Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death

Doxorubicin and 5-fluorouracil induced accumulation and transcriptional activity of p53 are independent of the phosphorylation at serine 15 in MCF-7 breast cancer cells

(2014) Matthew T Balmer et al.   CANCER BIOLOGY & THERAPY

ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation

(2014) C-Y Huang et al.   CELL DEATH AND DIFFERENTIATION

The E3 Ligase CHIP: Insights into Its Structure and Regulation

(2014) Indranil Paul et al.   Biomed Research International

The Ubiquitin Ligase CHIP Prevents SirT6 Degradation through Noncanonical Ubiquitination

(2013) Sarah M. Ronnebaum et al.   MOLECULAR AND CELLULAR BIOLOGY

CHIP has a protective role against oxidative stress-induced cell death through specific regulation of Endonuclease G

(2013) J S Lee et al.   Cell Death & Disease

IGF-2R-Mediated Signaling Results in Hypertrophy of Cultured Cardiomyocytes from Fetal Sheep1

(2012) Kimberley C.W. Wang et al.   BIOLOGY OF REPRODUCTION

The heat shock transcription factor 1 as a potential new therapeutic target in multiple myeloma

(2012) Tanja Heimberger et al.   BRITISH JOURNAL OF HAEMATOLOGY

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

(2012) Yanti Octavia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Activation of IGF-2R stimulates cardiomyocyte hypertrophy in the late gestation sheep fetus

(2012) Kimberley C. W. Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Heat shock transcription factor 1 inhibits H2O2-induced cardiomyocyte death through suppression of high-mobility group box 1

(2012) Ying Yu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease

(2011) Julius Anckar et al.   Annual Review of Biochemistry

Promotion of Heat Shock Factor Hsf1 Degradation via Adaptor Protein Filamin A-interacting Protein 1-Like (FILIP-1L)

(2011) Yanzhong Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevation of IGF-2 receptor and the possible underlying implications in end-stage heart failure patients before and after heart transplantation

(2011) Yingjie Wei et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Histone acetylation is essential for ANG-II-induced IGF-IIR gene expression in H9c2 cardiomyoblast cells and pathologically hypertensive rat heart

(2011) Chun-Hsien Chu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Fetal growth restriction and the programming of heart growth and cardiac insulin-like growth factor 2 expression in the lamb

(2011) Kimberley C. W. Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of heat shock factor-1 activation in the doxorubicin-induced heart failure in mice

(2010) Kaushik Vedam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Promotion of CHIP-Mediated p53 Degradation Protects the Heart From Ischemic Injury

(2010) Atsuhiko T. Naito et al.   CIRCULATION RESEARCH

Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor

(2010) Chang-Hoon Woo et al.   FASEB JOURNAL

CHIP-dependent p53 regulation occurs specifically during cellular senescence

(2010) Christina Sisoula et al.   FREE RADICAL BIOLOGY AND MEDICINE

Modulation of Heat Shock Transcription Factor 1 as a Therapeutic Target for Small Molecule Intervention in Neurodegenerative Disease

(2010) Daniel W. Neef et al.   PLOS BIOLOGY

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

(2009) Yi-Wei Zhang et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Cardioprotection by CaMKII-δB Is Mediated by Phosphorylation of Heat Shock Factor 1 and Subsequent Expression of Inducible Heat Shock Protein 70

(2009) Wei Peng et al.   CIRCULATION RESEARCH

Activation of the ubiquitin-proteasome system in doxorubicin cardiomyopathy

(2009) Mark J. Ranek et al.   CURRENT HYPERTENSION REPORTS

Co-chaperone CHIP Stabilizes Aggregate-prone Malin, a Ubiquitin Ligase Mutated in Lafora Disease

(2009) Sudheendra N. R. Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leu27IGF2 plays an opposite role to IGF1 to induce H9c2 cardiomyoblast cell apoptosis via Gαq signaling

(2009) Ray-Jade Chen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

A therapeutic dose of doxorubicin activates ubiquitin-proteasome system-mediated proteolysis by acting on both the ubiquitination apparatus and proteasome

(2008) Jinbao Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

HSF1 as a Mitotic Regulator: Phosphorylation of HSF1 by Plk1 Is Essential for Mitotic Progression

(2008) Y.-J. Lee et al.   CANCER RESEARCH

Activation of Insulin-Like Growth Factor II Receptor Induces Mitochondrial-Dependent Apoptosis through Gαq and Downstream Calcineurin Signaling in Myocardial Cells

(2008) Chun-Hsien Chu et al.   ENDOCRINOLOGY

IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via Gαq interaction and protein kinase C-α/CaMKII activation in H9c2 cardiomyoblast cells

(2008) Chun-Hsien Chu et al.   JOURNAL OF ENDOCRINOLOGY

IGF-II/mannose 6-phosphate receptor activation induces metalloproteinase-9 matrix activity and increases plasminogen activator expression in H9c2 cardiomyoblast cells

(2008) Mu-Hsin Chang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control

(2008) J.-N. Min et al.   MOLECULAR AND CELLULAR BIOLOGY