Article
Otorhinolaryngology
Daniel E. Killeen, John P. Marinelli, Christine M. Lohse, Katherine A. Lees, Michael J. Link, Matthew L. Carlson, Jacob B. Hunter
Summary: This study assessed the correlation between linear and volumetric changes in vestibular schwannomas (VS). Retrospective imaging review showed that changes in diameter were significantly correlated with changes in volume for both internal auditory canal (IAC) and cerebellopontine angle (CPA) tumors. However, diameter changes that did not meet the definition of linear growth (<2 mm) had corresponding median volume changes in excess of 20% for both IAC and CPA tumors.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Clinical Neurology
Jason Gurewitz, Zane Schnurman, Aya Nakamura, Ralph E. Navarro, Dev N. Patel, Sean O. McMenomey, J. Thomas Roland, John G. Golfinos, Douglas Kondziolka
Summary: This study aimed to investigate the relationship between hearing loss and tumor volumetric growth rates in patients with untreated vestibular schwannoma (VS). The results showed that larger initial tumor size and faster tumor growth rates were associated with an elevated risk of loss of class A and serviceable hearing.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Cathal John Hannan, Daniel Lewis, Claire O'Leary, Mueez Waqar, David Brough, Kevin N. Couper, Douglas P. Dyer, Andy Vail, Calvin Heal, Joshua Macarthur, Christopher Cooper, Charlotte Hammerbeck-Ward, D. Gareth Evans, Scott A. Rutherford, Simon K. Lloyd, Simon Richard Mackenzie Freeman, David John Coope, Andrew T. King, Omar Nathan Pathmanaban
Summary: There is evidence that macrophage infiltration in the tumor microenvironment promotes the growth of vestibular schwannoma (VS). The efficacy of bevacizumab in NF2-associated VS demonstrates the value of targeting the microvascular tumor microenvironment, and tumor-associated macrophages (TAMs) may represent another druggable target.
Article
Otorhinolaryngology
Sophia Tran, Daniel E. Killeen, Shafeen Qazi, Sanjana Balachandra, Jacob B. Hunter
Summary: This study assessed the impact of medication use, specifically statin, metformin, and aspirin, on the growth of vestibular schwannomas (VSs), and found that metformin is associated with reduced VS growth.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Zehan Zhang, Xuan Zheng, Ding Zhang, Jiashu Zhang, Fangye Li, Chong Li, Xiuying Wang, Jie Li, Dongyi Han, Jun Zhang
Summary: Tumor size plays a crucial role in the prognosis of vestibular schwannomas in young patients, with larger tumors associated with higher proliferation and risk of relapse. The cellular schwannoma subtype requires special attention and accurate histopathologic diagnosis for young patients, with a closer follow-up strategy recommended for this subtype.
WORLD NEUROSURGERY
(2022)
Article
Geriatrics & Gerontology
Xueyun Deng, Lihua Liu, Jiuhong Li, Hui Yao, Shuai He, Zhiwei Guo, Jiayu Sun, Wenke Liu, Xuhui Hui
Summary: Patients with acoustic neuroma show cognitive impairments in various domains, including memory, executive function, attention, and processing speed compared to healthy controls. Changes in the structural brain network, especially the efficiency of subnetworks and fiber connections, are associated with cognitive impairments in these patients. Including neuropsychological aspects in clinical evaluation and appropriate treatments may help improve the life quality of patients with acoustic neuroma.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Oncology
Vitor Moura Goncalves, Elisa-Maria Suhm, Vanessa Ries, Marco Skardelly, Ghazaleh Tabatabai, Marcos Tatagiba, Jens Schittenhelm, Felix Behling
Summary: Most patients with vestibular schwannomas can be cured with microsurgical resection, or tumor growth can be stabilized by radiotherapy in certain cases. Increased inflammatory cell infiltration is associated with larger tumor size but not with volumetric growth.
Review
Clinical Neurology
Mingbin Bao, Yunsen He, Ye Tao, Li Liu, Yuheng Li, Yongjun Zhu, Qinjiang Huang, Mengjun Zhang, Bo Wu, Hao Wang
Summary: This article reports a case of a giant vestibular schwannoma during pregnancy, highlighting the importance of early diagnosis and treatment, and providing insights into the optimal timing for surgery.
FRONTIERS IN NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Diego Cazzador, Laura Astolfi, Antonio Daloiso, Giulia Tealdo, Edi Simoni, Antonio Mazzoni, Elisabetta Zanoletti, Gino Marioni
Summary: Although there have been improvements in the diagnosis and treatment of vestibular schwannomas (VSs) in recent years, no factors have been identified as predictive of tumor growth. The tumor microenvironment (TME) plays a key role in tumorigenesis, drug response, and treatment outcome. This review aims to assess the current knowledge on TME in sporadic VSs, and highlights the need for further studies to identify TME-related biomarkers and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Otorhinolaryngology
Brian Kellermeyer, Erica Haught, Tyler Harper, Stephen Wetmore
Summary: This retrospective study investigated acoustic neuroma patients with vestibular schwannoma (VS) and normal or symmetric hearing loss from 1999 to 2012. The most common presenting symptom in these patients was dizziness, and 40% of them showed tumor growth. The study highlighted the importance of monitoring tumor growth in patients with VS who do not exhibit unilateral hearing loss.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)
Review
Medicine, Research & Experimental
Benjamin D. D. Lovin, Alex J. J. Wilkinson, Yun Qing, Mike Hernandez, Marc-Elie Nader, Shaan Raza, Franco DeMonte, Paul W. W. Gidley
Summary: This study systematically reviewed and evaluated the potential impact of metformin on vestibular schwannoma (VS) growth. The results suggest that metformin may reduce the odds of VS growth. A randomized trial is needed to determine the unbiased effect of metformin on VS growth.
Article
Clinical Neurology
Conrad Josef Villafuerte, David B. Shultz, Normand Laperriere, Fred Gentili, Robert Heaton, Monique van Prooijen, Michael D. Cusimano, Mojgan Hodaie, Michael Schwartz, Alejandro Berlin, David Payne, Suneil K. Kalia, Mark Bernstein, Justin Wang, Gelareh Zadeh, Julian Spears, Derek S. Tsang
Summary: Calibration dose rate and BED were not significantly associated with tumor control or edema post SRS treatment for acoustic neuroma. Salvage SRS and larger tumors were correlated with higher local failure rates, while cystic tumors were associated with lower local failure rates.
WORLD NEUROSURGERY
(2021)
Article
Otorhinolaryngology
Jungho Ha, Hantai Kim, Ga Young Gu, Young Jae Song, Jeong Hun Jang, Hun Yi Park, Yun-Hoon Choung
Summary: Simultaneous cochlear implantation (CI) and intracochlear schwannoma removal can successfully remove the tumor and achieve good hearing performance.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Neurosciences
Xueyun Deng, Lizhen Liu, Jun Luo, Lihua Liu, Xuhui Hui, Hua Feng
Summary: This study compared the cognitive function of patients with acoustic neuroma (AN) and healthy controls (HCs) and explored the possible underlying mechanisms. The results showed that patients with AN performed worse in neuropsychological evaluations and had widespread alterations in different diffusion tensor imaging (DTI) metrics, which correlated with cognitive function. It was also found for the first time that the decrease in fractional anisotropy (FA) in the minor forceps was related to cognitive decline, suggesting it could be a neurobiological marker of cognitive impairment in AN patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Clinical Neurology
Marina Neves Cavada, Michael Fook-Ho Lee, Nicholas Emmanuel Jufas, Richard John Harvey, Nirmal P. Patel
Summary: This study conducted a systematic review and meta-analysis on the management of intracanalicular vestibular schwannoma, including 71 studies. The primary outcome revealed that serviceable hearing preservation rates were 31% in the observation group, 56% in the radiotherapy group, and 51% in the surgery group. Facial nerve function was found to be best preserved in both observation and radiotherapy groups.
OTOLOGY & NEUROTOLOGY
(2021)
Editorial Material
Clinical Neurology
Daniel M. Heiferman, Hasan R. Syed, Daphne Li, Brian D. Rothstein, Ali Shaibani, Tadanori Tomita
OPERATIVE NEUROSURGERY
(2019)
Review
Clinical Neurology
Daphne Li, Tahaamin Shokuhfar, Julia Pantalone, Brian Rothstein, Tord D. Alden, Ali Shaibani, Amanda M. Saratsis
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2019)
Article
Clinical Neurology
Daniel M. Heiferman, Daphne Li, Joseph C. Serrone, Matthew R. Reynolds, Anand Germanwala, Clarence B. Watridge, Adam S. Arthur
JOURNAL OF NEUROSURGERY
(2020)
Article
Clinical Neurology
Elhaum Rezaii, Daphne Li, Daniel M. Heiferman, Caroline C. Szujewski, Brendan Martin, Adrienne Cobb, Giselle E. K. Malina, Kurt A. Grahnke, Ryan C. Hofler, John P. Leonetti, Douglas E. Anderson
WORLD NEUROSURGERY
(2019)
Review
Clinical Neurology
Daphne Li, Daniel M. Heiferman, Hasan R. Syed, Joao Gustavo Santos, Robin M. Bowman, Arthur J. DiPatri, Tadanori Tomita, Nitin R. Wadhwani, Tord D. Alden
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2019)
Article
Clinical Neurology
Daphne Li, Stephen Johans, Brendan Martin, Adrienne Cobb, Miri Kim, Anand Germanwala
Summary: There is a correlation between surgical volume and perioperative outcomes for transnasal transsphenoidal pituitary tumor resections, with higher volume centers showing superior outcomes. Despite the shift to endoscopic techniques, the volume-outcome relationship remains significant.
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2021)
Article
Clinical Neurology
Daphne Li, Elhaum Rezaii, G. Alexander Jones
WORLD NEUROSURGERY
(2020)
Article
Clinical Neurology
Michael P. Wemhoff, Kevin Swong, Daphne Li, Neal Mugve, Lisa A. Gramlich, Russ P. Nockels
JOURNAL OF NEUROSURGERY-SPINE
(2020)
Review
Pediatrics
Daphne Li, Wendy Stellpflug, Kathy Romanski, Maureen Kilgallon, Stacy Speck, Amanda M. Saratsis
FRONTIERS IN PEDIATRICS
(2020)
Article
Oncology
Shejuan An, Jeannie M. Camarillo, Tina Yi-Ting Huang, Daphne Li, Juliette A. Morris, Madeline A. Zoltek, Jin Qi, Mandana Behbahani, Madhuri Kambhampati, Neil L. Kelleher, Javad Nazarian, Paul M. Thomas, Amanda M. Saratsis
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2020)
Review
Clinical Neurology
Daphne Li, Kathy Romanski, Maureen Kilgallon, Stacy Speck, Robin Bowman, Arthur DiPatri, Tord Alden, Tadanori Tomita, Sandi Lam, Amanda M. Saratsis
Summary: The study evaluated the incidence of VAD access-associated infections in PHH patients and found that using a standardized VAD access kit and strict adherence to access protocol can significantly reduce the risk of infection.
JOURNAL OF NEUROSCIENCE NURSING
(2021)
Article
Multidisciplinary Sciences
Daphne Li, Erin R. Bonner, Kyle Wierzbicki, Eshini Panditharatna, Tina Huang, Rishi Lulla, Sabine Mueller, Carl Koschmann, Javad Nazarian, Amanda M. Saratsis
Summary: The study optimized ctDNA detection sensitivity and specificity on different ddPCR platforms, demonstrating reliable detection of ctDNA in the liquid biome for clinically feasible, reproducible, and minimally invasive approach to DMG diagnosis, molecular subtyping, and therapeutic monitoring.
SCIENTIFIC REPORTS
(2021)
Review
Clinical Neurology
Daphne Li, Edward Westfall, Margaret Aasen, Ewa Borys, John P. Leonetti, Douglas E. Anderson
Summary: This study presented a rare case of anaplastic HPC in the jugular foramen and conducted a systematic review of the literature concerning JF HPC/SFTs. It highlights the importance of tissue diagnosis and appropriate management in such cases.
WORLD NEUROSURGERY
(2021)
Review
Clinical Neurology
Daphne Li, Shawn Choe, Ewa Borys, Joseph C. Serrone, Anand Germanwala
Summary: Hemangioblastomas are benign vascular neoplasms that can occur sporadically or in association with Von Hippel-Lindau disease, with a minority occurring in the spine. A rare case of primary sporadic spinal hemangioblastoma as an intradural extramedullary lesion was presented, and successful gross total resection was performed. The majority of sporadic IDEM hemangioblastomas reported in the literature presented with pain, radiculopathy, or myelopathy, and were managed with maximal safe resection resulting in stable or improved clinical status.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Daphne Li, Russ P. Nockels
Summary: This study aims to share a novel set of radiographic parameters, the Circle, which can be used to guide the extent of fusion in surgical correction of spinal kyphotic deformities. The survey results showed a significant decrease in variance between predicted upper and lower instrumented vertebrae, as well as the length of construct, after the application of the Circle. Participants rated the ease of use of the Circle highly, and the majority stated that they would likely use it in the future as a radiographic tool for surgical planning.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Hyunjung Kim, Jhii-Hyun Ahn, Sung Min Ko, Jin Woo Kim
Summary: The pre-navigation balloon technique significantly reduces the occurrence of distal embolism and increases the first-pass effect (FPE) during stent retriever thrombectomy. This technique is particularly effective for patients with ICA occlusion, improving clinical outcomes.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Review
Clinical Neurology
Mehdi Khaleghi, Joshua Vignolles-Jeong, Bradley Otto, Ricardo Carrau, Daniel Prevedello
Summary: This study presented a rare case of symptomatic ectopic Rathke's cleft cyst (RCC), which was located posterior to the pituitary gland and caused extensive clival erosion. The surgical technique of wide marsupialization of the cyst using intraoperative ultrasound-assisted endoscopic endonasal transclival approach was described, and a systematic literature review of intracranial ectopic RCCs was conducted.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Article
Clinical Neurology
Oscar H. Del Brutto, Denisse A. Rumbea, Aldo F. Costa, Maitri Patel, Mark J. Sedler, Robertino M. Mera
Summary: This study found an association between cognitive impairment and mortality risk in adults of Amerindian ancestry living in rural Ecuador.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Article
Clinical Neurology
Yangjingyi Xia, Li Li, Yunze Li, Manyan Hu, Tianrui Zhang, Qinghua Feng, Wenlei Li, Yuan Zhu, Minghua Wu
Summary: This study shows that fasting blood glucose (FBG) level is significantly associated with unfavorable outcome after acute ischemic stroke (AIS) in patients. The risk of unfavorable outcome increases significantly when FBG is above 5.5 mmol/L.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)