Article
Polymer Science
Beatriz Guitton Renaud Baptista de Oliveira, Bianca Campos Oliveira, Gabriela Deutsch, Fernanda Soares Pessanha, Rossana Mara da Silva Moreira Thire, Selma Rodrigues de Castilho
Summary: The aim of this study was to evaluate the healing process of chronic wounds treated with carboxymethylcellulose loaded with recombinant human epidermal growth factor in patients with diabetes. The results showed that the use of epidermal growth factor was effective in treating chronic wounds, especially diabetic ulcers, resulting in a reduction in wound area and improvement in tissue and exudate quality.
Review
Dermatology
Yukie Kataoka, Mao Kunimitsu, Gojiro Nakagami, Sofoklis Koudounas, Carolina D. Weller, Hiromi Sanada
Summary: Chronic wounds are difficult to heal wounds caused by disrupted wound healing mechanisms, which have a high risk of infection and biofilm formation. Ultrasonic debridement has been introduced as a new method to decrease infection and promote healing of chronic wounds. Studies indicate that both non-contact and direct contact ultrasonic debridement devices have positive effects on wound healing by reducing biofilm formation or bacterial load. Further research on ultrasonic debridement in chronic wounds is needed to establish optimal settings and improve outcomes.
INTERNATIONAL WOUND JOURNAL
(2021)
Review
Nutrition & Dietetics
Nada Bechara, Jenny E. Gunton, Victoria Flood, Tien-Ming Hng, Clare McGloin
Summary: The review found a correlation between poor nutritional status and the presence of foot ulceration or a delay in healing in diabetes. However, it is still unknown whether the relationships are causal or only association. Further research is needed to determine if any forms of nutritional supplementation can improve foot ulcer healing.
Review
Medicine, General & Internal
Gisele Abreu Coelho, Philippe-Henri Secretan, Lionel Tortolano, Loic Charvet, Najet Yagoubi
Summary: This review aims to identify and discuss the different stages of chronic wound progression, focusing on the changes in the biochemical composition of the wound microenvironment, particularly in venous leg ulcers (VLUs). It provides detailed information about the pathophysiology of venous ulcers and reviews the known changes in the VLU microenvironment as the VLU evolves. Additionally, it discusses simulating conditions for VLU and highlights potentially relevant simulating media to assess the biological safety of medical devices intended to be in contact with these wounds.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dermatology
John P. McQuilling, Marissa J. Carter, Judith A. Fulton, Keyur Patel, Bryan Doner, Thomas E. Serena, Katie C. Mowry
Summary: Amniotic tissues have been used to treat chronic wounds, but few studies have evaluated how the wound microenvironment responds to these therapies. This study found that wounds treated with hypothermically stored amniotic membrane (HSAM) achieved significant reduction in size and re-epithelialization. Proteomic analysis showed specific protein level changes in wounds on a healing trajectory.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Medicine, General & Internal
Youn Hwan Kim, Hyung Sup Shim, Jihye Lee, Sang Wha Kim
Summary: The study compared the wound size reduction rate between patients receiving paste-type ADM and standard wound care over a 12-week period, showing significantly greater reduction rates in the ADM group, with most wounds achieving healing successfully.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Nicole Lafontaine, Jane Jolley, Mervyn Kyi, Sophie King, Laura Iacobaccio, Eva Staunton, Brent Wilson, Catherine Seymour, Sonja Rogasch, Paul Wraight
Summary: This study aimed to assess whether silver dressings in acute diabetes-related foot ulcers increased the proportion of ulcers healed. The results showed that silver dressings did not improve wound healing or reduce the need for antibiotics compared with non-silver dressings.
Review
Biochemistry & Molecular Biology
Mazlan Zawani, Mh Busra Fauzi
Summary: This paper reviews the use of injectable hydrogel as a polymer-based solution for diabetic foot ulcers, focusing on factors such as the socioeconomic burden of chronic wounds, biomaterials recommended by government, commercial hydrogel products, mechanism of injectable hydrogel, current research progress on novel injectable hydrogel, and future perspectives in DFU management.
Review
Emergency Medicine
Xuerong Wei, Minxiong Li, Zijun Zheng, Jun Ma, Yanbin Gao, Lianglong Chen, Yujie Peng, Shengxiang Yu, Lei Yang
Summary: Cellular senescence plays a crucial role in chronic wounds, and novel strategies targeting senescence can be applied for their treatment.
Article
Dermatology
Fran Game, Katie Gray, Daniel Davis, Rachelle Sherman, Kamal Chokkalingam, Zak Connan, Apostolos Fakis, Michael Jones
Summary: Recent reviews indicate that amniotic membrane products could potentially aid in the accelerated healing of diabetic foot ulcers. A pilot trial testing the addition of dried human amniotic membrane (dHAM) to standard care for diabetic foot ulcers showed promising results, with a higher healing rate and percentage wound area reduction in the dHAM group compared to standard care group. This suggests that dHAM preparation may be a safe and effective treatment option for diabetic foot ulcers.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Plant Sciences
Jialing Zou, Yanjuan Duan, Yi Wang, Aijun Liu, Yuanran Chen, Dongjie Guo, Wanjun Guo, Shuang Li, Zhou Su, Yang Wu, Hanzhi Lu, Yu Deng, Jianyong Zhu, Fulun Li
Summary: The study found that phellopterin has anti-inflammatory effects and promotes diabetic wound healing by attenuating chronic inflammation and promoting re-epithelialization. The potential mechanism of action is through upregulation of SIRT1 protein and downregulation of ICAM-1 protein.
Article
Biochemistry & Molecular Biology
Iveta Schmiedova, Alena Dembickaja, Ludmila Kiselakova, Beata Nowakova, Petr Slama
Summary: Amniotic membrane grafts have shown great therapeutic potential for wounds healing, with a treatment efficacy of 86% to 90% as indicated by the investigated data from publications and posters.
Review
Nanoscience & Nanotechnology
Jia-Ying Ji, Dan-Yang Ren, Ying-Zheng Weng
Summary: This review article discusses the recent developments and innovations of antibacterial hydrogels for diabetic chronic wound healing.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Nursing
Steven Smet, Sebastian Probst, Samantha Holloway, Anika Fourie, Hilde Beele, Dimitri Beeckman
Summary: This systematic review systematically identified assessment tools for chronic wounds and investigated their measurement properties. The review provided summaries of the data for each assessment tool, offering insights into the quality of evidence supporting their validity and reliability.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2021)
Article
Biochemistry & Molecular Biology
Matteo Giovarelli, Anais Serati, Silvia Zecchini, Fabiola Guelfi, Emilio Clementi, Chiara Mando
Summary: High-resolution respirometry (HRR) can provide valuable insights for clinical research and comparative medical studies. Long-term storage protocols for biopsies are needed to preserve mitochondrial activity. This study optimized a cryopreservation protocol for human placenta biopsies, which showed comparable oxygen consumption rate measurements between fresh and cryopreserved specimens.
MOLECULAR MEDICINE
(2023)