Article
Endocrinology & Metabolism
Celso E. Gomez-Sanchez, Desmare van Rooyen, William E. Rainey, Kazutaka Nanba, Amy R. Blinder, Radhakrishna Baliga
Summary: Aldosterone-producing adenoma is a rare cause of hypertension in children. This study describes a novel somatic KCNJ5 p.I157S mutation in an aldosterone-producing adenoma from a 16-year-old black female. Prompt diagnosis and early identification of gene mutations can lead to appropriate therapy and reduce cardiovascular sequelae.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Martina Tetti, Siyuan Gong, Franco Veglio, Martin Reincke, Tracy Ann Williams
Summary: Primary aldosteronism is the most common surgically curable form of hypertension. Recent advances in our understanding of the disease have focused on the underlying genetic variants that cause excess aldosterone production. The mechanisms of increased adrenal cortex mass are still not well understood, but the application of transcriptomics, metabolomics, and epigenetics has provided valuable insights.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Peripheral Vascular Disease
Ute Scholl
Summary: Primary aldosteronism is the most common cause of secondary hypertension, largely due to genetic mutations in ion channels and pumps. Somatic mutations are responsible for sporadic cases, while germline mutations cause familial hyperaldosteronism.
Article
Endocrinology & Metabolism
Eleftheria Gkaniatsa, Augustinas Sakinis, Magnus Palmer, Andreas Muth, Penelope Trimpou, Oskar Ragnarsson
Summary: The study found that imaging studies inaccurately predicted laterality in a significant number of young patients with PA. In contrast to current clinical guidelines, the results support the use of AVS for subtype evaluation in young adults with PA, including patients 35 years or younger.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Fatin Athirah Pauzi, Elena Aisha Azizan
Summary: Primary aldosteronism is a common curable form of secondary hypertension, often caused by the overproduction of aldosterone in the adrenal glands. The detection of aldosterone synthase through immunohistochemistry can identify aldosterone-producing cell clusters, potentially contributing to hyperaldosteronism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Peripheral Vascular Disease
Elle van de Wiel, Amir-Hossein Chaman Baz, Benno Kuesters, Kuniaki Mukai, Lidia van Bonzel, Merijn van Erp, Jaap Deinum, Johan Langenhuijsen
Summary: Based on the research on human ZG, we found that there is a correlation between age and CYP11B2 expression. As age increases, the relative CYP11B2 expressing area decreases, continuity decreases, gap length and CYP11B2 depth increase. These changes may indicate the involution of ZG and the formation of aldosterone-producing micronodules, and they occur bilaterally.
Article
Peripheral Vascular Disease
Lucie S. Meyer, Laura Handgriff, Jung Soo Lim, Aaron M. Udager, Isabella-Sabrina Kinker, Roland Ladurner, Moritz Wildgruber, Thomas Knoesel, Martin Bidlingmaier, William E. Rainey, Martin Reincke, Tracy Ann Williams
Summary: In surgically treated patients with unilateral primary aldosteronism, there are differences in histopathology, genotype, and postsurgical outcomes between classical and nonclassical groups. Patients with nonclassical histopathology have a higher incidence of postsurgical disease persistence and increased aldosterone production from the unresected gland.
Article
Endocrinology & Metabolism
Carmina Teresa Fuss, Katharina Brohm, Martin Fassnacht, Matthias Kroiss, Stefanie Hahner
Summary: Postural stimulation testing (PST) is a simple and noninvasive method for differentiating between unilateral and bilateral primary aldosteronism (PA). A study showed that when the aldosterone plasma concentration decreased by at least 28% after 4 hours in the upright position, PST had a specificity of 100% for identifying unilateral disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Linghui Kong, Jin Zhang, Lei Dong, Jianzhong Xu, Ping-Jin Gao, Ji-Guang Wang, Limin Zhu
Summary: This case report describes a 29-year-old female patient who underwent complete adrenalectomy for left aldosterone-producing adenoma in 2004 and partial right adrenalectomy for recurrent primary aldosteronism in 2018. Sanger sequencing revealed that both left and right adenomas carried the same aldosterone-driver KCNJ5 gene mutation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yuta Tezuka, Nanako Atsumi, Amy R. Blinder, Juilee Rege, Thomas J. Giordano, William E. Rainey, Adina F. Turcu
Summary: Unlike the ZG and ZR, the ZF and the total adrenal cortex areas enlarge with aging. An abrupt decline of the ZG occurs with age in men only, possibly contributing to sexual dimorphism in cardiovascular risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Fabrizio Buffolo, Jacopo Pieroni, Federico Ponzetto, Vittorio Forestiero, Denis Rossato, Paolo Fonio, Antonello Nonnato, Fabio Settanni, Paolo Mulatero, Giulio Mengozzi, Silvia Monticone
Summary: This study assessed the impact of asymmetrical cortisol secretion on the lateralization index during adrenal venous sampling, and the effectiveness of metanephrines as a normalization factor for aldosterone levels. The results showed that 18% of patients with primary aldosteronism had asymmetrical cortisol secretion, and the use of metanephrines as a normalization factor improved the accuracy of diagnosis compared to aldosterone to cortisol lateralization index.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Oncology
Jui-Hsiang Lin, Kang-Yung Peng, Yu-Ping Kuo, Hsuan Liu, Chin-Ming Bertrand Tan, Yuh-Feng Lin, Hui-Wen Chiu, Yen-Hung Lin, Yung-Ming Chen, Jeff S. Chueh, Vin-Cent Wu
Summary: This study found that one-third of patients with unilateral primary aldosteronism (uPA) also had autonomous cortisol secretion (ACS). The presence of multiple aldosterone-producing nodules/micronodules (mAPN/mAPM) in these patients was associated with larger tumor sizes and the interaction between them. Transcriptome analysis and bioinformatics revealed the significance of the HSD3B7/CYP11B1 signaling pathway in uPA adenomas with surrounding mAPN/mAPM. Furthermore, patients with concomitant mAPN/mAPM had lower rates of biochemical success after surgery.
ENDOCRINE-RELATED CANCER
(2022)
Review
Biochemistry & Molecular Biology
Kiyotaka Itcho, Kenji Oki, Haruya Ohno, Masayasu Yoneda
Summary: Primary aldosteronism (PA) is the most common form of secondary hypertension, with two main subtypes: aldosterone-producing adenoma (APA) and bilateral idiopathic hyperaldosteronism. Recent advancements in genetic analysis have led to the discovery of mutations in causative genes, contributing to a better understanding of the mechanism of excess aldosterone synthesis.
Article
Endocrinology & Metabolism
Tazuru Fukumoto, Hironobu Umakoshi, Masatoshi Ogata, Maki Yokomoto-Umakoshi, Yayoi Matsuda, Misato Motoya, Hiromi Nagata, Yui Nakano, Norifusa Iwahashi, Hiroki Kaneko, Norio Wada, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: This study aimed to explore the role of two confirmatory tests in the subtype diagnosis of primary aldosteronism (PA). The results showed that patients with discordant results between confirmatory tests are highly likely to have a bilateral subtype on adrenal vein sampling (AVS).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Adina F. Turcu, Richard Auchus
Summary: Recent studies have shown that primary aldosteronism (PA) has a higher prevalence among hypertensive patients than previously assumed, with the most common subtypes being aldosterone-producing adenomas (APAs) and bilateral hyperaldosteronism (BHA). Screening and distinguishing between different subtypes can be costly, and it is important to assess the likelihood of benefit from imaging and adrenal vein sampling before embarking on these studies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Peripheral Vascular Disease
Junhua Zhou, Brian Lam, Sudeshna G. Neogi, Giles S. H. Yeo, Elena A. B. Azizan, Morris J. Brown
Meeting Abstract
Peripheral Vascular Disease
J. Zhou, B. Y. H. Lam, S. G. Neogi, G. S. H. Yeo, A. E. D. Teo, C. Maniero, E. A. B. Azizan, M. J. Brown
JOURNAL OF HYPERTENSION
(2016)
Meeting Abstract
Peripheral Vascular Disease
C. Maniero, J. Zhou, E. Azizan, S. Neogi, G. Yeo, W. Zhao, M. J. Brown
JOURNAL OF HYPERTENSION
(2016)
Meeting Abstract
Peripheral Vascular Disease
Elena Azizan, Norlela Sukor, Nor Azmi Kamaruddin, A. Rahman A. Jamal, Jiri Ceral, Miroslav Solar, Isa Mohamed Rose, Geok Chin Tan
JOURNAL OF HYPERTENSION
(2016)
Article
Peripheral Vascular Disease
Geok Chin Tan, Giulia Negro, Alexandra Pinggera, Nur Maya Sabrina Tizen Laim, Isa Mohamed Rose, Jiri Ceral, Ales Ryska, Long Kha Chin, Nor Azmi Kamaruddin, Norfilza Mohd Mokhtar, A. Rahman A. Jamal, Norlela Sukor, Miroslav Solar, Joerg Striessnig, Morris Jonathan Brown, Elena Aisha Azizan
Review
Endocrinology & Metabolism
Afifah Binti Azam, Elena Aisha Binti Azizan
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2018)
Article
Endocrinology & Metabolism
Syahirah Kaja Mohideen, Muaatamarulain Mustangin, Nor Azmi Kamaruddin, Rohaizak Muhammad, A. Rahman A. Jamal, Norlela Sukor, Geok Chin Tan, Elena Aisha Azizan
FRONTIERS IN ENDOCRINOLOGY
(2019)
Review
Endocrinology & Metabolism
Fatin Athirah Pauzi, Elena Aisha Azizan
Summary: Primary aldosteronism is a common curable form of secondary hypertension, often caused by the overproduction of aldosterone in the adrenal glands. The detection of aldosterone synthase through immunohistochemistry can identify aldosterone-producing cell clusters, potentially contributing to hyperaldosteronism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Junhua Zhou, Elena A. B. Azizan, Claudia P. Cabrera, Fabio L. Fernandes-Rosa, Sheerazed Boulkroun, Giulia Argentesi, Emily Cottrell, Laurence Amar, Xilin Wu, Sam O'Toole, Emily Goodchild, Alison Marker, Russell Senanayake, Sumedha Garg, Tobias Akerstrom, Samuel Backman, Suzanne Jordan, Satyamaanasa Polubothu, Daniel M. Berney, Anna Gluck, Kate E. Lines, Rajesh V. Thakker, Antoinette Tuthill, Caroline Joyce, Juan Pablo Kaski, Fiona E. Karet Frankl, Lou A. Metherell, Ada E. D. Teo, Mark Gurnell, Laila Parvanta, William M. Drake, Eva Wozniak, David Klinzing, Jyn Ling Kuan, Zenia Tiang, Celso E. Gomez Sanchez, Per Hellman, Roger S. Y. Foo, Charles A. Mein, Veronica A. Kinsler, Peyman Bjorklund, Helen L. Storr, Maria-Christina Zennaro, Morris J. Brown
Summary: The study identified gain-of-function somatic mutations in GNA11 or GNAQ in CTNNB1-mutant aldosterone-producing adenomas. These mutations were often found in patients during puberty, pregnancy, or menopause, with elevated LHCGR expression. While most aldosterone-producing adenomas have gain-of-function somatic mutations, the presence of these mutations in aldosterone-producing cell clusters of normal adrenal glands indicates a necessity for codriver mutations in APAs.
Meeting Abstract
Peripheral Vascular Disease
Kha Chin Long, Norlela Sukor, Geok Chin Tan, Nor Azian Abdul Murad, Morris Jonathan Brown, Elena Aisha Azizan
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Siti Khadijah Syed Mohammed Nazri, Rozman Zakaria, Nor Azian Abdul Murad, Rohaizak Muhammad, Geok Chin Tan, Norlela Sukor, Elena Aisha Azizan
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Fatin Athirah Pauzi, Elena Aisha Azizan, Muaatamarulain Mustangin, Geok Chin Tan, Norlela Sukor, Ales Ryska, Jiri Ceral, Miroslav Solar, Azraai Bahari Nasruddin
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Nurfatin Syazreen Mohd Rizam, Muaatamarulain Mustangin, Geok Chin Tan, Norlela Sukor, Fatin Saparuddin, Fatin Athirah Pauzi, Siti Khadijah Syed Muhammad Nazri, Azraai Bahari Nasruddin, Elena Aisha Azizan
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Elena Aisha Azizan
JOURNAL OF HYPERTENSION
(2023)
Review
Endocrinology & Metabolism
Amalina Haydar Ali Tajuddin, Norazmi Kamaruddin, Norlela Sukor, Elena Aisha Azizan, Ahmad Marzuki Omar
Summary: This review summarizes the role of estrogen receptors in nonfunctioning pituitary neuroendocrine tumors, focusing on immunoexpression and gonadotroph cell proliferation and apoptosis. Estrogen predominantly acts through the ER alpha isoform in the pituitary and may contribute to nongenomic effects through GPER. ER alpha and ER beta have varying expression levels in different pituitary tumor subtypes, with implications for tumor invasiveness and potential therapeutic targets.
JOURNAL OF THE ENDOCRINE SOCIETY
(2021)