Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2

JAK2V617F+ myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2

(2014) Y. Kagoya et al.   BLOOD

Taming the chronic kidney disease epidemic: a global view of surveillance efforts

(2014) Jai Radhakrishnan et al.   KIDNEY INTERNATIONAL

Urine neutrophil gelatinase–associated lipocalin levels do not improve risk prediction of progressive chronic kidney disease

(2013) Kathleen D. Liu et al.   KIDNEY INTERNATIONAL

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanisms and Treatment of CKD

(2012) P. Ruggenenti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Proteinuria should be used as a surrogate in CKD

(2012) Paolo Cravedi et al.   Nature Reviews Nephrology

Cardiorenal End Points in a Trial of Aliskiren for Type 2 Diabetes

(2012) Hans-Henrik Parving et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells

(2012) I-Lun Hsin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

ER stress drives Lipocalin 2 upregulation in prostate cancer cells in an NF-κB-dependent manner

(2011) Navin R Mahadevan et al.   BMC CANCER

Calcium entry via TRPC6 mediates albumin overload-induced endoplasmic reticulum stress and apoptosis in podocytes

(2011) Shan Chen et al.   CELL CALCIUM

Multiple Apoptotic Defects in Hematopoietic Cells from Mice Lacking Lipocalin 24p3

(2011) Zhuoming Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Lipocalin 2 is essential for chronic kidney disease progression in mice and humans

(2010) Amandine Viau et al.   JOURNAL OF CLINICAL INVESTIGATION

Glomerular Structure and Function Require Paracrine, Not Autocrine, VEGF-VEGFR-2 Signaling

(2010) K. Sison et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Iron traffics in circulation bound to a siderocalin (Ngal)–catechol complex

(2010) Guanhu Bao et al.   Nature Chemical Biology

Albumin Overload Induces Apoptosis in Renal Tubular Epithelial Cells through a CHOP-Dependent Pathway

(2010) Xiaowei Wu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Small-Molecule Inhibitors of Store-Operated Calcium Entry

(2009) Zachary K. Sweeney et al.   ChemMedChem

A murine model of Denys–Drash syndrome reveals novel transcriptional targets of WT1 in podocytes

(2009) Julien Ratelade et al.   HUMAN MOLECULAR GENETICS

Podocin Inactivation in Mature Kidneys Causes Focal Segmental Glomerulosclerosis and Nephrotic Syndrome

(2009) G. Mollet et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Proteinuria and Hyperglycemia Induce Endoplasmic Reticulum Stress

(2008) M. T. Lindenmeyer et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Present and future drug treatments for chronic kidney diseases: evolving targets in renoprotection

(2008) Norberto Perico et al.   NATURE REVIEWS DRUG DISCOVERY

Carnosic acid, acatechol-typeelectrophilic compound, protects neurons bothin vitroandin vivothrough activation of the Keap1/Nrf2 pathway viaS-alkylation of targeted cysteines on Keap1

(2007) Takumi Satoh et al.   JOURNAL OF NEUROCHEMISTRY