Article
Medicine, Research & Experimental
Xiaoyang Zhang, Yanfeng Yan, Yunxia Lv, Xin Li, Leiyao Chen, Zihui Huang, Junbo Zhou, Yong Wang, Xiaoming Wang, Xu Wang, Hongwei Gu
Summary: Urinary tract infections (UTI) caused by uropathogenic Escherichia coli (UPEC) can be attenuated by Dendrobium officinale polysaccharides (DOPs), which possess anti-inflammatory properties and inhibit the activation of NLRP3 pathway and ROS signal. DOPs effectively mitigate UPEC-induced pyroptosis in macrophage cells by reducing cell damage and pro-inflammatory cytokine secretion.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Food Science & Technology
Chuanbo Sun, Nuo Zhang, Guangpei Xu, Ping Jiang, Shiping Huang, Qun Zhao, Yanfei He
Summary: This study demonstrates that Dendrobium officinale polysaccharides (DOP) have antitumor and immunomodulatory activities, inhibiting tumor growth through multiple pathways.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Biochemistry & Molecular Biology
Wen-hua Chen, Jian-jun Wu, Xue-fei Li, Jie-miao Lu, Wei Wu, Yi-qi Sun, Bo Zhu, Lu-ping Qin
Summary: Dendrobium officinale polysaccharides exhibit a variety of biological effects, including immunomodulatory, anti-tumor, and gastro-protective effects. Further research is needed to explore extraction, purification, and structural characteristics of these polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Environmental Sciences
Yi Mu, Bangwei Che, Kaifa Tang, Wenjun Zhang, Shenghan Xu, Wei Li, Jun He, Miao Liu, Peng Chen, Siwen Zhong, Guangyu Li
Summary: This study explored the protective effect of Dendrobium officinale polysaccharides (DOPs) on reproductive oxidative stress injury in male mice and its mechanism. The results showed that DOPs effectively reduced the oxidative stress injury of testicular tissue and improved sperm quality and hormone levels. The protective effect of DOPs was mediated by reducing oxidative stress levels, improving the hormone environment in testes, and regulating the expression of specific genes in Sertoli cells and spermatogenic cells.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Chen Li, Yunwei Wang, Zijia Huang, Yi Zhang, Jiao Li, Qing Zhang, Benjamin Kofi Simpson, Jingxue Wang
Summary: This study investigated the hypoglycemic and hypolipidemic effects of polysaccharides of Dendrobium officinale compound (DOCP) on streptozotocin induced type 2 diabetic mice. DOCP significantly decreased fasting blood glucose and insulin resistance, increased serum insulin content, reduced lipid levels, improved antioxidant capability, and protected liver and pancreas. DOCP also increased the diversity of intestinal flora and up-regulated the expression of key genes related to glucose metabolism.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Nutrition & Dietetics
Nkwachukwu Oziamara Okoro, Arome Solomon Odiba, Qi Yu, Bin He, Guiyan Liao, Cheng Jin, Wenxia Fang, Bin Wang
Summary: Dendrobium officinale, a widely used medicinal herb, has gained attention for its polysaccharide content and its potential medicinal properties. In this study, the anti-aging potential of polysaccharides extracted from D. officinale grown in different environments was investigated using Caenorhabditis elegans as a model. The findings showed that greenhouse-grown D. officinale polysaccharides had the optimal effect of extending lifespan and enhancing stress resistance. These results provide valuable information for the cultivation and medicinal applications of D. officinale.
Article
Food Science & Technology
Hang Chen, Xueqin Shi, Lanyan Cen, Lin Zhang, Yifeng Dai, Shuyi Qiu, Xiangyong Zeng, Chaoyang Wei
Summary: In this study, different fermentations were conducted on Dendrobium officinale polysaccharides, and it was found that yeast fermentation could effectively reduce the molecular weight and improve the antioxidant activity of the polysaccharides, indicating a potential way to enhance their antioxidant activity. Additionally, four homogeneous polysaccharides with different compositions and molecular weights were obtained. These findings are significant for further research on Dendrobium officinale polysaccharides.
Review
Cell Biology
Xiaoyu Xu, Cheng Zhang, Ning Wang, Yu Xu, Guoyi Tang, Lin Xu, Yibin Feng
Summary: Dendrobium officinale, a functional food and medicinal herb with a long history of use, contains abundant bioactive compounds that exhibit various biological properties and health benefits. This review summarizes the phytochemical studies, bioactivities, and safety of Dendrobium officinale, and discusses its potential for drug and functional food development as well as clinical applications.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Nutrition & Dietetics
Weijie Wu, Ziqi Zhao, Zhaoer Zhao, Dandan Zhang, Qianyi Zhang, Jiayu Zhang, Zhengyi Fang, Yiling Bai, Xiaohui Guo
Summary: In this review, the extraction, structure, health benefits, and related mechanisms of Dendrobium officinale polysaccharides (DOPs) were summarized. It was proposed that DOPs are potential prebiotics, influencing the composition of gut microbiota and providing health benefits. This has important implications for the development of functional foods and health products.
Article
Biotechnology & Applied Microbiology
Li Hao, Xin Shi, Shunwang Qin, Jiahong Dong, Huan Shi, Yuehua Wang, Yi Zhang
Summary: In this study, 25 DoSWEET genes were identified and analyzed in D. officinale. The research revealed the evolutionary relationship, conserved motifs, chromosomal location, and expression patterns of DoSWEETs. Different DoSWEET genes play different roles in sugar transport, and some genes are regulated under stress conditions. The correlation analysis and interaction network prediction provide a foundation for further functional verification.
Article
Medicine, Research & Experimental
Yingmin Liang, Ruixuan Du, Rui Chen, Pak Hin Chu, Mary Sau Man Ip, Kalin Yan Bo Zhang, Judith Choi Wo Mak
Summary: DOPs extracted from Dendrobium officinale showed therapeutic effects in reducing cigarette smoke-induced airway inflammation by decreasing oxidative stress and inflammatory cell infiltration, as well as inhibiting the activation of MAPK and NF-kappa B signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Yongtao Zhang, Shiquan You, Dongdong Wang, Dan Zhao, Jiachan Zhang, Quan An, Meng Li, Changtao Wang
Summary: In this study, the molecular characteristics of fermented Dendrobium officinale polysaccharides (FDOP) by Lactobacillus delbrueckil bulgaricus were analyzed using FT-IR, GPC-LC, and SEM. FDOP showed a smaller molecular structure and better water solubility. The protective effect of FDOP on human skin fibroblasts (HSF) damaged by UV radiation was investigated, and it was found that FDOP improved the antioxidant capacity of HSF and reduced the breakdown of collagen, elastin, and hyaluronic acid. The antioxidative and antiaging properties of FDOP were explored, and it was observed that FDOP could up-regulate the Nrf2/Keapl and TGF-beta/Smads pathways to reduce oxidative damage and aging effects.
FOOD SCIENCE & NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Yan Yang, Li Fan, Ying Peng, Chongsheng Peng, Xiaobo Li
Summary: This research demonstrates that the alcohol-soluble polysaccharide-enriched fractions from Dendrobium officinale flowers have significant antidepressant effects. The novel alcohol-soluble polysaccharide, ASP, is mainly composed of various sugars and has the ability to regulate gut microbiota and short-chain fatty acids, as well as activate the BDNF-TrkB-CREB pathway, leading to a protective effect against neuronal apoptosis and maintenance of the serotonin system. These findings highlight the potential use of Dendrobium officinale flowers as a rich source of polysaccharides for depression treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Nutrition & Dietetics
Yuan He, Lin Li, Hao Chang, Bin Cai, Huajun Gao, Guoyu Chen, Wen Hou, Zubaydan Jappar, Yizhe Yan
Summary: Dendrobium officinale is a traditional medicinal and food homologous plant that possesses polysaccharides with various biological activities, including antioxidant, hepatoprotective, immunomodulatory, gastrointestinal protection, hypoglycemic, and anti-tumor activities.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Ming Cai, Hua Zhu, Lei Xu, Jian Wang, Jing Xu, Zhenhao Li, Kai Yang, Jianyong Wu, Peilong Sun
Summary: This study aimed to investigate the antifatigue and prebiotic effects of three ethanol precipitated polysaccharides from Dendrobium officinale (EPDO-40, EPDO-60, and EPDO-80) and their relationships to the structure properties. EPDOs with antifatigue activity were screened through forced swimming test, and various indicators including blood lactic acid (BLA), blood urea nitrogen (BUN), superoxide dismutase (SOD), and gut microflora were examined. The purified EPDO-60, with a molecular weight of 277.3 kDa and a backbone consisting of 4-Manp and 4-Glcp, exhibited the best antifatigue activity by significantly prolonging forced swimming time, reducing BLA and BUN levels, and increasing SOD. Treatment with EPDO-60 also led to an increase in the proportion of Bacteroidetes and Firmicutes and the abundance of Lactobacillus and Bifidobacterium in gut microflora. Therefore, EPDO-60 could influence the community structure of gut microflora, promoting the balance of oxidation and antioxidation, and accelerating fatigue metabolism in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Wai Han Yiu, Sarah W. Y. Lok, Rui Xue, Jiaoyi Chen, Kar Neng Lai, Hui Yao Lan, Sydney C. W. Tang
Summary: Kidney inflammation contributes to the progression of chronic kidney disease (CKD). Modulation of Toll-like receptor 4 (TLR4) signaling is a potential therapeutic strategy for this pathology. In this study, tubule-specific deletion of TLR4 in mice provided protection against obstruction-induced kidney injury, with reduced inflammation and kidney fibrosis. Transcriptome analysis revealed the down-regulation of long noncoding RNA (lncRNA) Meg3 in the obstructed kidney, and silencing Meg3 ameliorated kidney fibrosis. These findings suggest a proinflammatory role of Meg3 in CKD and a novel regulatory pathway in TLR4-driven inflammatory responses.
Article
Biochemistry & Molecular Biology
Luhan Jiang, Dandan Cao, William S. B. Yeung, Kai-Fai Lee
Summary: This study used single-cell transcriptomics to uncover the cellular characteristics of mouse endometrial stromal cells (ESCs) and their role in modulating the microenvironment of a receptive endometrium. The results showed that both decidualized and non-decidualized ESCs are involved in extracellular remodeling and play a role in regulating endometrial receptivity and immune tolerance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kaifang Wang, Xiaona Wang, Minghuan Zhang, Zhenguang Ying, Zeyao Zhu, Kin Yip Tam, Chunman Li, Guowei Zhou, Feng Gao, Meiqi Zeng, Stephen Cho Wing Sze, Xia Wang, Ou Sha
Summary: In this study, the anti-tumor activity of Trichosanthin (TCS) extracted from the tuberous root of Trichosanthes was investigated in hepatocellular carcinoma (HCC). TCS induced apoptosis in HCC cells and promoted the recruitment of CD8(+) T cells to HCC tissues. Furthermore, TCS increased the expression of mannose-6-phosphate receptor (M6PR), the main receptor of Granzyme B (GrzB), in HCC tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
W. C. Kwok, J. C. M. Ho, T. F. Ma, D. C. L. Lam, J. W. M. Chan, M. S. M. Ip, T. C. C. Tam
Summary: This retrospective cohort study found that patients with baseline blood eosinophil count below 250 cells/µL at stable state are at increased risk of having hospitalised bronchiectasis exacerbations.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2023)
Article
Transplantation
Franco Wing Tak Cheng, Carlos King Ho Wong, Simon Xiwen Qin, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Eric Yuk Fai Wan, Esther W. Chan, Chi Ho Au, Xuxiao Ye, Sydney Chi Wai Tang, Ian Chi Kei Wong
Summary: A study conducted in Hong Kong using vaccination records found no evidence to suggest an increased risk of glomerular diseases following the BNT162b2 or CoronaVac vaccines.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Respiratory System
Wang Chun Kwok, Sze Him Isaac Leung, Terence Chi Chun Tam, James Chung Man Ho, David Chi-Leung Lam, Mary Sau Man Ip, Pak Leung Ho
Summary: This study compared the efficacy of mRNA vaccine and inactivated whole virus vaccine in patients with chronic respiratory diseases. The results showed that patients who received two doses of either vaccine had a lower risk of hospitalization and respiratory failure compared to those who were not vaccinated. Both vaccines were equally effective in preventing COVID-19-related hospitalization and respiratory failure.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Article
Transplantation
Sarah W. Y. Lok, Wai Han Yiu, Yixin Zou, Rui Xue, Hongyu Li, Jingyuan Ma, Jiaoyi Chen, Loretta Y. Y. Chan, Kar Neng Lai, Sydney C. W. Tang
Summary: In this study, the role of PAR-1 in the mechanisms of AKI-to-CKD transition was explored. It was found that PAR-1 deficiency reduced kidney inflammation and vascular injury during the early phase of AKI. Furthermore, PAR-1 deficiency protected kidney function and diminished tubulointerstitial fibrosis during the transition phase to CKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Respiratory System
Wang Chun Kwok, Ting Fung Ma, James Chung Man Ho, David Chi Leung Lam, Ko Yung Sit, Mary Sau Man Ip, Timmy Wing Kuk Au, Terence Chi Chun Tam
Summary: This study developed a prediction model based on readily available clinical information to accurately predict disease recurrence in stage I adenocarcinoma patients, which can help personalize follow-up strategies and future adjuvant therapy.
Article
Virology
Wang Chun Kwok, Man Fung Tsoi, Sze Him Isaac Leung, Chung Ki Tsui, Terence Chi Chun Tam, James Chung Man Ho, David Chi Leung Lam, Mary Sau Man Ip, Pak Leung Ho
Summary: A retrospective cohort study conducted in Hong Kong showed that both molnupiravir (MOV) and nirmatrelvir-ritonavir (NMV-r) are effective in preventing severe outcomes of COVID-19 in unvaccinated patients with chronic respiratory diseases.
Article
Respiratory System
Wang Chun Kwok, Chi Hung Chau, Terence Chi Chun Tam, Fai Man Lam, James Chung Man Ho
Summary: This study aimed to investigate the association between the variability of baseline blood eosinophil count and COPD exacerbation risk. The results showed that higher variability of baseline eosinophil count was associated with increased risk of COPD exacerbation. This association was particularly evident in patients with baseline eosinophil count below 300 cells/μL, where a variability cut-off of 50 cells/μL could predict exacerbation risk.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Review
Environmental Sciences
Pengfei Fu, Ruijin Li, Stephen Cho Wing Sze, Ken Kin Lam Yung
Summary: This study has found a significant association between PM2.5 exposure and increased risk of colorectal cancer (CRC), with multiple studies conducted across North America and Asia confirming this relationship. The study also revealed higher incidence and mortality rates in North America compared to Asia.
REVIEWS ON ENVIRONMENTAL HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Frankie Chi Fat Ko, Sheng Yan, Ka Wai Lee, Sze Kwan Lam, James Chung Man Ho
Summary: This review discusses the intracellular and extracellular biological functions of the 12 identified galectins in humans. These galectins play important roles in controlling immune responses within the tumor microenvironment and the infiltration of immune cells to fight against cancer cells. Galectin-3 and -9 inhibitors have been selected as candidates for clinical trials, along with investigation on their combination with immune checkpoint inhibitors. Inhibition of galectin has downstream effects on various immune cells and plays pro-inflammatory roles, supporting the fight against cancer cells.
Article
Urology & Nephrology
Kam Wa Chan, J. David Smeijer, Meir Schechter, Niels Jongs, Priya Vart, Donald E. Kohan, Ron T. Gansevoort, Adrian Liew, Sydney C. W. Tang, Christoph Wanner, Dick de Zeeuw, Hiddo J. L. Heerspink
Summary: Pain is common among patients with diabetes and chronic kidney disease, and the use of commonly prescribed drugs is limited due to their nephrotoxicity. This study investigated the association between the endothelin receptor antagonist atrasentan and pain and prescription of analgesics. The findings suggest that atrasentan may reduce pain-related events and the use of analgesics in patients with type 2 diabetes and chronic kidney disease.
KIDNEY INTERNATIONAL
(2023)
Article
Engineering, Biomedical
John Akrofi Kubi, Augustine Suurinobah Brah, Kenneth Man Chee Cheung, Yin Lau Lee, Kai-Fai Lee, Stephen Cho Wing Sze, Wei Qiao, Kelvin Wai-Kwok Yeung
Summary: Delayed bone defect repair has significant negative impacts on patients' health and socioeconomic status. Recombinant proteins like BMP-2 are commonly used for bone defect repairs, but they can cause adverse side effects. In this study, we have discovered a new osteogenic protein called HKUOT-S2, which accelerates bone defect repair by activating MSCs-derived osteoblasts and enhancing osteoblastic biomineralization. The protein also modulates the transcriptomic changes of macrophages, stem cells, and osteoblasts, facilitating osteogenesis. The HKUOT-S2 protein shows no toxicity and has great potential as an alternative treatment for bone defect healing.
BIOACTIVE MATERIALS
(2023)
Article
Urology & Nephrology
Davina N. W. Lie, Kam Wa Chan, Alexander H. N. Tang, Anthony T. P. Chan, Gary C. W. Chan, Kar Neng Lai, Sydney Chi-Wai Tang
Summary: This study aimed to investigate the long-term clinical outcomes of biopsy proven IgAN patients treated with aliskiren in addition to a maximally tolerated dose of ACEi/ARB. The study found that compared to patients using ACEi/ARB alone, IgAN patients treated with a direct renin inhibitor and ACEi/ARB for more than 6 months had poorer renal prognosis.
JOURNAL OF NEPHROLOGY
(2023)
