Article
Biochemistry & Molecular Biology
Bu Wang, Xin Gu, Bao-Li Xiang, Jian-Qing Zhao, Chang-Hong Zhang, Pan-Deng Huang, Zhi-Hua Zhang
Summary: Emerging research has shown the anticancer potential of tanshinone IIA, a bioactive ingredient from the traditional Chinese herb Salvia miltiorrhiza. However, the molecular mechanism of sodium tanshinone IIA sulfonate (STS) in its antilung cancer effect is not well understood. This study aimed to investigate the roles of STS and elongation factor-2 kinase (eEF-2K) in regulating the proliferation, migration, and invasion of A549 cells, and explore the pathways involved. The findings suggest that STS suppressed the survival and proliferation of A549 cells in a time- and dose-dependent manner. Knockdown of eEF-2K and treatment with STS had synergistic effects in inhibiting proliferation, migration, and invasion of A549 cells. These effects were mediated by the inhibition of tissue transglutaminase (TG2), leading to attenuation of the extracellular signal-regulated kinase (ERK) pathway. Overall, the inhibition of eEF-2K in combination with STS treatment exerts anticancer effects on lung adenocarcinoma cells via the TG2/ERK signaling pathway, providing a potential therapeutic target for lung adenocarcinoma.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Review
Immunology
Wenting Li, Xiaobing Duan, Xingxing Chen, Meixiao Zhan, Haichuan Peng, Ya Meng, Xiaobin Li, Xian-Yang Li, Guofu Pang, Xiaohui Dou
Summary: Epstein-Barr virus (EBV) is the first tumor virus in humans, and nasopharyngeal carcinoma (NPC) accounts for 60% of new tumor cases caused by EBV worldwide annually. Over 90% of patients with undifferentiated NPC are infected with EBV. Immunotherapy has shown significant breakthroughs in the treatment of recurrent or metastatic NPC, providing a broad prospect for NPC immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Mei Lin, Xiao-Long Zhang, Xiong Zou, Rui You, Qi Yang, Xiong Zou, Kai Yu, You-Ping Liu, Ru-Hai Zou, Yi-Jun Hua, Pei-Yu Huang, Jin Wang, Qi Zhao, Xiao-Bing Jiang, Jun Tang, Yang-Kui Gu, Tao Yu, Gui-Ping He, Yu-Long Xie, Zhi-Qiang Wang, Ting Liu, Si-Yuan Chen, Zhi-Xiang Zuo, Ming-Yuan Chen
Summary: By sequencing samples from 26 nasopharyngeal carcinoma patients, it was found that NPC has a higher neoantigen load compared to other cancers. Neoantigen depletion was more severe in metastatic sites, with the reduction occurring during metastasis.
Review
Oncology
Wai Tong Ng, James C. H. Chow, Jonathan J. Beitler, June Corry, William Mendenhall, Anne W. M. Lee, K. Thomas Robbins, Sandra Nuyts, Nabil F. Saba, Robert Smee, William A. Stokes, Primoz Strojan, Alfio Ferlito
Summary: This article discusses the considerations, practical pearls, and recent advances in radiotherapy for nasopharyngeal carcinoma (NPC), emphasizing the importance of optimal radiotherapy planning and precise beam delivery for treatment efficacy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xue-Song Sun, Zhi-Wen Xiao, Sai-Lan Liu, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Hai-Qiang Mai
Summary: This study developed and validated a nomogram model to predict the overall survival of patients with nasopharyngeal carcinoma without distant metastasis. The model incorporates clinical characteristics, serum biomarkers, and the presence of nasopharyngeal necrosis.
EUROPEAN RADIOLOGY
(2023)
Review
Otorhinolaryngology
Yue Yuan, Fei Ye, Jian-Hui Wu, Xiao-Yan Fu, Zhong-Xi Huang, Tao Zhang
Summary: This paper reviews recent advances in early screening for nasopharyngeal carcinoma (NPC) and cell-free DNA (cfDNA) methylation, highlighting the low positive predictive value (PPV) of current screening methods and the potential of combining cfDNA methylation analysis with Epstein-Barr virus (EBV) serological testing to improve PPV.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Review
Medical Laboratory Technology
Yiwen Liu, Jianping Wen, Weiguo Huang
Summary: Exosomes play important roles in nasopharyngeal carcinoma by manipulating the tumor microenvironment, participating in chemotherapy and radiation resistance, inducing immune suppression, promoting pathological angiogenesis, and supporting metastasis. They have the potential to be diagnostic biomarkers but face technical challenges in large-scale applications.
CLINICA CHIMICA ACTA
(2021)
Article
Medicine, General & Internal
Tingdong Li, Fugui Li, Xiaoyi Guo, Congming Hong, Xia Yu, Biaohua Wu, Shifeng Lian, Liuwei Song, Jiabao Tang, Shunhua Wen, Kaimin Gao, Mengling Hao, Weimin Cheng, Yingying Su, Shiyin Zhang, Shoujie Huang, Mujin Fang, Yingbin Wang, Mun-Hon Ng, Honglin Chen, Wenxin Luo, Shengxiang Ge, Jun Zhang, Ningshao Xia, Mingfang Ji
Summary: This study designed a peptide library representing highly ranked B-cell epitopes of EBV coding sequences to identify novel serologic biomarkers for nasopharyngeal carcinoma. The results suggest that P85-Ab is a promising novel biomarker for nasopharyngeal carcinoma screening, with higher sensitivity, specificity, and positive predictive value than the standard two-antibody method.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Immunology
Xiaojing Yang, Hanru Ren, Zhen Li, Xue Peng, Jie Fu
Summary: This article summarizes the application of immunotherapy in NPC, with a focus on the use of immunotherapy and radiotherapy in the treatment of NPC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hesong Shen, Xiaoqian Yuan, Daihong Liu, Yuanying Huang, Yu Wang, Shixi Jiang, Jiuquan Zhang
Summary: The study aimed to determine the optimal kiloelectron volt of noise-optimized virtual monoenergetic images for visualizing nasopharyngeal carcinoma and nasopharyngeal lymphoma, and explore the clinical value of quantitative parameters derived from dual-energy computed tomography for distinguishing between the two entities. Results showed that 40 keV VMI (+) reconstruction was optimal for visualizing NPC and NPL, and quantitative parameters derived from DECT were helpful for differentiation between the two.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Review
Immunology
Huimei Huang, Shisheng Li, Qinglai Tang, Gangcai Zhu
Summary: Nasopharyngeal carcinoma (NPC) is a malignant tumor characterized by geographic distribution and EBV infection. Metabolic reprogramming in NPC cells may facilitate cancer progression and immunosuppression through cell-cell communications with surrounding immune cells. This review discusses dysregulated metabolism processes in NPC and the potential connections between reprogrammed metabolism, tumor immunity, and therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
De-Pei Yin, Huanle Zhang, Hua Teng, Dan Zhang, Peipei Chen, Lixiao Xie, Ji-Sheng Liu
Summary: The expression and potential functions of G alpha i1 in nasopharyngeal carcinoma (NPC) were investigated in this study. G alpha i1 was found to be overexpressed in NPC tissues and correlated with poor survival in some patients. Its inhibition suppressed viability, proliferation, cell cycle progression, migration, and induced apoptosis in NPC cells. Conversely, ectopic G alpha i1 expression promoted tumorigenic activity, cell proliferation, and migration. G alpha i1 was also important for Akt-mTOR activation in NPC cells. Zinc finger protein 384 (ZNF384) was identified as a potential transcription factor of G alpha i1. In vivo studies showed that G alpha i1 downregulation or knockout inhibited NPC xenograft growth. Overall, overexpression of G alpha i1 is pro-tumorigenic in NPC, possibly through Akt-mTOR activation.
CELL DEATH & DISEASE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zongqiong Sun, Shudong Hu, Yuxi Ge, Linfang Jin, Jianfeng Huang, Weiqiang Dou
Summary: The study demonstrated that ASL perfusion imaging showed high diagnostic efficiency in differentiating between NPC and NPL, improving the accuracy of diagnosing malignancies in the nasopharynx.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Oncology
Elizabeth Tadesse Beyene, Siraw Girum Ketema, Assaye Nibret Alebachew, Mizan Yeshanew Saleh, Tsigereda Atumo Gebremariam
Summary: Nasopharyngeal cancer predominantly affects males, with a high percentage of patients presenting at late stages. Nonkeratinizing carcinoma is the most prevalent histologic variant, with juvenile cases constituting a significant portion of the study group.
Review
Oncology
Fangrui Zhao, Dashuai Yang, Xiangpan Li
Summary: Nasopharyngeal carcinoma is a malignant tumor mainly found in East and Southeast Asia. Radical radiotherapy is the primary treatment for this type of cancer. However, interruptions in radiotherapy can lead to reduced effectiveness and potential tumor progression. This review examines the effects of radiotherapy interruption and explores possible measures to address this issue.
FRONTIERS IN ONCOLOGY
(2023)