Journal
ACS COMBINATORIAL SCIENCE
Volume 18, Issue 5, Pages 262-270Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscombsci.6b00003
Keywords
1,3-dipolar cycloaddition; azomethine ylide; alpha-amino acid; isatin; pyrazolo[3,4-b]quinoline; spiro-oxindole; spiro-pyrrolidine
Funding
- University Grants Commission, New Delhi [42-242/2013 (S.R.)]
- Department of Science and Technology, New Delhi under IRHPA program
- Department of Science and Technology, New Delhi under PURSE program
- Deanship of Scientific Research at King Saud University [RGP-VPP-026]
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The stereoselective syntheses of a library of novel spiro-tethered pyrazolo[3,4-b]quinoline pyrrolidine/pyrrolothiazole/indolizine oxindole/acenaphthene hybrid heterocycles have been achieved through the 1,3-dipolar cycloaddition of azomethine ylides generated in situ from a amino acids and 1,2-diketones to dipolarophiles derived from pyrazolo [3,4-b]quinoline derivatives.
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