Article
Oncology
Yen-Yun Wang, Anupama Vadhan, Ping-Ho Chen, Yen-Lung Lee, Chih-Yeh Chao, Kuang-Hung Cheng, Yu-Chiuan Chang, Stephen Chu-Sung Hu, Shyng-Shiou F. Yuan
Summary: The study investigated the role of CD44 in lung cancer metastasis through clinical, in vitro, and in vivo studies, revealing that CD44 promotes migration and invasion abilities of lung cancer cells. Understanding and targeting CD44 may offer potential therapeutic strategies to decrease lung cancer metastasis.
Article
Oncology
Mohammad Aarif Siddiqui, Paradesi Naidu Gollavilli, Vignesh Ramesh, Beatrice Parma, Annemarie Schwab, Maria Eleni Vazakidou, Ramakrishnan Natesan, Ozge Saatci, Ida Rapa, Paolo Bironzo, Harald Schuhwerk, Irfan Ahmed Asangani, Ozgur Sahin, Marco Volante, Paolo Ceppi
Summary: The study identified a functional correlation between thymidylate synthase (TS), EMT, chemotherapy and metastasis in non-small cell lung cancer (NSCLC), establishing TS as a potential therapeutic marker. Further experiments revealed that TS may influence the occurrence and development of NSCLC by regulating EMT transcription factors and effectors.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cell Biology
Henriett Butz, Eva Saskoi, Lilla Krokker, Viktoria Vereczki, Alan Alpar, Istvan Liko, Erika Toth, Erika Szocs, Mihaly Cserepes, Katalin Nagy, Imre Kacskovics, Attila Patocs
Summary: This study aimed to uncover the context-dependent action of glucocorticoid receptors (GR) in breast cancer. Through multiple cohorts, it was found that GR expression is higher in ER- breast cancer cells and GR-regulated genes are mainly involved in cell migration. The study also revealed that GR action is independent of ligand availability, highlighting its ligand-independent role in breast cancer. Therefore, caution should be applied in the interpretation of immunohistochemistry results, and the importance of GR in disease progression, particularly in cell migration, is emphasized.
Article
Biology
Alvaro Gonzalez Rajal, Kamila A. Marzec, Rachael A. McCloy, Max Nobis, Venessa Chin, Jordan F. Hastings, Kaitao Lai, Marina Kennerson, William E. Hughes, Vijesh Vaghjiani, Paul Timpson, Jason E. Cain, D. Neil Watkins, David R. Croucher, Andrew Burgess
Summary: The study identified a non-genetic mechanism of resistance in human lung adenocarcinoma that is dependent on the cell cycle stage at the time of cisplatin exposure, using RNA sequencing and biosensors to track single-cell fates.
Article
Genetics & Heredity
Sylvan C. Baca, Cassandra Singler, Soumya Zacharia, Ji-Heui Seo, Tunc Morova, Faraz Hach, Yi Ding, Tommer Schwarz, Chia-Chi Flora Huang, Jacob Anderson, Andre P. Fay, Cynthia Kalita, Stefan Groha, Mark M. Pomerantz, Victoria Wang, Simon Linder, Christopher J. Sweeney, Wilbert Zwart, Nathan A. Lack, Bogdan Pasaniuc, David Y. Takeda, Alexander Gusev, Matthew L. Freedman
Summary: Many genetic variants affect disease risk by altering context-dependent gene regulation. The cistrome-wide association study (CWAS) is a powerful framework for identifying variants that influence traits through effects on chromatin state.
Article
Oncology
Huifeng Wang, Hui Dong, Lijiao Qiao, Yuanyuan Wu, Bo Wu, Xiangming Jin
Summary: Lung cancer is a prevalent cancer worldwide, and this study found that ZEB1 promotes proliferation, invasion, and metastasis of NSCLC cells by inhibiting miR-320a expression, and also promotes tumor growth in vivo by upregulating RAD51AP1 expression.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Immunology
Ding-Yu Rao, De-Fa Huang, Mao-Yan Si, Hua Lu, Zhi-Xian Tang, Zu-Xiong Zhang
Summary: As an important mediator of information transfer between cells, exosomes play a unique role in regulating tumor growth, supporting vascular proliferation, tumor invasion, and metastasis. Exosomes can be used as a potential tool for non-invasive liquid biopsy due to their presence in various body fluids. This study reviews the role of exosomes in liquid biopsy, tumor microenvironment formation, and epithelial-mesenchymal transition in non-small cell lung cancer (NSCLC). It also discusses the occurrence of EGFR+ exosomes and the role of exosomes and their contents in non-invasive detection and potential therapeutic targets in EGFR-mutated lung cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lucy LeBlanc, Nereida Ramirez, Jonghwan Kim
Summary: Hippo effectors YAP and TAZ play important roles in regulating cell fate and survival, but conflicting results and controversies exist regarding their functions in stem cells and cancer cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Oncology
Guangyao Ning, Chen Lu, Yu Chen, Menglong Jiang, Panpan Si, Renquan Zhang
Summary: This study found that transcription factor ZEB1 modulates the interaction between SKA3 and PLK1, promoting the proliferation, migration, and cell cycle of lung cancer cells. These findings provide new insights into lung cancer treatment.
Article
Medicine, General & Internal
Ruixue Yang, Yuanqun Liu, Yufei Wang, Xiaolin Wang, Hongfei Ci, Chao Song, Shiwu Wu
Summary: The study found that PRRX1 was expressed lower and ZEB1 was expressed higher in lung cancer tissues, with correlations to E-cadherin and MVD levels, indicating their potential as prognostic biomarkers for NSCLC patients.
Article
Biochemistry & Molecular Biology
Toshihiro Matsukawa, Mianmian Yin, Timour Baslan, Yang Jo Chung, Dengchao Cao, Ryan Bertoli, Yuelin J. Zhu, Robert L. Walker, Amy Freeland, Erik Knudsen, Scott W. Lowe, Paul S. Meltzer, Peter D. Aplan
Summary: The deficiency of Mcm2 proteins leads to genomic instability and cancer. In this study, mice with decreased expression of Mcm2 developed precursor T-cell lymphoblastic leukemia/lymphoma. However, when these mice were engrafted onto athymic nu/nu mice, pre-T LBL was prevented but B-cell precursor acute lymphoblastic leukemia occurred instead.
Article
Multidisciplinary Sciences
Jonuelle Acosta, Qinglan Li, Nelson F. Freeburg, Nivitha Murali, Alexandra Indeglia, Grant P. Grothusen, Michelle Cicchini, Hung Mai, Amy C. Gladstein, Keren M. Adler, Katherine R. Doerig, Jinyang Li, Miguel Ruiz-Torres, Kimberly L. Manning, Ben Z. Stanger, Luca Busino, Maureen Murphy, Liling Wan, David M. Feldser
Summary: Intertumoral heterogeneity in small-cell lung cancer (SCLC) influences the biological mechanisms of p53-mediated tumor suppression, and cyclophilins play a role in p53-dependent necrotic cell death.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Caleb J. Euhus, Taylor R. Ripley, Cristian G. Medina
Summary: This article clarifies the concept and definition of oligometastatic non-small cell lung cancer (NSCLC) and reviews the current results in the use of surgery for its management. Oligometastatic NSCLC refers to a subgroup of patients with limited metastases, who seem to have a slower disease progression compared to those with widespread metastases. A missed opportunity to improve survival may occur if palliative systemic therapy is prioritized over local aggressive treatment for these select patients.
Article
Biology
Seyyedeh Mahdokht Maddah, Golaleh Mostafavi, Mahlagha Amin Malek, Mohadese Anbarestani, Yasin Sharif, Zabih Mir Hassani
Summary: The combined application of cisplatin and salicylic acid showed synergistic effects on lung cancer cell lines A549 and Calu-6, exhibiting efficient inhibition and anti-proliferation effects while promoting apoptosis.
Review
Oncology
Henriett Butz, Attila Patocs
Summary: Glucocorticoids, particularly dexamethasone, have different effects and outcomes in breast cancer depending on the molecular subtype, highlighting the need to consider the context-dependent effects of glucocorticoids in personalized treatment design. This review examines the mechanisms behind context-dependent glucocorticoid actions in breast cancer, including the role of the glucocorticoid receptor and its interactions with other factors. It also discusses glucocorticoids' role in chemosensitivity and chemoresistance in breast cancer therapy and summarizes therapeutic options targeting the glucocorticoid receptor. This evidence can enhance our understanding of context-dependent glucocorticoid action in breast cancer and lead to advancements in personalized therapy.
CANCER AND METASTASIS REVIEWS
(2022)
Article
Health Care Sciences & Services
Jennifer G. Le-Rademacher, Kendrith Rowland, Pamela J. Atherton, Christopher Dakhil, Zhifu Sun, Angelina Tan, Lucy Schmidt, Phuong L. Nguyen, Carmen Radecki Breitkopf, Mark Pittelkow, Donald Tindall, Smitha Menon, Aminah Jatoi
AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Yuanyuan Wang, Yang Han, Zhongliang Guo, Yanan Yang, Tao Ren
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Genetics & Heredity
Xuewei Wang, Zhifu Sun, Michael T. Zimmermann, Andrej Bugrim, Jean-Pierre Kocher
BMC MEDICAL GENOMICS
(2019)
Article
Oncology
Yong-An Song, Ting Ma, Xue-Yan Zhang, Xiang-Song Cheng, Ayobami-Matthew Olajuyin, Zhi-Fu Sun, Xiao-Ju Zhang
CANCER CELL INTERNATIONAL
(2019)
Article
Multidisciplinary Sciences
Samantha J. McDonough, Aditya Bhagwate, Zhifu Sun, Chen Wang, Michael Zschunke, Joshua A. Gorman, Karla J. Kopp, Julie M. Cunningham
Article
Oncology
Haijing Liu, Bo Zhang, Zhifu Sun
CANCER COMMUNICATIONS
(2020)
Article
Infectious Diseases
Wei-xia Xuan, Jin-jin Li, Qun-cheng Zhang, Guan-nan Sun, Zhi-wei Xu, Zhi-fu Sun, Xiao-ju Zhang
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Genetics & Heredity
Xianfeng Chen, Zhifu Sun
Summary: This study utilized a novel lncRNA discovery pipeline and RNA-seq data resources to systematically discover novel lincRNAs in 30 major human tissue types, which defined the characteristics of each tissue type and demonstrated their reliability and tissue-specific expression. Tissue-specific genes were identified for each major tissue type, providing insight into each respective tissue's unique function and expanding interpretation of non-coding SNPs from genome-wide association studies.
Review
Cell Biology
Ziye Rong, Peipei Tu, Peiqi Xu, Yan Sun, Fangfang Yu, Na Tu, Lixia Guo, Yanan Yang
Summary: Mitochondria are essential organelles in eukaryotic cells that provide energy through oxidative phosphorylation. Mitochondrial DNA is prone to damage by DNA damaging agents, which can lead to dysfunction and contribute to various human diseases. Understanding mtDNA repair mechanisms is crucial for developing therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Peipei Tu, Bin Huang, Minggang Li, Yaofang Zhang, Shixiang Bao, Na Tu, Yanan Yang, Jingtao Lu
Summary: Type 2 diabetes (T2D) is a complex systemic disease that might benefit from treatment with exendin-4, as shown in this study on C57BL/6 J mice. The study investigated epigenetic alterations in pancreatic tissues of diabetic mice and demonstrated an improvement in T2D progression with exendin-4 treatment through modulation of histone acetylation and methylation patterns. Understanding these epigenetic changes may lead to novel therapeutic approaches for T2D.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Immunology
Chen Chen, Aibao Chen, Yanan Yang
Summary: Vector-borne diseases pose major health threats globally, and γδT cells play a crucial role in regulating host-pathogen interactions and disease progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yan Li, Lihong Fan, Jianming Zheng, Xiu Nie, Yu Sun, Qin Feng, Shenyi Lian, Wenqi Bai, Weijing Cai, Yanan Yang, Bo Su, Yanfeng Xi, Dongmei Lin
Summary: This study systematically investigated the pre-screening methods and characterized the genetic and clinical features of Lynch syndrome (LS) colorectal cancers (CRCs) in Asia. The results demonstrated that MMR IHC and MSI testing were effective methods for LS pre-screening and identified previously unreported pathogenic germline variants of MMR genes in LS patients.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Genetics & Heredity
Zhifu Sun, Saurabh Behati, Panwen Wang, Aditya Bhagwate, Samantha McDonough, Vivian Wang, William Taylor, Julie Cunningham, John Kisiel
Summary: Whole-genome methylation sequencing provides both DNA methylation and structural variant information. However, there is limited data on the reliability of obtaining this information simultaneously from low-input DNA using different library preparation and sequencing protocols. This study compared the performance of three protocols (EM-sequencing, QIA-sequencing, and Swift-sequencing) on CpG methylation measurement, SNV, and CNV detection. Results showed that at low DNA input, EM-sequencing was superior in most metrics except for CNV detection. EM-sequencing captured the highest number of CpGs and true SNVs, making it suitable for detecting methylation, SNVs, and CNVs from low-input DNA in a single sequencing.
Article
Oncology
Yung-Hung Luo, Han Liu, Jason A. Wampfler, Henry D. Tazelaar, Yalun Li, Tobias Peikert, Dan Liu, Konstantinos Leventakos, Yuh-Min Chen, Yanan Yang, Shih-Hwa Chiou, Ping Yang
Summary: This study demonstrates that osimertinib as a second or subsequent line of treatment in patients previously treated with EGFR-TKIs without identification of T790M mutation showed a lower risk of death compared to those who received first-line or second-generation TKIs without subsequent osimertinib. Patients with EGFR mutations and PD-L1 expression >= 50% had a higher risk of treatment failure with osimertinib and worse overall survival. These results suggest that osimertinib as a second-line or subsequent treatment may be a potential alternative for patients without identification of T790M, while high PD-L1 expression is associated with poor outcomes in patients receiving osimertinib.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Michelle M. Gonzalez, Adebowale O. Bamidele, Phyllis A. Svingen, Mary R. Sagstetter, Thomas C. Smyrk, Joseph M. Gaballa, Feda H. Hamdan, Robyn Laura Kosinsky, Hunter R. Gibbons, Zhifu Sun, Zhenqing Ye, Asha Nair, Guilherme P. Ramos, Manuel B. Braga Neto, Alexander Q. Wixom, Angela J. Mathison, Steven A. Johnsen, Raul Urrutia, William A. Faubion
Summary: Research has shown that BMI1 regulates the inflammatory enhancer network in Treg cells, and its loss leads to systemic inflammation and phenotypic conversion of Treg cells, which is relevant to CD4(+) T cells associated with Crohn's disease.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
