Article
Pharmacology & Pharmacy
L. Pkhaladze, M. Russo, V Unfer, M. Nordio, S. Basciani, A. Khomasuridze
Summary: The study showed that myo-Inositol treatment significantly reduced weight and BMI in lean teenagers with PCOS aged 13-16, while in older teenagers aged 17-19, myo-Inositol treatment in combination with OCP prevented weight and BMI increases, improved metabolic profiles, and ameliorated hormonal parameters. These results suggest that myo-Inositol may play an important role in the management of PCOS and could be a novel and effective treatment option for adolescents with this syndrome.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Vittorio Unfer, Michele Russo, Cesare Aragona, Gabriele Bilotta, Mario Montanino Oliva, Mariano Bizzarri
Summary: This study aimed to investigate the effects of myo-Inositol treatment on different phenotypes of polycystic ovary syndrome (PCOS). Through a retrospective study, it was found that myo-Inositol significantly improved metabolic and endocrine parameters in patients with hyperandrogenic PCOS, but had negligible effects on patients with non-hyperandrogenic PCOS.
Review
Chemistry, Medicinal
Riccardo Gambioli, Gianpiero Forte, Giovanni Buzzaccarini, Vittorio Unfer, Antonio Simone Lagana
Summary: Pregnancy is a complex process, and myo-inositol may have positive effects on fertility and preventing pregnancy-related pathologies, with potential therapeutic benefits.
Article
Biochemistry & Molecular Biology
Maryam Tabatabaie, Sadegh Amiri, Masoumeh Golestan Jahromi, Azadeh Akbari Sene, Zahra Zandieh, Mehdi Mehdizadeh, Fatemehsadat Amjadi
Summary: This study investigates the effect of Myo-Inositol as an adjuvant on oocyte maturation, fertilization rate, embryo quality, and ovarian steroidogenesis in cumulus cells of PCOS patients. The results suggest that Myo-Inositol has a positive impact in improving oocyte maturation, fertilization rate, and embryo quality in PCOS patients. Gene expression analysis reveals significant differences in gene expressions between different treatment groups. The study also highlights the phosphorylation levels of ERK1/2 and p-Akt as potential molecular mechanisms underlying the observed effects.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Pharmacology & Pharmacy
Yu-Hong Xie, Ling Wang, Ming-Liang Li, Zhi-Cheng Gong, Jie Du
Summary: Exogenous myo-inositol can reduce excessive apoptosis in cisplatin-induced acute kidney injury (AKI), indicating its protective role in AKI.
Article
Obstetrics & Gynecology
Hardik Jethaliya, Nirva Gajjar, Vrushank Patel, Shrikalp Deshpande, Roshni Patel
Summary: This meta-analysis study found that myo-inositol treatment does not significantly improve anthropometric, metabolic, and endocrine outcomes in patients with polycystic ovary syndrome (PCOS), except for slight improvements in androstenedione and prolactin levels.
REPRODUCTIVE SCIENCES
(2022)
Review
Pharmacology & Pharmacy
M. Azizi Kutenaei, S. Hosseini Teshnizi, P. Ghaemmaghami, F. Eini, N. Roozbeh
Summary: Comparison study found that myo-inositol may improve fertility outcomes by modulating hyperandrogenism in patients with PCOS. Randomized trials are needed to understand the specific mechanisms of myo-inositol compared to metformin in terms of fertility outcomes.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
T. Cantelmi, E. Lambiase, V. R. Unfer, R. Gambioli, V Unfer
Summary: PCOS women are more likely to develop psychological symptoms, such as depression or anxiety, with several risk factors associated. Inositol is considered a safe and effective approach for hormonal improvement and potential effects in psychiatry, making it a first-line therapy for PCOS women.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tomasz Antonowski, Adam Osowski, Damian Szczesny, Joanna Szablinska-Piernik, Jerzy Juskiewicz, Leslaw Lahuta, Andrzej Rynkiewicz, Joanna Wojtkiewicz
Summary: This study investigated the concentration change of myo-inositol solution in the serum of Wistar rats after oral administration. The results showed that the myo-inositol concentration reached its peak in the first hour and then rapidly declined. However, even after 24 hours, the concentration remained higher than before administration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Public, Environmental & Occupational Health
Philippe Merviel, Pandora James, Sarah Bouee, Mathilde Le Guillou, Camille Rince, Charlotte Nachtergaele, Veronique Kerlan
Summary: Myo-inositol is effective in normalizing ovarian function and improving oocyte and embryo quality in PCOS patients undergoing assisted reproductive technologies, but further large multicentre randomized controlled trials are needed to assess its impact on clinical pregnancy and live birth rates in ART.
REPRODUCTIVE HEALTH
(2021)
Article
Green & Sustainable Science & Technology
Tengsheng Qiao, Yongteng Zhao, Benyong Han, Tao Li, Peng Zhao, Jun-Wei Xu, Li Huang, Xuya Yu
Summary: MI treatment significantly enhanced lipid production and nutrients removal of Monoraphidium sp. QLY-1 from molasses wastewater, by regulating key lipogenic genes expression and enhancing phytohormones contents.
Article
Fisheries
Wei-Dan Jiang, Shuang-An Li, Hai-Feng Mi, Lu Zhang, Lin Feng, Pei Wu, Yang Liu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Cheng-Bo Zhong, Xiao-Qiu Zhou
Summary: The study showed that optimal intake of myo-inositol decreased oxidative stress, inhibited cell apoptosis, promoted cell proliferation, and maintained intercellular structural integrity in the gills of grass carp, possibly through various signaling pathways. The calculated optimal myo-inositol intake for grass carp was 285.8 and 305.4 mg/kg diet, respectively.
Article
Pharmacology & Pharmacy
P. G. Artini, E. Malacarne, V Tomatis, A. D. Genazzani
Summary: PCOS is an endocrine disorder affecting 8-10% of women of reproductive age, characterized by insulin resistance. Inositols have shown positive effects on the metabolic and hormonal profiles of PCOS patients, improving fertility outcomes.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Andrew F. Paquettea, Beatrice E. Carbone, Seth Vogel, Erica Israel, Sarah D. Maria, Nikita P. Patil, Saroj Sah, Dhrubajyoti Chowdhury, Ilona Kondratiuk, Beau Labhart, Ardythe L. Morrow, Shay C. Phillips, Chenzhong Kuang, Dirk Hondmann, Neeraj Pandey, Thomas Biederer
Summary: By analyzing human milk samples from different populations, we found that the carbocyclic sugar myo-inositol promotes brain development. Myo-inositol is most abundant during early lactation when neuronal connections rapidly form in infants. It enhances synapse abundance in human excitatory neurons and cultured rat neurons in a dose-dependent manner by improving their ability to respond to transsynaptic interactions. In mice, dietary supplementation of myo-inositol increases the size of excitatory postsynaptic sites in the developing cortex. Moreover, myo-inositol is bioactive in mature brain tissue, as it increases the number and size of postsynaptic specializations and excitatory synapse density in organotypic slices. This study advances our understanding of the role of human milk in infant brain development and identifies myo-inositol as a component that promotes the formation of neuronal connections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Multidisciplinary
Haonan Cao, Tianyun Guo, Xuemei Deng, Xing Huo, Shouchu Tang, Jian Liu, Xiaolei Wang
Summary: Selective photoredox reactions allow direct alkylation of unprotected myo-inositol at C4, offering a possibility for selective C-H alkylations without the need for multi-step protection-deprotection strategies.
CHEMICAL COMMUNICATIONS
(2022)