Article
Biochemistry & Molecular Biology
Noura S. Dosoky, Prabodh Satyal, William N. Setzer
Summary: Citrus essential oils are commonly adulterated due to the lack of regulations or reliable authentication methods. This study developed and validated a sensitive UPLC-MS/MS method for quantifying 14 coumarins and furanocoumarins. The method was then used to analyze the essential oils of 12 different Citrus species. The results showed significant variations in coumarin and furanocoumarin levels among different crop varieties and origins within the same species. The study also revealed patterns in furanocoumarin profiles that aligned with known variations among Citrus ancestral taxa, but also detected unexpected compounds in certain Citrus species.
Article
Biochemical Research Methods
Hanting Yang, Qian Li
Summary: In this study, the antioxidant activity and components of Angelica dahurica were investigated using GC-MS and three antioxidant evaluation methods. The results showed that ultrasonic extraction with 80% methanol as the solvent was the optimal condition for extracting the antioxidant components. Isoimperatorin and byakangelicol were identified as the main antioxidant components in Angelica dahurica through spectrum-effect relationship analysis.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Plant Sciences
Lingrong Wen, Ting Zhou, Yueming Jiang, Liang Gong, Bao Yang
Summary: The study identified four prenylated phenolics in mulberry leaf, with moracin N demonstrating good neuroprotective activity by inhibiting oxidative stress through multiple mechanisms and enhancing antioxidant defense and regulation of iron death.
Article
Agricultural Engineering
Sonia Yahiaoui, Djamel-Edine Kati, Lamiaa M. A. Ali, Khaled El Cheikh, Alain Morere, Chantal Menut, Mostapha Bachir-bey, Nadir Bettache
Summary: The aim of this study was to evaluate the antioxidant, cytotoxicity, and anti-inflammatory activities of three cultivars of Ficus carica latex. The results showed that the latex of the ABR cultivar exhibited the highest antioxidant and anti-inflammatory activities, while the latex of the AGH cultivar had a strong inhibitory effect on alpha-glucosidase. The latex of the ELB cultivar had the lowest activity.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Chemistry, Applied
Jinle Xiang, Yuan Yuan, Lin Du, Youyang Zhang, Chunqiu Li, Trust Beta
Summary: Changes in phenolic profiles and antioxidant activity of three varieties of proso millet during germination were investigated. Germination significantly increased the total phenolic content (TPC) and total flavonoid content (TFC), with up to 8.66-fold and 116.18% increase, respectively. Different phenolic compounds, including feruloylquinic acid and N,N'-bis-(p-coumaroyl)-putrescine, were identified for the first time in proso millets during germination. Germinated proso millets exhibited higher antioxidant activity compared to ungerminated samples, suggesting that germination is an effective method for improving phenolic profiles and antioxidant capacity.
Review
Pharmacology & Pharmacy
Hui Zhao, Ya-Long Feng, Ming Wang, Jing-Jing Wang, Tian Liu, Jun Yu
Summary: Angelica dahurica root is a well-known edible medicinal herb in China. It contains numerous active compounds, including coumarins and volatile oils. Modern pharmacological studies have shown that the root of A. dahurica and its active components have various bioactivities, such as anti-inflammatory, anti-tumor, anti-oxidant, analgesic, and effects on the cardiovascular system and neuroprotection.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agricultural Engineering
Liangliang Han, Libo Zhang, Yuedong He, Lijing Liao, Junde Li, Sheng Xu, Yucheng Zhao, Xiaohong Bian, Yuanzheng Xia
Summary: As a popular medicinal plant, Angelica dahurica has garnered attention in herbal medicine due to its active compounds, furanocoumarins (FCs), which have antioxidant, anti-tumor, and anti-virus activities. However, the enzymes responsible for the biosynthesis of FCs have not been identified. This study screened six prenyltransferase-coding sequences and identified two C-PTs (AdPT1, 2) and one O-PT (AdPT3) that are involved in the conversion of different compounds. The study also conducted structural analysis and mutagenesis experiments, revealing important amino acids for the activity of AdPT1. This study provides insights into the biosynthetic pathways of FCs in A. dahurica for further evolutionary studies.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Applied
Ting Li, Mu Zhao, Jingjing Yang, Qingxin Chuai, Ali Raza, Ping Yang, Mingguang Yu, Die Hu, Tingting Zou, Huanlu Song
Summary: This study investigated the effect of boiling on the flavor of Angelica dahurica through molecular sensory methods. Key aroma-active compounds were identified and their correlation with sensory properties established. Major key aroma-active compounds in boiled liquid were linalool and (E)-2-nonenal, showing positive correlation with green and citrus flavors.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Food Science & Technology
Sulem Yali Granados-Balbuena, Ericka Santacruz-Juarez, Daniel Canseco-Gonzalez, Lucia Aztatzi-Rugerio, Lilia Sanchez-Minutti, Carolina Ramirez-Lopez, Erik Ocaranza-Sanchez
Summary: This study explores the potential of Dahlia pinnata flowers as a source of anthocyanins. The results show that these flowers have a proximate composition similar to other edible flowers and exhibit high antioxidant activity. Additionally, the anthocyanin profile of the flowers contains unique major anthocyanin components, providing opportunities for research in areas such as natural pigment stabilization, food additives, and antioxidants.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Food Science & Technology
Xinyue Pang, Yongshuai Jing, Pengyue Li, Xiaoyue Qiu, Yuguang Zheng, Qian Wang, Lanfang Wu
Summary: This study aimed to optimize the extraction conditions of Angelica dahurica polysaccharides (ADP), characterize its structure, and evaluate its antioxidant activity. The ultrasonic-assisted extraction (UAE) method was improved using the response surface method and the purified polysaccharides showed significant antioxidant activity.
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2022)
Article
Biochemistry & Molecular Biology
Dong Ryun Gu, Hyun Yang, Seong Cheol Kim, Youn-Hwan Hwang, Hyunil Ha
Summary: Angelica dahurica radix has traditional use in China and Korea for treating headaches, cold-damp pain, and skin diseases. This study found that the water extract of Angelica dahurica radix effectively inhibits osteoclast differentiation and alleviates bone loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Yihang Liu, Xiaopin Tan, Yiling Zhang, Fei Ling, Tianqiang Liu, Gaoxue Wang
Summary: The study found that isoimperatorin from Angelica dahurica showed significant efficacy in eradicating Gyrodactylus kobayashii in goldfish, reducing infection prevalence and intensity without causing significant toxicity to the host. Isoimperatorin damaged the tegument of G. kobayashii and disrupted its homeostasis, providing insufficient energy for the parasite, which led to promising anthelmintic effects.
Article
Biochemistry & Molecular Biology
Piotr Okinczyc, Jaroslaw Widelski, Jakub Szperlik, Magdalena Zuk, Tomasz Mroczek, Krystyna Skalicka-Wozniak, Zuriyadda Sakipova, Gabriela Widelska, Piotr Marek Kus
Summary: The study focused on profiling 19 different Eurasian propolis samples, mostly from countries like Russia, Kazakhstan, Kyrgyzstan, Poland, Ukraine, and Slovakia. These propolis samples exhibited significant contents of polyphenols and flavonoids, along with potent antiradical and reducing activities. Marker compounds were used to classify propolis samples into different types, with poplar, aspen-birch, and aspen-birch-poplar types identified. The antioxidant properties of propolis samples were correlated with flavonoids, total polyphenols, or other polyphenols besides flavonoids content, showing variable activity among different propolis types.
Article
Chemistry, Applied
Hong Duan, Wei Wang, Yongxiang Li, Ghulam Jilany Khan, Yuan Chen, Tianci Shen, Nina Bao, Jing Hua, Zhenglian Xue, Kefeng Zhai, Zhaojun Wei
Summary: The study identified 18 compounds in the stem of Premna microphylla Turcz., with 6 compounds being identified for the first time within this genus and plant. These compounds highlight the strong therapeutic potential of Premna microphylla Turcz. stem extract against oxidation-related diseases.
Article
Biochemistry & Molecular Biology
Xiao-dan Dong, Yi-ning Liu, Yan Zhao, An-jun Liu, Hai-yu Ji, Juan Yu
Summary: The novel Angelica dahurica polysaccharide (ADP) is an acidic polysaccharide containing various sugar components. In vivo experiments showed that ADP has anti-tumor effects by inhibiting tumor growth, increasing lymphocyte and NK cell activities, and modulating cytokine levels, indicating its potential application in functional foods.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Medicinal
Hong Yao, Shaowen Xie, Xiaoqian Ma, Junkai Liu, Hongyu Wu, Aijun Lin, Hequan Yao, Dahong Li, Shengtao Xu, Dong-Hua Yang, Zhe-Sheng Chen, Jinyi Xu
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Review
Chemistry, Medicinal
Yuxi Fang, Haonan Li, Bao Ji, Keguang Cheng, Bo Wu, Zhanlin Li, Chao Zheng, Huiming Hua, Dahong Li
Summary: Renieramycins, a member of tetrahydroisoquinoline family of marine natural products, show strong antitumor activities with potential for further drug development and innovation. Researches mainly focus on their pharmacological activities and structural modification for enhanced anti-proliferative effects. However, challenges in extraction and separation hinder their development.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Jian Qiao, Mingying Wang, Menghan Cui, Yuxi Fang, Haonan Li, Chao Zheng, Zhanlin Li, Yongnan Xu, Huiming Hua, Dahong Li
Summary: Nitroreductase catalyzes the conversion of nitro aromatic compounds to aromatic amines. Its upregulation in hypoxic tumor cells is directly related to the degree of hypoxia, making effective detection of nitroreductase important for cellular hypoxia studies, tumor diagnosis, and treatment. The latest advances in small-molecule fluorescent probes for nitroreductase detection and the development trends in this field were summarized in this review.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Review
Chemistry, Medicinal
Gang Gao, Yanbing Wang, Huiming Hua, Dahong Li, Chunlan Tang
Summary: Dolastatin 10 is a marine pentapeptide derived from the Indian Ocean mollusk Dolabella auricularia, which has shown significant potency in inducing apoptosis of tumor cells. It has been developed into commercial drugs for specific lymphomas and further research using ADCs has shown promising antitumor activity with enhanced targeting and reduced systemic toxicity.
Article
Chemistry, Medicinal
Shengtao Xu, Hong Yao, Yangyi Qiu, Manzhen Zhou, Dahong Li, Liang Wu, Dong-Hua Yang, Zhe-Sheng Chen, Jinyi Xu
Summary: The study identified a novel compound (7f) based on Evodiamine as a topoisomerase I inhibitor, showing potent antitumor activity against triple-negative breast cancer by inducing DNA damage and forming irreversible DNA-protein complexes.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Gang Xing, Dahong Li, Anthony Yiu-Ho Woo, Zhengxing Zhi, Lei Ji, Ruijuan Xing, Hailiang Lv, Bin He, Hui An, Haiyan Zhao, Bin Lin, Li Pan, Maosheng Cheng
Summary: Asthma patients in resource-poor countries face difficulties in accessing basic asthma medications, which are mostly inhalants. This study focuses on creating oral antiasthmatic drugs with high beta 2/beta 1-selectivity, potentially reducing treatment costs. Compound 1a was identified as the lead compound and showed remarkable beta 2-selectivity and good oral bioavailability. It holds great potential for drug development as an oral antiasthmatic agent.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Hongyu Wu, Hong Yao, Chen He, Yilin Jia, Zheying Zhu, Shengtao Xu, Dahong Li, Jinyi Xu
Summary: Molecular glues can induce protein aggregation to modulate biological functions. They have been used as protein degraders and play important roles in complex stabilization, interactome modulation, and transporter inhibition. Discovering and designing molecular glues systematically is important for drug discovery.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pharmacology & Pharmacy
Peilu Song, Fan Zhao, Dahong Li, Jiqiang Qu, Miao Yao, Yuan Su, Hanxun Wang, Miaomiao Zhou, Yujie Wang, Yinli Gao, Feng Li, Dongmei Zhao, Fengjiao Zhang, Yu Rao, Mingyu Xia, Haitao Li, Jian Wang, Maosheng Cheng
Summary: This study reports a novel series of compounds with high potential and specificity towards group II PAKs. Compound 55 exhibited excellent inhibitory activity, selectivity, and demonstrated superior anti-migratory and anti-invasive properties, as well as potent in vivo antitumor metastatic efficacy.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Medicinal
Huajian Zhu, Yuchen Tan, Chen He, Yang Liu, Yiping Duan, Wenjian Zhu, Tiandong Zheng, Dahong Li, Jinyi Xu, Dong-Hua Yang, Zhe-Sheng Chen, Shengtao Xu
Summary: A series of novel multifunctional vascular disrupting agents (VDAs) was designed and synthesized, among which compound TH-6 showed the most potent antiproliferative activity against a panel of cancer cell lines. TH-6 inhibited tubulin assembly and increased the acetylation level of HDAC substrate proteins, leading to effective tumor growth inhibition without apparent toxicity. Furthermore, TH-6 disrupted both the internal and peripheral tumor vasculatures, contributing to persistent tumor inhibitory effects. Therefore, TH-6 deserves further investigation for its potential as a new approach in clinical cancer therapy.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Chunyu Jiang, Mengyue Yang, Chunxue Zhao, Fangshen Liu, Hangao Yang, Zhanlin Li, Tong Han, Bin Lin, Dahong Li, Huiming Hua
Summary: Twenty one abietane diterpenes were isolated from Cephalotaxus oliveri Mast, including 7 undescribed diterpenoids named cephaloliverins A-G. Metaglyptin A exhibited the strongest cytotoxicity against three human tumor cell lines (MCF-7, HepG2, and A549) and further investigations were conducted on its effects on colony formation and apoptosis in HepG2 cells.
Article
Biochemistry & Molecular Biology
Chunyu Jiang, Fangshen Liu, Hangao Yang, Mengyue Yang, Zhanlin Li, Tong Han, Dahong Li, Huiming Hua
Summary: Plants of the Cephalotaxus genus, including Cephalotaxus oliveri, contain diverse and bioactive components. In this study, several undescribed flavonolignans and biflavonoids were isolated from C. oliveri, along with known compounds. The isolated compounds showed neuroprotective activity against H2O2-induced cell injury and umcephabiflovin B demonstrated the strongest effect.
Article
Biochemistry & Molecular Biology
Mingying Wang, Xiaoyuan Chen, Ying Qu, Qingyinglu Ma, Huaqi Pan, Haonan Li, Huiming Hua, Dahong Li
Summary: A total of 25 brefeldin A-isothiocyanate derivatives were synthesized and tested. Most derivatives showed selectivity between HeLa and L-02 cells. In particular, derivative 6 exhibited potent antiproliferative activity against HeLa cells with no cytotoxic effects on L-02 cells. Mechanism studies revealed that derivative 6 induced cell cycle arrest at G1 phase and apoptosis through the mitochondrial-dependent pathway.
Article
Chemistry, Multidisciplinary
Nianwei Wang, Yuxi Fang, Xuan Wang, Jiao Bai, Huiming Hua, Dahong Li
Summary: We developed a photoactivated H2S donor, Bhc-TCN-Ph, derived from 6-bromo-7-hydroxycoumarinmethyl thiocarbonate. COS is released upon 365nm light exposure, generating H2S and coumarin fluorescence for visualization. This process does not produce electrophilic by-products. In vitro evaluations demonstrate good cytochemical and cytocompatibility characteristics.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Chun-Xue Zhao, Hui Liu, Xin Zhang, Meng-Yue Yang, Yue-Tong Wang, Yi-Jia Xing, Jun-Xin Hua, Qin Zhang, Da-Hong Li, Jiao Bai, Yong-Kui Jing, Hui-Ming Hua
Summary: In this study, a range of new alkaloid compounds were isolated from Cephalotaxus fortunei, and their inhibitory effects on leukemia cells were evaluated in vitro.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Organic
Chunyu Jiang, Xiaojie Fan, Deli Zou, Zhanlin Li, Tong Han, Bin Lin, Huiming Hua, Dahong Li
Summary: Cephaloliverols A and B, two new meroterpenoids based on a sterol and an abietane diterpene, were isolated from the twigs and leaves of Cephatotaxus oliveri. Their structures were determined by spectroscopic analysis and quantum chemical calculation. The compounds and their precursors showed a dose-dependent decrease in NO production in LPS-stimulated RAW 264.7 macrophages.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
