Article
Pharmacology & Pharmacy
Yunyan Hu, Yunkao Zeng, Jing Yang, Xiaomin Zeng, Dan Cao, Biqun Ou, Guanrong Zhang, Liang Zhang
Summary: This study investigated the changes in intraocular pressure after intravitreal injection of Conbercept and evaluated the associated risk factors. The results showed that intravitreal injection of Conbercept may cause a rapid spike in intraocular pressure, but is safe in the short term. Older age and shorter axial length are associated with higher intraocular pressure after injection.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Teresa Araujo, Guilherme Aresta, Ursula Schmidt-Erfurth, Hrvoje Bogunovic
Summary: This study performs a comparative analysis of uncertainty estimation methods for out-of-distribution (OOD) detection in automated screening and staging of age-related macular degeneration (AMD) using retinal OCT imaging. The combination of cosine distance in the feature space and a few-shot outlier exposure (OE) approach improves the near-OOD detection performance, providing robust and reliable diagnostic systems.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Ana Navarrete, Brice Vofo, Katherine Matos, Antonio Rivera, Itay Chowers, Jaime Levy
Summary: The study aimed to determine the anatomical consequences of delaying intravitreal injection therapy with anti-vascular endothelial growth factor. The results showed a significant correlation between treatment delay and increased macular thickness, which may impact visual outcomes.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Xingguo Wang, Yanyan Zhang, Yuhui Ma, William Robert Kwapong, Jianing Ying, Jiayi Lu, Shaodong Ma, Qifeng Yan, Quanyong Yi, Yitian Zhao
Summary: In this study, a new automated framework driven by deep learning was introduced to extract three-dimensional parameters from retinal OCT images for quantification of retinal HRF in DME patients. The results revealed significant differences in the amount and volume of HRF subtypes and showed that the distance between HRF and retinal pigmented epithelium decreased after treatment. The improvement in central macular thickness was positively correlated with the distance from HRF subtypes to the fovea.
FRONTIERS IN MEDICINE
(2023)
Review
Ophthalmology
Mali Okada, Paul Mitchell, Robert P. Finger, Bora Eldem, S. James Talks, Ceri Hirst, Luciano Paladini, Jane Barratt, Tien Yin Wong, Anat Loewenstein
Summary: Nonadherence and nonpersistence significantly impact the treatment outcomes for patients with neovascular age-related macular degeneration (nAMD), necessitating further research to clarify contributing factors and improvement strategies. There is significant variation in definitions and rates of nonadherence and nonpersistence, with moderate certainty results highlighting some relevant factors. Factors such as treatment condition, baseline vision, and treatment response may influence nonadherence and nonpersistence.
Review
Pharmacology & Pharmacy
Lorenzo Ferro Desideri, Carlo Enrico Traverso, Massimo Nicolo, Marion R. Munk
Summary: Intravitreal anti-vascular endothelial growth factor (VEGF) drugs have become the first-line treatment for macular exudative diseases, but they still have limitations. Faricimab, a bispecific antibody targeting both VEGF-A and the angiopoietin/Tie pathway, has shown potential in maintaining clinical efficacy with a longer treatment regimen and a good safety profile based on phase III trials for wet age-related macular degeneration and diabetic macular edema.
Review
Pharmacology & Pharmacy
Lorenzo Ferro Desideri, Carlo Enrico Traverso, Massimo Nicolo
Summary: Simultaneously targeting the VEGF and Ang/Tie pathways may be more beneficial than monotherapy in patients with exudative retinal diseases. Among the investigational drugs targeting the Ang/Tie pathway, faricimab has shown promising results in phase II/III trials and in the near future may represent a viable treatment option for the management of exudative macular diseases.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Review
Pharmacology & Pharmacy
Pengxiang Zhou, Siqian Zheng, Ente Wang, Peng Men, Suodi Zhai
Summary: Conbercept is well-tolerated and effective in improving vision and fundus condition in patients with neovascular age-related macular degeneration and diabetic macular edema compared with laser photocoagulation, intravitreal triamcinolone acetonide, and placebo. Further large-sample and long-term studies are needed.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Slawomir Liberski, Malgorzata Wichrowska, Jaroslaw Kociecki
Summary: Diabetic macular edema and neovascular age-related macular degeneration are common causes of blindness in developed countries. Current treatment with anti-VEGF agents has limitations, necessitating the development of new therapeutic methods. The Ang/Tie-2 pathway and the use of faricimab as a bispecific monoclonal antibody show promise in improving disease management and reducing treatment burden.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Patricia Mirete, Carmen Munoz-Morata, Cesar Albarran-Diego, Enrique Espana-Gregori
Summary: This study aimed to analyze the variation in subfoveal choroidal thickness (SFCT) and its relationship with the variation in central macular thickness (CME) in response to intravitreal therapy with an antiangiogenic (anti-VEGF) drug or corticosteroid in type 2 diabetic patients with diabetic macular edema (DME). The results showed that SFCT significantly decreased in response to intravitreal therapy with anti-VEGF or corticosteroids, and the reduction in CME was greater when using corticosteroid treatment. SFCT can be used to monitor the response to treatment but is not a good predictor of CME response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Fusae Kato, Miho Nozaki, Aki Kato, Tsutomu Yasukawa
Summary: This study used OCTA to investigate microvascular changes after intravitreal TA treatment. The results showed that TA can decrease the number of microaneurysms and increase the foveal avascular zone area.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Tsung-Cheng Hsieh, Guang-Hong Deng, Yung-Ching Chang, Fang-Ling Chang, Ming-Shan He
Summary: This study aimed to investigate optical coherence tomography (OCT) biomarkers of diabetic macular edema (DME) refractory to anti-vascular endothelial growth factor (anti-VEGF) therapy. The results showed that partially continuous inner segment-outer segment (IS-OS) layers were predictive of better response, while epiretinal membrane (ERM) was a significant predictor of poor response.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Lianghui Xu, Liejun Wang, Shuli Cheng, Yongming Li
Summary: This article discusses three common retinal diseases and proposes a hybrid attention mechanism for identifying and classifying different types of retinopathy images. Experimental results demonstrate that this mechanism can effectively extract key features and improve classification accuracy.
Article
Pharmacology & Pharmacy
Alaa Din Abdin, Wissam Aljundi, Khalil El Jawhari, Shady Suffo, Isabel Weinstein, Berthold Seitz
Summary: The study aimed to evaluate the morphological and functional outcomes of intravitreal brolucizumab treatment for refractory neovascular age-related macular degeneration (nAMD) in the first year. Results showed that brolucizumab could stabilize visual acuity and reduce the number of injections. It also improved anatomical outcomes by reducing subretinal fluid and pigment epithelial detachment. However, adverse events such as intraocular inflammation were observed.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Health Care Sciences & Services
Gagan Kalra, Sudeshna Sil Kar, Duriye Damla Sevgi, Anant Madabhushi, Sunil K. Srivastava, Justis P. Ehlers
Summary: The management of retinal diseases relies heavily on digital imaging data, including OCT and FA. Advances in computational technology, such as deep learning and radiomics, open new doors for developing personalized disease characterization, enhancing opportunities in precision medicine.
JOURNAL OF PERSONALIZED MEDICINE
(2021)