Article
Biochemistry & Molecular Biology
Raul Lopez-Fernandez-Sobrino, Jorge R. Soliz-Rueda, Javier Avila-Roman, Anna Arola-Arnal, Manuel Suarez, Begona Muguerza, Francisca Isabel Bravo
Summary: The study found that wine lees powder has antihypertensive effects related to flavanols, anthocyanins, and endothelial factors, reducing blood pressure by affecting NO and prostacyclin production. Additionally, the antihypertensive effect of wine lees powder is mediated by SIRT1, leading to increased expression of eNos and Sirt1 genes.
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Qing Li, Yushi Du, Panyin Xiang, Guanyu Chen, Xiaoxian Qian, Shuangshuang Li, Yihui Mao, Wenhua Ling, Dongliang Wang
Summary: Brussels chicory, a typical vegetable in Mediterranean diets, has been found to stabilize advanced atherosclerotic plaques in the brachiocephalic artery of apoE-deficient mice. This study investigated the mechanism behind this effect and found that Brussels chicory improved oxidative stress, leading to the stabilization of aortic plaques and inhibition of monocyte adhesion.
Article
Biochemistry & Molecular Biology
Yin Wu, Ye Ding, Tharmarajan Ramprasath, Ming-Hui Zou
Summary: This review highlights the importance of nitric oxide in maintaining vascular homeostasis and its role in hypertension. Recent studies suggest that BH4 treatment could be a promising therapeutic for hypertension, but abnormalities in BH4 availability can trigger pathological events that affect blood pressure regulation. Continued research in this area is crucial to improve potential therapies for treating hypertension.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Peripheral Vascular Disease
Kai Huang, Taro Narumi, Yixuan Zhang, Qiang Li, Priya Murugesan, Yusi Wu, Norika Mengchia Liu, Hua Cai
Summary: Our study reveals a critical role of microRNA-192-5p in mediating NOX-dependent DHFR deficiency and AAA formation, and inhibition of which effectively attenuates the development of AAA. Since the sequences of mouse and human microRNA-192-5p are identical, microRNA-192-5p inhibitors may offer a potential therapeutic option for AAA treatment.
Article
Physiology
Mutay Aslan, Filiz Basrali, Pinar Ulker, Zerrin Barut, Cagatay Yilmaz, Tugce ceker, Nur Ozen, Aleyna Oztuzun, Ozlem Elpek
Summary: Asperglaucide (ASP), an aurantiamide found in purslane, demonstrated positive effects on endothelial function, eNOS expression, vascular fluidity, and ROS/RNS production in a rat model of renovascular arterial hypertension. In addition, ASP increased eNOS protein expression in human umbilical vein endothelial cells (HUVEC). The results suggest that ASP may have future potential as an anti-hypertensive agent.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chih-Hsien Wu, Yi-Lin Chiu, Chung-Yueh Hsieh, Guo-Shiang Tsung, Lian-Shan Wu, Cheng-Chung Cheng, Tsung-Neng Tsai
Summary: Cilostazol exerts antithrombotic and vasculoprotective effects in endothelial cells by activating KLF2 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Horticulture
Sitthisak Intarasit, Kobkiat Saengnil
Summary: The study found that exogenously applied Ascorbic acid (AsA) treatment in longan fruit pericarp resulted in reduced browning, which was closely associated with the generation of hydrogen peroxide (H2O2) and nitric oxide (NO) signaling molecules, activating the antioxidant defense mechanism to resist stress-induced H2O2 and NO production.
SCIENTIA HORTICULTURAE
(2021)
Article
Pharmacology & Pharmacy
Bozena Badzynska, Ivana Vaneckova, Janusz Sadowski, Silvie Hojna, Elzbieta Kompanowska-Jezierska
Summary: This study investigated the effects of ETA and ETB receptor blockade on blood pressure, medullary blood flow, and tissue NO in different rat models. The results confirmed the dominant role of ETA receptors in regulating blood pressure and renal hemodynamics in both normotensive and hypertensive rats. Additionally, ETB stimulation was found to preserve medullary perfusion under conditions of endothelin system activation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Y. Xu, C. Li, G. Liu, H. Zhang, S. Tian, H. Hao, Y. Hao
Summary: This study found that Ang 1-7 significantly increased NO synthesis in rat VSMCs cultured under high glucose conditions by regulating Cav-1 expression, Cav-1-eNOS interaction, oxidative stress, and intracellular Ca2+ levels.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Peripheral Vascular Disease
Sarah M. McCann Haworth, Zhengbing Zhuge, Carina Nihlen, Matilda Fornell Von Rosen, Eddie Weitzberg, Jon O. Lundberg, Rafael T. Krmar, Josefine Nasiell, Mattias Carlstrom
Summary: This study reveals that in patients with pre-eclampsia, red blood cells exhibit increased arginase activity and expression, which are correlated with disease severity. Red blood cells can mediate endothelial dysfunction in pre-eclampsia through arginase-dependent and oxidative stress-dependent mechanisms. Targeting red blood cell arginase may offer a novel treatment approach for pre-eclampsia.
JOURNAL OF HYPERTENSION
(2021)
Article
Medicine, Research & Experimental
Jun -Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: Endothelial TAZ is involved in the production of nitric oxide (NO) and inhibits damage-induced liver fibrosis. It regulates NO production by transcriptional regulation of Nos3. Loss of TAZ leads to capillarization of liver sinusoidal endothelial cells and a decrease in NO concentration, accelerating liver fibrosis.
Article
Nutrition & Dietetics
Ma Josefina Ruiz de Azua, Alvaro Cruz-Carrion, Begona Muguerza, Gerard Aragones, Anna Arola-Arnal, Maria Paz Romero, Francisca Isabel Bravo, Manuel Suarez
Summary: This study evaluated the metabolic consequences of consuming Ekstasis tomatoes from different geographical origins and in different seasons in Fischer 344 rats. The results showed that seasonal consumption of local tomatoes reduced cardiovascular risk and atherogenic coefficient. Additionally, the photoperiod significantly affected blood glucose, insulin levels, and the expression of Srep1-c, Fas1, and Acc1 in the liver.
Article
Nutrition & Dietetics
Francisca Isabel Bravo, Enrique Calvo, Rafael A. Lopez-Villalba, Cristina Torres-Fuentes, Begona Muguerza, Almudena Garcia-Ruiz, Diego Morales
Summary: Hypertension is a major contributor to premature deaths worldwide and can be prevented by managing cardiovascular diseases. Protein hydrolysates containing antihypertensive peptides derived from agri-food industry byproducts, such as chicken slaughterhouse byproducts, have shown potential in lowering blood pressure. These byproducts, including blood, bones, skins, and chicken feet, have been used to produce protein hydrolysates with angiotensin-converting enzyme (ACE) inhibitory activity. Mechanisms underlying their effects include increased levels of antioxidant compounds, reduced ACE activity, and improved endothelial dysfunction associated with hypertension. However, further clinical studies are needed to confirm these antihypertensive properties and enhance the value of these byproducts in the circular economy model of slaughterhouses.
Article
Nutrition & Dietetics
Veronica Arreaza-Gil, Javier Avila-Roman, Ivan Escobar-Martinez, Begona Muguerza, Manuel Suarez, Anna Arola-Arnal, Cristina Torres-Fuentes
Summary: Seasonal rhythms can influence gut microbiota, bioactive compounds, and inflammation. This study aimed to investigate the effects of photoperiod on the modulation of oxylipins (OXLs) in healthy and obesogenic conditions. The results showed that photoperiods affected OXLs levels influenced by gut microbiota, and the grape seed proanthocyanidin extract (GSPE) had an impact on prostaglandin E2 (PGE2) levels under certain photoperiod conditions. This is the first study to demonstrate the effects of photoperiod on OXLs metabolites.
Article
Plant Sciences
Alvaro Cruz-Carrion, Ma Josefina Ruiz de Azua, Begona Muguerza, Miquel Mulero, Francisca Isabel Bravo, Anna Arola-Arnal, Manuel Suarez
Summary: A study compared thirteen plant-based foods cultivated in organic (ORG) and non-organic (NORG) farming systems in terms of antioxidant capacity and phenolic compound content. The results showed that NORG fruits had higher phenolic compounds content, while ORG fruits had more antioxidant capacity. NORG legume stood out for having higher values from all parameters analyzed. ORG nuts had higher flavan-3-ols and flavonols content but lower antioxidant capacity compared to their NORG counterparts. ORG vegetables displayed higher phenolics and anthocyanins content, resulting in higher antioxidant capacity than NORG ones. These findings suggest that farming systems modulate phenolic compound composition and antioxidant capacity based on the plant species studied.
Review
Endocrinology & Metabolism
Cristina Cuesta-Marti, Friederike Uhlig, Begona Muguerza, Niall Hyland, Gerard Clarke, Harriet Schellekens
Summary: Oxytocin is closely related to gut microbiota and plays an important role in appetite regulation and social behavior.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Food Science & Technology
Veronica Arreaza-Gil, Ivan Escobar-Martinez, Miquel Mulero, Begona Muguerza, Manuel Suarez, Anna Arola-Arnal, Cristina Torres-Fuentes
Summary: This study evaluates the influence of different photoperiod exposures on the bioavailability of grape seed proanthocyanidins (GSPEs) extract and found that photoperiods affect its bioavailability. Moreover, photoperiods also influence the gut microbiota composition and the bioavailability of polyphenols in the body, which in turn affects the health effects of obesity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Nutrition & Dietetics
Elia Navarro-Masip, Marina Colom-Pellicer, Francesca Manocchio, Anna Arola-Arnal, Francisca Isabel Bravo, Begona Muguerza, Gerard Aragones
Summary: Seasonal rhythms and photoperiod can influence metabolism and adipose tissue functionality. Supplementation with grape-seed proanthocyanidins extract (GSPE) has shown potential in preventing obesity-related alterations. In this study, GSPE supplementation was found to prevent excessive body weight gain and restore serum cholesterol and non-esterified fatty acids (NEFAs) concentrations depending on the photoperiod. GSPE also helped combat obesity-induced adipocyte hypertrophy and upregulated adiponectin mRNA levels. Overall, GSPE administration reduced the impact of obesity on adipose tissue depending on the photoperiod and type of adipose depots.
Article
Food Science & Technology
Elia Navarro-Masip, Francesca Manocchio, Romina M. M. Rodriguez, Francisca Isabel Bravo, Cristina Torres-Fuentes, Begona Muguerza, Gerard Aragones
Summary: Grape-seed proanthocyanidin extract (GSPE) affects the expression of metabolic markers in white adipose tissue (WAT) and brown adipose tissue (BAT) in a photoperiod-dependent manner.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Food Science & Technology
Elia Navarro-Masip, Francesca Manocchio, Marina Colom-Pellicer, Xavier Escote, Lisard Iglesias-Carres, Enrique Calvo, Francisca Bravo, Begona Muguerza, Yves Desjardins, Gerard Aragones
Summary: This study examines the seasonal effects of red grapes on metabolic markers of adipose tissue in healthy rats. The results show that consuming organic red grapes can increase energy expenditure and enhance UCP1 protein expression in brown adipose tissue. Furthermore, red grape consumption affects the gene expression profile of white adipose tissue, regulating browning markers and adipogenic/lipolytic markers in a photoperiod-dependent manner.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jorge R. Soliz-Rueda, Raul Lopez-Fernandez-Sobrino, Cristina Torres-Fuentes, Francisca I. Bravo, Manuel Suarez, Miquel Mulero, Begona Muguerza
Summary: Changes in light/dark cycles and obesogenic diets are related to the disruption of circadian rhythms and metabolic disorders. Grape seed flavanols have shown beneficial effects on metabolic diseases and recently a circadian system modulation has been suggested to mediate their health-enhancing properties.
Article
Biochemistry & Molecular Biology
Antonio J. Cortes-Espinar, Nestor Ibarz-Blanch, Jorge R. Soliz-Rueda, Enrique Calvo, Francisca Isabel Bravo, Miquel Mulero, Javier Avila-Roman
Summary: Disruptions of the light/dark cycle and unhealthy diets can lead to oxidative stress. Grape seed proanthocyanidin extract (GSPE) has antioxidant properties and has shown positive effects in regulating circadian disruptions. This study examined the impact of GSPE administration on the liver oxidant system of rats undergoing a sudden photoperiod shift. The results indicate that GSPE improved the antioxidant response under specific photoperiod conditions, suggesting its potential in treating circadian-related disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Diego Morales, Roger Gutierez-Pensado, Francisca Isabel Bravo, Begona Muguerza
Summary: This study aimed to obtain alternative kombucha drinks enriched in phenolic compounds and with a high antioxidant activity using fruits instead of tea leaves. Fruit-based kombuchas prepared with different fruits and microbial consortia were evaluated for their pH, carbohydrate, ethanol, phenolic levels, and in vitro antioxidant capacity during fermentation. The results showed that fruit-based kombuchas, especially the strawberry kombucha, had higher levels of phenolic compounds and exhibited high in vitro antioxidant activity.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
