Structure of the TBC1D7–TSC1 complex reveals that TBC1D7 stabilizes dimerization of the TSC1 C-terminal coiled coil region

TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal Transition

(2015) Antje Thien et al.   DEVELOPMENTAL CELL

Regulation of mTORC1 by PI3K signaling

(2015) Christian C. Dibble et al.   TRENDS IN CELL BIOLOGY

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

TBC1D7Mutations are Associated with Intellectual Disability, Macrocrania, Patellar Dislocation, and Celiac Disease

(2014) Ali Abdullah Alfaiz et al.   HUMAN MUTATION

Striatins Contain a Noncanonical Coiled Coil That Binds Protein Phosphatase 2A A Subunit to Form a 2:2 Heterotetrameric Core of Striatin-interacting Phosphatase and Kinase (STRIPAK) Complex

(2014) Cuicui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Regions Critical for the Integrity of the TSC1-TSC2-TBC1D7 Complex

(2014) Arthur Jorge Santiago Lima et al.   PLoS One

Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly

(2013) José-Mario Capo-Chichi et al.   JOURNAL OF MEDICAL GENETICS

Genome-wide meta-analysis identifies new susceptibility loci for migraine

(2013) Verneri Anttila et al.   NATURE GENETICS

Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci

(2013) Yan Zhang et al.   Nature Communications

Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations

(2013) Wei Sun et al.   Nature Communications

The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits

(2012) Marianne Hoogeveen-Westerveld et al.   BMC BIOCHEMISTRY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

(2012) Christian C. Dibble et al.   MOLECULAR CELL

De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes

(2012) Jean-Baptiste Rivière et al.   NATURE GENETICS

De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly

(2012) Jeong Ho Lee et al.   NATURE GENETICS

Structural basis for the recognition of Asef by adenomatous polyposis coli

(2011) Zhenyi Zhang et al.   CELL RESEARCH

Analysis of TSC1 truncations defines regions involved in TSC1 stability, aggregation and interaction

(2010) Marianne Hoogeveen-Westerveld et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The tuberous sclerosis complex

(2009) Ksenia A. Orlova et al.   Annals of the New York Academy of Sciences

Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment

(2009) K. Inoki et al.   HUMAN MOLECULAR GENETICS

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase

(2008) J. Hu et al.   GENES & DEVELOPMENT

Fifty years of coiled-coils and α-helical bundles: A close relationship between sequence and structure

(2008) David A.D. Parry et al.   JOURNAL OF STRUCTURAL BIOLOGY