Journal
CURRENT PSYCHIATRY REPORTS
Volume 18, Issue 10, Pages -Publisher
SPRINGER
DOI: 10.1007/s11920-016-0729-7
Keywords
Obsessive-compulsive disorder; Biomarkers; Functional magnetic resonance; Voxel-based morphometry; Diffusion tensor imaging; Proton magnetic resonance spectroscopy
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Funding
- D'Or Institute for Research and Education
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In this integrative review, we discuss findings supporting the use neuroimaging biomarkers in the diagnosis and treatment of obsessive-compulsive disorder (OCD). To do so, we have selected the most recent studies that attempted to identify the underlying pathogenic process associated with OCD and whether they provide useful information to predict clinical features, natural history or treatment responses. Studies using functional magnetic resonance (fMRI), voxel-based morphometry (VBM), diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy (1H MRS) in OCD patients are generally supportive of an expanded version of the earlier cortico-striatal-thalamus-cortical (CSTC) model of OCD. Although it is still unclear whether this information will be incorporated into the daily clinical practice (due to current conceptual approaches to mental illness), statistical techniques, such as pattern recognition methods, appear promising in identifying OCD patients and predicting their outcomes.
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