Journal
ARABIAN JOURNAL OF CHEMISTRY
Volume 9, Issue 6, Pages 825-834Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.arabjc.2015.04.010
Keywords
Chemoselective aminolysis; Thenoyl-pyruvanthranilic; Cu(II)-complexes; Bactericidal; Antibiofouling
Categories
Funding
- DFG [Ja466/24-1]
- STDF [STDF-STF-Cycle4-6392]
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Biofouling is a serious problem and very difficult to overcome, since the marine biofilm-producing microorganisms resist the host defense mechanism and antibiotic therapy. Therefore, there is an urgent need to develop potent anti-biofouling agent to effectively eradicate unwanted biofilms. Our work represents antibacterial susceptibility and antibiofilm forming assay of new copper(II) N-pyruvoyl anthranilate architectures (4a-d) against Staphylococcus aureus and Escherichia coli, marine isolates. The preliminary biofilm susceptibility tests revealed that, the most potent staphylococcalcidal (MIC/MBC = 9.25/10.50 mM) and E. coli-tidal (MIC/MBC = 13.25/13.50 mM) agent, 4d, exhibits significant biofilm inhibition. Complex 4d can therefore provide an antibiofilm-forming agent candidate to curb the formation of biofilms. (C) 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
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