PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic Drugs

Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds

(2016) Roberto Würth et al.   DRUG DISCOVERY TODAY

In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors

(2015) Federica Barbieri et al.   BMC CANCER

Metformin increases peroxisome proliferator-activated receptor γ Co-activator-1α and utrophin a expression in dystrophic skeletal muscle

(2015) Vladimir Ljubicic et al.   MUSCLE & NERVE

Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA

(2015) Serena Vella et al.   Scientific Reports

Metformin and Ara-a Effectively Suppress Brain Cancer by Targeting Cancer Stem/Progenitor Cells

(2015) Tarek H. Mouhieddine et al.   Frontiers in Neuroscience

Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer

(2015) Igor Vujic et al.   Oncotarget

Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma

(2015) Ambrish Kumar et al.   Oncotarget

Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current

(2015) Marta Gritti et al.   Oncotarget

Metformin Protects Endothelial Function in Diet-Induced Obese Mice by Inhibition of Endoplasmic Reticulum Stress Through 5′ Adenosine Monophosphate–Activated Protein Kinase–Peroxisome Proliferator–Activated Receptor δ Pathway

(2014) Wai San Cheang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Silencing histone deacetylase 2 using small hairpin RNA induces regression of fibrotic plaque in a rat model of Peyronie's disease

(2014) Ki-Dong Kwon et al.   BJU INTERNATIONAL

Metformin inhibition of neuroblastoma cell proliferation is differently modulated by cell differentiation induced by retinoic acid or overexpression of NDM29 non-coding RNA

(2014) Delfina Costa et al.   Cancer Cell International

Oral Pharmacologic Treatment of Type 2 Diabetes Mellitus: A Clinical Practice Guideline From the American College of Physicians

(2013) Amir Qaseem et al.   ANNALS OF INTERNAL MEDICINE

Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells

(2013) Emelie Karnevi et al.   BMC CANCER

Synergistic Effects of Metformin Treatment in Combination with Gefitinib, a Selective EGFR Tyrosine Kinase Inhibitor, in LKB1 Wild-type NSCLC Cell Lines

(2013) F. Morgillo et al.   CLINICAL CANCER RESEARCH

Rosiglitazone promotes neurite outgrowth and mitochondrial function in N2A cells via PPARgamma pathway

(2013) Ming-Chang Chiang et al.   MITOCHONDRION

NDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid β secretion

(2012) Sara Massone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty

(2012) Jeffrey A. Magee et al.   CANCER CELL

Metformin Prevents the Development of Oral Squamous Cell Carcinomas from Carcinogen-Induced Premalignant Lesions

(2012) L. Vitale-Cross et al.   Cancer Prevention Research

Metformin selectively affects human glioblastoma tumor-initiating cell viability

(2012) Roberto Würth et al.   CELL CYCLE

Peroxisome proliferator-activated receptor δ agonist attenuates hepatic steatosis by anti-inflammatory mechanism

(2012) Mi Young Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Effects of PPARγ agonists on the expression of leptin and vascular endothelial growth factor in breast cancer cells

(2012) Marianna Terrasi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Probing cytoskeleton organisation of neuroblastoma cells with single-cell force spectroscopy

(2012) Andrea Mescola et al.   JOURNAL OF MOLECULAR RECOGNITION

Metformin: An Emerging New Therapeutic Option for Targeting Cancer Stem Cells and Metastasis

(2012) Ramandeep Rattan et al.   Journal of Oncology

Activated AMPK inhibits PPAR-α and PPAR-γ transcriptional activity in hepatoma cells

(2011) Margaret S. Sozio et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth

(2011) G. Z. Rocha et al.   CLINICAL CANCER RESEARCH

Metformin prevents anti-osteogenic in vivo and ex vivo effects of rosiglitazone in rats

(2011) Claudia Sedlinsky et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice

(2011) Evelin M. Elia et al.   FERTILITY AND STERILITY

Acquisition of neuron-like electrophysiological properties in neuroblastoma cells by controlled expression of NDM29 ncRNA

(2011) Paola Gavazzo et al.   JOURNAL OF NEUROCHEMISTRY

Cells of origin in cancer

(2011) Jane E. Visvader   NATURE

In vivo effects of rosiglitazone in a human neuroblastoma xenograft

(2010) I Cellai et al.   BRITISH JOURNAL OF CANCER

Neuroblastoma: Therapeutic strategies for a clinical enigma

(2010) Shakeel Modak et al.   CANCER TREATMENT REVIEWS

Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice

(2010) A. Maida et al.   DIABETOLOGIA

An Alu-like RNA promotes cell differentiation and reduces malignancy of human neuroblastoma cells

(2010) Manuele Castelnuovo et al.   FASEB JOURNAL

Peroxisome proliferator-activated receptor γ ligands regulate neural stem cell proliferation and differentiation in vitro and in vivo

(2010) Jose A. Morales-Garcia et al.   GLIA

Neuroblastoma: Biology, Prognosis, and Treatment

(2010) Julie R. Park et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

The Effect of the PPAR-γ Agonist Rosiglitazone on Neuroblastoma SK-N-SH Cells in a Metastatic Xenograft Mouse Model

(2010) Nina Krieger-Hinck et al.   ONCOLOGY RESEARCH

PPARs in Human Neuroepithelial Tumors: PPAR Ligands as Anticancer Therapies for the Most Common Human Neuroepithelial Tumors

(2010) Elisabetta Benedetti et al.   PPAR Research

The peroxisome proliferator-activated receptor-α (PPAR-α) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats

(2009) Wolfgang Linz et al.   ACTA PHARMACOLOGICA SINICA

Metformin Disrupts Crosstalk between G Protein-Coupled Receptor and Insulin Receptor Signaling Systems and Inhibits Pancreatic Cancer Growth

(2009) K. Kisfalvi et al.   CANCER RESEARCH

Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner

(2009) R. Rattan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PPARγ stimulation promotes neurite outgrowth in SH-SY5Y human neuroblastoma cells

(2009) Gianluca Miglio et al.   NEUROSCIENCE LETTERS

Direct rosiglitazone action on steroidogenesis and proinflammatory factor production in human granulosa-lutein cells

(2009) Qiuju Chen et al.   Reproductive Biology and Endocrinology

Glucose represses PPARαgene expression via AMP-activated protein kinase but not via p38 mitogen-activated protein kinase in the pancreatic β-cell

(2009) Erik JOLY et al.   Journal of Diabetes

Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

(2008) D. M. Nathan et al.   DIABETES CARE

Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth

(2008) C. Algire et al.   ENDOCRINE-RELATED CANCER

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

(2008) I Ben Sahra et al.   ONCOGENE

Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons

(2008) J. Brodbeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARγin Neuroblastoma

(2008) Alessandro Peri et al.   PPAR Research