Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 20, Issue -, Pages 139-147Publisher
ELSEVIER
DOI: 10.1016/j.jff.2015.10.026
Keywords
Staghorn sumac; Rhus hirta L.; Anti-inflammatory activity; Antioxidant activity; IL-8; NF-kappa B
Categories
Funding
- A-Base Research of Agriculture and Agri-Food Canada [RBPI 1004]
- National Science Foundation of China [81160412]
- Special Fund for Young Teacher Development Plan (visiting scholars) in universities of Jiangxi Province, China
Ask authors/readers for more resources
The antioxidant and anti-inflammatory activities of the novel pyranoanthocyanins and other polyphenols from staghom sumac (Rhus hirta L.) were examined. The results not only confirmed the previously found antioxidant activity by chemical based assays, but more importantly strong anti-inflammatory activity for the first time in cell-based assays. These unique compounds significantly inhibited the production of pro-inflammatory cytokine IL-8 production stimulated by H2O2 and TNF-alpha. It was also found that these activities of the crude extract were primarily from the individual polyphenols, particularly the unique pyranoanthocyanins and 7-methoxyanthocyanins. Pyranoanthocyanin 1, in particular, showed. a markedly strong anti-inflammatory activity at 1 M, followed by pyranoanthocyanin 2 and a 7-methoxyanthocyanin 5. Further mechanism investigation showed that the anti-inflammatory activity was likely mediated through inhibition of NF-kappa B activation via phosphorylation of I kappa B alpha. Results from the present study warrant further investigation into the in vivo anti-inflammatory effect and health benefits using animal models or human subjects. (C) 2015 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available