Article
Oncology
Yuanzheng Hou, Ye Li, Qiongge Li, Yang Yu, Jie Tang
Summary: In this study, the authors retrospectively reviewed the use of intraoperative ultrasound (iUS) and intraoperative MRI (iMRI) in a full-course resection control strategy for initial glioma surgeries. The results showed that this strategy can achieve good surgical outcomes and may improve efficiency by reducing the number of iMRI scans and shortening surgery time.
FRONTIERS IN ONCOLOGY
(2022)
Review
Clinical Neurology
Danielle Golub, Jonathan Hyde, Siddhant Dogra, Joseph Nicholson, Katherine A. Kirkwood, Paulomi Gohel, Stephen Loftus, Theodore H. Schwartz
Summary: The study compared the efficacy of 5-ALA and IMRI in optimizing EOR in HGG, finding both to be superior to conventional neuronavigation. However, no clear difference in effectiveness was found between IMRI and 5-ALA.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Stefanie Lietke, Michael Schmutzer, Christoph Schwartz, Jonathan Weller, Sebastian Siller, Maximilian Aumiller, Christian Heckl, Robert Forbrig, Maximilian Niyazi, Rupert Egensperger, Herbert Stepp, Ronald Sroka, Jorg-Christian Tonn, Adrian Ruhm, Niklas Thon
Summary: Malignant glioma, especially in recurrent situations, has a poor prognosis. Interstitial photodynamic therapy (iPDT) using 5-aminolevulinic acid-induced protoporphyrin IX as a cytotoxic photosensitizer shows promising results in treating recurrent malignant gliomas. Heterogeneous treatment response was observed without significant association with patient characteristics, treatment-related factors, or molecular markers. Further prospective evaluation is needed to identify mechanisms and prognostic factors of favorable treatment response.
Article
Clinical Neurology
Stephanie Schipmann, Michael Muther, Louise Stogbauer, Sebastian Zimmer, Benjamin Brokinkel, Markus Holling, Oliver Grauer, Eric Suero Molina, Nils Warneke, Walter Stummer
Summary: Combining 5-ALA FGR and PDT provides an innovative and safe method of local tumor control resulting in promising progression-free survival (PFS). Further prospective studies are warranted to evaluate long-term therapeutic effects.
JOURNAL OF NEUROSURGERY
(2021)
Review
Oncology
Shan Jiang, Huihui Chai, Qisheng Tang
Summary: Surgery is crucial in treating malignant glioma. However, distinguishing tumor margins is challenging due to infiltrative growth and brain shift. Thus, we introduce four intraoperative technologies, including magnetic resonance imaging, fluorescence-guided surgery, Raman histology, and mass spectrometry, to precisely delineate malignant glioma margins. We review their advantages, disadvantages, and future trends.
FRONTIERS IN ONCOLOGY
(2023)
Review
Clinical Neurology
Anant Naik, Emily J. Smith, Ariana Barreau, Mark Nyaeme, Samuel W. Cramer, Daniel Najafali, David T. Krist, Paul M. Arnold, Wael Hassaneen
Summary: A network meta-analysis comparing 5-ALA, IMRI, and FS as intraoperative navigation methods for high-grade glioma resection showed that IMRI, FS, and 5-ALA all led to higher rates of gross total resection and improved overall survival and progression-free survival.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Oncology
Abel Ferres, Alberto Di Somma, Alejandra Mosteiro, Thomaz Eduardo Topczewski, Pedro Roldan, Leire Pedrosa, Dioulde Diao, Estela Pineda, Angels Sierra, Joaquim Ensenat, Jose Juan Gonzalez-Sanchez
Summary: In this study, an inadvertent effect of 5-ALA-mediated photodynamic therapy has been detected in vivo. This finding opens up possibilities for further research on this promising therapeutic tool.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Maximilien Vermandel, Clement Dupont, Fabienne Lecomte, Henri-Arthur Leroy, Constantin Tuleasca, Serge Mordon, Constantinos G. Hadjipanayis, Nicolas Reyns
Summary: The study confirmed the feasibility and safety of intraoperative 5-ALA photodynamic therapy for treating GBM after maximal tumor resection, while also improving patient survival rates and survival time.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marek Mazurek, Dariusz Szczepanek, Anna Orzylowska, Radoslaw Rola
Summary: This article summarizes the current knowledge on the differences in the level of emitted fluorescence in glial tumors. It discusses how the level of fluorescence may depend on the histological type and genetic profile of the tumor, as well as the activity and expression of enzymes involved in the intracellular metabolism of fluorescent dyes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Keith Simfukwe, Iurii Iakimov, Rinat Sufianov, Luis Borba, Luciano Mastronardi, Alina Shumadalova
Summary: This study documents the use of intraoperative ultrasonography (iUS) as a primary navigational tool in neurosurgery cases and discusses its advantages compared to other neuronavigation techniques.
FRONTIERS IN SURGERY
(2022)
Review
Oncology
Tiffany A. Eatz, Daniel G. Eichberg, Victor M. Lu, Long Di, Ricardo J. Komotar, Michael E. Ivan
Summary: 5-aminolevulinic acid (5-ALA) has been shown to enhance the outcomes of high-grade glioma (HGG) surgery, including extent of resection and patient survival. However, its impact on postoperative neurological function remains inconclusive.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Oncology
Julia Klingenschmid, Aleksandrs Krigers, Johannes Kerschbaumer, Claudius Thome, Daniel Pinggera, Christian F. Freyschlag
Summary: This study analyzed the surgical treatment outcomes of elderly patients with malignant glioma. The results showed that gross total resection (GTR) can achieve better functional outcomes and survival in elderly patients. Age seems to have little influence on overall survival in surgically treated patients, but high preoperative functional performance is necessary.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Kazuhide Shimizu, Kaoru Tamura, Shoko Hara, Motoki Inaji, Yoji Tanaka, Daisuke Kobayashi, Takashi Sugawara, Hiroaki Wakimoto, Tadashi Nariai, Kenji Ishii, Ichiro Sakuma, Taketoshi Maehara
Summary: This study aimed to investigate the correlation between preoperative MET-PET signals and intraoperative 5-ALA-induced fluorescence in malignant brain tumor surgery. The results showed that strong tumor fluorescence correlated with high MET-PET uptake and cellular proliferation, providing valuable tumor biology information for surgery in situations where MET-PET is not accessible.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jianqiang Wei, Chunman Zhang, Liujia Ma, Chunrui Zhang
Summary: This study aimed to examine the application value of an artificial intelligence algorithm-based intraoperative magnetic resonance imaging (iMRI) in neurosurgical glioma resection. The results showed that the experimental group had a higher average tumor resection rate, a smaller number of postoperative neurological deficits, and a similar infection rate compared to the control group.
CONTRAST MEDIA & MOLECULAR IMAGING
(2022)
Review
Clinical Neurology
Hao You, Hui Qiao
Summary: In surgeries for gliomas involving eloquent areas, balancing maximal resection and neurological protection is crucial. Intraoperative neuromonitoring techniques like SSEP, DES, MEP, EMG, and ECoG are effective for enhancing localization of eloquent areas and epilepsy foci, reducing postoperative dysfunction and improving patients' quality of life. Advancements in technology may lead to more effective IONM strategies and programs in the future.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Hyunjung Kim, Jhii-Hyun Ahn, Sung Min Ko, Jin Woo Kim
Summary: The pre-navigation balloon technique significantly reduces the occurrence of distal embolism and increases the first-pass effect (FPE) during stent retriever thrombectomy. This technique is particularly effective for patients with ICA occlusion, improving clinical outcomes.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Review
Clinical Neurology
Mehdi Khaleghi, Joshua Vignolles-Jeong, Bradley Otto, Ricardo Carrau, Daniel Prevedello
Summary: This study presented a rare case of symptomatic ectopic Rathke's cleft cyst (RCC), which was located posterior to the pituitary gland and caused extensive clival erosion. The surgical technique of wide marsupialization of the cyst using intraoperative ultrasound-assisted endoscopic endonasal transclival approach was described, and a systematic literature review of intracranial ectopic RCCs was conducted.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Article
Clinical Neurology
Oscar H. Del Brutto, Denisse A. Rumbea, Aldo F. Costa, Maitri Patel, Mark J. Sedler, Robertino M. Mera
Summary: This study found an association between cognitive impairment and mortality risk in adults of Amerindian ancestry living in rural Ecuador.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Article
Clinical Neurology
Yangjingyi Xia, Li Li, Yunze Li, Manyan Hu, Tianrui Zhang, Qinghua Feng, Wenlei Li, Yuan Zhu, Minghua Wu
Summary: This study shows that fasting blood glucose (FBG) level is significantly associated with unfavorable outcome after acute ischemic stroke (AIS) in patients. The risk of unfavorable outcome increases significantly when FBG is above 5.5 mmol/L.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
