Article
Biochemistry & Molecular Biology
Nur Shukriyah Mohamad Hazir, Nor Hamdan Mohamad Yahaya, Muhamad Syahrul Fitri Zawawi, Hanafi Ahmad Damanhuri, Norazlina Mohamed, Ekram Alias
Summary: This study assessed the changes in mitochondrial bioenergetics and substrate utilization during polyethylene-induced osteoclastogenesis, and investigated the effects of tocotrienols-rich fraction (TRF) treatment. The results showed that PE-induced osteoclastogenesis caused alterations in the mitochondrial function and substrate oxidation, while TRF treatment reduced osteoclast formation, bone resorption activity, and ROS levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Valeria Sorrenti, Agata Grazia D'Amico, Ignazio Barbagallo, Valeria Consoli, Salvo Grosso, Luca Vanella
Summary: The overexpression of HO-1 in NSCLC cells and the inhibitory effect of SnMP on cell proliferation and migration, as well as the increase in oxidative stress, suggest that HO activity inhibition may be a potential target for selective chemotherapy in lung cancer subtypes.
Article
Pharmacology & Pharmacy
Leyi Yao, Yali Hao, Guanmei Wen, Qingzhong Xiao, Penglong Wu, Jinheng Wang, Jinbao Liu
Summary: The study revealed an important regulatory role for the HO-1 pathway in immune cell regulation and atherosclerosis, suggesting that modulating HO-1 signaling represents a potential therapeutic strategy against atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jose A. Fernandez-Albarral, Elena Salobrar-Garcia, Jose A. Matamoros, Cristina Fernandez-Mendivil, Eric del Sastre, Lejing Chen, Rosa de Hoz, Ines Lopez-Cuenca, Lidia Sanchez-Puebla, Jose M. Ramirez, Juan J. Salazar, Manuela G. Lopez, Ana Ramirez
Summary: This study evaluated the impact of the lack of microglial HO-1 on retinal microgliosis and macrogliosis in aged subjects and found that reducing microglial HO-1 could be beneficial in preventing tauopathy-induced neuroinflammation.
Article
Food Science & Technology
Yanling Li, Ling Zhang, Jian Wang, Ying Zheng, Jian Cui, Guifeng Yuan
Summary: The study confirmed the anti-osteolysis potential of tanshinone IIA (TAN) and explored its mechanism of action. TAN was found to alleviate UHMWPE-induced tissue destruction and inflammation, and inhibit FOXO3 while balancing the levels of OPG and RANKL by modulating miR-155-5p.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Medicine, Research & Experimental
Xuhua Yu, Tiantian Cai, Long Fan, Ziyao Liang, Qiuling Du, Qi Wang, Zifeng Yang, Ross Vlahos, Lei Wu, Lin Lin
Summary: Utilizing the JPYFII formulation in a mouse model exposed to cigarette smoke and IAV infection effectively reduced acute inflammation by decreasing cell count, proinflammatory cytokines, chemokines, superoxide production, and viral load. However, JPYFII treatment alone during smoke exposure did not have the same effect.
Article
Pharmacology & Pharmacy
Qiang Xu, Guiping Chen, Huaen Xu, Guoming Xia, Meisong Zhu, Haibo Zhan, Bin Zhang, Min Dai, Hongxian Fan, Xuqiang Liu
Summary: Celastrol has shown promising potential in preventing aseptic prosthetic loosening and osteoporosis by inhibiting osteoclast formation and function, making it a potential treatment for osteolytic diseases induced by disrupted osteoclast function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Polymer Science
Ayaka Takazawa, Masaki Kakiage, Takeshi Yamanobe, Hiroki Uehara, Yui Shimizu, Takuya Ohnishi, Yasutake Wakabayashi, Kei Inatomi, Shigehiko Abe, Kouki Aoyama
Summary: This study investigates the effect of blending a small amount of high-density polyethylene (HDPE) on molecular entanglements during the melt-drawing process of ultrahigh-molecular-weight polyethylene (UHMW-PE). The results show that the addition of a small amount of HDPE significantly reduces the amount of molecular entanglements in UHMW-PE, affecting its crystallization behavior.
Article
Pharmacology & Pharmacy
Liangwei Mei, Yi Zheng, Teng Ma, Bing Xia, Xue Gao, Yiming Hao, Zhuojing Luo, Jinghui Huang
Summary: In this study, a novel antioxidant compound, JSH-23, was found to restore bone homeostasis by scavenging intracellular ROS during both osteoclastogenesis and osteoblastogenesis. Mechanically, JSH-23 inhibited RANKL-induced osteoclastogenesis and bone resorption via suppression of the NF-kappa B signaling pathway, as well as suppressed ROS generation through the TRAF6/Rac1/NOX1 pathway and enhanced Nrf2/HO-1 expression. Additionally, JSH-23 attenuated H2O2-induced apoptosis and mineralization reduction in osteoblasts by reducing ROS production and enhancing Nrf2/HO-1 expression, ultimately showing protective effects on bone mass in vivo.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Wei Zhang, Yao Feng, Jalal T. Althakafy, Yi Liu, Hala M. Abo-Dief, Mina Huang, Liangchun Zhou, Fengmei Su, Chuntai Liu, Changyu Shen
Summary: In this study, a neutron shielding composite of UPEF/BN/PU was fabricated, which exhibited high shielding efficiency, small density, and flexibility. The composite showed excellent neutron shielding performance and mechanical properties.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2022)
Article
Mechanics
Vincenzo Ianniello, Salvatore Costanzo, Rossana Pasquino, Giovanni Ianniruberto, Enrico Troisi, Theo A. Tervoort, Nino Grizzuti
Summary: This study investigates the linear rheology of ultrahigh molecular weight polyethylene (UHMWPE) solutions with the aim of determining the polymer's molecular weight distribution. By dissolving UHMWPE in oligo-ethylene and using a heuristic approach to extrapolate the linear viscoelastic behavior of the melt, the molecular weight distribution of UHMWPE is obtained.
JOURNAL OF RHEOLOGY
(2022)
Article
Oncology
Lina Zhang, Xuece Zhang, Ting Wu, Xu Pan, Zhi Wang
Summary: 0.7% ISO exerts neuroprotective effects in SAE by activating HO-1 and demonstrating anti-inflammatory, antioxidative, and anti-apoptotic properties.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Orthopedics
Hannah Prock-Gibbs, Cyrus Anthony Pumilia, Teerin Meckmongkol, John Lovejoy, Aadil Mumith, Melanie Coathup
Summary: The study compared the incidence of osteolysis, aseptic loosening, and revision following the use of HXLPE or CPE in medium to long-term follow-up in primary THA. Results showed that HXLPE liners reduced the incidence of these complications compared to CPE, regardless of age and implant fixation method.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Polymer Science
Xiaochuan Chen, Xiaotong Wang, Yanhong Feng, Jinping Qu, Dingshan Yu, Changlin Cao, Xudong Chen
Summary: This study demonstrates that UHMWPE can be processed at a lower temperature without processing aids using an eccentric rotor extruder. Additionally, the residence time of samples can regulate the polymeric chain mobility, affecting the morphology, rheological behavior, and molecular orientation.
Article
Engineering, Chemical
Ashok Kumar Bakshi, Anup K. Ghosh
Summary: This study thoroughly investigated the influence of molecular weight of olefin wax as a plasticizer on the processability and properties of ultrahigh-molecular-weight polyethylene (UHMWPE). The results showed that a lower molecular weight wax was more efficient in uncoiling the entanglements among the amorphous phase of UHMWPE. The optimum plasticization effect and processability were achieved with 10 phr content of H5 wax.
POLYMER ENGINEERING AND SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Cheng Kong, Lei Liang, Guang Liu, Lutao Du, Yongzhi Yang, Jianqiang Liu, Debing Shi, Xinxiang Li, Yanlei Ma
Summary: This study investigated the interactions between gut microbiome, metabolites, and microbial enzymes in early-onset colorectal cancer (EO-CRC) patients. The results showed distinct associations between microbiome and metabolome in EO-CRC compared to late-onset CRC (LO-CRC). The study identified potential biomarkers for EO-CRC and achieved a powerful classification performance for distinguishing EO-CRC from controls. This research provides valuable insights into the pathogenesis of EO-CRC and highlights the potential of microbiome-derived biomarkers for non-invasive detection.
Article
Engineering, Civil
Haoran Chen, Xuedong Yan, Xiaobing Liu, Tao Ma
Summary: With the rapid development of internet technologies and shared mobility services, online ridesharing services have become popular worldwide. This study compares the operational performance of two major online ridesharing modes, ridesplitting and carpooling, using actual operating data provided by DiDi Chuxing. The findings indicate that ridesplitting has lower fuel-saving and distance-saving ratios compared to carpooling, and online ridesharing is not considered fuel-saving in terms of transportation system's fuel economy.
Article
Information Science & Library Science
Pengzhen Yin, Chuang Wang, Liang Liang
Summary: This study examines the antecedents (i.e. characteristics of MICT) and outcomes (i.e. employee affective and cognitive well-being) of routine MICT use in the remote work context. The findings show that routine MICT use increases employee affective well-being, such as job satisfaction, and mitigates cognitive well-being issues, such as technology overload. The study also highlights the mediation effects of routine MICT use on the relationship between its characteristics and employee well-being.
INFORMATION TECHNOLOGY & PEOPLE
(2023)
Article
Chemistry, Physical
Zengqi Lu, Xiaolong Fu, Jiamao Li, Jingwei Hou, Guangming Ran, Chengjian Xiao, Xiaolin Wang
Summary: A hydrophobic microscopic reaction environment was constructed through the modification of mesoporous silica, which helped improve the catalytic activity of the LPCE reaction. The Pt@SBA-15-tetramethyldisilazane catalyst, prepared by modifying the SBA-15 carrier and loading metal Pt, exhibited a superhydrophobic structure with a water contact angle of 158 degrees. This structure enhanced the catalytic performance and prevented catalyst deactivation. Experimental results showed that the catalyst had good catalytic activity in tritium water and maintained high activity after 30 days.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Agriculture, Multidisciplinary
Yuxiang Gu, Haoran Chen, Xing Li, Dan Li, Yue Sun, Lin Yang, Ying Ma, Eric Chun Yong Chan
Summary: This study found that Lactobacillus paracasei IMC 502 can prevent and alleviate type 2 diabetes by mediating the gut microbiota-SCFA-hormone/inflammation pathway.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liyun Zheng, Chun Yang, Liang Liang, Shengxiang Rao, Yongming Dai, Mengsu Zeng
Summary: This study aimed to explore the feasibility of pancreatic imaging at 5 T and evaluate the practical improvement of T2-weighted MRI and diffusion-weighted imaging (DWI) at 5 T as compared with 3 T. The results showed that imaging at 5 T provided higher image quality ratings and SNR compared to 3 T for both T2-weighted and DWI images. However, there were no significant differences in the mean ADC values and CV of ADC between 3 T and 5 T measurements.
Article
Chemistry, Organic
Mao-Lin Yang, Hao-Ran Chen, Long Zhao, Ming-Wu Ding
Summary: A new efficient synthesis method for the preparation of 6,12-dihydro-5H-quinazolino[3,2-a]quinazolin-5-ones has been developed. This method involves sequential Ugi/Staudinger/aza-Wittig/addition/nucleophilic acyl substitution reactions and provides a domino and effective strategy for the preparation of various substituted quinazolino[3,2-a]quinazolin-5-ones under mild reaction conditions.
SYNTHESIS-STUTTGART
(2023)
Article
Rheumatology
Haoran Chen, Huarui Liu, Wenting Lyu, Yin Liu, Mei Huang, Yingwei Zhang, Yuying Qiu, Yonglong Xiao, Hourong Cai, Jinghong Dai
Summary: This study retrospectively analyzed the clinical characteristics and risk factors of clinical recurrence in interstitial lung disease related to antisynthetase syndrome (ARS-ILD). Recurrence of ARS-ILD was common during medication intensity reduction, and age, lactate dehydrogenase (LDH), medication tapering duration, and discontinuation were identified as risk factors for recurrence.
CLINICAL RHEUMATOLOGY
(2023)
Article
Automation & Control Systems
Yuanmao Ye, Yongbin Zhang, Xiaolin Wang, Ka-Wai Eric Cheng
Summary: This article presents a new type of step-up multilevel inverter (MLI) using a front-side quasi-Z-source unit, which effectively limits the charging current variation and enhances the total voltage gain.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
Yuanmao Ye, Minhao Chen, Xiaolin Wang, Lingling Cao
Summary: This article introduces a new boost-type common-ground photovoltaic (PV) inverter, which solves the problems of inrush charging current, input current quality, and boost capability by inserting a quasi-Z-source (qZS) unit into an SC-based common-ground inverter, and is experimentally verified.
INTERNATIONAL JOURNAL OF ELECTRICAL POWER & ENERGY SYSTEMS
(2023)
Article
Engineering, Electrical & Electronic
Jianqiang Luo, Fei Teng, Siqi Bu, Zhongda Chu, Ning Tong, Anbo Meng, Ling Yang, Xiaolin Wang
Summary: This paper proposes a solution to address the traditional operational constraint issue in power systems considering converter-driven stability and elaborates on a power sensitivity-based power dispatch method to enhance stability margin and update operational constraint solutions.
INTERNATIONAL JOURNAL OF ELECTRICAL POWER & ENERGY SYSTEMS
(2023)
Review
Chemistry, Multidisciplinary
Hui-Ying Tan, Jiali Wang, Sheng-Chih Lin, Tsung-Rong Kuo, Hao Ming Chen
Summary: Single-atom catalysts (SACs) are promising electrocatalysts for energy conversion and storage due to their efficient atom utilization and unique electronic properties. The local coordination structures of single metal centers play a significant role in catalytic performances, and understanding the dynamic changes of SACs during reactions is crucial for improving catalytic activity.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Gastroenterology & Hepatology
Xiaoduan Zhuang, Shaoheng Zhang, Guiquan Chen, Zongqi Luo, Huiqin Hu, Wenfeng Huang, Yu Guo, Yongwen Ouyang, Liang Peng, Qing Qing, Huiting Chen, Bingsheng Li, Jie Chen, Xinying Wang
Summary: This study aimed to explore the unsatisfactory histologically complete resection (CR) rate of small rectal neuroendocrine tumors (RNETs) and its associated risk factors and clinical outcomes. The study found that polypectomy, a central depression, and treatment in the early period were risk factors for incomplete resection (IR). Further analysis revealed that an atypical hyperemic appearance and treatment in the early period were significant predisposing factors for inappropriate choice of polypectomy.
GASTROENTEROLOGY REPORT
(2023)
Article
Automation & Control Systems
Zhongjing Yu, Gangyi Zhang, Jingyu Chen, Haoran Chen, Duo Zhang, Qinli Yang, Junming Shao
Summary: This paper proposes a noise-resistant graph embedding method, called NGE, which leverages subspace clustering information to capture community structure and reinforce the relationship between topology and attributes. Experimental results demonstrate the superiority of this method in tasks such as community detection, link prediction, and node classification.
IEEE TRANSACTIONS ON CYBERNETICS
(2023)
Article
Chemistry, Multidisciplinary
Zhijie Chen, Mengyuan Lv, Jing Liang, Kai Yang, Fan Li, Zhi Zhou, Minglong Qiu, Haoyi Chen, Zhengwei Cai, Wenguo Cui, Zhanchun Li
Summary: Postmenopausal osteoporosis is often associated with neuroendocrine changes in the hypothalamus, which are closely related to the microbial diversity, community composition, and intestinal metabolites of gut microbiota. This study revealed the existence of a neuroendocrine signal called neuropeptide Y (NPY) that mediates the brain-gut-bone axis and affects bone metabolism. The findings suggest that targeting NPY-mediated changes in gut microbiota could be a novel approach for treating postmenopausal osteoporosis.