Article
Radiology, Nuclear Medicine & Medical Imaging
Ahmet Demirkiran, Mariella E. C. J. Hassell, Pankaj Garg, Mohammed S. M. Elbaz, Ronak Delewi, John P. Greenwood, Jan J. Piek, Sven Plein, Rob J. van der Geest, Robin Nijveldt
Summary: In this study, the researchers used 4D flow cardiovascular magnetic resonance (CMR) to investigate the differences in left ventricular (LV) flow between chronic myocardial infarction (MI) patients with and without left ventricular thrombus (LVT), as well as healthy controls. They found that MI patients with LVT had altered LV flow components, irregular vorticity vector fields, and changes in diastolic vortex ring geometric properties compared to those without LVT. These findings suggest potential links between global LV flow characteristics and LVT formation.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Medicine, General & Internal
Chen Zhang, Hongbo Zhang, Lei Zhao, Zhipeng Wei, Yongqiang Lai, Xiaohai Ma
Summary: This study found differential expression of miRNAs in myocardial tissues of patients with hypertrophic cardiomyopathy (HCM). Some miRNAs were found to be correlated with left ventricular mass index and late gadolinium enhancement quantification. These myocardial miRNA levels could be potential biomarkers for LV hypertrophy, fibrosis, and remodeling.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xi Liu, Yue Gao, Ying-Kun Guo, Chun-Chao Xia, Rui Shi, Li Jiang, Meng-Ting Shen, Lin-Jun Xie, Wan-Lin Peng, Wen-Lei Qian, Ming-Yan Deng, Li-Ling Deng, Yan Ren, Zhi-Gang Yang
Summary: The objective of this study was to evaluate myocardial fibrosis using cardiac magnetic resonance (CMR) T1 mapping in type 2 diabetes mellitus (T2DM) patients and investigate the association between left ventricular (LV) subclinical myocardial dysfunction and myocardial fibrosis. The results showed that T1 mapping could detect abnormal myocardial fibrosis early in patients with T2DM, which can cause a decline in the LV diastolic function. The study also found an independent association between diabetes duration and extracellular volumes (ECVs).
EUROPEAN RADIOLOGY
(2022)
Article
Medicine, General & Internal
Giedre Balciunaite, Ieva Rudinskaite, Darius Palionis, Justinas Besusparis, Edvardas Zurauskas, Vilius Janusauskas, Aleksejus Zorinas, Nomeda Valeviciene, Kestutis Rucinskas, Peter Sogaard, Sigita Glaveckaite
Summary: The optimal timing for aortic valve replacement in aortic stenosis patients is still controversial. This study found that electrocardiographic strain can serve as a marker for adverse left ventricular remodeling and myocardial fibrosis in severe AS patients. Lack of improvement in electrocardiographic strain following surgery indicates more advanced baseline LV injury and higher levels of myocardial fibrosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Wei Huang, Ran Sun, Wenbin Liu, Rong Xu, Ziqi Zhou, Wei Bai, Ruilai Hou, Huayan Xu, Yingkun Guo, Li Yu, Lu Ye
Summary: In this study, the clinical and cardiovascular magnetic resonance data of 75 patients with left ventricular noncompaction were retrospectively analyzed. The results showed a correlation between late gadolinium enhancement types and major adverse cardiovascular events. A specific ring-like pattern and involvement of the free wall or mid-wall were associated with an increased risk of adverse cardiovascular events. The extent of late gadolinium enhancement greater than 7.5% and the presence of ring-like, multiple segments, and free-wall enhancement were significantly associated with major adverse cardiovascular events.
Article
Cardiac & Cardiovascular Systems
Xiaorong Chen, Jiangfeng Pan, Yi Hu, Hongjie Hu, Yonghao Pan
Summary: This study investigated the feasibility of using one breath-hold compressed sensing cine protocol for 3D left ventricular global and regional strain analysis. The results showed that this protocol can be used for global strain analysis, but regional strain should still be computed using the conventional cine protocol. Additionally, the shortest breath-hold compressed sensing cine protocol had poor agreement with the conventional cine protocol for both global and regional strain.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liping Yang, Shaodong Cao, Wei Liu, Tianzuo Wang, Hanshan Xu, Chao Gao, Lingbo Zhang, Kezheng Wang
Summary: This study used CMR-FT technology to evaluate left ventricular deformation in CMI patients, finding that GPLS, GPRS, and GPCS were significantly decreased in the CMI group, while PRS and PCS were significantly lower in the TI group compared to the SI group, with no significant difference in PLS. LVEF showed a strong correlation with GPCS, GPLS, and GPRS in CMI patients.
ACADEMIC RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Charlene A. Mauger, Sachin Govil, Radomir Chabiniok, Kathleen Gilbert, Sanjeet Hegde, Tarique Hussain, Andrew D. McCulloch, Christopher J. Occleshaw, Jeffrey Omens, James C. Perry, Kuberan Pushparajah, Avan Suinesiaputra, Liang Zhong, Alistair A. Young
Summary: The study quantified the relationships between biventricular morphology and wall motion with pulmonary regurgitation in rTOF patients. Regional RV dilation, LV reduction, LV septal-lateral flattening, and increased RV strain were all associated with increased PRV.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Review
Cardiac & Cardiovascular Systems
Yonghao Lan, Wei Liu, Yujie Zhou
Summary: COVID-19, caused by SARS-CoV-2, has led to a global pandemic with significant morbidity and mortality. While primarily affecting the respiratory system, there is also evidence of myocardial injury in severe cases, particularly with right ventricular damage being associated with higher mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Elena Michelucci, Silvia Rocchiccioli, Melania Gaggini, Rudina Ndreu, Sergio Berti, Cristina Vassalle
Summary: This study found that specific ceramide species are associated with cardiovascular risk, inflammation, and disease severity in acute myocardial infarction (AMI). A detailed analysis of ceramides may help to better understand cardiovascular pathobiology and suggest these new biomarkers as possible risk predictors and pharmacological targets in AMI patients.
Article
Cardiac & Cardiovascular Systems
Yue Gao, Rui Shi, Yuan Li, Ying-kun Guo, Hua-Yan Xu, Ke Shi, Zhi-gang Yang
Summary: This study found that diabetes mellitus (DM) has an additive deleterious effect on left ventricular function and deformation in patients after acute myocardial infarction (MI), and HbA1c level is associated with impaired left ventricular strain.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zheng Sun, Yu Wang, Yingying Hu, Fang Wu, Nan Zhang, Zhi Liu, Jie Lu, Kuncheng Li
Summary: This study investigated the associations between myocardial dyssynchrony parameters and myocardium damage in patients with anterior STEMI. The results suggest that myocardial injury reduces the radial strain contractility, and a septal strain-contraction reserve cut-off point can be used when the extent of transmural myocardial infarction is greater than 75%.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Abbasin Zegard, Osita Okafor, Joseph de Bono, Manish Kalla, Mauro Lencioni, Howard Marshall, Lucy Hudsmith, Tian Qiu, Richard Steeds, Berthold Stegemann, Francisco Leyva
Summary: In patients with coronary artery disease (CAD) and a left ventricular ejection fraction (LVEF) >35%, greyzone fibrosis (GZF) mass on cardiovascular magnetic resonance (CMR) was strongly associated with ventricular arrhythmic endpoint, indicating its potential use in identifying patients at risk of arrhythmic events.
Article
Cardiac & Cardiovascular Systems
Qiang Zhang, Matthew K. Burrage, Mayooran Shanmuganathan, Ricardo A. Gonzales, Elena Lukaschuk, Katharine E. Thomas, Rebecca Mills, Joana Leal Pelado, Chrysovalantou Nikolaidou, Iulia A. Popescu, Yung P. Lee, Xinheng Zhang, Rohan Dharmakumar, Saul G. Myerson, Oliver Rider, Keith M. Channon, Stefan Neubauer, Stefan K. Piechnik, Vanessa M. Ferreira
Summary: A new technology called VNE has been developed for noninvasive assessment of myocardial scars. VNE uses artificial intelligence to generate virtual images similar to late gadolinium enhancement (LGE) without the need for contrast agents. The study showed that VNE provided high-quality images and had strong agreement with LGE in quantifying scar size and transmurality, as well as good visuospatial agreement with histopathology.
Article
Cardiac & Cardiovascular Systems
Takeru Nabeta, Shunsuke Ishii, Yuki Ikeda, Kenji Maemura, Takumi Oki, Mayu Yazaki, Teppei Fujita, Takashi Naruke, Takayuki Inomata, Junya Ako
Summary: A study on patients with recent-onset DCM found that 28% of patients experienced re-worsening of LVEF after initial improvement. High LGE burden, elevated B-type natriuretic peptide levels, and lower LVEF at initial LVEF recovery were independent predictors of re-worsening of LVEF in DCM patients.
Article
Oncology
Jan J. Jobsen, Henk Struikmans, Ester Siemerink, Job van der Palen, Harald J. Heijmans
Summary: This study describes the impact of classification methods on ipsilateral breast tumor recurrence, confirming the prognostic value of TR and NP for disease-specific survival and distant metastasis-free survival. It emphasizes the importance of developing and validating a widely accepted classification form.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Critical Care Medicine
Sharina Kort, Marjolein Brusse-Keizer, Hugo Schouwink, Emanuel Citgez, Frans H. de Jongh, Jan W. G. van Putten, Ben van den Borne, Elisabeth A. Kastelijn, Daiana Stolz, Milou Schuurbiers, Michel M. van den Heuvel, Wouter H. van Geffen, Job van der Palen
Summary: This study developed and validated a prediction model to distinguish patients with non-small cell lung cancer from non-lung cancer subjects using exhaled breath analysis. It also investigated the impact of adding clinical variables to improve the diagnosis. The results showed that combining exhaled breath data and clinical variables can effectively differentiate lung cancer patients from non-lung cancer subjects in a noninvasive manner, paving the way for the implementation of exhaled breath analysis in lung cancer diagnosis.
Article
Rehabilitation
Ann M. Hepping, Britt Barvelink, Joris J. W. Ploegmakers, Job van der Palen, Jan H. B. Geertzen, Sjoerd K. Bulstra, Jorrit S. Harbers, Martin Stevens
Summary: Studies on functional recovery after pediatric forearm fractures are rare. This study aimed to provide insight into normal recovery by evaluating limitations, post-traumatic symptoms, range of motion (ROM), and dexterity. Findings showed that mild limitations are common, and pain and restricted movement are common post-traumatic symptoms. Further investigation is needed for the recovery of range of motion.
DISABILITY AND REHABILITATION
(2023)
Article
Pharmacology & Pharmacy
N. G. M. Oonk, L. D. A. Dorresteijn, A. D. van den Berg, J. van der Palen, K. L. L. Movig, H. W. Nijmeijer, M. E. van Kesteren, H. Koffijberg
Summary: Patients with Parkinson's disease often face complex medication regimens, leading to suboptimal adherence and diminished therapy efficacy. Medication review could potentially tackle these issues by optimizing drug treatment. This study aimed to gain more insight into the health benefits and costs of a structured medication review in Parkinson's disease.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Psychiatry
Marleen Wensink, Gerko Schaap, Peter M. ten Klooster, Carine J. M. Doggen, Job van der Palen, Harald E. Vonkeman, Christina Bode
Summary: This exploratory study aimed to assess the momentary associations between physical and mental fatigue, quality of sleep, and behaviors in patients with post-COVID syndrome. The results showed a strong association between physical and mental fatigue, with longer sleep duration associated with lower fatigue levels the following day. Strenuous relaxation and social contacts were associated with fatigue, while performing household chores decreased fatigue. Eating and drinking increased physical fatigue.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Review
Medicine, General & Internal
Sinthia Bosnic-Anticevich, Nawar Diar Bakerly, Henry Chrystyn, Mark Hew, Job van der Palen
Summary: Maintenance therapy delivered via inhaler is crucial for the management of asthma and COPD. However, poor adherence and inhalation technique errors have long been major challenges. Technological innovations have the potential to overcome these barriers.
PATIENT PREFERENCE AND ADHERENCE
(2023)
Article
Neuroimaging
E. W. Koevoets, M. I. Geerlings, E. M. Monninkhof, R. Mandl, L. Witlox, E. van der Wall, M. M. Stuiver, G. S. Sonke, M. J. Velthuis, J. J. Jobsenj, J. van der Palenj, M. E. M. M. Bos, E. Goker, M. B. E. Menke-Pluijmers, D. W. Sommeijer, A. M. May, M. B. de Ruiter, S. B. Schagen
Summary: This study investigated the effects of exercise intervention on brain structure and memory function in breast cancer patients. The results showed no significant effects on brain volume and memory for the entire intervention group, but an unexpected finding was seen in highly fatigued patients where hippocampal volume decreased but memory function improved after the intervention.
NEUROIMAGE-CLINICAL
(2023)
Article
Gastroenterology & Hepatology
Floris W. Haijer, Cornelis B. Van Vliet, Marjolein G. J. Brusse-Keizer, Job A. M. van der Palen, Marjo J. Kerbert-Dreteler, Jeroen J. Kolkman
Summary: Itch frequently occurs in patients with chronic cholestasis, but the reason why some patients have pruritus and others do not is still unclear. A clinical observation found that cholestatic patients without itch had a relatively high serum gamma-glutamyl transpeptidase (GGT) compared to their serum bilirubin. This study aimed to validate this observation.
INTERNATIONAL JOURNAL OF HEPATOLOGY
(2023)
Article
Orthopedics
Sanharib Al Shaer, Job van der Palen, Joris Teunissen, Alexandra Fink, Brigitte van der Heijden, Oliver Zophel, Hand Wrist Study Grp
Summary: A novel technique using a distally based extensor carpi ulnaris tendon strip combined with ulnar shortening osteotomy has been found to effectively restore distal radioulnar stability in patients with irreparable degenerative triangular fibrocartilage complex injuries due to ulnar impaction syndrome.
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Emmie W. Koevoets, Jan Petr, Evelyn M. Monninkhof, Mirjam I. Geerlings, Lenja Witlox, Elsken van Der Wall, Martijn M. Stuiver, Gabe S. Sonke, Miranda J. Velthuis, Jan J. Jobsen, Job van Der Palen, Henk J. M. M. Mutsaerts, Michiel B. de Ruiter, Anne M. May, Sanne B. Schagen, PAM Study Grp
Summary: Exercise intervention did not affect cerebral blood flow (CBF) in cognitively impaired breast cancer patients. Changes in physical fitness were associated with changes in CBF, but CBF changes were not associated with memory functioning.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Medicine, General & Internal
Sanne H. B. van Dijk, Marjolein G. J. Brusse-Keizer, Charlotte C. Bucsan, Job van der Palen, Carine J. M. Doggen, Anke Lenferink
Summary: This article introduces how to use the AI tool 'ASReview' to conduct a transparent and reliable systematic review, which can accelerate the process and save time.
Article
Neurosciences
Gerlinde van der Maten, Matthijs F. L. Meijs, Job Palen, Paul J. A. M. Brouwers, Clemens von Birgelen, Jurren van Opstal, Heleen M. den Hertog
Summary: Outpatient cardiac rhythm monitoring for 7 days after ischemic stroke or TIA can detect new atrial fibrillation in 4.6% of patients. Patients with AF have significantly more cardiovascular risk factors. Although approximately 50% of first AF episodes occur on the first day of monitoring, new AF can still be detected up to day 7, indicating that the recommended minimum of 3-day cardiac rhythm monitoring after ischemic stroke of undetermined cause is insufficient. Long-term rhythm monitoring should be considered for selected patients.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Multidisciplinary Sciences
Bharath Kumar Tirupakuzhi Vijayaraghavan, Saptarshi Bishnu, Joaquin Baruch, Barbara Wanjiru Citarella, Christiana Kartsonaki, Aronrag Meeyai, Zubair Mohamed, Shinichiro Ohshimo, Benjamin Lefevre, Abdulrahman Al-Fares, Jose A. Calvache, Fabio Silvio Taccone, Piero Olliaro, Laura Merson, Neill K. J. Adhikari, ISARIC Clinical Characterisation Grp
Summary: Using a large dataset, this study evaluated the prevalence and severity of liver enzyme abnormalities in COVID-19 patients and found that these abnormalities are associated with worse outcomes.
Article
Respiratory System
Mirthe I. de Vries, Tanja W. Effing, Job van der Palen, Jade Schrijver, Paul van der Valk, Anke Lenferink
Summary: In clinical practice, clinicians focus on COPD exacerbations and symptoms, while patients prefer periods free of exacerbations and deteriorated symptoms. Patients emphasize a positive health approach that centralizes people and their beliefs.
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Meeting Abstract
Respiratory System
J. Schrijver, T. Effing, J. Van Helden, M. Brusse-Keizer, J. Van der Palen, P. Van der Valk, A. Lenferink
EUROPEAN RESPIRATORY JOURNAL
(2022)