Article
Biochemistry & Molecular Biology
Linfeng Mao, Weijie Yuan, Kaimei Cai, Chen Lai, Changhao Huang, Yi Xu, Shangwei Zhong, Chen Yang, Ran Wang, Pengwei Zeng, Heyuan Huang, Zhikang Chen, Zihua Chen
Summary: EphA2, YES1, and ANXA2 form a signaling axis that promotes gastric cancer invasion and metastasis. Overexpression of YES1 increases invasion and migration of gastric cancer cells, while knockdown of ANXA2 decreases these processes.
Article
Biochemistry & Molecular Biology
Wei Kang, Jinglin Zhang, Tingting Huang, Yuhang Zhou, Chi Chun Wong, Ronald C. K. Chan, Yujuan Dong, Feng Wu, Bin Zhang, William K. K. Wu, Michael W. Y. Chan, Alfred S. L. Cheng, Jun Yu, Nathalie Wong, Kwok Wai Lo, Ka Fai To
Summary: Aberrant activation of NOTCH3 has been linked to poor clinical outcomes in gastric cancer, partially attributed to the silencing of tumor suppressor miRNAs miR-491-5p and miR-875-5p. PHLDB2 was identified as a functional downstream modulator of NOTCH3 in gastric carcinogenesis, with positive correlation with NOTCH3 and negative correlation with miR-491-5p. The NOTCH3-PHLDB2-Akt cascade acts oncogenically in gastric carcinogenesis and may serve as a potential therapeutic target.
Article
Oncology
Chuntao Li, Bo Chen, Junxia Zhang, Jingxuan Yang, Muzi Guo, Yu Ren, Zhijun Zhou, Kar-Ming Fung, Min Li, Liyang Zhang, Zhixiong Liu
Summary: SEM1 is highly expressed in gliomas and correlated with malignant features and poor prognosis. SEM1 plays a critical role in the proliferation, apoptosis, invasion, and migration of glioma cells through regulating the PI3K-Akt pathway. The SEM1 malignant regulatory network shows significant importance for the prognosis and treatment of gliomas.
Article
Biotechnology & Applied Microbiology
Liang Ma, Yunshan Jiang, Ning Wu
Summary: This study revealed that lncRNA CCL2 regulates the proliferation, migration, and invasion of gastric cancer through the miR-128/PARP2 signaling pathway. These findings provide a potential new strategy for the treatment of gastric cancer.
Article
Food Science & Technology
Yu Kou, Rentao Zhu, Qidi Sun, Zhuoqun Li, Xuan Feng, Hairong Xu
Summary: This study found that Dioscin can inhibit the proliferation, invasion, and metastasis of gastric cancer by increasing the expression of Connexin 43 (Cx43) and suppressing the phosphorylation of the PI3K/Akt signaling pathway, thus inhibiting epithelial-mesenchymal transition (EMT).
FOOD SCIENCE & NUTRITION
(2023)
Article
Plant Sciences
Dan Qiao, Jian Xing, Yunxiao Duan, Shiyu Wang, Guangyuan Yao, Shengjun Zhang, Jingchun Jin, Zhenhua Lin, Liyan Chen, Yingshi Piao
Summary: Baicalein inhibits the progression of gastric cancer by regulating the miR-7/FAK/AKT signaling pathway, leading to the suppression of proliferation, metastasis, and angiogenesis in gastric cancer cells.
Article
Biochemistry & Molecular Biology
Junfeng Wang, Zhengwu Cheng, Dafei Dai, Hao Li, Xinyu Shao, Menglin Xu
Summary: Gastric cancer is a leading cause of cancer deaths worldwide. TYRO3 has been identified as a potential therapeutic target for GC as its expression is increased in GC tissues and is associated with poor prognosis, clinicopathological indicators, and the AKT-mTOR pathway. Functional assays showed that TYRO3 plays an oncogenic role by activating the AKT-mTOR pathway, and knocking down TYRO3 can inhibit tumor cell proliferation and migration. This study provides a theoretical basis for the potential association between TYRO3 and AKT-mTOR and offers a new strategy for GC-targeted therapy.
MOLECULAR CARCINOGENESIS
(2023)
Article
Biotechnology & Applied Microbiology
Zhen Zhai, Tianlong Mu, Lina Zhao, Yiliang Li, Dongsheng Zhu, Yanshu Pan
Summary: miR-181a-5p facilitates tumor progression by activating the PTEN/AKT signaling pathway through its regulation of NDRG2.
Article
Medicine, Research & Experimental
Chen Li, Xu Li
Summary: The research demonstrates that circPTEN can upregulate PTEN expression by binding with miR-4470 in CRC cells, and inhibit the phosphorylation of AKT by competitively binding with TRAF6, thus suppressing the proliferation, migration, and invasion of CRC cells while promoting apoptosis.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biotechnology & Applied Microbiology
Zhiguo Guo, Erbo Liang, Wei Li, Leilei Jiang, Fachao Zhi
Summary: EME1 is upregulated in both gastric cancer cells and clinically obtained tumors, and is strongly associated with the differentiation level of GC and lymph node metastasis. Knockdown of EME1 significantly suppresses the proliferative, migratory, and invasive abilities of GC cells while enhancing apoptotic cell death.
Article
Biotechnology & Applied Microbiology
Mingming Zhang, Yingheng Jiang
Summary: Gastric cancer is a highly prevalent and fatal malignancy worldwide. The study discovered that circular RNA circ-HN1 regulates cellular processes in gastric cancer. By acting as a sponge for miR-485-5p, circ-HN1 negatively regulates its expression in gastric cancer cells and targets GSK3A. Silencing the circ-HN1-miR-485-5p-GSK3A regulatory network inhibits gastric cancer cell proliferation, migration, and invasion.
Article
Biotechnology & Applied Microbiology
Xuehan Bi, Xiao Lv, Dajiang Liu, Hongtao Guo, Guang Yao, Lijuan Wang, Xiaolei Liang, Yongxiu Yang
Summary: METTL3 promotes the maturation of miR-126-5p through m6A modification, which in turn targets PTEN to activate the PI3K/Akt/mTOR pathway in ovarian cancer progression. This study provides potential targets for future ovarian cancer treatment and reveals tumorigenic mechanisms regulated by m6A modification.
CANCER GENE THERAPY
(2021)
Article
Cell Biology
Hui Li, Bingxin Guan, Sen Liu, Haiting Liu, Lin Song, Guohao Zhang, Ruinan Zhao, Chengjun Zhou, Peng Gao
Summary: Gastric cancer is a highly heterogeneous disease with poor prognosis. Protein tyrosine phosphatases, specifically PTPN14, play a vital role in gastric cancer by promoting cell proliferation, migration, and invasion.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Zhe Gong, Yanqiu Zhang, Yue Yang, Yanan Yang, Jieyun Zhang, Yixuan Wang, Liqin Zhao, Nuoya Yu, Zhenhua Wu, Weijian Guo
Summary: Long noncoding RNAs (lncRNAs) have been recently found to play a key role in various types of cancer. In this study, we identified a lncRNA LINC01094 that is associated with the metastasis of gastric cancer (GC) through next-generation sequencing. High expression of LINC01094 is linked to advanced T and N stages and poor prognosis in GC patients. We demonstrated that LINC01094 promotes the proliferation and metastasis of GC both in vitro and in vivo. Furthermore, we discovered that LINC01094 interacts with AZGP1, leading to downregulation of PTEN expression and activation of the AKT pathway.
Article
Oncology
Mengjie Wu, Yongfeng Ding, Nan Wu, Junjie Jiang, Yingying Huang, Fanyu Zhang, Haiyong Wang, Quan Zhou, Yan Yang, Wei Zhuo, Lisong Teng
Summary: The role of Follistatin-like protein 1 (FSTL1) in tumorigenesis and cancer progression is conflicting. Nevertheless, this study shows that FSTL1 is frequently upregulated in primary GC tissues and significantly correlated with the progression and poor prognosis of gastric cancer. FSTL1 contributes to GC proliferation, migration, and invasion by regulating the AKT signaling pathway.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)