Journal
CLINICAL NEUROPATHOLOGY
Volume 34, Issue 2, Pages 83-88Publisher
DUSTRI-VERLAG DR KARL FEISTLE
DOI: 10.5414/NP300794
Keywords
focal cortical dysplasia; balloon cells; glutamine synthetase; epilepsy
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Glutamine synthetase is an enzyme involved in the clearance of glutamate, the most potent excitatory neurotransmitter. We studied the immunohistochemical expression of glutamine synthetase in neocortical samples from 5 children who underwent surgery for pharmacoresistant epilepsy and a histological diagnosis of focal cortical dysplasia lib. In all cases, balloon cells, but not dysmorphic neurons, were immunopositive for glutamine synthetase. This finding suggests that balloon cells can be involved in the neutralization of glutamate and play a protective anti-seizure role.
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