseppe Basile, Lance J. Hampton, Fernando J. Kim, Umberto Capitanio, Jihad Kaouk, Riccardo Autorino
Summary: This study compared the outcomes of RAPN and PTA in treating completely endophytic renal masses. The results show that PTA treatment has low complications and good mid-term functional and oncologic outcomes. RAPN is more suitable for younger patients with fewer comorbidities.
JOURNAL OF ENDOUROLOGY
(2023)
Article
Oncology
Lorenzo Bianchi, Francesco Ceci, Francesco Costa, Eleonora Balestrazzi, Matteo Droghetti, Pietro Piazza, Alessandro Pissavini, Riccardo Mei, Andrea Farolfi, Paolo Castellucci, Stefano Puliatti, Alessandro Larcher, Giorgio Gandaglia, Daniele Robesti, Alexandre Mottrie, Alberto Briganti, Alessio Giuseppe Morganti, Stefano Fanti, Francesco Montorsi, Riccardo Schiavina, Eugenio Brunocilla
Summary: This study aims to evaluate the oncologic outcomes of patients with recurrent prostate cancer who received PSMA-PET. The results of PSMA-PET had no significant impact on the oncologic outcomes of recurrent prostate cancer patients who never received previous salvage therapies. However, for recurrent prostate cancer patients who had previous salvage therapies, positive PSMA-PET results were associated with worse oncologic outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Federico Zagni, Sara Vichi, Giulia Paolani, Miriam Santoro, Giuseppe Della Gala, Silvia Strolin, Paolo Castellucci, Luigia Vetrone, Stefano Fanti, Alessio Giuseppe Morganti, Lidia Strigari
Summary: This paper presents a novel Monte Carlo-based tool for calculating the activity and dose of Re-188-based resin. The tool allows personalized calculation of treatment parameters and has been experimentally validated. The results demonstrate the accuracy of the tool in calculating the activity distribution of Re-188 resin.
Article
Oncology
Francesca Serani, Wolfgang P. Fendler, Paolo Castellucci, Christoph Berliner, Francesco Barbato, Ken Herrmann, Andrea Farolfi, Stefano Fanti
Summary: This study aimed to determine the incidence of bone-only metastasis in castration-resistant prostate cancer (CRPC) and identify potential predictors of bone-only spread. PSMA PET/CT scans of 179 patients were analyzed, and it was found that 20% of patients had cancer that had spread only to the bones, with the most common sites being the spine, ribs, and hips. Factors such as lymph-node spread at diagnosis and hormone treatment were associated with bone-only spread. These findings highlight the importance of personalized treatment for bone-only disease and the role of PSMA PET scans in accurately detecting prostate cancer.
Article
Oncology
Lorenzo Bianchi, Francesco Ceci, Eleonora Balestrazzi, Francesco Costa, Matteo Droghetti, Pietro Piazza, Alessandro Pissavini, Massimiliano Presutti, Andrea Farolfi, Riccardo Mei, Paolo Castellucci, Giorgio Gandaglia, Alessandro Larcher, Daniele Robesti, Alexandre Mottrie, Alberto Briganti, Alessio Giuseppe Morganti, Stefano Fanti, Francesco Montorsi, Riccardo Schiavina, Eugenio Brunocilla
Summary: In this study, researchers retrospectively analyzed 113 patients with recurrent prostate cancer after radical prostatectomy and salvage therapies. The study found that patients who underwent second-line PSMA-guided metastases-directed therapy (MDT) had better outcomes in terms of metastases-free survival and castration-resistant prostate cancer-free survival compared to those who received conventional management.
Article
Oncology
Caterina Gaudiano, Margherita Mottola, Lorenzo Bianchi, Beniamino Corcioni, Lorenzo Braccischi, Makoto Taninokuchi Tomassoni, Arrigo Cattabriga, Maria Adriana Cocozza, Francesca Giunchi, Riccardo Schiavina, Stefano Fanti, Michelangelo Fiorentino, Eugenio Brunocilla, Cristina Mosconi, Alessandro Bevilacqua
Summary: This study explores the role of multiparametric magnetic resonance imaging (mpMRI) as a stand-alone tool for early and non-invasive detection of prostate cancer (PCa) in PI-RADS 3 lesions through radiomic analysis. The results show that mpMRI achieves 80% positive predictive value, 76% specificity, and 78% sensitivity. This study offers a pathway to improve the interpretation of PI-RADS 3 lesions and image-driven PCa diagnosis.
