Article
Pharmacology & Pharmacy
Wen Shi, Yan Wu, Donghui Bian
Summary: The study showed that the expression of p75NTR was significantly upregulated in scar tissue at 3 and 6 months after burn injury, but returned to normal at 12 months. Silencing of p75NTR inhibited proliferation, migration, and ECM deposition of HSF by activating autophagy.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Oncology
Xianpeng Ma, Lili Liu
Summary: The study indicated that the long non-coding RNA FAM225B could inhibit scar fibroblast proliferation by suppressing autophagy process, offering a potential treatment strategy for patients with hypertrophic scars after glaucoma surgery.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Geriatrics & Gerontology
Jieting Peng, Xun Xiao, Shizhen Li, Xing Lyu, Hui Gong, Shengyu Tan, Lini Dong, Yan Y. Sanders, Xiangyu Zhang
Summary: This study investigates the effects of aspirin on lung fibroblast differentiation and pulmonary fibrosis. The results show that aspirin reduces the expression of fibrotic markers, promotes autophagy, and decreases lung fibrosis. The mechanism involves the PI3K/AKT/mTOR-dependent autophagy pathway.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Cell Biology
Fabrizio Marcucci, Cristiano Rumio
Summary: There is ample evidence that glycolysis can induce epithelial-mesenchymal transition (EMT) and autophagy in tumor cells. Furthermore, upregulation of glycolysis can result in a mixed mesenchymal/autophagic phenotype in tumor cells.
Article
Biochemistry & Molecular Biology
Jun-Kui Li, Hai-Tao Sun, Xiao-Li Jiang, Yi-Fei Chen, Zhu Zhang, Ying Wang, Wen-Qing Chen, Zhang Zhang, Stephen Cho Wing Sze, Pei-Li Zhu, Ken Kin Lam Yung
Summary: Polyphyllin II (PPII), a natural steroidal saponin, has been shown to exhibit anti-cancer activity against a variety of cancer cells. In this study, PPII was found to induce autophagy by inhibiting the PI3K/AKT/mTOR signaling pathway and inhibit the activation of STAT3, leading to decreased proliferation and increased apoptosis in CRC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yao Huang, Tingting Peng, Wanshan Hu, XinYi Gao, Yangyan Chen, Qian Zhang, Chuanbin Wu, Xin Pan
Summary: This study proposes a novel photodynamic therapy that utilizes hyaluronidase and metformin to enhance therapeutic efficacy. By improving the stiffness and permeability of dissolving microneedles, the photosensitizer can penetrate deep lesions more effectively. Meanwhile, metformin can intervene in cellular respiration and autophagy process, amplifying the effectiveness of photodynamic therapy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Cell Biology
Rekha Tripathi, Tanya Aggarwal, Frida A. Lindberg, Anna H. Klemm, Robert Fredriksson
Summary: SLC38A10 is a member of the SLC38 family and plays a role in regulating protein synthesis and cellular stress responses. The study reveals that SLC38A10 is also involved in glutamate homeostasis and mTOR signaling, and its deficiency may result in lower cholesterol levels, which could be implicated in neurodegenerative diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Shiyi Li, Jinxiu Yang, Jiachen Sun, Minliang Chen
Summary: This study demonstrates that human adipose-derived mesenchymal stem cells (AD-MSCs) can effectively cure hypertrophic scars by promoting the apoptosis of hypertrophic scar fibroblasts (HSFs) and inhibiting their proliferation and migration. The therapeutic effect is associated with the inhibition of nuclear factor erythroid-2-related factor 2 (Nrf2) expression in HSFs. AD-MSCs may provide an alternative approach for treating hypertrophic scars.
Article
Biochemistry & Molecular Biology
U. Sarma, M. Maiti, A. Nair, S. Bhadange, Y. Bansode, A. Srivastava, B. Saha, D. Mukherjee
Summary: The study found that the IL10-STAT3 signaling axis exhibits specificity during crosstalk with other signaling pathways; experimental results show that STAT3 exhibits bell-shaped dose-response when treated with different doses of IFN gamma or IL10; furthermore, negative regulation of the IFN gamma pathway during co-stimulation plays a key role in the robustness of the IL10-STAT3 signaling axis.
Article
Pharmacology & Pharmacy
Ling He, Jihong Wang, Yuting Yang, Pengtao Zou, Zirong Xia, Juxiang Li
Summary: This study found that SIRT4 overexpression could protect against DOX-induced cardiotoxicity by inhibiting Akt/mTOR-dependent autophagy. These findings may provide a potential therapeutic target for DIC.
Article
Dermatology
Xingwang Deng, Fang Zhao, Dan Zhao, Qing Zhang, Yongzhao Zhu, Qian Chen, Lijuan Qiang, Nan Xie, Jiaxiang Ma, Xiaoliang Pan, Yinsheng Wu, Lifeng Guan, Yan Xie
Summary: The study demonstrates that oxymatrine promotes scar repair by inhibiting fibroblast autophagy, reducing fibroblast activity and collagen, inducing cell apoptosis, and improving the final outcome of hypertrophic scars.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Huimin Zhang, Chengyu Zang, Wen Zhao, Linfeng Zhang, Rui Liu, Zhang Feng, Jie Wu, Rongtao Cui
Summary: The study reveals that TNFSF13 activates the NF-κB signaling pathway by interacting with HSPG2, regulating the proliferation, migration, fibrosis and inflammatory response of HSF. MSC-exo inhibits the proliferation and migration of HSF by suppressing TNFSF13 and HSPG2.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Cell Biology
Kexiang Zhang, Song Wu, Hongwei Wu, Li Liu, Jiahui Zhou
Summary: The study demonstrated that activation of Notch1 by doxycycline effectively suppressed cell proliferation and induced S phase arrest in osteosarcoma cells, while also triggering apoptosis and autophagy. Notch1 activation inhibited the PI3K/Akt/mTOR signaling pathway to induce apoptosis and autophagy.
Article
Biochemistry & Molecular Biology
Ke Chen, Bo Yu, Jie Liao
Summary: This study showed that lncRNA SOX2OT alleviates the pathogenesis of DN by regulating Akt/mTOR-mediated autophagy, suppressing the proliferation and fibrosis of mesangial cells.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Cheng Qian, Jiayue Lu, Xiajing Che, Lulin Min, Minzhou Wang, Ahui Song, Renhua Lu, Leyi Gu, Kewei Xie
Summary: Diabetic nephropathy is a major cause of chronic renal failure worldwide. In this study, increased Adenosine triphosphate (ATP) content was found in the urine of diabetic mice. The expression of purinergic P2X7 receptor (P2X7R) was significantly increased in the renal cortex of wild-type diabetic mice and partially co-localized with podocytes. P2X7R inhibition restored podocyte autophagy and may be a potential treatment for diabetic nephropathy.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)