Article
Multidisciplinary Sciences
Yuegui Guo, Zhehui Zhu, Zhenyu Huang, Long Cui, Wei Yu, Wanjin Hong, Zhaocai Zhou, Peng Du, Chen-Ying Liu
Summary: In this study, the researchers found that HHEX acts as a positive regulator of YAP/TEAD, promoting colorectal tumorigenesis. HHEX interacts with and stabilizes the YAP/TEAD complex, coregulating the expression of YAP/TEAD target genes. CK2 phosphorylates HHEX to enhance its interaction with TEAD4. The elevated expression of HHEX is associated with poor prognosis of CRC patients.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Yun Li, Jian-Bo Xiong, Zhi-Gang Jie, Hui Xiong
Summary: This study found that the expression of HADHB was low in stomach adenocarcinoma (STAD), and HADHB may act as a tumor suppressor gene in STAD by regulating the Hippo-YAP pathway.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Zheng-wei Shi, Yuan Tuo, Chao-shuai Feng, Lei Zhu, Zong-rang Song, Tuan-jiang Liu, Ding-jun Hao
Summary: Intervertebral disc degeneration (IVDD) is a common cartilage-degenerative disease and a major cause of low back pain (LBP). The Hippo-YAP/TAZ signaling pathway, as an evolutionarily and functionally conserved pathway, plays a crucial role in IVDD progression. This review discusses the regulation of Hippo-YAP/TAZ signaling, its role in cartilage homeostasis and IVDD, and the potential of using Hippo-YAP/TAZ signaling for IVDD treatments.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Yu Ting Ong, Jorge Andrade, Max Armbruster, Chenyue Shi, Marco Castro, Ana S. H. Costa, Toshiya Sugino, Guy Eelen, Barbara Zimmermann, Kerstin Wilhelm, Joseph Lim, Shuichi Watanabe, Stefan Guenther, Andre Schneider, Francesca Zanconato, Manuel Kaulich, Duojia Pan, Thomas Braun, Holger Gerhardt, Alejo Efeyan, Peter Carmeliet, Stefano Piccolo, Ana Rita Grosso, Michael Potente
Summary: Ong et al. report on the intersection of YAP/TAZ and mTORC1 signalling in endothelial cells, showing their role in regulating nutrient acquisition and vascular growth. YAP/TAZ promote angiogenesis by stimulating the import of amino acids and other essential nutrients, leading to mTORC1 activation. This study highlights the importance of coordinated nutrient fluxes in the vasculature.
Article
Immunology
Joo Young Kim, You-Na Sung, Seung-Mo Hong
Summary: YAP and TEAD4 expression levels are associated with aggressive behavior and poor prognosis in surgically resected gallbladder cancer. High levels of YAP or TEAD4 alone, as well as the combined YAP(high) TEAD4(high) group, were significantly linked to worse survival outcomes in both univariate and multivariate analyses.
Article
Medicine, Research & Experimental
Wenjing Du, Zhao Tang, Fangyong Yang, Xijun Liu, Jingcheng Dong
Summary: The study demonstrated that icariin can alleviate bleomycin-induced pulmonary fibrosis in rats by inhibiting YAP, a core transcriptional regulator of the Hippo pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Yan Gu, Yanrong Chen, Lai Wei, Shuang Wu, Kaicheng Shen, Chengxiang Liu, Yan Dong, Yang Zhao, Yue Zhang, Chi Zhang, Wenling Zheng, Jiangyi He, Yunlong Wang, Yifei Li, Xiaoxin Zhao, Hongwei Wang, Jun Tan, Liting Wang, Qi Zhou, Ganfeng Xie, Houjie Liang, Juanjuan Ou
Summary: Loss of ABHD5 promotes the activation of c-Met via a non-canonical pathway, sustaining the stemness of colorectal cancer cells.
NATURE COMMUNICATIONS
(2021)
Article
Environmental Sciences
Duanyu Su, Zhian Lin
Summary: The antitumor effects of dichloroacetate (DCA) in hepatocellular carcinoma (HCC) have been explored, showing that DCA may attenuate HCC cell stemness by activating the Hippo pathway and promoting nucleus-cytoplasm translocation of YAP. The inhibition of Hippo pathway partially abrogated DCA-induced effects on HCC cell stemness, suggesting DCA as a potential inhibitor for HCC progression.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoyan Li, Zhengming Wu, Jing He, Yiting Jin, Chengyu Chu, Yun Cao, Fei Gu, Hongying Wang, Chenjian Hou, Xiuping Liu, Qiang Zou
Summary: The incidence of thyroid cancer is increasing globally, with poor prognosis associated with distant metastases. OGT and YAP play critical roles in papillary thyroid cancer, suggesting potential for targeted therapies.
Article
Cardiac & Cardiovascular Systems
Masum M. Mia, Dasan Mary Cibi, Siti Aishah Binte Abdul Ghani, Anamika Singh, Nicole Tee, Viswanathan Sivakumar, Hanumakumar Bogireddi, Stuart A. Cook, Junhao Mao, Manvendra K. Singh
Summary: Yap/Taz play an important regulatory role in MI-induced cardiac fibrosis by controlling fibroblast proliferation, transdifferentiation into myofibroblasts, and fibroinflammatory program.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biology
Guillaume Jacquemin, Annabelle Wurmser, Mathilde Huyghe, Wenjie Sun, Zeinab Homayed, Candice Merle, Meghan Perkins, Fairouz Qasrawi, Sophie Richon, Florent Dingli, Guillaume Arras, Damarys Loew, Danijela Vignjevic, Julie Pannequin, Silvia Fre
Summary: This study reveals a paracrine mechanism by which intestinal cancer cells reactivate fetal and regenerative transcriptional programs in neighboring wildtype epithelial cells, rendering them adapted to thrive in the tumor context. The glycoprotein thrombospondin- 1 (THBS1) is identified as the essential factor mediating non-cell-autonomous morphological and transcriptional responses. The THBS1-YAP axis is shown to be the mechanistic link mediating paracrine interactions between epithelial cells in intestinal tumors.
Article
Biochemistry & Molecular Biology
Ya Li, Xiangzhan Zhu, Minglei Yang, Yingying Wang, Jianhui Li, Jiarui Fang, Wenna Guo, Shanshan Ma, Fangxia Guan
Summary: In esophageal squamous cell carcinoma (ESCC), aberrant expression of KIF4A is positively correlated with tumor stage and poor prognosis. Through the YAP/TEAD4 pathway, KIF4A regulates cell growth, migration, cell cycle, and apoptosis. YAP activates KIF4A transcriptional expression by binding to the KIF4A promoter via TEAD4.
MOLECULAR CARCINOGENESIS
(2021)
Article
Cell Biology
Xinhao Wang, Xiangdang Liang, Lujun Zhou, Shen Liu, Zhuoqun Fang, Chuanzhong Hu, Yigong Hou, Zhanshe Guo
Summary: This study tested the impact of different intensities of mechanical stretch on the proliferation and apoptosis of vascular smooth muscle cells (VSMCs), as well as the role of Yes-associated protein (YAP). The results showed that 10% elongation inhibited cell proliferation and promoted apoptosis, while 15% elongation had the opposite effect. YAP played a different role in regulating VSMCs' proliferation and apoptosis under different mechanical stretch intensities.
Article
Environmental Sciences
Yu-Ling Chung, Vincent Laiman, Po-Nien Tsao, Chung -Ming Chen, Didik Setyo Heriyanto, Kian Fan Chung, Kai-Jen Chuang, Hsiao-Chi Chuang
Summary: Prenatal exposure to traffic-related air pollution, specifically diesel exhaust particles (DEPs), inhibits lung development in mice fetuses. DEP exposure decreases lung branching morphogenesis and impairs the expression of lung development-related genes. DEPs disrupt the Hippo signaling pathway and induce early cellular senescence in fetal lung fibroblast cells. These findings highlight the adverse effects of air pollution on fetal lung development.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Medicine, Research & Experimental
Xiao Zhang, Keke Yu, Lifang Ma, Zijun Qian, Xiaoting Tian, Yayou Miao, Yongjie Niu, Xin Xu, Susu Guo, Yueyue Yang, Zhixian Wang, Xiangfei Xue, Chuanjia Gu, Wentao Fang, Jiayuan Sun, Yongchun Yu, Jiayi Wang
Summary: Endogenous glutamate accumulation determines ferroptosis sensitivity by suppressing YAP in LUAD cells in response to system X-C- inhibition. ADCY10 acts as a key downstream target, affecting the PKA-dependent suppression of GFPT1 by glutamate. High ADCY10 expression in advanced-stage LUAD leads to increased sensitivity to ferroptosis, especially in therapy-resistant tumors.
Article
Biochemistry & Molecular Biology
Yang-Yang Zhao, Miao-Wei Mao, Wen-Jing Zhang, Jue Wang, Hai-Tao Li, Yi Yang, Zefeng Wang, Jia-Wei Wu
NUCLEIC ACIDS RESEARCH
(2018)
Review
Cell Biology
Xiaowei Song, Zhenyu Zeng, Huanhuan Wei, Zefeng Wang
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2018)
Article
Cell Biology
Ziran Zhu, Dan Chen, Wenjing Zhang, Jinyao Zhao, Lili Zhi, Fang Huang, Haoyu Ji, Jinrui Zhang, Han Liu, Lijuan Zou, Yang Wang
CELL DEATH & DISEASE
(2018)
Article
Biochemistry & Molecular Biology
Jinrui Zhang, Ge Zhang, Wenjing Zhang, Lu Bai, Luning Wang, Tiantian Li, Li Yan, Yang Xu, Dan Chen, Wenting Gao, Chuanzhou Gao, Chaoqun Chen, Menglin Ren, Yuexia Jiao, Hongqiang Qin, Yu Sun, Lili Zhi, Yangfan Qi, Jinyao Zhao, Quentin Liu, Han Liu, Yang Wang
Summary: The RNA binding protein RBMS1 is prevalent in immune-cold triple-negative breast cancers (TNBC) and plays a role in regulating the stability of programmed death ligand 1 (PD-L1). Depletion of RBMS1 enhances cytotoxic T cell mediated anti-tumor immunity and combination with immune checkpoint blockade or CAR-T treatment further enhances anti-tumor T-cell immunity. Our findings provide a new immunotherapeutic strategy targeting the immunosuppressive RBMS1 in TNBC.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Multidisciplinary Sciences
Xiaojuan Fan, Yun Yang, Chuyun Chen, Zefeng Wang
Summary: Circular RNAs (circRNAs) have been found to be translated through IRES-driven mechanism. Short elements that drive circRNA translation have been identified, suggesting a pervasive cap-independent translation in the human transcriptome.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Wenjian Han, Wendi Huang, Tong Wei, Yanwen Ye, Miaowei Mao, Zefeng Wang
Summary: This study reports a new RNA editing system that allows precise gene editing using a single engineered protein, without the need for auxiliary RNA. The system achieves high editing efficiency and low off-target effects, making it applicable for correcting disease-associated gene mutations.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Oncology
Yufang Bao, Sirui Zhang, Xiaoyu Zhang, Yunjian Pan, Yueren Yan, Ning Wang, Yunpeng Ren, Ji Zuo, Wei-Xing Zong, Zefeng Wang, Yongbo Wang
Summary: Loss-of-function mutations in RBM10 frequently co-occur with oncogenic EGFR mutations in lung adenocarcinoma (LUAD). Understanding the functional consequences and therapeutic impact of RBM10 loss in EGFR-mutant LUAD could lead to more effective treatment strategies.
Article
Multidisciplinary Sciences
Miaowei Mao, Yajie Qian, Wenyao Zhang, Siyu Zhou, Zefeng Wang, Xianjun Chen, Yi Yang
Summary: In this study, a stable monomeric tag (SULI) based on a single light-oxygen-voltage domain from Neurospora crassa was engineered for yeast and zebrafish. SULI allows control of protein stability by inducing degradation in dark conditions and provides spatiotemporal modulation of protein levels.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Ning Wang, Yue Hu, Zefeng Wang
Summary: Eukaryotic gene expression is tightly regulated at multiple levels, including alternative splicing, which generates multiple mRNA isoforms from a single gene. Epigenetic modifications play crucial roles in the regulation of alternative splicing by affecting transcription, splicing factor recruitment, and splicing factor expression/activity. Dysregulation of epigenetics and splicing is common in cancer and can have functional consequences. Understanding the complex regulation of gene expression layers can provide new insights into modulating disease-related splicing dysregulation.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Article
Medicine, Research & Experimental
Wenjing Zhang, Yu Sun, Lu Bai, Lili Zhi, Yun Yang, Qingzhi Zhao, Chaoqun Chen, Yangfan Qi, Wenting Gao, Wenxia He, Luning Wang, Dan Chen, Shujun Fan, Huan Chen, Hai-Long Piao, Qinglong Qiao, Zhaochao Xu, Jinrui Zhang, Jinyao Zhao, Sirui Zhang, Yue Yin, Chao Peng, Xiaoling Li, Quentin Liu, Han Liu, Yang Wang
Summary: RBMS1 is a key regulator of ferroptosis in lung cancer development and its high expression is associated with reduced patient survival. Depletion or inhibition of RBMS1 can promote ferroptosis and sensitize radioresistant lung cancer cells to radiotherapy. RBMS1 interacts with eIF3d to regulate translation of SLC7A11, playing a critical role in ferroptosis evasion during lung cancer progression.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Yangfan Qi, Wei Han, Dan Chen, Jinyao Zhao, Lu Bai, Fang Huang, Zhenwei Dai, Gang Li, Chaoqun Chen, Wenjing Zhang, Jinrui Zhang, Bilian Jin, Yang Wang
Summary: Researchers developed Engineering circRNA regulators (ECRRs) to enhance circRNA biogenesis by combining RNA binding motifs of human Pumilio 1 with dimerization functional domains. The application of ECRRs could stimulate circRNA production of exogenous mini-gene reporters in a time- and dose-dependent manner with designed specificity. Moreover, ECRRs could promote the generation of endogenous circRNAs circ10720 and circBIRC6, offering a novel avenue to investigate circRNA biogenesis and manipulate disease-related circRNA production.
Article
Biochemistry & Molecular Biology
Yuesheng Lv, Wenjing Zhang, Jinyao Zhao, Bing Sun, Yangfan Qi, Haoyu Ji, Chaoqun Chen, Jinrui Zhang, Junxiu Sheng, Taishu Wang, Daniel Dominguez, Han Liu, Quentin Liu, Songshu Meng, Xiaoling Li, Yang Wang
Summary: SRSF1 is identified as an autophagy suppressor that inhibits autophagosome formation by promoting the splicing of Bcl-x and disrupting the Beclin1-PIK3C3 complex. The decrease of SRSF1 stabilizes the Beclin1 and PIK3C3 complex, activating autophagy, while starvation- and oxidative stresses-induced autophagy can degrade SRSF1 through interacting with LC3-II. This positive feedback mechanism is crucial for inhibiting Gefitinib-resistant cancer cell progression.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Cell Biology
Quan Yang, Jinyao Zhao, Wenjing Zhang, Dan Chen, Yang Wang
JOURNAL OF MOLECULAR CELL BIOLOGY
(2019)
Article
Biochemical Research Methods
Yun Yang, Zefeng Wang
CIRCULAR RNAS: METHODS AND PROTOCOLS
(2018)