Journal
ONCOTARGETS AND THERAPY
Volume 9, Issue -, Pages 6127-6135Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S87778
Keywords
miR-126; v-crk sarcoma virus CT10 oncogene homologue; prognosis; real-time quantitative polymerase chain reaction
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Background: MicroRNA (miR)- 126, acting as a tumor suppressor, has been reported to inhibit the invasion of gastric cancer cells in part by targeting v-crk sarcoma virus CT10 oncogene homologue (CRK). The aim of this study was to investigate the clinical significance of miR-126/CRK axis in gastric cancer. Methods: miR- 126 and CRK mRNA expression levels were detected by real-time quantitative reverse transcription polymerase chain reaction in 220 self-pairs of gastric cancer and adjacent noncancerous tissues. Results: Expression levels of miR- 126 and CRK mRNA in gastric cancer tissues were, respectively, lower and higher than those in adjacent noncancerous tissues (both P<0.001). Low miR- 126 expression and high CRK expression, alone or in combination, were all significantly associated with positive lymph node and distant metastases and advanced TNM stage of human gastric cancer (all P<0.05). We also found that the overall survival rates of the patients with low miR- 126 expression and high CRK expression were, respectively, shorter than those with high miR- 126 expression and low CRK expression. Interestingly, miR- 126-low/CRK-high expression was associated with a significantly worse overall survival of all miR- 126/CRK groups (P<0.001). Moreover, multivariate analysis identified miR- 126 and/or CRK expression as independent prognostic factors for patients with gastric cancer. Notably, the prognostic relevance of miR- 126 and/or CRK expression was more obvious in the subgroup of patients with TNM stage IV. Conclusion: Dysregulation of miR- 126/CRK axis may promote the malignant progression of human gastric cancer. miR- 126 and CRK combined expression may serve as an independent predictor of overall survival in patients with advanced gastric cancer.
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