Article
Cardiac & Cardiovascular Systems
Jiayu Feng, Pengchao Tian, Lin Liang, Yuyi Chen, Yunhong Wang, Mei Zhai, Yan Huang, Qiong Zhou, Xuemei Zhao, Lang Zhao, Boping Huang, Liyan Huang, Yuhui Zhang, Jian Zhang
Summary: This study compared the prognostic value of NT-proBNP and hs-CRP in MDCM and DCM. The results showed that higher levels of hs-CRP were associated with adverse outcomes in MDCM patients, while NT-proBNP was not associated with prognosis.
Review
Biochemistry & Molecular Biology
Hamza El Hadi, Anne Freund, Steffen Desch, Holger Thiele, Nicolas Majunke
Summary: Cardiomyopathies are a diverse group of heart muscle disorders with potentially fatal consequences such as arrhythmias and heart failure. They are a leading cause of heart transplantation worldwide. Recent advancements in understanding the molecular basis and diagnostic evaluation have paved the way for targeted therapies. However, further research is needed to improve risk assessment and prevention strategies for sudden cardiac death.
Article
Biochemistry & Molecular Biology
Jan Haas, Karen S. Frese, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Rewati Tappu, Rouven Nietsch, Oguz Firat Tugrul, Michael Wisdom, Carsten Dietrich, Ali Amr, Tanja Weis, Torsten Niederdraenk, Michael P. Murphy, Thomas Krieg, Marcus Doerr, Uwe Voelker, Jens Fielitz, Norbert Frey, Stephan B. Felix, Andreas Keller, Hugo A. Katus, Benjamin Meder
Summary: This study identified a new set of metabolomic biomarkers for heart failure (HF) through a multi-OMICS approach, revealing underlying biological cascades that potentially represent suitable intervention targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yihao Zhu, Xiaojing Yang, Yao Zu
Summary: This study identified driver genes highly associated with dilated cardiomyopathy (DCM) with heart failure (HF) and established a diagnostic model using machine learning classifiers. NPPA, OMD, and PRELP were identified as diagnostic biomarkers for DCM with HF, and the TGF-beta signaling pathway was identified as a potential mechanism underlying the condition.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Martin Brundin, Dick Wagsater, Urban Alehagen, Carl-Johan Carlhall
Summary: This study compared serum levels of specific miRs and cardiac magnetic resonance imaging parameters between patients with DCM and IHD, finding that miR-29-5p levels were increased in DCM and miR-320a levels were elevated in DCM compared to healthy controls.
Article
Cardiac & Cardiovascular Systems
Hiromitsu Kanamori, Akihiro Yoshida, Genki Naruse, Susumu Endo, Shingo Minatoguchi, Takatomo Watanabe, Tomonori Kawaguchi, Toshiki Tanaka, Yoshihisa Yamada, Nobuhiro Takasugi, Takuma Ishihara, Atsushi Mikami, Nagisa Miyazaki, Kazuhiko Nishigaki, Shinya Minatoguchi, Tatsuhiko Miyazaki, Hiroyuki Okura
Summary: The study revealed that autophagy serves as a predictive marker for LVRR in DCM patients, with prognostic value. LVRR-positive patients had a higher number of autophagic vacuoles and higher expression levels. Autophagy may offer novel pathologic insights into strategies for treating the failing DCM heart.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anna Gaertner, Lidia Burr, Baerbel Klauke, Andreas Brodehl, Kai Thorsten Laser, Karin Klingel, Jens Tiesmeier, Uwe Schulz, Edzard zu Knyphausen, Jan Gummert, Hendrik Milting
Summary: This study reported a patient with muscular dystrophy and early onset dilated cardiomyopathy who carried compound heterozygous variants in FKTN. The research demonstrated that compound heterozygous mutations in FKTN result in loss of fully glycosylated alpha-dystroglycan, leading to cardiomyopathy and end-stage heart failure at a young age.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Laura Keil, Filip Berisha, Stella Ritter, Johanna Skibowski, Hariharan Subramanian, Viacheslav O. Nikolaev, Christian Kubisch, Rixa Woitschach, Larissa Fabritz, Raphael Twerenbold, Stefan Blankenberg, Soeren Weidemann, Tanja Zeller, Paulus Kirchhof, Daniel Reichart, Christina Magnussen
Summary: This study aims to phenotype and genotype the different subtypes of dilated cardiomyopathy (DCM) and lay the foundation for individualized therapy.
Review
Biochemistry & Molecular Biology
Matteo Ponzoni, John G. Coles, Jason T. Maynes
Summary: To improve the development of new therapeutic strategies for heart failure, preclinical models that accurately emulate the human condition are necessary. Rodent models of heart failure provide a strategic compromise between similarity to human in vivo conditions and the ability to conduct numerous experiments and explore various therapeutic candidates. This review summarizes currently available rodent models of heart failure, including their physiopathological basis, development timeline, and specific clinical features. It also provides a detailed overview of the advantages and possible drawbacks of each model to facilitate future investigation planning in the field of heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Chathurika Henpita, Rajesh Vyas, Chastity L. Healy, Tra L. Kieu, Aditi U. Gurkar, Matthew J. Yousefzadeh, Yuxiang Cui, Aiping Lu, Luise A. Angelini, Ryan D. O'Kelly, Sara J. McGowan, Sanjay Chandrasekhar, Rebecca R. Vanderpool, Danielle Hennessy-Wack, Mark A. Ross, Timothy N. Bachman, Charles McTiernan, Smitha P. S. Pillai, Warren Ladiges, Mitra Lavasani, Johnny Huard, Donna Beer-Stolz, Claudette M. St. Croix, Simon C. Watkins, Paul D. Robbins, Ana L. Mora, Eric E. Kelley, Yinsheng Wang, Timothy D. O'Connell, Laura J. Niedernhofer
Summary: Cardiomyopathy is a progressive disease of the myocardium leading to impaired contractility. This study shows that endogenous genotoxic stress contributes to the development of cardiomyopathy by activating the p53 pathway and increasing oxidative stress, leading to cardiac myocyte apoptosis, dilated cardiomyopathy, and sudden death.
Article
Cardiac & Cardiovascular Systems
Brian P. Halliday, John G. F. Cleland
Summary: Remission of heart failure refers to a state where symptoms disappear, cardiac function returns to normal, and natriuretic peptide levels normalize. The continuation of treatments necessary for sustained remission remains unclear, and factors such as myocardial susceptibility, persistence or recurrence of triggers, and myocardial workload should be considered. Personalized therapy informed by evidence from randomized trials of targeted therapeutic strategies is recommended.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Medicine, General & Internal
Xinyi Li, Xiaonan Zhang, Yaoxin Liu, Fen Shu, Sisi Shao, Ning Tan, Lei Jiang
Summary: Serum chloride concentration is a prognostic indicator in elderly patients with NIDCM, and hypochloremia is significantly associated with both in-hospital and long-term poor outcomes.
Article
Cardiac & Cardiovascular Systems
Divyang Patel, Anirudh Kumar, Laurie Ann Moennich, Kevin Trulock, David M. Nemer, Eoin Donnellan, Zachary J. Il'Giovine, Trejeeve Martyn, Thomas D. Callahan, Ayman A. Hussein, Khaldoun G. Tarakji, Mohamed Kanj, Daniel J. Cantillon, Bryan Baranowski, Randall C. Starling, W. H. Wilson Tang, Oussama M. Wazni, Niraj Varma, Bruce L. Wilkoff, John Rickard
Summary: Chemotherapy-induced cardiomyopathy, specifically anthracycline-induced cardiomyopathy (AIC), can be treated effectively with cardiac resynchronisation therapy (CRT). Patients with AIC who respond positively to CRT show improved left ventricular remodelling and long-term survival rates comparable to patients with other non-ischaemic cardiomyopathies.
Article
Genetics & Heredity
Karolina Melinyte-Ankudavice, Marius Sukys, Jurgita Plisiene, Renaldas Jurkevicius, Egle Ereminiene
Summary: A case report of a 22-year-old male patient who visited a cardiologist after experiencing his first episode of atrial fibrillation (AF) is presented. The patient was found to have decreased left ventricular systolic function and dilation. Genetic testing revealed a pathogenic variant of the BAG3 gene. Due to the high risk of heart failure progression and ventricular arrhythmias, the patient received an event recorder implant and pathogenetic heart failure treatment. His father was also diagnosed with dilated cardiomyopathy and recurrent AF.
Article
Medicine, Research & Experimental
Wei Wu, Mark Ziemann, Kevin Huynh, Gang She, Zheng-Da Pang, Yi Zhang, Thy Duong, Helen Kiriazis, Tian-Tian Pu, Ru-Yue Bai, Jing-Jing Li, Yu Zhang, Ming-Xia Chen, Junichi Sadoshima, Xiu-Ling Deng, Peter J. Meikle, Xiao-Jun Du
Summary: The study revealed that the Hippo signaling pathway mediates mitochondrial damage by repressing mitochondrial genes, which causally promotes the development of dilated cardiomyopathy (DCM). Mitochondria in the hearts of DCM mice showed overt structural abnormalities and dysfunction.
Article
Cardiac & Cardiovascular Systems
Alberto Aimo, Michele Senni, Andrea Barison, Giorgia Panichella, Claudio Passino, Antoni Bayes-Genis, Michele Emdin
Summary: HFpEF is a syndrome with multifaceted pathophysiology and clinical heterogeneity, which calls for personalized approaches in treatment. The recent discovery of SGLT2i therapy provides new perspectives on reducing the risk of death or hospitalization for patients with HFpEF.
HEART FAILURE REVIEWS
(2023)
Letter
Cardiac & Cardiovascular Systems
Miguel Lorenzo, Rafael de la Espriella, Ingrid Cardells, Joso Luis Gorriz, Antoni Bayes-Genis, Julio Nunez
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Article
Cardiac & Cardiovascular Systems
Victoria Vilalta, German Cediel, Siamak Mohammadi, Helena Lopez, Dimitri Kalavrouziotis, Helena Resta, Eric Dumont, Pierre Voisine, Francois Philippon, Claudia Escabia, Andrea Borrellas, Alberto Alperi, Eduard Fernandez-Nofrerias, Xavier Carrillo, Vassili Panagides, Antoni Bayes-Genis, Josep Rodes-Cabau
Summary: This study evaluated the incidence, predictive factors, and prognostic value of new-onset persistent left bundle branch block (NOP-LBBB) in patients undergoing sutureless surgical aortic valve replacement (SU-SAVR). The results showed that NOP-LBBB occurred in approximately a quarter of the patients and was associated with a decrease in left ventricular ejection fraction (LVEF) and an increased risk of permanent pacemaker implantation (PPI).
Review
Medicine, Research & Experimental
Gemma Ferrer-Curriu, Carolina Soler-Botija, Sandra Charvatova, Benjamin Motais, Santiago Roura, Carolina Galvez-Monton, Marta Monguio-Tortajada, Oriol Iborra-Egea, Michele Emdin, Josep Lupon, Alberto Aimo, Juli R. Bago, Antoni Bayes Genis
Summary: Fibrosis is a common feature in myocardial disorders and can lead to heart failure. Current therapies targeting excessive fibrosis are limited, making the development of more effective treatments necessary. CAR T cell immunotherapy, which redirects T lymphocytes to eliminate target cells, has shown efficacy in mouse models of hypertensive cardiac fibrosis. Although associated with toxicities, CAR natural killer cells provide a potential alternative with improved safety and efficacy. CAR immunotherapy offers promise for reducing fibrosis and restoring cardiac function in patients with myocardial fibrosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Stefan D. Anker, Muhammad Shariq Usman, Markus S. Anker, Javed Butler, Michael Boehm, William T. Abraham, Marianna Adamo, Vijay K. Chopra, Mariantonietta Cicoira, Francesco Cosentino, Gerasimos Filippatos, Ewa A. Jankowska, Lars H. Lund, Brenda Moura, Wilfried Mullens, Burkert Pieske, Piotr Ponikowski, Jose R. Gonzalez-Juanatey, Amina Rakisheva, Gianluigi Savarese, Petar Seferovic, John R. Teerlink, Carsten Tschoepe, Maurizio Volterrani, Stephan von Haehling, Jian Zhang, Yuhui Zhang, Johann Bauersachs, Ulf Landmesser, Shelley Zieroth, Konstantinos Tsioufis, Antoni Bayes-Genis, Ovidiu Chioncel, Felicita Andreotti, Enrico Agabiti-Rosei, Jose L. Merino, Marco Metra, Andrew J. S. Coats, Giuseppe M. C. Rosano
Summary: HFpEF is a highly heterogeneous clinical syndrome influenced by many comorbidities in its development and progression. Left ventricular diastolic dysfunction may result from various cardiovascular, metabolic, pulmonary, renal, and geriatric conditions. Therefore, individualized treatment tailored to each patient's clinical profile may be the most effective approach to improve clinical outcomes. In this joint position paper, the Heart Failure Association of the European Society of Cardiology, the European Heart Rhythm Association, and the European Hypertension Society have developed an algorithm to identify the most common HFpEF phenotypes and recommend evidence-based treatment strategies for each, considering the complexities of multiple comorbidities and polypharmacy.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Domenico D'Amario, David Meerkin, Attilio Restivo, Hueseyin Ince, Horst Sievert, Andrea Wiese, Ulrich Schaefer, Carlo Trani, Antoni Bayes-Genis, Francisco I. Leyva, Zachary Whinnett, Carlo Di Mario, Michael Jonas, Habib J. Manhal, Ignacio Amat-Santos, Maria Del Trigo, Tuvia Ben Gal, Binyamin Ben Avraham, Tal Hasin, Sebastian Feickert, Giuseppe D'Ancona, Omar Abdul-Jawad Altisent, Oran Koren, Oren T. Caspi, William Abraham, Filippo D. Crea, Stefan Anker, Ran Kornowski, Leor Perl
Summary: The study evaluated a novel left atrial pressure (LAP) monitoring system in heart failure patients and found that it was safe and provided a good correlation with invasive pulmonary capillary wedge pressure (PCWP). Initial evidence also suggests possible improvement in heart failure clinical symptoms.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Marco Metra, Daniela Tomasoni, Marianna Adamo, Antoni Bayes-Genis, Gerasimos Filippatos, Magdy Abdelhamid, Stamatis Adamopoulos, Stefan D. Anker, Laura Antohi, Michael Boehm, Frieder Braunschweig, Tuvia Ben Gal, Javed Butler, John G. F. Cleland, Alain Cohen-Solal, Kevin Damman, Finn Gustafsson, Loreena Hill, Ewa A. Jankowska, Mitja Lainscak, Lars H. Lund, Theresa McDonagh, Alexandre Mebazaa, Brenda Moura, Wilfried Mullens, Massimo Piepoli, Piotr Ponikowski, Amina Rakisheva, Arsen Ristic, Gianluigi Savarese, Petar Seferovic, Rajan Sharma, Carlo Gabriele Tocchetti, Mehmet Birhan Yilmaz, Cristiana Vitale, Maurizio Volterrani, Stephan von Haehling, Ovidiu Chioncel, Andrew J. S. Coats, Giuseppe Rosano
Summary: Episodes of worsening symptoms and signs are common in patients with chronic heart failure and are associated with negative outcomes. Diuretic therapy is often necessary, along with additional treatments such as guideline-recommended medical therapy. Prevention of worsening heart failure is crucial, and early and rapid administration of appropriate treatments can help achieve this goal. The clinical consensus statement by the Heart Failure Association of the European Society of Cardiology provides an update on the management and prevention of worsening heart failure in clinical practice.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Letter
Cardiac & Cardiovascular Systems
Iolanda Lazaro, Josep Lupon, German Cediel, Aleix Sala-Vila, Antoni Bayes-Genis
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ricardo Rodriguez-Calvo, Minerva Granado-Casas, Alejandra Perez-Montes de Oca, Maria Teresa Julian, Mar Domingo, Pau Codina, Evelyn Santiago-Vacas, German Cediel, Josep Julve, Joana Rossell, Lluis Masana, Didac Mauricio, Josep Lupon, Antoni Bayes-Genis, Nuria Alonso
Summary: This study aimed to explore the prognostic value of cardiac-specific fatty acid binding proteins (FABP3) and adipose-tissue-specific fatty acid binding proteins (FABP4) in chronic heart failure (CHF) patients, with and without type 2 diabetes mellitus (T2D). It was found that the concentrations of FABP3 and FABP4 were associated with all-cause and cardiovascular mortality, particularly in patients with T2D. The study suggests that serum FABP3 and FABP4 concentrations can serve as independent predictors for the occurrence of all-cause and cardiovascular mortality in ambulatory CHF subjects with T2D.
Editorial Material
Cardiac & Cardiovascular Systems
Ana Ayesta, Beatriz Diaz-Molina, Antoni Bayes-Genis, Adrian Baranchuk, Manuel Martinez-Selles
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Antoni Bayes-Genis, Josep Lupon, Pau Codina
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Petar M. Seferovic, Marija Polovina, Giuseppe Rosano, Biykem Bozkurt, Marco Metra, Stephane Heymans, Wilfried Mullens, Johann Bauersachs, Karen Sliwa, Rudolf A. de Boer, Dimitrios Farmakis, Thomas Thum, Iacopo Olivotto, Claudio Rapezzi, Ales Linhart, Domenico Corrado, Carsten Tschope, Ivan Milinkovic, Antoni Bayes Genis, Gerasimos Filippatos, Andre Keren, Milika Asanin, Gordana Krljanac, Ruzica Maksimovic, Hadi Skouri, Tuvia Ben Gal, Brenda Moura, Maurizio Volterrani, Magdy Abdelhamid, Yuri Lopatin, Ovidiu Chioncel, Andrew J. S. Coats
Summary: Cardiomyopathies play a significant role in cardiovascular morbidity and mortality. Progress has been made in understanding the genetic background and pathophysiological mechanisms, leading to improved diagnostic and risk stratification approaches. Targeted therapies and standard care have the potential to improve outcomes in various types of cardiomyopathies.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Antoni Bayes-Genis, Kieran F. Docherty, Mark C. Petrie, James L. Januzzi, Christian Mueller, Lisa Andreson, Biykem Bozkurt, Javed Butler, Ovidiu Chioncel, John G. F. Cleland, Ruxandra Christodorescu, Stefano Del Prato, Finn Gustafsson, Carolyn S. P. Lam, Brenda Moura, Rodica Pop-Busui, Petar Seferovic, Maurizio Volterrani, Muthiah Vaduganathan, Marco Metra, Giuseppe Rosano
Summary: Diagnosing heart failure is often difficult due to non-specific symptoms. This document explores the use of NT-proBNP as a biomarker for diagnosing heart failure in different clinical scenarios. Validated cut-points are provided for ruling in or ruling out acute and de novo heart failure. The concept of 'heart stress' is introduced, and a simple acronym FIND-HF is proposed for early diagnosis of heart failure.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Antoni Bayes-Genis, Rafael de la Espriella, Julio Nunez
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Pau Codina, David Dobarro, Javier de Juan-Baguda, Fernando De Frutos, Josep Lupon, Antoni Bayes-Genis, Jose Gonzalez-Costello, Spanish LEVO D Registry Collaborators
Summary: This study aimed to evaluate the mortality prediction performance of the MAGGIC-HF risk score and the BCN-Bio-HF model in advanced HF patients receiving levosimendan as destination therapy. The results showed suboptimal discrimination and calibration of these two risk scores, with an underestimation of risk. Specific risk scores for advanced HF are needed.
