HRMS using a Q-Exactive series mass spectrometer for regulated quantitative bioanalysis: how, when, and why to implement

Quantitation of a PEGylated protein in monkey serum by UHPLC-HRMS using a surrogate disulfide-containing peptide: A new approach to bioanalysis and in vivo stability evaluation of disulfide-rich protein therapeutics

(2016) Naiyu Zheng et al.   ANALYTICA CHIMICA ACTA

Differential Mobility Spectrometry Coupled with Multiple Ion Monitoring in Regulated LC-MS/MS Bioanalysis of a Therapeutic Cyclic Peptide in Human Plasma

(2016) Yunlin Fu et al.   ANALYTICAL CHEMISTRY

Validation of the Mass-Extraction-Window for Quantitative Methods Using Liquid Chromatography High Resolution Mass Spectrometry

(2016) Gaétan Glauser et al.   ANALYTICAL CHEMISTRY

Modify on the fly: triple quad to high resolution in support of a dermal clinical study requiring an ultra low LLOQ

(2016) Chester L Bowen et al.   Bioanalysis

Application of high-resolution MS for development of peptide and large-molecule drug candidates

(2016) John F Kellie et al.   Bioanalysis

Novel membrane devices and their potential utility in blood sample collection prior to analysis of dried plasma spots

(2015) Robert Sturm et al.   Bioanalysis

Strategy to Improve the Quantitative LC-MS Analysis of Molecular Ions Resistant to Gas-Phase Collision Induced Dissociation: Application to Disulfide-Rich Cyclic Peptides

(2014) Eugene Ciccimaro et al.   ANALYTICAL CHEMISTRY

Quantitative proteomics using the high resolution accurate mass capabilities of the quadrupole-orbitrap mass spectrometer

(2014) Sebastien Gallien et al.   Bioanalysis

Automated direct extraction and analysis of dried blood spots employing on-line SPE high-resolution accurate mass bioanalysis

(2014) Regina V Oliveira et al.   Bioanalysis

Application of high-resolution MS in the quantification of a therapeutic monoclonal antibody in human plasma

(2014) Kevork Mekhssian et al.   Bioanalysis

Quantification of ghrelin and des-acyl ghrelin in human plasma by using cubic-selected reaction-monitoring LCMS

(2014) Jonathan Sidibé et al.   Bioanalysis

Recognizing the potential benefits and pitfalls of high-resolution MS

(2013) J Larry Campbell et al.   Bioanalysis

Method development and validation of six bile acids for regulated bioanalysis: improving selectivity and sensitivity

(2013) Troy Voelker et al.   Bioanalysis

High-throughput bioanalysis of bile acids and their conjugates using UHPLC coupled to HRMS

(2013) Jie Ding et al.   Bioanalysis

Applications of high-resolution MS in bioanalysis

(2013) Mike-Qingtao Huang et al.   Bioanalysis

Performance assessment of microflow LC combined with high-resolution MS in bioanalysis

(2013) Hongxia Wang et al.   Bioanalysis

High-resolution MS in regulated bioanalysis: where are we now and where do we go from here?

(2013) Eliza N Fung et al.   Bioanalysis

High-resolution MS: first choice for peptide quantification?

(2013) Lieve Dillen et al.   Bioanalysis

Current applications of high-resolution mass spectrometry in drug metabolism studies

(2012) Markus R. Meyer et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Quantitative determination of atenolol in dried blood spot samples by LC–HRMS: A potential method for assessing medication adherence

(2012) Graham Lawson et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Quantification of acetaminophen and two of its metabolites in human plasma by ultra-high performance liquid chromatography–low and high resolution tandem mass spectrometry

(2012) David Tonoli et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Parallel Reaction Monitoring for High Resolution and High Mass Accuracy Quantitative, Targeted Proteomics

(2012) Amelia C. Peterson et al.   MOLECULAR & CELLULAR PROTEOMICS

Analysis and quantification of vitamin D metabolites in serum by ultra-performance liquid chromatography coupled to tandem mass spectrometry and high-resolution mass spectrometry - a method comparison and validation

(2012) Stephen J. Bruce et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Comparison of unit resolution SRM and TOF-MS at 12,000 mass resolution for quantitative bioanalysis of 11 steroids from human plasma

(2012) Timo Rousu et al.   Bioanalysis

Cassette incubation followed by bioanalysis using high-resolution MS for in vitro ADME screening assays

(2012) Jun Zhang et al.   Bioanalysis

Comparison of the quantification of a therapeutic protein using nominal and accurate mass MS/MS

(2012) Robert S Plumb et al.   Bioanalysis

High-throughput quantitation of large molecules using multiplexed chromatography and high-resolution/accurate mass LC–MS

(2012) Keeley Murphy et al.   Bioanalysis

Quantitation of polypeptides (glucagon and salmon calcitonin) in plasma samples by ‘high resolution’ on a triple quadrupole mass spectrometer

(2012) Yong-Xi Li et al.   Bioanalysis

Comparison of triple quadrupole and high-resolution TOF-MS for quantification of peptides

(2012) Lieve Dillen et al.   Bioanalysis

Utility of high-resolution accurate MS to eliminate interferences in the bioanalysis of ribavirin and its phosphate metabolites

(2012) Cong Wei et al.   Bioanalysis

Large molecule bioanalysis using Q-TOF without predigestion and its data processing challenges

(2012) Suma Ramagiri et al.   Bioanalysis

High-resolution mass spectrometry for integrated qualitative and quantitative analysis of pharmaceuticals in biological matrices

(2011) Gérard Hopfgartner et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Full-scan high resolution accurate mass spectrometry (HRMS) in regulated bioanalysis: LC–HRMS for the quantitation of prednisone and prednisolone in human plasma

(2011) Eliza N. Fung et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

It is time for a paradigm shift in drug discovery bioanalysis: from SRM to HRMS

(2011) Ragu Ramanathan et al.   JOURNAL OF MASS SPECTROMETRY

High-resolution mass spectrometry will dramatically change our drug-discovery bioanalysis procedures

(2011) Walter Korfmacher   Bioanalysis

Dried blood spots as a sampling technique for the quantitative determination of guanfacine in clinical studies

(2011) Yuanyuan Li et al.   Bioanalysis

Interpretation of Tandem Mass Spectra Obtained from Cyclic Nonribosomal Peptides

(2009) Wei-Ting Liu et al.   ANALYTICAL CHEMISTRY

Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry

(2009) Haiying Zhang et al.   JOURNAL OF MASS SPECTROMETRY

Quantitative-qualitative data acquisition using a benchtop orbitrap mass spectrometer

(2009) Kevin P. Bateman et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

LC-FAIMS-MS/MS for Quantification of a Peptide in Plasma and Evaluation of FAIMS Global Selectivity from Plasma Components

(2008) Yuan-Qing Xia et al.   ANALYTICAL CHEMISTRY