Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity

Lack of autophagy induces steroid-resistant airway inflammation

(2016) Yuzo Suzuki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

ICOS:ICOS-Ligand Interaction Is Required for Type 2 Innate Lymphoid Cell Function, Homeostasis, and Induction of Airway Hyperreactivity

(2015) Hadi Maazi et al.   IMMUNITY

Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation

(2015) Ari B. Molofsky et al.   IMMUNITY

Cigarette Smoke Silences Innate Lymphoid Cell Function and Facilitates an Exacerbated Type I Interleukin-33-Dependent Response to Infection

(2015) Jennifer Kearley et al.   IMMUNITY

Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33

(2015) Susana Castanhinha et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The biology of innate lymphoid cells

(2015) David Artis et al.   NATURE

Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

(2014) Timotheus Y.F. Halim et al.   IMMUNITY

Innate lymphoid cells and asthma

(2014) Sanhong Yu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nicotine Primarily Suppresses Lung Th2 but Not Goblet Cell and Muscle Cell Responses to Allergens

(2014) N. C. Mishra et al.   JOURNAL OF IMMUNOLOGY

Type 2 Innate Lymphoid Cells Drive CD4+ Th2 Cell Responses

(2014) A. S. Mirchandani et al.   JOURNAL OF IMMUNOLOGY

Nicotine-Mediated Cell Proliferation and Tumor Progression in Smoking-Related Cancers

(2014) Courtney Schaal et al.   MOLECULAR CANCER RESEARCH

Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera

(2013) Sun Huang et al.   BIOCHEMICAL JOURNAL

Is ?7-nAChR a Possible Target for Lung Cancer and Malignant Pleural Mesothelioma Treatment?

(2013)   CURRENT DRUG TARGETS

IL-33 is more potent than IL-25 in provoking IL-13–producing nuocytes (type 2 innate lymphoid cells) and airway contraction

(2013) Jillian L. Barlow et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Development of ferret as a human lung cancer model by injecting 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

(2013) Koichi Aizawa et al.   LUNG CANCER

Lack of PD-L1 Expression by iNKT Cells Improves the Course of Influenza A Infection

(2013) Hadi Maazi et al.   PLoS One

Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells

(2013) R. G. J. Klein Wolterink et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain

(2012) Atilla Akdemir et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Transcription Factor GATA3 Is Essential for the Function of Human Type 2 Innate Lymphoid Cells

(2012) Jenny Mjösberg et al.   IMMUNITY

The Transcription Factor GATA-3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid Cells

(2012) Thomas Hoyler et al.   IMMUNITY

Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation

(2012) Timotheus Y.F. Halim et al.   IMMUNITY

Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity

(2012) Jerome Kerzerho et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In Search of Allosteric Modulators of α7-nAChR by Solvent Density Guided Virtual Screening

(2012) Raja Dey et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

The airway epithelium in asthma

(2012) Bart N Lambrecht et al.   NATURE MEDICINE

Nicotinic acetylcholine receptors: From basic science to therapeutics

(2012) Raymond Hurst et al.   PHARMACOLOGY & THERAPEUTICS

Nicotine-induced differential modulation of autoimmune arthritis in the Lewis rat involves changes in interleukin-17 and anti-cyclic citrullinated peptide antibodies

(2011) Hua Yu et al.   ARTHRITIS AND RHEUMATISM

IL-33-Responsive Lineage-CD25+CD44hi Lymphoid Cells Mediate Innate Type 2 Immunity and Allergic Inflammation in the Lungs

(2011) K. R. Bartemes et al.   JOURNAL OF IMMUNOLOGY

Discovery and Development of α7 Nicotinic Acetylcholine Receptor Modulators

(2011) Anatoly A. Mazurov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity

(2011) Hong-Erh Liang et al.   NATURE IMMUNOLOGY

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity

(2011) Ya-Jen Chang et al.   NATURE IMMUNOLOGY

Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist

(2011) Shu-Xing Li et al.   NATURE NEUROSCIENCE

Effects of the α7 Nicotinic Acetylcholine Receptor Agonist Gts-21 on the Innate Immune Response in Humans

(2011) Matthijs Kox et al.   SHOCK

Continuous administration of a selective α7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice

(2010) Karen E. Stevens et al.   BRAIN RESEARCH

Nicotine Inhibits Fc RI-Induced Cysteinyl Leukotrienes and Cytokine Production without Affecting Mast Cell Degranulation Through  7/ 9/ 10-Nicotinic Receptors

(2010) N. C. Mishra et al.   JOURNAL OF IMMUNOLOGY

Stimulation of  7 Nicotinic Acetylcholine Receptor by Nicotine Increases Suppressive Capacity of Naturally Occurring CD4+CD25+ Regulatory T Cells in Mice In Vitro

(2010) D.-w. Wang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

The many paths to asthma: phenotype shaped by innate and adaptive immunity

(2010) Hye Young Kim et al.   NATURE IMMUNOLOGY

Linkage between smoking and asthma

(2009) A. Pietinalho et al.   ALLERGY

Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

(2009) Ryan E Hibbs et al.   EMBO JOURNAL

Activation of the Cholinergic Anti-Inflammatory System by Nicotine Attenuates Neuroinflammation via Suppression of Th1 and Th17 Responses

(2009) E. Nizri et al.   JOURNAL OF IMMUNOLOGY

The mDial Formin Is Required for Neutrophil Polarization, Migration, and Activation of the LARG/RhoA/ROCK Signaling Axis during Chemotaxis

(2009) Y. Shi et al.   JOURNAL OF IMMUNOLOGY

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

(2008) Edy Y Kim et al.   NATURE MEDICINE