Article
Chemistry, Multidisciplinary
Jiang He, Zhijie Wu, Qingqing Gu, Yuanshuai Liu, Shengqi Chu, Shaohua Chen, Yafeng Zhang, Bing Yang, Tiehong Chen, Aiqin Wang, Bert M. Weckhuysen, Tao Zhang, Wenhao Luo
Summary: By confining ultra-small Ru metal nanoclusters within the micropores of zeolite Y, the chemical selectivity towards the production of pentanoic biofuels can be significantly enhanced, leading to potential applications in the biomass conversion process. The addition of La element can maintain the activity site intimacy and prevent zeolite lattice deconstruction, thus improving catalyst stability during the HDO process.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Hwi Yul Jo, Jeong Min Lee, Ewa Pietrasiak, Eunsung Lee, Young Ho Rhee, Jaiwook Park
Summary: A new method for synthesizing N-H imines efficiently has been developed, with high yields of the products. Furthermore, the N-H imines can react with specific amines to form stable compounds.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Min Cao, Hongliang Wang, Yingang Ma, Chen-Ho Tung, Lei Liu
Summary: A manganese-catalyzed C-H azidation reaction with high site- and enantioselectivity has been developed. This practical method enables the azidation of tertiary benzylic C-H bonds with good functional group tolerance, leading to the efficient synthesis of diverse tertiary azide-containing indolines. The generality of the method was demonstrated by applying it to secondary azide-containing indolines. The method allows for the installation of various nitrogen-based functional groups and bioactive molecules with excellent site-, chemo-, and enantioselectivity at the C3 position of indoline frameworks.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Ke Yang, Zhi Li, Chong Liu, Yunjian Li, Qingyue Hu, Mazen Elsaid, Bijin Li, Jayabrata Das, Yanfeng Dang, Debabrata Maiti, Haibo Ge
Summary: The transient directing group strategy enables direct β-C(sp(3))-H functionalization of unmasked aliphatic aldehydes. In this study, a direct Pd-catalyzed methylene β-C-H arylation reaction was developed using 3-amino-3-methylbutanoic acid as a transient directing group and 2-pyridone as an external ligand.
Article
Chemistry, Organic
Dan Li, Li Wei, Wenfang Xiong, Huanfeng Jiang, Chaorong Qi
Summary: A palladium-catalyzed reductive formylation of aryl iodides with carbon dioxide as the carbonyl source was achieved using Pd(PCy3)2Cl2 and di-2-pyridyl ketone as the catalyst and phenylsilane as the reductive reagent under mild reaction conditions. The reaction provided a variety of aromatic aldehydes in moderate to excellent yields and exhibited good substrate scope, functional group tolerance, and easy operation.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xiang Li, Xintuo Yang, Pinhong Chen, Guosheng Liu
Summary: In this study, a remote hydro-oxygenation method of alkenes under palladium catalysis is reported, which efficiently yields linear alcohols from both terminal and internal alkenes. The use of a compatible SelectFluor/silane redox system plays a crucial role in achieving excellent chemo- and regioselectivities. The reaction exhibits a broad substrate scope and excellent functional group compatibility.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Xiaoyi Zhu, Ruibo Li, Hequan Yao, Aijun Lin
Summary: The palladium-catalyzed allenamide carbopalladation/allylation reaction with active methine compounds resulted in the formation of indoles and isoquinolinones bearing a quaternary carbon center. This reaction demonstrated good efficiency, a broad substrate scope, and good functional group tolerance by forming two new C-C bonds in one pot.
Article
Chemistry, Organic
Yinlong He, Bing Sun, Xuelian Lu, Yirong Zhou, Fang -Lin Zhang
Summary: Direct C-H amidation of alpha-ketoesters was achieved using organic azides as amino sources through transient directing group strategy and iridium catalysis. The reaction displayed excellent tolerance towards various functional groups and wide substrate scope under simple and mild conditions. The steric hindrance of the ester moiety was found to be crucial for the reaction efficacy. Moreover, gram-scale reaction and construction of useful heterocycles via one-step late-stage derivatization were demonstrated.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Milan Kumar Bisai, Kritika Gour, Tamal Das, Kumar Vanka, Sakya S. Sen
Summary: A selective and efficient method for the deoxygenative reduction of primary to tertiary amides to corresponding amines using pinacolborane (HBpin) and 2,6-di-tert-butyl phenolate lithium center dot THF (1a) as a catalyst has been achieved. Both experimental and DFT studies provide mechanistic insight into the process.
DALTON TRANSACTIONS
(2021)
Article
Multidisciplinary Sciences
Qing-Nan Wang, Xianghui Liu, Kai Wang, Yan Liu, Sheng-Mei Lu, Can Li
Summary: A green and direct method for selective synthesis of p-MBA from acetaldehyde using a specific catalyst was reported in this study, achieving a high acetaldehyde conversion rate of up to 99.8% and p-MBA selectivity of over 90%. Experimental results revealed the conversion mechanism and catalytic process involved.
Article
Multidisciplinary Sciences
Jonathan Yaacov Weinstein, Carlos Marti-Gomez, Rosalie Lipsh-Sokolik, Shlomo Yakir Hoch, Demian Liebermann, Reinat Nevo, Haim Weissman, Ekaterina Petrovich-Kopitman, David Margulies, Dmitry Ivankov, David M. McCandlish, Sarel J. Fleishman
Summary: Mutations in a protein's active site can lead to dramatic and useful changes in protein activity. However, due to a high density of molecular interactions, the active site is sensitive to mutations, making it difficult to obtain functional multipoint mutants. A new approach called high-throughput Functional Libraries (htFuncLib) has been introduced to design a sequence space where mutations can form low-energy combinations, reducing the risk of incompatible interactions. This approach has been successfully applied to GFP, resulting in the discovery of thousands of unique designs with improved functional properties.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Eliezer Ortiz, Yu-Hsiang Chang, Jonathan Z. Shezaf, Weijia Shen, Michael J. Krische
Summary: The first enantioselective ruthenium-catalyzed carbonylvinylations via hydrogen autotransfer are described. The study shows that primary alcohols and alkynes react to form chiral allylic alcohols with excellent levels of absolute stereocontrol. In addition, it is discovered that 1,2-diols can participate in site-selective C-C coupling, which allows for asymmetric carbonyl vinylation without premetalated reagents, exogenous reductants, or hydroxyl protecting groups.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Luxia Guo, Jiaqi Li, Luigi Vaccaro, Minghao Li, Yanlong Gu
Summary: A direct synthesis method catalyzed by kalinite has been developed for the efficient preparation of N-substituted 3-carbonylpyrroles, with potential applications in biological and material fields.
Article
Chemistry, Organic
Peng Wu, Joachim Demaerel, Deshen Kong, Ding Ma, Carsten Bolm
Summary: NH-Sulfonimidamides are prepared by copper-catalyzed coupling of primary sulfinamides with secondary amines without the need for a ligand or additive. Air is used as the terminal oxidant. The reactions take place at room temperature, exhibit good functional group tolerance, and result in high product yields. A sulfanenitrile is proposed as an intermediate in this oxidative amination reaction.
Article
Chemistry, Organic
Qiao-Lin Wang, Quan Zhou, Jia Liao, Zan Chen, Bi-Quan Xiong, Guo-Jun Deng, Ke-Wen Tang, Yu Liu
Summary: A novel and mild Cu-catalyzed dual arylation method is proposed for the synthesis of cyanoarylated oxindoles, involving the arylating of acrylamides with 3-aminoindazoles. Utilizing a radical process, this method includes 3-aminoindazole oxidation, two-C-N-bond cleavage, cyanoaryl radical addition, and intramolecular cyclization.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Viktoria Steck, Gopeekrishnan Sreenilayam, Rudi Fasan
Article
Oncology
Pierre-Antoine Bissey, Pauline Mathot, Catherine Guix, Melissa Jasmin, Isabelle Goddard, Clelia Costechareyre, Nicolas Gadot, Jean-Guy Delcros, Sachitanand M. Mali, Rudi Fasan, Andre-Patrick Arrigo, Robert Dante, Gabriel Ichim, Patrick Mehlen, Joanna Fombonne
Article
Chemistry, Physical
Xinkun Ren, Ajay L. Chandgude, Rudi Fasan
Article
Chemistry, Multidisciplinary
Andrew E. Owens, Jacob A. Iannuzzelli, Yu Gu, Rudi Fasan
ACS CENTRAL SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Maria Agustina Vila, Viktoria Steck, Sonia Rodriguez Giordano, Ignacio Carrera, Rudi Fasan
Article
Chemistry, Multidisciplinary
Viktoria Steck, Joshua N. Kolev, Xinkun Ren, Rudi Fasan
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Biochemistry & Molecular Biology
Alfons J. Pineda-Knauseder, David A. Vargas, Rudi Fasan
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Sai Shashank Chavali, Sachitanand M. Mali, Jermaine L. Jenkins, Rudi Fasan, Joseph E. Wedekind
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Chemistry, Organic
Anirban Mukherjee, Arshad J. Ansari, S. Rajagopala Reddy, Gourab Kanti Das, Ritesh Singh
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Medicinal
Muthuraj Prakash, Yukihiro Itoh, Yoshie Fujiwara, Yukari Takahashi, Yuri Takada, Paolo Mellini, Elghareeb E. Elboray, Mitsuhiro Terao, Yasunobu Yamashita, Chika Yamamoto, Takao Yamaguchi, Masayuki Kotoku, Yuki Kitao, Ritesh Singh, Rohini Roy, Satoshi Obika, Makoto Oba, Dan Ohtan Wang, Takayoshi Suzuki
Summary: This study aimed to design novel FTO-selective inhibitors by merging fragments of previously reported FTO inhibitors, resulting in compound 11b selectively inhibiting FTO. Treatment with a prodrug of 11b decreased the viability of acute monocytic leukemia cells, altered the level of the FTO substrate N-6-methyladenosine in mRNA, and induced changes in expression of FTO target genes MYC and RARA.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Anirban Mukherjee, Ritesh Singh, Kishor D. Mane, Gourab Kanti Das
Summary: Pure quantum mechanical calculations were used to determine the regioselectivity under metalloradical catalysis by Co(II)-porphyrin. The study found that regioselectivity is inherent to the aminyl radical generated from the sulfamoyl azide substrate. Different conformations for the transition state were analyzed to find the most stable conformation for preferable selectivity, in agreement with experimental results.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Ritesh Singh, Elagandhula Sathish, Ashis K. Gupta, Sophiya Goyal
Summary: Direct C-H bond amination is an emerging area of research in synthetic chemistry, with the use of 3d transition metals as catalytic promoters for C-H to C-N bond formation. The update showcases recent developments, outlines the scope and limitations of the methods developed, and highlights the focus areas for future research.
Review
Chemistry, Organic
Deeksha, Ritesh Singh
Summary: Aza-oxyallyl cations have diverse reactivity profiles for constructing N-scaffolds of biological interest and recent studies have reported new variations in their reactivity, making them versatile tools for organic synthesis.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Arshad J. Ansari, Ayushi Yadav, Anirban Mukherjee, Elagandhula Sathish, Kommu Nagesh, Ritesh Singh
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Jacob A. Iannuzzelli, Rudi Fasan
Article
Chemistry, Multidisciplinary
Alexander M. Prophet, Kritanjan Polley, Gary J. Van Berkel, David T. Limmer, Kevin R. Wilson
Summary: The oxidation kinetics of iodide by ozone at the air-water interface is studied in single microdroplets. Molecular simulations and kinetic modeling are used to understand the underlying multiphase mechanism.
Article
Chemistry, Multidisciplinary
Rong Zhang, Jiajing Lan, Fei Wang, Shumei Chen, Jian Zhang
Summary: By utilizing 1,1'-ferrocene dicarboxylic acid as a chelating and surface protection ligand, we have synthesized multi-nuclear indium oxide clusters with varying nuclear sizes, including heptanuclear and thirteen-nuclear clusters. These clusters possess labile coordination sites, allowing for structural modification and self-assembly, resulting in the formation of various cluster structures.
Article
Chemistry, Multidisciplinary
Hui Wang, Hui Liu, Mingsen Wang, Jiaheng Hou, Yongjun Li, Yuancheng Wang, Yingjie Zhao
Summary: Two supramolecular complexes were prepared using CBs and M1, and their single-crystal structures were analyzed by SCXRD. The unexpected 1:2 self-assembly structure between M1 and CB[8] was discovered for the first time. These complexes exhibit unique photophysical properties and provide valuable information about the structure and photophysical properties of supramolecular complexes.
Article
Chemistry, Multidisciplinary
Chang-Hee Lee, Sookil Park, Sanggil Kim, Ji Young Hyun, Hyun Soo Lee, Injae Shin
Summary: The epidermal growth factor receptor (EGFR) is a cell-surface glycoprotein involved in cell proliferation and tumor development. This study used a fluorescently labeled EGFR to investigate its time-dependent endocytosis in live cells and found that appended glycans affect EGFR internalization. Additionally, the study detected sialic acid residues attached to EGFR on the live cell surface using FRET-based imaging. This research provides valuable insights into the cellular functions of EGFR.
Article
Chemistry, Multidisciplinary
Subhankar Sahu, Lokesh Kumar, Sumita Das, Dipti Gupta, Ruchi Anand
Summary: This study proposes a strategy that combines organic electronics with biosensor scaffolds to create a compact device for monitoring environmental aromatic pollution. By coupling biosensing protein MopR with an organic electrochemical transistor (OECT), a sensor module capable of efficient detection of phenol was designed. Exclusive phenol detection with minimal loss of sensitivity could be achieved in complex pollutant mixtures and real environmental samples.
Review
Chemistry, Multidisciplinary
Changseok Lee, Hyung-Joon Kang, Sungwoo Hong
Summary: The formation of C-N bonds through hydroamination reactions catalyzed by nickel hydrides has been a topic of recent interest. This approach offers a way to efficiently transform a variety of alkene and alkyne substrates into compounds enriched with C-N bonds. The review provides a concise overview of the underlying reaction mechanisms and aims to stimulate further progress in NiH-catalytic techniques and catalyst design.
Article
Chemistry, Multidisciplinary
Yueci Wu, Lu-Lu Sun, Hai-Hao Han, Xiao-Peng He, Weiguo Cao, Tony D. James
Summary: Drug-induced liver injury (DILI) is a common cause of acute liver failure in the USA and Europe, but most cases can be recovered or prevented by discontinuing the offending drug. Recent research has found that peroxynitrite (ONOO-) can be used as a potential indicator for early diagnosis of DILI, and there is an urgent need to establish a method to detect and track peroxynitrite in DILI cases. In this study, a FRET-based nano fluorescent probe CD-N-I was developed, which showed high selectivity and sensitivity in detecting peroxynitrite. The probe successfully detected exogenous peroxynitrite in live cells and endogenous peroxynitrite in APAP-induced liver injury of HepG2 cells.
Article
Chemistry, Multidisciplinary
Dmitry L. Lipilin, Mikhail O. Zubkov, Mikhail D. Kosobokov, Alexander D. Dilman
Summary: This article describes a direct photocatalytic method for the thiolation of unprotected acids, which was previously challenging. By using a thionocarbonate reagent with an N-O bond, the efficient conversion of carboxylic acids to thiols is achieved.
Article
Chemistry, Multidisciplinary
Jason Malenfant, Lucille Kuster, Yohann Gagne, Kouassi Signo, Maxime Denis, Sylvain Canesi, Mathieu Frenette
Summary: Raman microscopy can reveal compound-specific vibrational fingerprints without sample preparation. The combination of efficient theoretical calculations and a user-friendly software can accurately predict peak positions and provide match scores to assist with structure determination.
Article
Chemistry, Multidisciplinary
Jayoh A. Hernandez, Paul S. Micus, Sean Alec Lois Sunga, Luca Mazzei, Stefano Ciurli, Gabriele Meloni
Summary: Essential trace metals play crucial roles in the survival and virulence of bacterial pathogens. Helicobacter pylori requires nickel for colonization and persistence in the stomach, and NixA is an essential nickel transporter in this process. This study characterizes the selectivity and electrogenic nature of NixA-mediated nickel transport.
Article
Chemistry, Multidisciplinary
Tarali Devi, Kuheli Dutta, Jennifer Deutscher, Stefan Mebs, Uwe Kuhlmann, Michael Haumann, Beatrice Cula, Holger Dau, Peter Hildebrandt, Kallol Ray
Summary: This study emphasizes the importance of subtle electronic changes and secondary interactions in the stability of biologically relevant metal-dioxygen intermediates. It also shows that the role of the chloride ligand in stabilizing the Fe-III-(OOBu)-Bu-t moiety can extend to other anions, including the thiolate ligand.
Article
Chemistry, Multidisciplinary
Jacqueline R. Santhouse, Jeremy M. G. Leung, Lillian T. Chong, W. Seth Horne
Summary: By studying the folding kinetics and mechanism of the BdpA sequence, researchers found that altering the backbone connectivity can affect protein folding. This suggests that protein mimetic chains have a significant degree of plasticity in transitioning between unfolded and folded states.
Article
Chemistry, Multidisciplinary
Divanshu Gupta, Ralf Einholz, Holger F. Bettinger
Summary: This study presents the first direct spectroscopic evidence of a cyclic seven-membered iminoborane. Compared to linear amino-iminoboranes, this cyclic iminoborane exhibits weakened bond strength and lower Lewis acidity value. The study suggests that the reduced ring strain of cyclic iminoborane prevents nitrogen fixation but allows facile (2 + 2) cycloaddition reaction with C2H4.
Article
Chemistry, Multidisciplinary
Renny Mathew, Aniruddha Mazumder, Praveen Kumar, Julie Matula, Sharmarke Mohamed, Petr Brazda, Mahesh Hariharan, Brijith Thomas
Summary: This study reveals the packing arrangement of partially disordered nitro-perylenediimide (NO2-PDI) using a synergistic approach that combines 3D ED, ssNMR, and DFT techniques. By overcoming these challenges, this methodology opens up new avenues for material characterization, driving exciting advancements in the field.