Article
Neurosciences
Zhipeng Xu, Xiaoyun Zhang, Hao Chang, Yue Kong, Yangyue Ni, Ran Liu, Xiaolin Zhang, Yang Hu, Zhi Yang, Min Hou, Rui Mao, Wen-Tao Liu, Yasong Du, Shunying Yu, Zhen Wang, Minjun Ji, Zikai Zhou
Summary: Xu et al. developed a new animal model of maternal immune activation using a parasite mimetic, showing that immune and behavioral abnormalities in adult offspring can be reversed by adoptive transfer of regulatory T cells. Notably, pathogen-activated maternal T-reg cells show greater rescue efficacy than those from control donors.
NATURE NEUROSCIENCE
(2021)
Article
Immunology
Gry Persson, Christophe Picard, Gregory Marin, Cecilie Isgaard, Christina Seefeldt Staehr, Nicolas Molinari, Jacques Chiaroni, Morten Lebech, Thomas Vauvert F. Hviid, Julie Di Cristofaro
Summary: This study identified maternal HLA class Ib genetic factors associated with anti-HLA allo-immunization during pregnancy, with HLA-E*01:06, HLA-F*01:03, and HLA-G UTR4 being significant factors. These findings highlight the importance of certain HLA class Ib alleles in reducing the risk for allo-immunization in pregnancy and suggest the need for further research on their roles.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Tamarra James-Todd, Marta Ponzano, Andrea Bellavia, Paige L. Williams, David E. Cantonwine, Antonia M. Calafat, Russ Hauser, Marlee R. Quinn, Ellen W. Seely, Thomas F. McElrath
Summary: The study demonstrates a link between phthalate exposures during pregnancy and gestational diabetes mellitus. The metabolites of these chemicals were found to be associated with maternal glucose intolerance, suggesting both long-term and short-term health implications.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Immunology
Jinli Ding, Yan Zhang, Xiaopeng Cai, Lianghui Diao, Chaogang Yang, Jing Yang
Summary: The immune tolerance microenvironment at the maternal-fetal interface is crucial for pregnancy establishment and maintenance. Macrophages and trophoblasts play essential roles in this process and their interaction influences trophoblast behaviors and the state of the maternal-fetal immune microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Baimei Zhuang, Jin Shang, Yuanqing Yao
Summary: HLA-G plays a crucial role in maternal-fetal immune tolerance, maintaining immune homeostasis and considered a key factor for successful pregnancies. Understanding the characteristics of HLA-G is important for treating pathological pregnancies and other immune-related diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Joon Ho Moon, Hak Chul Jang
Summary: Gestational diabetes mellitus (GDM) is a common complication during pregnancy, associated with adverse pregnancy outcomes and long-term complications. There are two diagnostic approaches with controversial clinical benefits.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Multidisciplinary Sciences
Ai Ing Lim, Taryn McFadden, Verena M. Link, Seong-Ji Han, Rose-Marie Karlsson, Apollo Stacy, Taylor K. Farley, Djalma S. Lima-Junior, Oliver J. Harrison, Jigar V. Desai, Michail S. Lionakis, Han-Yu Shih, Heather A. Cameron, Yasmine Belkaid
Summary: Research suggests that maternal restricted infection during pregnancy can have permanent and tissue-specific impacts on offspring immunity, with maternal interleukin-6 playing a key role in this process. This may indicate that maternal infection can affect fetal intestinal immune homeostasis, leading to altered inflammatory immune responses in offspring.
Article
Pediatrics
Caitlin Dreisbach, Stephanie Prescott, Anna Maria Siega-Riz, John McCulloch, Laura Habermeyer, Donald Dudley, Giorgio Trinchieri, Caroline Kelsey, Jeanne Alhusen
Summary: This study explores the association between the composition of the maternal microbiome and neonatal birth weight in different pre-gravid BMI groups. The results show that pre-gravid BMI, microbiome composition, and maternal blood glucose are significantly related to neonatal birth weight. The study suggests that the maternal microbiome in the late second trimester has an important association with neonatal birth weight.
PEDIATRIC RESEARCH
(2023)
Article
Reproductive Biology
Jisoo Han, Inkyu Yoo, Soohyung Lee, Yugyeong Cheon, Cheol-Heui Yun, Hakhyun Ka
Summary: The expression of IL10 and IL12 in the endometrium of pigs shows a specific pattern during pregnancy. IL10 may provide anti-inflammatory conditions for maternal immune tolerance.
BIOLOGY OF REPRODUCTION
(2022)
Article
Multidisciplinary Sciences
Ashley L. Severance, Jeremy M. Kinder, Lijun Xin, Ashley R. Burg, Tzu-Yu Shao, Giang Pham, Tamara Tilburgs, Wendy A. Goodman, Sam Mesiano, Sing Sing Way
Summary: During pregnancy, progesterone stimulates the expansion of regulatory T cells to promote immune tolerance, ensuring fetal growth and preventing rejection from the mother's immune system. This study reveals the role of progesterone in promoting fetal tolerance and establishes a molecular link between immune and other physiological adaptations during pregnancy.
Article
Obstetrics & Gynecology
Jessica Alana Hoffmann, Kathleen Gruendler, Dagmar- Ulrike Richter, Johannes Stubert
Summary: This study evaluates the performance of CCL2 and CXCL10 as biomarkers for predicting spontaneous preterm birth in high-risk women. The results suggest that high CXCL10 serum levels are associated with a higher risk of preterm birth before 34 weeks, while low CCL2 serum levels are associated with a higher risk of preterm birth within seven days. Additionally, the CXCL10/CCL2 ratio shows the best predictive performance for preterm birth.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Multidisciplinary Sciences
Shirley Greenbaum, Inna Averbukh, Erin Soon, Gabrielle Rizzuto, Alex Baranski, Noah F. Greenwald, Adam Kagel, Marc Bosse, Eleni G. Jaswa, Zumana Khair, Shirley Kwok, Shiri Warshawsky, Hadeesha Piyadasa, Mako Goldston, Angie Spence, Geneva Miller, Morgan Schwartz, Will Graf, David Van Valen, Virginia D. Winn, Travis Hollmann, Leeat Keren, Matt van de Rijn, Michael Angelo
Summary: A spatiotemporal atlas of the human maternal-fetal interface in the first half of pregnancy was constructed using a multiomics approach. The study revealed that gestational age significantly influenced the frequency of maternal immune and stromal cells, with tolerogenic subsets becoming enriched at later time points. Spiral artery remodeling was primarily correlated with extravillous trophoblast invasion and was defined by distinct transcriptional pathways.
Article
Biochemistry & Molecular Biology
Sourav Panja, John T. Benjamin, Bibhash C. Paria
Summary: Maternal infection-induced early pregnancy complications are linked to perturbation of the immune environment at the uterine early blastocyst implantation site. Research found that exposure to LPS can lead to defects in the implantation site, possibly involving the activation of the Tlr4-MyD88 dependent inflammatory pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Bo Pang, Cong Hu, Huimin Li, Xinyu Nie, Keqi Wang, Chen Zhou, Huanfa Yi
Summary: Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells derived from myeloid progenitors, with well-known roles in tumors and autoimmune diseases. Their role in reproduction has gained increasing attention, particularly their association with recurrent implantation failure, pathological pregnancy, and neonatal health. This review focuses on the interaction between MDSCs and other cell types during the reproductive process, and discusses molecular mechanisms that could be targeted for therapeutic purposes. It aims to encourage further research in maternal-fetal interface immunity to identify pathways driving MDSCs accumulation and effectively target their role in promoting embryo implantation, reducing pathological pregnancy, and improving neonatal health.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Helen Zukin, Brenda Eskenazi, Nina Holland, Kim G. Harley
Summary: In a study of 415 pregnant Latina women, prenatal phthalate levels were not associated with hyperglycemia, impaired glucose tolerance, or gestational diabetes. However, there was an increased risk of excessive gestational weight gain.
ENVIRONMENTAL RESEARCH
(2021)
Article
Physiology
D. Paparini, S. Gori, E. Grasso, W. Scordo, G. Calo, C. Perez Leiros, R. Ramhorst, G. Salamone
Article
Cell Biology
Laura Fraccaroli, Esteban Grasso, Vanesa Hauk, Daniel Paparini, Elizabeth Soczewski, Gil Mor, Claudia Perez Leiros, Rosanna Ramhorst
JOURNAL OF LEUKOCYTE BIOLOGY
(2015)
Article
Developmental Biology
Daniel Paparini, Esteban Grasso, Guillermina Calo, Daiana Vota, Vanesa Hauk, Rosanna Ramhorst, Claudia Perez Leiros
MOLECULAR HUMAN REPRODUCTION
(2015)
Article
Obstetrics & Gynecology
Guillermina Calo, Florencia Sabbione, Daiana Vota, Daniel Paparini, Rosanna Ramhorst, Analia Trevani, Claudia Perez Leiros
HUMAN REPRODUCTION
(2017)
Review
Multidisciplinary Sciences
Rosanna Ramhorst, Guillermina Calo, Daniel Paparini, Daiana Vota, Vanesa Hauk, Lucila Gallino, Fatima Merech, Esteban Grasso, Claudia Perez Leiros
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2019)
Article
Cell Biology
Esteban Grasso, Soledad Gori, Daniel Paparini, Elizabeth Soczewski, Laura Fernandez, Lucila Gallino, Gabriela Salamone, Gustavo Martinez, Marcela Irigoyen, Claudio Ruhlmann, Claudia Perez Leiros, Rosanna Ramhorst
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Vanesa Hauk, Daiana Vota, Lucila Gallino, Guillermina Calo, Daniel Paparini, Fatima Merech, Federico Ochoa, Elsa Zotta, Rosanna Ramhorst, James Waschek, Claudia Perez Leiros
Article
Endocrinology & Metabolism
Esteban Grasso, Daniel Paparini, Mariana Agueero, Gil Mor, Claudia Perez Leiros, Rosanna Ramhorst
JOURNAL OF ENDOCRINOLOGY
(2014)
Article
Multidisciplinary Sciences
Daiana Vota, Daniel Paparini, Vanesa Hauk, Ayelen Toro, Fatima Merech, Cecilia Varone, Rosanna Ramhorst, Claudia Perez Leiros
SCIENTIFIC REPORTS
(2016)
Article
Pharmacology & Pharmacy
Daniel E. Paparini, Ruhul H. Choudhury, Daiana M. Vota, Magdalena Karolczak-Bayatti, Sarah Finn-Sell, Esteban N. Grasso, Vanesa C. Hauk, Rosanna Ramhorst, Claudia Perez Leiros, John D. Aplin
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Article
Cell Biology
Guillermina Calo, Florencia Sabbione, Natalia Pascuali, Irene Keitelman, Daiana Vota, Daniel Paparini, Rosanna Ramhorst, Fernanda Parborell, Analia Trevani, Claudia Perez Leiros
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Fatima Merech, Elizabeth Soczewski, Vanesa Hauk, Daniel Paparini, Rosanna Ramhorst, Daiana Vota, Claudia Perez Leiros
SCIENTIFIC REPORTS
(2019)
Article
Developmental Biology
Elizabeth Soczewski, Esteban Grasso, Lucila Gallino, Vanesa Hauk, Laura Fernandez, Soledad Gori, Daniel Paparini, Claudia Perez Leiros, Rosanna Ramhorst
Article
Physiology
Daniel Esteban Paparini, Esteban Grasso, Laura del Carmen Fernandez, Fatima Merech, Rodrigo Weingrill-Barbano, Simone Correa-Silva, Gustavo Izbizky, Jose Ignacio Abasolo, Vanesa Hauk, Rosanna Ramhorst, Estela Bevilaqcua, Claudia Perez Leiros
Summary: The study investigates the functional profile of circulating monocytes and decidual macrophages in term human pregnancy and their contribution to tissue repair when stimulated with decidual factors and VIP ex vivo. Results show that conditioning monocytes with decidual factors and VIP can support processes required for tissue repair and homeostasis maintenance in term placenta.