Journal
EXPERT REVIEW OF HEMATOLOGY
Volume 9, Issue 4, Pages 389-400Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/17474086.2016.1140034
Keywords
Anti-prothrombin antibodies; Anti-phospholipid syndrome; Detection; Anti-beta 2 glycoprotein I antibodies; Pregnancy complications; Thrombosis; Lupus anticoagulant
Categories
Funding
- Ricerca Corrente of the Istituto Auxologico Italiano
Ask authors/readers for more resources
The term lupus anticoagulant (LA) refers to a heterogeneous group of immunoglobulins behaving as acquired in vitro inhibitors of coagulation. These antibodies, namely anti-beta 2GPI and anti-prothrombin antibodies, induce the in vitro elongation of clotting time interfering with phospholipid-dependent coagulation cofactors. Positive LA is associated with thrombosis and pregnancy complications, providing one of the three laboratory criteria for the classification of the anti-phospholipid syndrome. LA is the strongest predictor of clinical events, especially when associated with other anti-phospholipid antibodies. Much more controversial is the risk conveyed by isolated and weak LA. LA detection is technically laborious, envisaging screening, mixing and confirming tests. Hopefully critical issues in LA detection, such as the interference of anticoagulants, will be overcome, in the next future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available