Article
Chemistry, Physical
Ferruh Lafzi, Deryanur Kilic, Melike Yildiz, Nurullah Saracoglu
Summary: This study involved the design, synthesis, and evaluation of urea/thiourea derivatives containing heteroaromatic scaffolds, indicating activity against gram-positive bacteria. Molecular docking studies revealed interactions with proteins involved in peptidoglycan synthesis. ADME calculations suggested oral absorption for these compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Applied
Lei Sun, Xiaoyu Wang, Paul Fleurat-Lessard, Claude P. Gros, Frederic Bolze, Haijun Xu
Summary: The synthesis and spectroscopic characterization of a series of benzazole derivatives with different carbazole substituents were reported in this article. The photophysical properties of these molecules in different solvents were investigated using UV-vis absorption and fluorescence spectroscopy. The dyes exhibited strong absorption bands in the near ultraviolet region, fluorescence emission in the blue-green region, and large Stokes' shifts. Molecular modeling was utilized to explain their spectroscopic behavior, and they were found to possess high thermal stability.
Article
Chemistry, Physical
Meryem Erol, Ismail Celik, Gulcan Kuyucuklu
Summary: In this study, new benzoxazole derivatives were synthesized and their antimicrobial activities were investigated against various bacteria and fungi. Molecular docking and dynamics simulations showed that some compounds interacted well with the DNA gyrase enzyme. Additionally, the predicted ADME profiles of the compounds were in line with important drug design rules.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Physical
Umut Dogan, Ozge Ozcan, Gizem Alaca, Aydan Ari, Salih Gunnaz, H. Tansel Yalcin, Onur Sahin, Sevil Irisli
Summary: Three new Platinum complexes were synthesized and characterized, showing moderate cytotoxic activities against cancer cell lines and antimicrobial effects on both gram positive and gram negative bacteria.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Engineering, Chemical
Decheng Liu, Chen Tian, Meixia Shan, Junyong Zhu, Yatao Zhang
Summary: Benzimidazole-linked polymers (BILPs) are porous organic frameworks with high microporosity and exceptional thermal and chemical stabilities. The microstructure and separation capability of BILPs membranes can be controlled by synthetic parameters. The optimized composite membrane exhibits high water permeance, selectivity, and antimicrobial activity.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Chemistry, Medicinal
Hazem Elkady, Khaled El-Adl, Helmy Sakr, Adel S. Abdelraheem, Sally I. Eissa, Mohamed Ayman El-Zahabi
Summary: Eleven novel benzoxazole/benzothiazole-based thalidomide analogs were designed and synthesized as new effective antitumor immunomodulatory agents. The open analogs with semicarbazide and thiosemicarbazide moieties exhibited higher cytotoxic activities than derivatives with closed glutarimide moiety. Compound 13a and 14 demonstrated the highest anticancer activities and significant immunomodulatory effects on TNF-α, CASP8, VEGF, and NF-κB p65 in HCT-116 cells. Additionally, the synthesized compounds showed favorable in silico ADMET profiles.
ARCHIV DER PHARMAZIE
(2023)
Review
Pharmacology & Pharmacy
Ahmed Abdullah Al Awadh
Summary: This article summarizes the significant applications of organic heterocyclic compounds such as indole, benzoxazole, benzothiazole, and benzimidazole in fields such as pharmacy, industries, dyes, medicine, polymers, and food packages. It also discusses the medicinal applications of their metal complexes, highlighting their potential in various areas such as anti-ulcerogenic, anti-cancer, antihypertensive, antifungal, anti-inflammatory, antitubercular, antiparasitic, anti-obesity, antimalarial, antiglycation, antiviral, antineuropathic, analgesic, antioxidant, antihistaminic, and antibacterial properties. The article aims to assist researchers in the design and synthesis of novel and potent compounds with significant applications.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Chemistry, Medicinal
Livio Racane, Katarina Zlatic, Maja Cindric, Emina Mehic, Grace Karminski-Zamola, Martin C. Taylor, John M. Kelly, Silvana Raic Malic, Marijana Radic Stojkovic, Marijeta Kralj, Marijana Hranjec
Summary: Novel benzo[b]thienyl and 2,2'-bithienyl-derived benzothiazoles and benzimidazoles were synthesized and tested for their antiproliferative and antitrypanosomal activities in vitro. The benzothiazole derivatives showed higher activity compared to the benzimidazole analogs. Among them, the 2,2'-bithienyl-substituted benzothiazoles with unsubstituted and 2-imidazolinyl amidine exhibited the most potent antitrypanosomal activity, while the benzimidazole derivatives bearing isopropyl, unsubstituted, and 2-imidazolinyl amidine showed the greatest selectivity. The 2,2'-bithiophene derivatives showed the most selective antiproliferative activity, with the benzothiazoles selectively active against lung carcinoma and the benzimidazoles selectively active against cervical carcinoma cells.
Article
Biochemistry & Molecular Biology
Himani Chaurasia, Vishal K. Singh, Richa Mishra, Aditya K. Yadav, Nand K. Ram, Prashant Singh, Ramendra K. Singh
Summary: A series of novel N-1-(beta-D-ribofuranosyl) benzimidazole derivatives were designed and synthesized as potential antimicrobial agents, showing excellent inhibitory activity against various pathogenic bacteria and fungi. Structurally, less polar and more hydrophobic substituents were found to enhance antibacterial activity, while more polar and hydrophilic substituents favored antifungal activity. This study suggests these compounds may serve as promising candidates for drug development against drug-resistant strains.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Elvan Ustun, Neslihan Sahin, Ilknur Ozdemir, Selami Gunal, Nevin Gurbuez, Ismail Ozdemir, David Semeril
Summary: Two series of silver(I) nitrate complexes, bis(1-alkylbenzimidazole)silver(I) nitrate and bis(1-alkyl-5,6-dimethylbenzimidazole)silver(I) nitrate, were synthesized and characterized. These complexes showed moderate antimicrobial activity against both Gram-negative and Gram-positive bacteria, as well as good antifungal activity against Candida albicans and Candida glabrata. Molecular docking and reactivity descriptor calculations were also performed.
ARCHIV DER PHARMAZIE
(2023)
Review
Biochemistry & Molecular Biology
Yue Zou, Yong Zhang, Xing Liu, Hongyi Song, Qingfeng Cai, Sheng Wang, Chongfen Yi, Jixiang Chen
Summary: Benzoxazole and benzothiazole have shown a wide range of agricultural activities as antibacterial, antiviral, and herbicidal agents, making them important structures in agrochemical research. Recent progress has been made in the development of herbicides and insecticides based on benzoxazoles and benzothiazoles. The widespread use of these compounds suggests the potential for more new products in the future. This review provides a comprehensive analysis of their application, including the discovery of active compounds and their activities, as well as the structure-activity relationship and mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Muhammed Tilahun Muhammed, Gulcan Kuyucuklu, Fatma Kaynak-Onurdag, Esin Aki-Yalcin
Summary: This study aimed to synthesize benzoxazole derivatives and investigate their antimicrobial activity and mechanism of action through antimicrobial susceptibility testing and computational analysis. The results showed that benzoxazole derivatives without a methylene bridge exhibited higher antimicrobial activity by inhibiting DNA gyrase. The compounds also demonstrated favorable pharmacokinetic properties. Further in vitro or in vivo studies are recommended to validate the findings from molecular modeling.
LETTERS IN DRUG DESIGN & DISCOVERY
(2022)
Review
Infectious Diseases
Maria Marinescu
Summary: The synthesis of new compounds with antimicrobial and antiviral properties is crucial in combating the COVID-19 pandemic. Benzimidazole and pyrazole compounds possess diverse biological activities, making them important in medicinal chemistry.
Article
Chemistry, Physical
Reddymasu Sireesha, Reddymasu Sreenivasulu, Choragudi Chandrasekhar, Surender Singh Jadav, Y. Pavani, Mandava Venkata Basaveswara Rao, Mannam Subbarao
Summary: A new series of benzimidazole/benzoxazole linked beta-carbolines were designed and synthesized, showing significant anti-cancer activity, especially against MCF-7 cell lines. These hybrid beta-carbolines also exhibited potential as kinase binders in molecular interaction analysis, suggesting promising future applications in cancer research.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Physical
Tamer El Malah, Mohamed Hegab, Hassan M. Awad, Mohamad T. Abdelrahman, Farouk M. E. Abdel-Megeid, Ahmed H. Shamroukh, Randa E. Abdel Mageid, Hany F. Nour
Summary: A new series of benzothiazole-1,2,3-triazole compounds were synthesized and tested for their antibacterial and antifungal activities. One derivative showed high antibacterial activity against Escherichia coli, most compounds exhibited remarkable inhibitory effects against Pseudomonas aeruginosa, while another derivative displayed high activity against Candida albicans. Several derivatives also showed high antioxidant activity.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Chemistry, Applied
Suryapratap J. Sharma, Nagaiyan Sekar
Summary: Dyes with a coumarin core are highly valuable for their ability to absorb and emit light in the deep-red to NIR region. They play essential roles in biology, DSSC, NLO materials, and LASER dyes. This review summarizes the photophysical features, synthetic methodologies, and applications of these dyes. The relevance of DFT and TD-DFT techniques in obtaining the desired photophysical characteristics of coumarin dyes before synthesis is also discussed.
Article
Chemistry, Organic
Smita Bait, Suvidha Shinde, Ravindra Adivarekar, Nagaiyan Sekar
Summary: In this study, fluorescent acid azo dyes with excited state intramolecular proton transfer (ESIPT) core, based on benzothiazole and benzimidazole, were synthesized and characterized. The spectral characteristics of these dyes in different solvents showed distinct Stokes shifts. The dyed wool and silk fabrics exhibited high exhaustion percentages and demonstrated antibacterial and UV protective properties.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Multidisciplinary
Milind S. Thakare, Nilesh S. Pawar, Vishnu A. Adole, Dipak B. Patil, Vikas Patil
Summary: A novel strategy using coumarin based fluorophore was established for the selective detection of Au3+ species. The detection mechanism involves the anchoring and un-anchoring of the fluorophore, triggered by the alkynophilicity of gold ions. The synthesized CEB probe showed high sensitivity in response to Au3+ ions, inducing a turn-on fluorescence change through the activation of a triple bond.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
Vandana Kumari Shukla, Suryapratap J. Sharma, Nagaiyan Sekar
Summary: Using density functional theory (DFT) and time-dependent DFT methods, the properties of four donor-pi-acceptor (D-pi-A) type sensitizers were investigated. The introduction of auxiliary acceptor and spacer bridge was found to have significant effects on the band gap. The experimentally determined light harvesting efficiency (LHE) was correlated with calculated global descriptors, showing a direct relation with electrophilicity index and an inverse relation with hyperhardness.
INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Milind S. Thakare, Dipak B. Patil, Jayashree Patil, Siddhant Kokate, Nilesh S. Pawar, Vikas Patil
Summary: A new reaction-based fluorescent probe was designed and synthesized for the detection of hydrazine. The probe exhibited a significant fluorescence increase and a color change in the presence of hydrazine, making it a promising tool for both quantitative and qualitative detection of hydrazine.
Review
Chemistry, Multidisciplinary
Zeba Khan, Nagaiyan Sekar
Summary: Xanthene dyes have remarkable photophysical properties and photostability, making them promising candidates for imaging/sensing/tracking/labeling probes. However, their emission wavelength ≤ 600 nm and small Stokes shift restrict their use in biological applications. This review provides a comprehensive list of deep red to NIR xanthene-hemicyanine and xanthene-coumarin hybrids, along with synthetic strategies and discussions on the effects of substituents, pi-conjugation, and ring structure on their photophysical properties. Applications of these hybrids based on fluorophore-linker strategy and spirocyclization are also discussed. This review emphasizes the structure-spectroscopic relationships, which will aid in the design of new deep red to NIR xanthene analogs.
Article
Materials Science, Textiles
Praful. S. S. Patil, Puja. O. O. Gupta, Gauri. S. S. Ingole, Nagaiyan Sekar
Summary: Anthrone- and aniline-based azo dyes were synthesized, characterized, and applied to various fabrics. The dyed fabrics showed different fastness properties, with polyester and nylon performing better than wool and acrylic. The dyes also exhibited strong ultraviolet protection activity and antibacterial properties. In addition, the chemical reactivity descriptors were calculated using density functional theory.
FIBERS AND POLYMERS
(2023)
Article
Chemistry, Multidisciplinary
Lina Jadhav, Rahul Patil, Nikhil Borane, Satish V. Patil, Satyendra Mishra, Vikas Patil
Summary: A nanostructured polyurea composite was synthesized through successive three-step reactions of lignin amine, and its properties were determined by combining different lignin-polyamines with various di-isocyanates. The tosylated lignin was obtained by reacting lignin with tosyl chloride, and the aminated lignin was synthesized by replacing the tosyl functional group with an amine. Finally, a polyurea composite was formed through the reaction of aminated lignin with different di-isocyanates.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Supriya H. Ramugade, Sekar Nagaiyan
Summary: Disperse Red 177(9a), Disperse Red 343(9b), Disperse Blue 165(9c), Disperse Blue 165.1(9d), Disperse Blue 366 (9e), and Disperse Blue 148(9f) were studied in a solvent. The use of 9 (a-f) azo disperse dyes on polyester fabric, along with traditional and silicone nanomicelle techniques, resulted in equal washing, light, and rubbing fastness. The reduction in particle size of azo dyes through nanoemulsions allowed for direct transportation into the fiber core, eliminating the need for auxiliary dyes.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
(2023)
Article
Energy & Fuels
Rahul Patil, Lina Jadhav, Nikhil Borane, Satyendra Mishra, Satish V. Patil, Vikas Patil
Summary: Lignosulphonate-based azo pigments were synthesized through a diazo coupling reaction using industrial waste lignosulphonate material. The pigments showed dispersion and metal surface protection functions by coating. Various methods including H-1-NMR, FT-IR, HRMS, and UV spectroscopy confirmed the pigment formation. TGA and DSC analysis revealed the thermal behavior of the pigments.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Review
Chemistry, Applied
Vandana Kumari Shukla, Goutam Chakraborty, Alok K. Ray, Sekar Nagaiyan
Summary: BODIPY dyes have excellent features but their application is limited due to narrow absorption and emission range. Recent developments in introducing fused BODIPYs and aza-BODIPYs have shown promise in red shifting the photophysical properties. This review summarizes their properties, synthesis, and applications in biomedical and optoelectronic fields.
Article
Chemistry, Multidisciplinary
Harshada More, Vandana Kumari Shukla, Praful Patil, Nagaiyan Sekar
Summary: This study investigates the growth inhibitory potential of fifteen coumarin molecules with substitutions at positions C-3 and C-6 using DFT and TD-DFT. The experimentally determined toxicity values are correlated to the calculated molecular descriptors, revealing direct or inverse trends.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Suryapratap J. Sharma, Nagaiyan Sekar
Summary: In this study, three quinoid zwitterionic dye sensitizers were investigated for their applications in dye-sensitized solar cells and nonlinear optical properties. The computational results showed that one of the dyes (ZIDM) exhibited better charge transfer and higher light harvesting efficiency compared to the others. It was also found that the dyes could easily bind with the TiO2 cluster through a monodentate binding mode. Moreover, ZIDM demonstrated higher nonlinear optical properties than the other dyes.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
Suryapratap J. Sharma, Keval K. Sonigara, Hiren K. Machhi, Saurabh S. Soni, Nagaiyan Sekar
Summary: Dye-sensitizers designed from coumarin backbone have versatile performance in dye-sensitized solar cells (DSSC). In this study, different coumarin-based sensitizers were designed and computational calculations were performed to predict their light harvesting capability and non-linear optical properties. The reaction between the sensitizers and TiO2 revealed different binding modes for different anchoring groups. Sensitizers with 2-cyanoacrylic acid anchors showed a more planar geometry and higher power conversion efficiency in the DSSC device.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Multidisciplinary Sciences
Suvidha Shinde, Nagaiyan Sekar
Summary: This study found that benzothiazole is responsible for enhancing the fastness properties of dyes. Comparison of the total electronic energies revealed that the benzothiazolyl series is more stable than the naphthol series. Frontier Molecular Orbitals (FMOs) showed charge transfer in benzothiazole-containing compounds but not in the naphthol series. Among the benzothiazolyl isomers, the hydrazone form was found to be the most stable and responsible for fluorescence possession. The HOMO-LUMO energy band gap confirmed the same. Both series had positive electrophilicity index and hyper-hardness values, indicating photo stability and reactivity. Thus, the benzothiazolyl series was found to be more stable and had enhanced light fastness.
PHYSICAL SCIENCES REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Wafa A. Bawazir, Maymoona A. Al-Mahmood, Rawan S. Almalki, Ghadi F. Alofi, Raghad S. Alharbi, Zoya Zaheer
Summary: This study investigates the interaction between sulfathiazole and three types of surfactants using UV-visible spectroscopy and conductivity measurements. The results show that the critical micelle concentration of cationic and anionic surfactants decreases with increasing sulfathiazole concentration, while the interaction with non-ionic surfactant is weak.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Musaad K. Aleid, Khalid N. Alharbi, Mona A. Aljufareen, Areej S. Aloliwi, Alhanouf K. Almutairi, Rahaf S. Alsaif, Nada K. Alshayeb, Mohammed S. Almoiqli
Summary: This study assessed the levels of trihalomethane compounds in the water network of Riyadh city and identified the factors influencing their formation. The concentrations of trihalomethane compounds were within the permissible limits, indicating the water's safety for human consumption. The presence of bromide ions, organic carbon, free chlorine, and pH values were found to affect trihalomethane formation.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Said Arhzaf, Jamal Houssaini, Mohammed Naciri Bennani, Marwa Alaqarbeh, Mohammed Bouachrine
Summary: The study shows that Mg-Al hydrotalcite catalysts intercalated with acetate and carbonate anions exhibit superior catalytic activity in the aldol condensation reaction between furfural and acetone. The optimal reaction conditions are at 90 degrees C for 2 hours, achieving conversion rates of over 98% with high selectivity towards F2A for the acetate catalyst.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Uyen-Chi Nguyen Le, Ngoc Xuan Dat Mai, Kieu-Minh Le, Hoang Anh Vu, Huynh-Nhu Thi Tran, Tan Le Hoang Doan
Summary: This study aimed to enhance the bioavailability of rosmarinic acid, a bioactive compound with high anticancer activity, by encapsulating it in tetrasulfide-based porous organosilica nanoparticles. The synthesized nanoparticles were small in size and had a high surface area and an average pore diameter. The nanoparticles showed effective accumulation in cancer cells without toxicity to normal cells. Treatment with rosmarinic acid-containing nanoparticles resulted in significant cell death in cancer cells. Overall, these findings suggest that the synthesized nanoparticles can enhance the pharmacological effects of rosmarinic acid.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Jiamin Qi, Hengxi Zhu, Tianyu Yang, Xingyuan Wang, Zixuan Wang, Xiaoli Lei, Bin Li, Wenmin Qian
Summary: This study synthesized a novel iron-biochar adsorbent using the iron content in red mud to remove heavy metals from wastewater. The adsorbent showed excellent removal efficiency and sustainability. This method addresses both industrial waste recovery and heavy metal adsorption issues.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Bo Yi, Li Zhang, Haiyang Zhou
Summary: Plasma protein binding plays a crucial role in the pharmacokinetics and pharmacodynamics of therapeutic bioactive materials. In this study, the interaction of nordentatin, a member of coumarins, with human alpha-1 acid glycoprotein (AGP) was investigated, and the anticancer potency of nordentatin against human colorectal cancer cells was evaluated. The results showed that nordentatin binds to AGP through a static quenching mechanism and exhibits inhibitory effects on the growth of HCT-116 cells by increasing intracellular ROS and [Ca2+] levels and triggering apoptosis-related gene overexpression. Therefore, nordentatin could be a promising plant-based therapy for colorectal cancer.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Qiming Pang, Cui Wang, Bangtao Li, Suli Zhang, Jiaoyang Li, Shuo Gu, Xueyu Shi
Summary: This study evaluated the effects of resveratrol loaded in copolymer nanoparticles on cerebral ischemia/reperfusion (I/R) injury in rats. The results showed that RES.CP.NPs could have neuroprotective effects through their antioxidant and anti-inflammatory activities, leading to improved neurological disability scores and decreased oxidative stress levels.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Maryam Rachmawati Sumitra, Lung-Ching Chen, Wei-Chen Tsai, Muhamad Ansar, Bashir Lawal, Ntlotlang Mokgautsi, Jih-Hwa Guh, Alexander T. H. Wu, Hsu-Shan Huang
Summary: Tetraheterocyclic compounds derived from natural sources and contemporary pharmaceuticals have shown promise as multitarget therapeutic agents. In this study, a series of synthesized compounds were evaluated for their potential in breast cancer treatment. Compounds 18 and 20 demonstrated significant antiproliferative activity against breast cancer cell lines and their mode of action was revealed through molecular docking simulations.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Mohammad Khosravani, Mohsen Dehghani Ghanatghestani, Farid Moeinpour, Hossein Parvaresh
Summary: The aim of removing Pb(II) from water is to minimize the potential harm posed by toxic metals to both human health and the environment. A covalent organic framework adsorbent called TFPOTDB-SO3H was developed with excellent properties such as high repeatability, selectivity, and easy solid-liquid separation. The adsorbent showed impressive capability of adsorbing Pb(II) and effective removal of it from a solution with various ions, suggesting its potential for effectively adsorbing and removing Pb(II) heavy metal ions from wastewater.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Ashraf H. Farha, Mohamed S. Shams, Hasna A. Alali, Zakia H. Alhashem, Shehab A. Mansour, Shrouq H. Aleithan, Ragab A. Elsad
Summary: The current study examines the dielectric and thermal properties of transformer oil incorporated with Mn0.5 Zn0.5 Fe2O4 nanoparticles. The results show that the addition of Mn-Zn ferrite NPs improves the dielectric constant, dissipation factor, AC breakdown voltage, and convective heat transfer of the nanofluid.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Limin Hou, Zongpei Jiang, Minqi Ye, Xueyan Sun, Kexin Liu, Yifan Zhu, Xiaoyu Wang, Liangzhu Chen, Ruiheng Gu, Binghu Fang
Summary: The excessive accumulation of antibiotic residue in animal-derived foods poses a threat to health. Therefore, it is necessary to establish a rapid, simple, effective, safe, and highly sensitive method for detecting lincomycin residues. By using a pre-column derivatization method on high-performance liquid chromatography equipped with ultraviolet, the UV absorption of lincomycin is improved, allowing for detection and quantification.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Kun Tang, Xin-Xin Wang, Jin-Jin Zhao, Ning Ren, Jian-Jun Zhang
Summary: This study reports the synthesis, crystal structures, and thermal degradation properties of three new rare earth coordination compounds. Compounds 1-3 exhibit binuclear structures which can form chain-like structures via hydrogen bonding. Compound 2 shows potential application value in the orange-red luminescence region.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Seoyoun Yang, Eunbi Yu, See-Hyoung Park, Sae Woong Oh, Kitae Kwon, Su Bin Han, Soo Hyun Kang, Jung Hyun Lee, Heejun Ha, Minkyung Song, Jae Youl Cho, Jongsung Lee
Summary: This study investigated the effects of blue light on the hypodermis and found that it has antiadipogenic properties by reducing lipid accumulation and downregulating the expression of adipogenic genes. Blue light also increased the phosphorylation of PPAR gamma and TRPV1, suggesting its anti-adipogenic effect through these signaling pathways.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Abdul Nasir, Abdul Waheed Khan, Hamid Rafiq Khattak, Abdus Samad, Sami Ullah, Haroon Khan, Muhammad Faheem, Qian Bai
Summary: This study evaluated the effects of isoxazolone derivatives on cisplatin-induced neuropathy in a rat model. The results showed that isoxazolone derivatives effectively reversed mechanical allodynia, similar to the known therapeutic agent pregabalin. Molecular docking analysis indicated that isoxazolone derivatives have strong binding affinity for relevant receptors and potential inhibitory activity against relevant signaling pathways. This study has innovative implications for the treatment of cisplatin-induced neuropathic pain.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Shahid Wahab, Haroon Muhammad Ali, Maham Khan, Tariq Khan, Chandran Krishnaraj, Soon-Il Yun
Summary: In this study, we synthesized chitosan nanoparticles, silver nanoparticles, and chitosan/silver nanocomposites using aqueous ginger extract as a green approach. These nanomaterials showed significant antibacterial properties and low toxicity. Furthermore, the nanomaterials conjugated with tobramycin demonstrated enhanced antibacterial efficacy and exhibited interactions with Pseudomonas aeruginosa.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
