Article
Chemistry, Applied
Rafael Viteri, Ady Giordano, Gloria Montenegro, Flavia Zacconi
Summary: Eucryphia cordifolia, a native species from the Temperate Forest in southern Chile, is a crucial melliferous plant with high commercial value. Methanolic extracts from its branches showed excellent antioxidant and antibacterial activities, making them potentially valuable in the nutraceutical and phytopharmaceutical industry.
NATURAL PRODUCT RESEARCH
(2022)
Article
Agronomy
Jyoti Singh, Baskaran Stephen Inbaraj, Sawinder Kaur, Prasad Rasane, Vikas Nanda
Summary: This study assessed the bioactivity and physicochemical characteristics of dried corn silk powder, finding it to have high protein and ash contents, as well as high phenolic and flavonoid contents, leading to its strong antioxidant activity and thermal stability.
Article
Plant Sciences
Aminu Shehu Abubakar, Xiaoyu Huang, Ziggiju Mesenbet Birhanie, Gang Gao, Xinkang Feng, Chunming Yu, Ping Chen, Jikang Chen, Kunmei Chen, Xiaofei Wang, Aiguo Zhu
Summary: Apocynum hendersonii is a medicinal plant with potential health benefits due to its rich bioactive components. This study evaluated the reactivity and composition of different solvent extracts of A. hendersonii leaves. The extracts were found to contain important bioactive constituents such as phenols, flavonoids, and polysaccharides. Methanol extract showed the highest flavonoid content and antioxidant capacity, while ethanol extract exhibited the strongest antibacterial activity and inhibition of enzymes. Principal component analysis indicated a positive correlation between constituents, bioactivities, and extracts. These findings suggest that A. hendersonii can be a valuable natural source of antimicrobial and antioxidant compounds with potential applications in pharmaceutical and food industries.
Article
Multidisciplinary Sciences
Shimaa K. Ali, Sara M. Mahmoud, Samar S. El-Masry, Dalal Hussien M. Alkhalifah, Wael N. Hozzein, Moustafa A. Aboel-Ainin
Summary: This study analyzed the chemical composition and biological activities of Opuntia ficus-indica peel extracts. It found that the extracts have antioxidant, antimicrobial, and anticancer properties. Further research in animal models is needed to validate their pharmacological applications.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Plant Sciences
Wiem Mnafgui, Valeria Rizzo, Giuseppe Muratore, Hicham Hajlaoui, Amine Elleuch
Summary: This study evaluated the effects of lead on the morphological and phytochemical responses of fenugreek. It found that fenugreek can be used for lead phytoremediation and remains safe for consumption after lead treatments.
Article
Chemistry, Multidisciplinary
Huma Rao, Saeed Ahmad, Hanan Y. Aati, Abdul Basit, Imtiaz Ahmad, Bilal Ahmad Ghalloo, Muhammad Nadeem Shehzad, Rahat Nazar, Muhammad Zeeshan, Muhammad Jawad Nasim, Kashif ur Rehman Khan
Summary: This study evaluated the chemical composition and biological properties of Trigonella hamosa. The plant showed potential antioxidant, antimicrobial, and antidiabetic activities. GC-MS analysis was used to identify the chemical constituents of the plant.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Timothy M. Kegode, Joel L. Bargul, Hosea O. Mokaya, H. Michael G. Lattorff
Summary: This study aimed to investigate the chemical composition and bio-functional properties of Kenyan propolis. The results showed that the sampling region had a significant impact on the propolis's composition and functionality. The propolis contained abundant phytochemicals and exhibited antioxidant and antimicrobial activities. It was found that propolis collected from hotter climatic conditions had a higher phytochemical content and stronger antioxidant and antimicrobial activities.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Plant Sciences
Abinaya Manivannan, Prabhakaran Soundararajan, Yoo Gyeong Park, Byoung Ryong Jeong
Summary: The study investigates the effects of red and blue LED lights on growth, antioxidant properties, phytochemical contents, and protein expression in Scrophularia kakudensis during in vitro cultivation. Results show that LED treatments can enhance the growth, phytochemical contents, and antioxidant enzyme activities, while modulating protein expressions. The findings suggest that incorporating red or blue LED lights during in vitro propagation can be beneficial for improving the quality and medicinal values of S. kakudensis.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Tanawuth Tiranakwit, Wimonwan Puangpun, Kawintra Tamprasit, Natthapong Wichai, Sirithon Siriamornpun, Tarapong Srisongkram, Natthida Weerapreeyakul
Summary: The antioxidant activity of a traditional Thai formula and its individual plant components were studied. The formula showed high antioxidant activity, with the roots and stem of Caesalpinia digyna exhibiting the highest activity. The study also revealed a positive correlation between antioxidant activity and chemical constituents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agricultural Engineering
Ana Rita Silva, Manuel Ayuso, Carla Pereira, Maria Ines Dias, Marina Kostic, Ricardo C. Calhelha, Marina Sokovic, Pablo A. Garcia, Isabel C. F. R. Ferreira, Lillian Barros
Summary: This study investigated the phenolic profile and bioactive properties of the parasitic plant Cytinus hypocistis and its host Halimium lasianthum, revealing significant differences in composition and activities between the two species. C. hypocistis exhibited excellent antioxidant properties and effective cytotoxicity against tumor cells.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Multidisciplinary Sciences
Shaimaa G. Abdel Salam, Mohamed M. Rashed, Nabih A. Ibrahim, Emam A. Abdel Rahim, Tahany A. A. Aly, Ammar AL-Farga
Summary: The impact of household processes on fenugreek leaves and seeds was analyzed, and it was found that air-dried fenugreek leaves had high total phenolic and total flavonoid content, as well as strong antioxidant, antimicrobial, and anti-inflammatory properties. However, the in-vitro biological activities of processed seeds were significantly reduced.
SCIENTIFIC REPORTS
(2023)
Review
Plant Sciences
Sebastian Kanak, Barbara Krzeminska, Rafal Celinski, Magdalena Bakalczuk, Katarzyna Dos Santos Szewczyk
Summary: The genus Alchemilla is a rich source of secondary metabolites that exhibit a variety of biological activities. This review focuses on the phenolic compound composition and antioxidative activity of Alchemilla species. It highlights the importance of phytomedicine and natural products chemistry in protecting the human body.
Article
Horticulture
Clarissa Marcelle Naidoo, Yougasphree Naidoo, Yaser Hassan Dewir, Moganavelli Singh, Aliscia Nicole Daniels, Hassan El-Ramady
Summary: This study investigated the antioxidant potential of leaf, stem, and latex extracts of Tabernaemontana ventricosa and evaluated their cytotoxic activity in HEK293, HeLa, and MCF-7 cell lines. The results showed that all parts of T. ventricosa exhibited strong antioxidant activity, which correlated with cytotoxicity.
Article
Plant Sciences
Arpine Ayvazyan, Thomas Stegemann, Mayra Galarza Perez, Manuel Pramsohler, Serhat Sezai cicek
Summary: In this study, the phytochemical composition of blue fenugreek was analyzed using various analytical methods. The most dominant metabolites, fatty acid profile, and taste-relevant alpha-keto acids were determined. The study also identified the volatiles contributing to the aroma of blue fenugreek and discovered health-beneficial compounds. These findings provide an explanation for the characteristic aroma and health effects of blue fenugreek.
Article
Biochemistry & Molecular Biology
Anna Muzykiewicz-Szymanska, Anna Nowak, Dania Wira, Adam Klimowicz
Summary: This study analyzed the impact of different parameters on the antioxidant activity and compound content in coffee brewing process, showing that infusions from roasted beans had higher antioxidant activity and content. The hot brew method increased antioxidant activity, while cold brew method had higher caffeine content, and the phenolic compound content in infusions depended on the roasting process.
Article
Chemistry, Multidisciplinary
Mohammed Hawash, Mohammad Qneibi, Nidal Jaradat, Murad Abualhasan, Johnny Amer, EL-Hamouz Amer, Tasneem Ibraheem, Siham Hindieh, Sama Tarazi, Shorooq Sobuh
Summary: Water pipe smoking is prevalent in developing countries, where tobacco smoking is a leading factor in increased cancer risk. A novel filtration system using silica was found to be more effective than traditional water filtration, with lower toxicity impacts on normal and cancer cells.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nidal Jaradat, Samer Abdallah, Nawaf Al-Maharik, Mohammad Altamimi, Mohammed Hawash, Mohammad Qneibi, Abeer Abu Khair, Anaal Zetawi, Leena Jabarin
Summary: This study found that the essential oils of Salvia fruticosa have antibacterial and cytotoxic effects, and can inhibit the migration of cancer cells.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Agricultural Engineering
Nidal Jaradat, Mohammad Qneibi, Mohammed Hawash, Nawaf Al-Maharik, Mohammad Qadi, Murad N. Abualhasan, Ola Ayesh, Jamila Bsharat, Malak Khadir, Roaa Morshed, Saja Yaaqbeh, Shaima'a Marei, Shahed Hamayel, Ahmed Mousa, Maysa Daqqa, Sosana Bdir
Summary: Artemisia arborescens essential oil from Bethlehem and Jenin regions in Palestine exhibit antimicrobial and cytotoxic effects, different COX enzyme inhibitory activities, and significant influences on neuronal receptors. The essential oils may have therapeutic potential in preventing and treating pathogenic infections, cancers, inflammations, and neurodegenerative diseases.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Nawaf Al-Maharik, Nidal Jaradat, Najlaa Bassalat, Mohammed Hawash, Hilal Zaid
Summary: The chemical constituents of the flavonoids fraction from Mandragora autumnalis ripe fruit were isolated and identified, and its effects on scavenging free radicals, inhibiting enzymes, cytotoxicity, antimicrobial activity, and antidiabetic activity were evaluated. The results showed that the flavonoids from Mandragora autumnalis have potential medicinal properties for the treatment of various ailments.
Article
Biochemistry & Molecular Biology
Nawaf Al-Maharik, Nidal Jaradat
Summary: Satureja nabateorum is a perennial herb found in the mountains of Jordan and Palestine. Its essential oil exhibits antibacterial, antioxidant, and antifungal activities, indicating potential applications.
Article
Biochemistry & Molecular Biology
Nidal Jaradat, Mohammed Hawash, Mohammad Qadi, Murad Abualhasan, Aseel Odetallah, Ghfran Qasim, Reem Awayssa, Amna Akkawi, Ibtesam Abdullah, Nawaf Al-Maharik
Summary: Pelargonium graveolens leaves are widely used in traditional medicine and food industry. This study comprehensively investigated the chemical and pharmacological properties of P. graveolens essential oil from Palestine, showing strong antioxidant, antimicrobial, and cytotoxic activities, as well as inhibitory effects on metabolic enzymes. The results highlight the medicinal potential of this plant.
Article
Integrative & Complementary Medicine
Abdalsalam Kmail, Nidal Jaradat, Bayan Mansour, Ruhuf Abu-Labdeh, Sondos Zakarneh, Sawsan Abu-Farha, Fatima Hussein, Linda Issa, Bashar Saad
Summary: The plant extracts of Arum palaestinum, Ocimum basilicum, and Trigonella foenum-graecum demonstrated anti-inflammatory effects by suppressing the production of pro-inflammatory mediators while enhancing the production of anti-inflammatory cytokine. Additionally, these extracts exhibited concentration-dependent inhibition of macrophage growth.
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Integrative & Complementary Medicine
Reem Sbieh, Saad Al-Lahham, Nidal Jaradat
Summary: This study investigated the antioxidant, antimicrobial, and cytotoxic properties of Chiliadenus iphinoides collected from Jenin, Palestine for the first time. The results showed that acetone and hexane extracts had strong anti-proliferative effects mediated via apoptosis. Acetone, hexane, and methanol extracts exhibited broad-spectrum antimicrobial effects. Acetone, aqueous, and methanol extracts showed strong antioxidant effects. Interestingly, the aqueous extract could serve as a potential safe source of antioxidant agents and natural preservatives.
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Naseef Hani, Nawaf Al-Maharik, Abdullah K. Rabba, Majid Sharifi-Rad, Mohammed Hawash, Nidal Jaradat
Summary: This study identified the chemical constituents of Lavandula coronopifolia (LC) aerial parts volatile oil (VO) from Palestine and demonstrated its potent bactericidal, anti-inflammatory, and cytotoxic effects. The results suggest that LC-VO is a promising alternative for treating various infectious diseases, cancer, and chronic inflammation.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Polymer Science
Ahmad M. Eid, Hani Naseef, Nidal Jaradat, Lina Ghanim, Roaa Moqadeh, Miasar Yaseen
Summary: The study aimed to create a BPO nanoemulgel formulation to enhance its antibacterial properties. The formulation was prepared by combining BPO nanoemulsion with Carbopol hydrogel, and its solubility was tested in different oils and surfactants. The results showed that the nanoemulgel formulation had better antimicrobial activity against bacteria and acne compared to the market product. In conclusion, nanoemulgel is a promising approach for delivering BPO as it improves drug stability and antibacterial efficacy.
Article
Biochemistry & Molecular Biology
Nidal Jaradat
Summary: This study investigated the effects of different extraction methods on the yield, phytochemical constituents, and antifungal activity of Cymbopogon flexuosus aromatic oil. The results showed that steam distillation and microwave-ultrasonic methods are promising processes for extracting C. flexuosus aromatic oil with potent antifungal effects.
Article
Biochemistry & Molecular Biology
Mohammed Hawash, Derar Al-Smadi, Anil Kumar, Barbara Olech, Paulina Maria Dominiak, Nidal Jaradat, Sarah Antari, Sarah Mohammed, Ala'a Nasasrh, Murad Abualhasan, Ahmed Musa, Shorooq Suboh, Irfan Capan, Mohammad Qneibi, Hiba Natsheh
Summary: In this study, benzodioxol carboxamide derivatives were synthesized and their potential as antidiabetic agents was investigated. Compounds IIa and IIc showed potent inhibition against alpha-amylase in vitro, with negligible effects on normal cells, indicating their safety. Compound IId exhibited significant activity against multiple cancer cell lines. In vivo experiments demonstrated that compound IIc effectively lowered blood glucose levels in mice. These findings highlight the potential of benzodioxol derivatives as candidates for the development of synthetic antidiabetic drugs.
Article
Chemistry, Multidisciplinary
Mohammed Hawash, Nidal Jaradat, Rozan Sabobeh, Murad Abualhasan, Mohammed T. Qaoud
Summary: The aim of this research was to develop and evaluate a new series of thiazolecarboxamide derivatives for their effects on cyclooxygenase (COX) suppression and anticancer activity. The compounds were characterized using various analysis methods and their selectivity towards COX-1 and COX-2 was assessed. Cytotoxicity and molecular docking studies were also conducted to determine the potential binding patterns and anticancer activity. The results showed promising COX suppressor and anticancer properties for certain compounds, with low cytotoxicity against normal cell lines.
Article
Plant Sciences
Nidal Jaradat, Nawaf Al-Maharik, Mohammed Hawash, Mohammad Qadi, Linda Issa, Rashad Anaya, Ayham Daraghmeh, Lobna Hijleh, Tasneem Daraghmeh, Amal Alyat, Ro'a Aboturabi
Summary: This study analyzed the chemical composition of Eucalyptus camaldulensis essential oil and evaluated its antioxidant, anti-obesity, anti-diabetic, and antimicrobial properties. The results showed that the essential oil exhibited strong antimicrobial effects against several microorganisms, including methicillin-resistant Staphylococcus aureus (MRSA) and Candida albicans.
Article
Multidisciplinary Sciences
Malik Alqub, Nidal Jaradat, Mohammed Hawash, Mohammad Qadi, Nihad Al-Othman, Amal Bani Fadel, Hend Bsharat, Lama Tabooq, Marah Bani Fadel, Fatima Hussein, Linda Issa, Abdulraziq Zarour
Summary: This study characterized the phytoconstituents of the hydrophilic and lipophilic extracts of Chiliadenus sericeus subsp. virescens (CVS) and evaluated their antimicrobial, antioxidant, antidiabetic, and antiproliferative capabilities. The hydrophilic extract showed potent antimicrobial activity against Methicillin-resistant Staphylococcus aureus (MRSA) strains, surpassing the effectiveness of the antibiotic ciprofloxacin. The lipophilic extract exhibited cytotoxic effects on all cancer cells tested. These findings suggest that CVS extracts have potential as alternative synthetic drugs for treating oxidative stress-induced illnesses, diabetes, microbial infections, and cancer.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2023)
