Article
Environmental Sciences
Yiqun Zhu, Zhaoyi Pan, Danrong Jing, Huaying Liang, Jun Cheng, Dianwu Li, Xin Zhou, Fengyu Lin, Hong Liu, Pinhua Pan, Yan Zhang
Summary: This study found an association between air pollution and adult-onset asthma, and the size of this association was modified by genetic risk and lifestyle factors. Air pollution was found to increase the risk of adult-onset asthma, especially among individuals with low genetic risk or unfavorable lifestyles. Integrated interventions for environmental pollution and adherence to healthy lifestyles are necessary to prevent adult-onset asthma.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Engineering, Environmental
Min Hyung Ryu, Cristina Gomez, Agnes C. Y. Yuen, Jeffrey R. Brook, Craig E. Wheelock, Christopher Carlsten
Summary: This study indicates that co-exposure to allergen and diesel exhaust may lead to lung function impairment, and eicosanoids may play a role in the mechanism. Co-exposure to allergen and DE caused an increase in specific eicosanoid metabolites, which was suppressed by particle reduction. Genetic risk score also influenced the changes in eicosanoid metabolites following co-exposure. Causal mediation analysis showed that airflow impairment induced by allergen was mediated by leukotriene E-4 and tetranor-prostaglandin D metabolite.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Immunology
Aurore C. A. Gay, Martijn C. Nawijn
Summary: Segmental allergen challenge in allergic patients with asthma reveals a new role for monocytes in TH2-dependent inflammation, while allergen unresponsiveness in allergic controls without asthma is maintained through epithelial-myeloid cell cross-talk that prevents TH2 cell activation.
SCIENCE IMMUNOLOGY
(2023)
Article
Environmental Sciences
Jian Cheng, Shilu Tong, Hong Su, Zhiwei Xu
Summary: Short-term exposure to ambient air pollution, particularly ozone and nitrogen dioxide, is associated with an increased risk of childhood asthma exacerbations within a few hours. The risk varies among different age groups and genders in response to different pollutants.
ENVIRONMENTAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Logan C. Dearborn, Marnie F. Hazlehurst, Christine T. Loftus, Adam A. Szpiro, Kecia N. Carroll, Paul E. Moore, Margaret A. Adgent, Emily S. Barrett, Ruby H. N. Nguyen, Sheela Sathyanarayana, Kaja Z. LeWinn, Nicole R. Bush, Joel D. Kaufman, Catherine J. Karr
Summary: This study found that early life air pollution can influence the development of asthma and wheezing in children aged 4-6 years with a history of bronchiolitis. The research was conducted by observing and evaluating a longitudinal cohort from six US cities, estimating the exposure of these children to fine particulate matter, nitrogen dioxide, and ozone pollution from ages 1 to 3 years, and controlling for other factors. The results showed that for every 2 ppb increase in ozone concentration, the risk of developing asthma in children increased by 1.4 times, and the risk of developing wheezing increased by 1.3 times.
Article
Multidisciplinary Sciences
Salvatore D'Antona, Isabella Castiglioni, Danilo Porro, Claudia Cava
Summary: This study reveals the causal relationships and genetic correlations between respiratory diseases and pollutants through analyzing a database and genome-wide association studies. It identifies potential clinical targets and interventions for respiratory-related disorders, emphasizing the importance of air quality and transportation in modern society.
Article
Environmental Sciences
David Olsson, Bertil Forsberg, Lennart Braback, Camilla Geels, Jurgen Brandt, Jesper H. Christensen, Lise M. Frohn, Anna Oudin
Summary: This study examined how different exposure windows of various pollutants affect the risk of asthma in early life. It found that exposure to PM2.5, pOC, and SOA in the first three years of life increased the risk of childhood asthma. Additionally, the study showed that the risk associated with PM2.5 and specific components of air pollution was higher in areas with lower socioeconomic status.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Physics, Fluids & Plasmas
Erwan Taillanter, Marc Barthelemy
Summary: Most cities in the United States and around the world were structured around car traffic, but the future of large urban areas and the structures built for reducing car traffic congestion is uncertain. Empirical data and analysis suggest that there are two thresholds for the emergence of urban freeways and ring roads in U.S. cities. A cost-benefit analysis model is proposed to understand these thresholds and predict future scenarios, such as the potential removal of urban freeways due to externalities. This information is valuable for cities facing decisions on renovating or repurposing these aging structures.
Article
Environmental Sciences
Ingrid Nordeide Kuiper, Cecilie Svanes, Iana Markevych, Simone Accordini, Randi J. Bertelsen, Lennart Braback, Jesper Heile Christensen, Bertil Forsberg, Thomas Halvorsen, Joachim Heinrich, Ole Hertel, Gerard Hoek, Mathias Holm, Kees de Hoogh, Christer Janson, Andrei Malinovschi, Alessandro Marcon, Roy Miodini Nilsen, Torben Sigsgaard, Ane Johannessen
Summary: The study found that childhood, adolescence, and adult exposure to air pollution were associated with an increased risk of asthma attacks, rhinitis, and low lung function in adulthood. Greenness was not associated with asthma or rhinitis, but was a risk factor for decreased lung function.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Rashmi Yadav, Aditya Nagori, Aparna Mukherjee, Varinder Singh, Rakesh Lodha, Sushil Kumar Kabra, Geetika Yadav, Jitendra Kumar Saini, Kamal Kumar Singhal, Kana Ram Jat, Karan Madan, Mohan P. George, Kalaivani Mani, Parul Mrigpuri, Raj Kumar, Randeep Guleria, Ravindra Mohan Pandey, Rohit Sarin, Rupinder Singh Dhaliwal
Summary: The study revealed a correlation between increasing levels of daily ambient air pollution and rising emergency room visits for acute respiratory symptoms in children in Delhi, with particulate matter and nitrogen dioxide being the main influencing factors.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Oncology
Jun Wang, Wenshuai Xu, Xinlun Tian, Yanli Yang, Shao-Ting Wang, Kai-Feng Xu
Summary: The study found that air pollution has a negative impact on the lung function of adults with asthma. Exposure to carbon monoxide and particles less than 2.5 micrometers in diameter is associated with decreased large airway function. Chronic exposure to sulfur dioxide is associated with reduced lung function, particularly in patients with severe asthma.
FRONTIERS OF MEDICINE
(2022)
Article
Environmental Sciences
Rachit Sharma, Jamie L. Humphrey, Lisa Frueh, Ellen J. Kinnee, Perry E. Sheffield, Jane E. Clougherty
Summary: This study explores the association between asthma morbidity among children aged 5-17 years and exposures to pollution, temperature, social stressors, and neighborhood violent crime and socioeconomic deprivation. Results indicate that different pollutants and temperature exposures have varying effects on asthma morbidity depending on season and lag days, and the effects are modified by violent crime and socioeconomic deprivation in a non-linear manner.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Ying-Ying Meng, Dahai Yue, John Molitor, Xiao Chen, Jason G. Su, Michael Jerrett
Summary: This study examines the impact of the Emission Reduction Plan for Ports and Goods Movement in California on air pollution exposures and emergency room visits among Medicaid enrollees with asthma and/or chronic obstructive pulmonary disease. The results show that participants living near goods movement corridors experienced greater reductions in nitrogen dioxide exposures and emergency room visits compared to those in control areas.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Zhebin Yu, Gerard H. Koppelman, Jolanda M. A. Boer, Gerard Hoek, Jules Kerckhoffs, Judith M. Vonk, Roel Vermeulen, Ulrike Gehring
Summary: The study found that long-term exposure to ultrafine particles (UFP) is associated with an increased risk of asthma development, but this association becomes non-significant after adjusting for other pollutants.
ENVIRONMENTAL RESEARCH
(2022)
Article
Chemistry, Analytical
Yi-Giien Tsai, Ruei-Hao Shie, Chi-Hsiang Huang, Chih-Dao Chen, Wei-Chi Lin, Hsiao-Yu Yang
Summary: This study aimed to use an electronic nose to detect small airway dysfunction in elementary schoolchildren at risk of asthma and evaluate the acute effects of air pollution on respiration. The results showed that the E-nose had high accuracy in detecting small airway dysfunction, and the analysis of exhaled breath could be used to assess the impact of air pollution on respiratory health.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Allergy
Stefania Arasi, Ulugbek Nurmatov, Audrey Dunn-Galvin, Shahd Daher, Graham Roberts, Paul J. Turner, Sayantani B. Shinder, Ruchi Gupta, Philippe Eigenmann, Anna Nowak-Wegrzyn, Mario A. Sanchez Borges, Ignacio J. Ansotegui, Montserrat Fernandez-Rivas, Stavros Petrou, Luciana Kase Tanno, Marta Vazquez-Ortiz, Brian P. Vickery, Gary Wing-Kin Wong, Motohiro Ebisawa, Alessandro Fiocchi
Summary: This systematic review examined the severity of IgE-mediated food allergy, finding heterogeneous scoring systems and outcomes across studies. The research highlighted various factors related to severe food allergy, but also noted discrepancies in quality and ratings among different studies.
WORLD ALLERGY ORGANIZATION JOURNAL
(2021)
Article
Allergy
Luciana Kase Tanno, Pascal Demoly, Bryan Martin, Jonathan Berstein, Mario Morais-Almeida, Michael Levin, Alessandro Fiocchi, Mario Sanchez-Borges, Luis R. Caraballo, Gary Wong, Jose Antonio Ortega-Martell, Philip Rouadi, Anahi Yanez, Liang Lu Wang, David B. Peden, Manana Chikhladze, Sandra N. Gonzalez-Diaz, Jean-Francois Fontainet, James Sublett, Yoon-Seok Chang, Giovanni Passalacqua, Ignacio J. Ansotegui, Motohiro Ebisawa, Gianenrico Senna, Marco Caminati
Summary: The COVID-19 outbreak posed unprecedented challenges to the world, prompting the allergy societies to produce guidance documents. An international survey revealed that managing allergic patients during the pandemic does not increase the risk of contracting COVID-19. This data can serve as a starting point for feedback on recommendations and new strategies for healthcare professionals.
WORLD ALLERGY ORGANIZATION JOURNAL
(2021)
Article
Allergy
Agnes S. Y. Leung, Elizabeth Huiwen Tham, Jing Li, Punchama Pacharn, Takumi Takizawa, Eun Lee, Yuhan Xing, Ting-Fan Leung, Soo-Jong Hong, Gary W. K. Wong
Summary: Asthma is becoming increasingly common in Asian countries, with higher prevalence rates documented in urban areas compared to rural areas. Environmental factors such as air pollution, dietary patterns, viral infections, and early microbial exposure play crucial roles in the pathogenesis of asthma. Understanding these factors can help in developing primary preventive strategies against this global disease.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Allergy
Johanna Theodorou, Elisabeth Nowak, Andreas Boeck, Michael Salvermoser, Claudia Beerweiler, Kathrin Zeber, Paulina Kulig, Miranda S. Tsang, Chun-Kwok Wong, Gary W. K. Wong, Marjut Roponen, Joerg Kumbrink, Fahd Alhamdan, Florian Michel, Holger Garn, Vinko Tosevski, Bianca Schaub, Omer Kalayci
Summary: The study found that children with asthma have lower levels of DUSP1, but after exposure to farm dust stimulation, their DUSP1 expression is upregulated, and inflammatory MAPK is downregulated at the gene and protein level. The farm environment regulates inflammatory MAPK in various immune cell types, contributing to anti-inflammatory characteristics.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Allergy
Torsten Zuberbier, Tamara Doerr, Werner Aberer, Montserrat Alvaro, Elizabeth Angier, Stefania Arasi, Hasan Arshad, Barbara Ballmer-Weber, Joan Bartra, Lisa Beck, Philippe Begin, Carsten Bindslev-Jensen, Jovanka Bislimovska, Jean Bousquet, Knut Brockow, Andrew Bush, Antonella Cianferoni, Michael J. Cork, Adnan Custovic, Ulf Darsow, Nicolette Jong, Diana Deleanu, Stefano Del Giacco, Antoine Deschildre, Audrey Dunn Galvin, Motohiro Ebisawa, Montserrat Fernandez-Rivas, Marta Ferrer, Alessandro Fiocchi, Roy Gerth van Wijk, Maia Gotua, Kate Grimshaw, Josefine Gruenhagen, Enrico Heffler, Michihiro Hide, Karin Hoffmann-Sommergruber, Cristoforo Incorvaia, Christer Janson, Swen Malte John, Carla Jones, Marek Jutel, Norito Katoh, Benjamin Kendziora, Tamar Kinaciyan, Edward Knol, Oksana Kurbacheva, Susanne Lau, Richard Loh, Carlo Lombardi, Mika Makela, Mary Jane Marchisotto, Michael Makris, Marcus Maurer, Rosan Meyer, Dragan Mijakoski, Jordan Minov, Joaquim Mullol, Caroline Nilsson, Anna Nowak-Wegrzyn, Bright Nwaru, Mikela Odemyr, Giovanni Battista Pajno, Sushil Paudel, Nikolaos G. Papadopoulos, Harald Renz, Giampaolo Ricci, Johannes Ring, Barbara Rogala, Hugh Sampson, Gianenrico Senna, Brigita Sitkauskiene, Peter Kenneth Smith, Katarina Stevanovic, Sasho Stoleski, Hania Szajewska, Akio Tanaka, Ana Todo-Bom, Fatih Alexander Topal, Erkka Valovirta, Ronald Van Ree, Carina Venter, Stefan Woehrl, Gary W. K. Wong, Zuotao Zhao, Margitta Worm
Summary: Based on a systematic review, it is unlikely that cross-contamination of major food allergens below 0.5 mg/100 g will endanger most food allergic patients when consuming a standard portion of food. The suggestion is to use a voluntary declaration on processed food packages stating that the product contains named allergens and may contain traces of other contaminations at concentrations less than 0.5 mg per 100 g of the product, which can be technically achieved in most processed foods. Further research on threshold levels is encouraged for a legally binding solution in the future.
Article
Allergy
Man Fung Tang, Agnes Sze Yin Leung, Noelle Anne Ngai, Oi Man Chan, Gary Wing Kin Wong, Ting Fan Leung
Summary: Female, previous use of inhaled corticosteroids, and frequent asthma exacerbations are predictors for persistent childhood asthma. Patients with persistent asthma have lower lung function indices and poorer lung function growth.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Allergy
Agnes S. Y. Leung, Rebecca M. Y. Li, Ann W. S. Au, Jaime Sou Rosa Duque, Po Ki Ho, Gilbert T. Chua, Chi Hang Wong, David C. K. Luk, Mike Y. W. Kwan, Yat Sun Yau, Gary W. K. Wong, Ting Fan Leung
Summary: Anaphylaxis incidence is increasing among children in Hong Kong, with food-induced anaphylaxis, particularly from peanuts and shellfish, being the most common triggers. Most episodes are severe (Grade 4) and often misdiagnosed, with adrenaline underutilized in management, indicating a need for improved awareness and management strategies.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Review
Allergy
Yuhan Xing, Gary Wing-Kin Wong
Summary: The Asia-Pacific region shows variations in prevalence rates of allergic diseases, with even slight increases translating into overwhelming numbers of patients due to its large population. As urbanization and industrialization progress, measures must be taken to reduce the magnitude of future allergy epidemics.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2022)
Review
Allergy
Valerie Chiang, Agnes S. Y. Leung, Elaine Y. L. Au, Marco H. K. Ho, Tak Hong Lee, Adrian Y. Y. Wu, Gary W. K. Wong, Philip H. Li
Summary: The Hong Kong Institute of Allergy formulated and updated a set of consensus statements on COVID-19 Vaccine Allergy Safety, providing recommendations for individuals with different allergic histories and promoting safe vaccine uptake. The updated statements are based on local and international experience and address concerns regarding vaccine-associated allergic reactions.
ASIA PACIFIC ALLERGY
(2022)
Article
Allergy
Christine Y. Y. Wai, Nicki Y. H. Leung, Agnes S. Y. Leung, Sai Ming Ngai, Punchama Pacharn, Yat Sun Yau, Jaime Sou Da Rosa Duque, Mike Y. W. Kwan, Orathai Jirapongsananuruk, Wai Hung Chan, Gilbert T. Chua, Qun Ui Lee, Surapon Piboonpocanun, Po Ki Ho, Joshua S. C. Wong, Shanshan Li, Kary J. Y. Xu, Gary W. K. Wong, Ka Hou Chu, Patrick S. C. Leung, Pakit Vichyanond, Ting Fan Leung
Summary: The clinical management of shrimp allergy is limited by the lack of accurate tests. In this study, the allergen repertoire of shrimp was comprehensively investigated, and the sensitization pattern and diagnostic value of these allergens in allergic subjects from different populations were compared using molecular diagnosis.
Article
Allergy
Yuhan Xing, Maggie H. Wang, Ting-Fan Leung, Chun-Kwok Wong, Marjut Roponen, Bianca Schaub, Jing Li, Gary W. K. Wong
Summary: It has been confirmed that living in a rural environment has a protective effect against asthma in children, and exposure to poultry and agricultural farming are the most important factors associated with this protection.
Article
Allergy
Agnes Sze Yin Leung, Elizabeth Huiwen Tham, Miny Samuel, Daniel Munblit, Derek K. Chu, Lamia Dahdah, Kiwako Yamamoto-Hanada, Thulja Trikamjee, Vijay Warad, Andre van Niekerk, Santiago Martinez, Anne Ellis, Leonard Bielory, Gustavo Cuadros, Hugo van Bever, Dana Wallace, Mimi Tang, James Sublett, Gary Wing Kin Wong
Summary: This study aims to systematically review clinical practice guidelines on the primary prevention of food allergy and atopic dermatitis. The evaluation will focus on methodological quality, consistency, and global applicability. The results will be summarized in tabular and narrative formats.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Zhaowei Yang, Zhong Chen, Xinliu Lin, Siyang Yao, Mo Xian, Xiaoping Ning, Wanyi Fu, Mei Jiang, Naijian Li, Xiaojun Xiao, Mulin Feng, Zexuan Lian, Wenqing Yang, Xia Ren, Zhenyu Zheng, Jiefeng Zhao, Nili Wei, Wenju Lu, Marjut Roponen, Bianca Schaub, Gary W. K. Wong, Zhong Su, Charles Wang, Jing Li
Summary: Rural environments and microbiota are linked to a reduction in the prevalence of allergies. This study found that rural children have fewer allergies and a unique gut microbiota with fewer Bacteroides and more Prevotella. Indoor dusts in rural environments have higher endotoxin levels and a greater diversity of bacteria and fungi compared to indoor urban dusts.
Article
Allergy
Wanyi Fu, Zhenyu Zheng, Jiefeng Zhao, Mulin Feng, Mo Xian, Nili Wei, Rundong Qin, Yuhan Xing, Zhaowei Yang, Gary W. K. Wong, Jing Li
Summary: There is a difference in rates of allergic diseases and allergen sensitization between rural and urban children. The development of allergic diseases and allergen sensitization is associated with specific urban/rural environmental exposures in early life.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Review
Allergy
Yuhan Xing, Agnes Sze-Yin Leung, Gary Wing-Kin Wong
Summary: Wheezing is common among preschool children, and environmental factors play a key role in the development from preschool wheezing to childhood asthma. Risk factors include severe respiratory infections, allergic sensitization, and exposure to tobacco smoke. On the contrary, a farming/rural environment is associated with asthma protection.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
