Higher-order structural interrogation of antibodies using middle-down hydrogen/deuterium exchange mass spectrometry

Pepsin-Containing Membranes for Controlled Monoclonal Antibody Digestion Prior to Mass Spectrometry Analysis

(2015) Yongle Pang et al.   ANALYTICAL CHEMISTRY

Structure of FcγRI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding

(2015) Jinghua Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Approach to Characterization of the Higher Order Structure of Disulfide-Containing Proteins Using Hydrogen/Deuterium Exchange and Top-Down Mass Spectrometry

(2014) Guanbo Wang et al.   ANALYTICAL CHEMISTRY

Middle-Down Analysis of Monoclonal Antibodies with Electron Transfer Dissociation Orbitrap Fourier Transform Mass Spectrometry

(2014) Luca Fornelli et al.   ANALYTICAL CHEMISTRY

Subzero Temperature Chromatography and Top-Down Mass Spectrometry for Protein Higher-Order Structure Characterization: Method Validation and Application to Therapeutic Antibodies

(2014) Jingxi Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Investigating the Interaction between the Neonatal Fc Receptor and Monoclonal Antibody Variants by Hydrogen/Deuterium Exchange Mass Spectrometry

(2014) Pernille Foged Jensen et al.   MOLECULAR & CELLULAR PROTEOMICS

The effect of sugar removal on the structure of the Fc region of an IgG antibody as observed with single molecule Förster Resonance Energy Transfer

(2014) Michael T. Kelliher et al.   MOLECULAR IMMUNOLOGY

Top-down mass spectrometry and hydrogen/deuterium exchange for comprehensive structural characterization of interferons: Implications for biosimilars

(2014) Jingxi Pan et al.   PROTEOMICS

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

(2014) J. B. Munro et al.   SCIENCE

Emerging Principles for the Therapeutic Exploitation of Glycosylation

(2014) Martin Dalziel et al.   SCIENCE

Mass Spectrometry Methods for Studying Structure and Dynamics of Biological Macromolecules

(2013) Lars Konermann et al.   ANALYTICAL CHEMISTRY

Top-Down Structural Analysis of an Intact Monoclonal Antibody by Electron Capture Dissociation-Fourier Transform Ion Cyclotron Resonance-Mass Spectrometry

(2013) Yuan Mao et al.   ANALYTICAL CHEMISTRY

Conformer-specific characterization of nonnative protein states using hydrogen exchange and top-down mass spectrometry

(2013) G. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein hydrogen exchange at residue resolution by proteolytic fragmentation mass spectrometry analysis

(2013) Z.-Y. Kan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the Role of Glycosylation in the Structure of Human IgG Fc

(2012) M. Jack Borrok et al.   ACS Chemical Biology

Spatially Resolved Protein Hydrogen Exchange Measured by Subzero-Cooled Chip-Based Nanoelectrospray Ionization Tandem Mass Spectrometry

(2012) Sabine Amon et al.   ANALYTICAL CHEMISTRY

Biosimilar, Biobetter, and Next Generation Antibody Characterization by Mass Spectrometry

(2012) Alain Beck et al.   ANALYTICAL CHEMISTRY

Nepenthesin from Monkey Cups for Hydrogen/Deuterium Exchange Mass Spectrometry

(2012) Martial Rey et al.   MOLECULAR & CELLULAR PROTEOMICS

A protease for 'middle-down' proteomics

(2012) Cong Wu et al.   NATURE METHODS

Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars

(2012) Steven A. Berkowitz et al.   NATURE REVIEWS DRUG DISCOVERY

Structural Analysis of Intact Monoclonal Antibodies by Electron Transfer Dissociation Mass Spectrometry

(2011) Yury O. Tsybin et al.   ANALYTICAL CHEMISTRY

Epitope Mapping of a 95 kDa Antigen in Complex with Antibody by Solution-Phase Amide Backbone Hydrogen/Deuterium Exchange Monitored by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

(2011) Qian Zhang et al.   ANALYTICAL CHEMISTRY

Dynamics of the β2-Adrenergic G-Protein Coupled Receptor Revealed by Hydrogen−Deuterium Exchange

(2010) Xi Zhang et al.   ANALYTICAL CHEMISTRY

Hydrogen exchange mass spectrometry for studying protein structure and dynamics

(2010) Lars Konermann et al.   CHEMICAL SOCIETY REVIEWS

Post-translational Modifications Differentially Affect IgG1 Conformation and Receptor Binding

(2010) Damian Houde et al.   MOLECULAR & CELLULAR PROTEOMICS

H/D Exchange and Mass Spectrometry in the Studies of Protein Conformation and Dynamics: Is There a Need for a Top-Down Approach?

(2009) Igor A. Kaltashov et al.   ANALYTICAL CHEMISTRY

Protein Hydrogen Exchange Measured at Single-Residue Resolution by Electron Transfer Dissociation Mass Spectrometry

(2009) Kasper D. Rand et al.   ANALYTICAL CHEMISTRY

Hydrogen/Deuterium Exchange Mass Spectrometry with Top-Down Electron Capture Dissociation for Characterizing Structural Transitions of a 17 kDa Protein

(2009) Jingxi Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electron Transfer Dissociation Facilitates the Measurement of Deuterium Incorporation into Selectively Labeled Peptides with Single Residue Resolution

(2008) Martin Zehl et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electron Capture Dissociation of Electrosprayed Protein Ions for Spatially Resolved Hydrogen Exchange Measurements

(2008) Jingxi Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY